iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
WBGene00002207	B0302.1a.1	B0302.1a.1
WBGene00002207	B0302.1b.1	B0302.1b.1
WBGene00002207	B0302.1c	B0302.1c

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Post-translational Modifications (PTMs)
dbPAF	dbPTM	Phospho.ELM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UBA	36.48	2.00e-88	325.00	IUUC-Mmu-063861

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Caenorhabditis elegans

Functional Description
(View)

Tyrosine-protein kinase which plays a role in RNA-mediated gene silencing by mediating import of double-stranded RNA (dsRNA) into cells. Not required for import of ingested dsRNA into intestinal cells but involved in subsequent export from intestinal cells to internal tissues.

Protein Sequence
(Fasta)

MASTSGALVD DNVLEVLRKA QLDAFISQFV FLFNVRRFDH FSHVRDKDML EIGMQQVQIR 60
QLREQILKMS REMWNRSDPK QVYIQADQSM PAQNSIDEKA LIPNEQIKLY ELIGEGSFAV 120

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Nucleotide Sequence
(Fasta)

ATTGTCAGAT ATTTGAATAA TGTACCCTCC AGTTGACAAT TTTCAATTCA ATACAAAAGT 60
TCCACTTTTT CATTAAGTTT CTGATATTTT TGTAGCATTT TCTTTTATTT CTGAGAGTAT 120

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Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0943--RNA-mediated gene silencing
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR015116--Cdc42_binding_dom-like
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR011511--SH3_2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR

Pfam

PF09027--GTPase_binding
PF07714--Pkinase_Tyr
PF07653--SH3_2

PRINTS

PR00109--TYRKINASE

SMART

SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0016246--P:RNA interference
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

cel:CELE_B0302.1

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002166	Ailuropoda melanoleuca	37.04	7.00e-81	294.00
IUUC-Ame-011350	Astyanax mexicanus	36.43	1.00e-87	317.00
IUUC-Bta-012325	Bos taurus	37.23	3.00e-88	318.00
IUUC-Cja-019545	Callithrix jacchus	35.70	4.00e-77	281.00
IUUC-Cfa-020706	Canis familiaris	37.04	1.00e-87	317.00
IUUC-Cpo-022032	Cavia porcellus	37.31	4.00e-88	318.00
IUUC-Csa-023936	Chlorocebus sabaeus	37.82	4.00e-88	318.00
IUUC-Csv-026328	Ciona savignyi	35.05	6.00e-80	290.00
IUUC-Dre-028714	Danio rerio	38.11	5.00e-92	331.00
IUUC-Dno-029525	Dasypus novemcinctus	37.82	4.00e-89	321.00
IUUC-Dme-031778	Drosophila melanogaster	37.56	1.00e-79	290.00
IUUC-Ete-032225	Echinops telfairi	39.57	2.00e-79	290.00
IUUC-Fca-035664	Felis catus	37.43	1.00e-88	320.00
IUUC-Gmo-039543	Gadus morhua	35.35	3.00e-79	288.00
IUUC-Gga-040241	Gallus gallus	39.16	2.00e-92	333.00
IUUC-Gac-041457	Gasterosteus aculeatus	35.85	3.00e-86	312.00
IUUC-Ggo-045333	Gorilla gorilla	37.82	7.00e-88	317.00
IUUC-Hsa-046670	Homo sapiens	37.82	6.00e-88	317.00
IUUC-Itr-048054	Ictidomys tridecemlineatus	37.62	3.00e-88	318.00
IUUC-Lch-049670	Latimeria chalumnae	41.77	1.00e-82	300.00
IUUC-Loc-052870	Lepisosteus oculatus	38.07	2.00e-92	332.00
IUUC-Laf-053782	Loxodonta africana	36.12	5.00e-81	295.00
IUUC-Mcc-055874	Macaca mulatta	37.82	4.00e-88	318.00
IUUC-Mga-059717	Meleagris gallopavo	38.39	7.00e-94	337.00
IUUC-Mdo-062270	Monodelphis domestica	37.70	7.00e-89	320.00
IUUC-Mmu-063861	Mus musculus	37.23	1.00e-88	320.00
IUUC-Mpu-066127	Mustela putorius furo	37.11	8.00e-82	297.00
IUUC-Mlu-067937	Myotis lucifugus	37.43	6.00e-89	321.00
IUUC-Nle-069298	Nomascus leucogenys	41.28	1.00e-75	276.00
IUUC-Ont-072437	Oreochromis niloticus	36.72	1.00e-88	320.00
IUUC-Ola-087023	Oryzias latipes	37.02	2.00e-87	316.00
IUUC-Psi-093401	Pelodiscus sinensis	34.54	1.00e-74	273.00
IUUC-Pfo-097455	Poecilia formosa	36.69	4.00e-88	318.00
IUUC-Rno-105586	Rattus norvegicus	37.43	2.00e-88	319.00
IUUC-Sha-106868	Sarcophilus harrisii	37.48	3.00e-88	318.00
IUUC-Smo-109113	Selaginella moellendorffii	33.33	2.00e-18	85.50
IUUC-Ssc-116250	Sus scrofa	37.14	3.00e-87	315.00
IUUC-Tgu-116592	Taeniopygia guttata	37.77	2.00e-91	329.00
IUUC-Tru-117852	Takifugu rubripes	36.70	7.00e-71	261.00
IUUC-Tsy-119087	Tarsius syrichta	44.44	4.00e-65	241.00
IUUC-Tni-120826	Tetraodon nigroviridis	36.73	5.00e-87	315.00
IUUC-Xtr-132069	Xenopus tropicalis	40.18	4.00e-87	315.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence