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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046948
UUCD1 version UUC-HoS-01203
Ensembl Protein ID ENSP00000356982.5
UniProt Accession Q9Y3C8; A8K9R1; D3DVF9; Q549X0; Q5VTX1; Q9BS96; Q9P009; UFC1_HUMAN
Genbank Protein ID BAD15374.1; AAD34121.1; AAF29119.1; BAF85465.1; CAH72141.1; EAW52646.1; EAW52647.1; AAH05187.1
Protein Name Ubiquitin-fold modifier-conjugating enzyme 1
Genbank Nucleotide ID AB154405; AF151884; AF161504; AK292776; AL590714; CH471121; CH471121; BC005187
Gene Name UFC1; CGI-126; HSPC155
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000143222.11 ENST00000368003.5 ENSP00000356982.5
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPHOSIDABioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E2/Other E2/Other 17825256; 19101823; 20018847; 21264253
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage.
 E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage.
Protein Sequence
(Fasta)
MADEATRRVV SEIPVLKTNA GPRDRELWVQ RLKEEYQSLI RYVENNKNAD NDWFRLESNK 60
EGTRWFGKCW YIHDLLKYEF DIEFDIPITY PTTAPEIAVP ELDGKTAKMY RGGKICLTDH 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046948|E2,E2/Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGCGGTGGCT CACGCCTGTA ATCCCAGCAC CTTGGGAGGC TGAGGCAGGT GGATCACCTG 60
AGGTCAGGAG TTCAAGACCA ACCTGGCCAA CATGGCGAAA CCCGGTCTCT ACTAAAAATA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046948|E2,E2/Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR016135--UBQ-conjugating_enzyme/RWD
IPR014806--Ufc1
Pfam

PF08694--UFC1
Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0071568--F:UFM1 transferase activity
GO:1990592--P:protein K69-linked ufmylation
GO:0071569--P:protein ufmylation
GO:0034976--P:response to endoplasmic reticulum stress
KEGG hsa:51506
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000219 Aegilops tauschii 68.35 2.00e-30 124.00
IUUC-Aml-001773 Ailuropoda melanoleuca 97.60 2.00e-96 343.00
IUUC-Atr-002519 Amborella trichopoda 65.84 1.00e-67 248.00
IUUC-Aca-004597 Anolis carolinensis 89.02 5.00e-88 316.00
IUUC-Aly-005549 Arabidopsis lyrata 66.67 5.00e-66 243.00
IUUC-Ath-007416 Arabidopsis thaliana 66.67 5.00e-66 243.00
IUUC-Ame-011281 Astyanax mexicanus 87.35 4.00e-87 313.00
IUUC-Bta-012940 Bos taurus 99.40 1.00e-97 348.00
IUUC-Bdi-014987 Brachypodium distachyon 62.96 5.00e-62 229.00
IUUC-Bol-016532 Brassica oleracea 66.05 5.00e-66 243.00
IUUC-Bra-017971 Brassica rapa 66.05 3.00e-66 243.00
IUUC-Cel-018620 Caenorhabditis elegans 71.88 7.00e-72 262.00
IUUC-Cja-019762 Callithrix jacchus 100.00 2.00e-97 347.00
IUUC-Cfa-021172 Canis familiaris 98.80 2.00e-97 347.00
IUUC-Cpo-021575 Cavia porcellus 99.40 2.00e-97 347.00
IUUC-Cre-022894 Chlamydomonas reinhardtii 60.62 3.00e-60 224.00
IUUC-Csa-024240 Chlorocebus sabaeus 95.81 1.00e-93 335.00
IUUC-Cho-024457 Choloepus hoffmanni 100.00 4.00e-29 120.00
IUUC-Cin-025708 Ciona intestinalis 77.44 7.00e-77 279.00
IUUC-Csv-026307 Ciona savignyi 78.05 3.00e-77 280.00
IUUC-Cgl-026671 Colletotrichum gloeosporioides 24.47 3.10e-02 32.30
IUUC-Dre-027752 Danio rerio 87.80 7.00e-88 315.00
IUUC-Dno-028957 Dasypus novemcinctus 97.90 2.00e-82 297.00
IUUC-Dor-030637 Dipodomys ordii 99.40 1.00e-97 348.00
IUUC-Dme-032033 Drosophila melanogaster 79.27 3.00e-81 293.00
IUUC-Ete-033056 Echinops telfairi 97.01 1.00e-95 341.00
IUUC-Eca-034260 Equus caballus 100.00 5.00e-98 349.00
IUUC-Eeu-034785 Erinaceus europaeus 60.00 1.00e-19 87.80
IUUC-Fca-035879 Felis catus 99.40 4.00e-96 343.00
IUUC-Gmo-039023 Gadus morhua 82.82 6.00e-85 306.00
IUUC-Gga-040475 Gallus gallus 84.03 3.00e-73 266.00
IUUC-Gac-041574 Gasterosteus aculeatus 78.66 7.00e-79 285.00
IUUC-Gma-043338 Glycine max 63.58 2.00e-65 241.00
IUUC-Ggo-044713 Gorilla gorilla 98.43 3.00e-73 266.00
IUUC-Hvu-047147 Hordeum vulgare 63.35 1.00e-61 228.00
IUUC-Itr-048742 Ictidomys tridecemlineatus 100.00 5.00e-98 349.00
IUUC-Lch-049654 Latimeria chalumnae 87.43 7.00e-89 319.00
IUUC-Lpe-051422 Leersia perrieri 63.35 4.00e-62 230.00
IUUC-Loc-051920 Lepisosteus oculatus 89.63 2.00e-89 321.00
IUUC-Laf-054338 Loxodonta africana 100.00 5.00e-98 349.00
IUUC-Mcc-054927 Macaca mulatta 100.00 5.00e-98 349.00
IUUC-Meu-056831 Macropus eugenii 96.34 3.00e-93 333.00
IUUC-Mtr-058091 Medicago truncatula 64.20 6.00e-65 239.00
IUUC-Mga-059933 Meleagris gallopavo 75.76 1.00e-44 170.00
IUUC-Mmr-061433 Microcebus murinus 98.80 2.00e-97 347.00
IUUC-Mdo-061994 Monodelphis domestica 95.73 1.00e-92 331.00
IUUC-Mmu-063398 Mus musculus 97.01 3.00e-96 343.00
IUUC-Mac-064536 Musa acuminata 62.35 3.00e-63 234.00
IUUC-Mpu-066795 Mustela putorius furo 99.40 1.00e-97 348.00
IUUC-Mlu-067983 Myotis lucifugus 97.60 9.00e-96 342.00
IUUC-Nle-069720 Nomascus leucogenys 100.00 5.00e-63 231.00
IUUC-Opr-070723 Ochotona princeps 99.40 1.00e-97 348.00
IUUC-Ont-071509 Oreochromis niloticus 80.49 1.00e-80 291.00
IUUC-Oan-073541 Ornithorhynchus anatinus 89.36 7.00e-23 98.20
IUUC-Ocu-074044 Oryctolagus cuniculus 100.00 9.00e-96 342.00
IUUC-Oba-075612 Oryza barthii 62.96 4.00e-62 230.00
IUUC-Obr-076432 Oryza brachyantha 62.96 4.00e-62 230.00
IUUC-Ogl-077071 Oryza glaberrima 62.96 4.00e-62 230.00
IUUC-Ogu-078427 Oryza glumaepatula 62.96 4.00e-62 230.00
IUUC-Oin-079963 Oryza indica 62.96 4.00e-62 230.00
IUUC-Olo-080455 Oryza longistaminata 62.96 4.00e-62 230.00
IUUC-Oni-082562 Oryza nivara 62.96 4.00e-62 230.00
IUUC-Opu-083688 Oryza punctata 62.73 1.00e-61 229.00
IUUC-Oru-084472 Oryza rufipogon 62.96 4.00e-62 230.00
IUUC-Osa-085623 Oryza sativa 62.96 4.00e-62 230.00
IUUC-Oga-088366 Otolemur garnettii 100.00 5.00e-98 349.00
IUUC-Oar-089754 Ovis aries 98.80 4.00e-97 346.00
IUUC-Ptr-090679 Pan troglodytes 99.40 9.00e-98 348.00
IUUC-Psi-093472 Pelodiscus sinensis 92.74 4.00e-68 249.00
IUUC-Ppa-095568 Physcomitrella patens 67.90 5.00e-68 249.00
IUUC-Pfo-097314 Poecilia formosa 79.88 8.00e-80 288.00
IUUC-Pab-098562 Pongo abelii 99.40 1.00e-97 348.00
IUUC-Pop-099506 Populus trichocarpa 64.20 3.00e-65 241.00
IUUC-Pca-101030 Procavia capensis 89.76 3.00e-85 306.00
IUUC-Ppe-101757 Prunus persica 64.81 1.00e-65 241.00
IUUC-Pva-102948 Pteropus vampyrus 98.80 3.00e-97 347.00
IUUC-Rno-105014 Rattus norvegicus 98.20 4.00e-97 346.00
IUUC-Sha-107297 Sarcophilus harrisii 95.21 2.00e-94 337.00
IUUC-Sit-110317 Setaria italica 62.35 3.00e-61 227.00
IUUC-Sly-111332 Solanum lycopersicum 64.81 4.00e-65 240.00
IUUC-Stu-112719 Solanum tuberosum 64.81 4.00e-65 240.00
IUUC-Sbi-114869 Sorghum bicolor 62.35 2.00e-61 228.00
IUUC-Ssc-116009 Sus scrofa 100.00 5.00e-98 349.00
IUUC-Tru-117527 Takifugu rubripes 82.32 6.00e-82 296.00
IUUC-Tsy-119195 Tarsius syrichta 95.04 1.00e-76 277.00
IUUC-Tni-120417 Tetraodon nigroviridis 80.49 8.00e-81 292.00
IUUC-Tca-120972 Theobroma cacao 66.05 6.00e-66 243.00
IUUC-Tae-124763 Triticum aestivum 63.35 2.00e-61 228.00
IUUC-Tur-126831 Triticum urartu 63.35 1.00e-61 228.00
IUUC-Tbe-128019 Tupaia belangeri 100.00 4.00e-82 296.00
IUUC-Ttr-129013 Tursiops truncatus 99.40 1.00e-97 348.00
IUUC-Vvi-131214 Vitis vinifera 64.81 1.00e-64 238.00
IUUC-Xtr-132182 Xenopus tropicalis 88.41 2.00e-88 317.00
IUUC-Xma-133877 Xiphophorus maculatus 79.88 1.00e-79 288.00
Created Date 25-Jun-2017

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