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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046365
UUCD1 version UUC-HoS-00353
Ensembl Protein ID ENSP00000339659.5
UniProt Accession Q9C040; D3DP09; O60272; Q9BSI9; Q9UFZ1; TRIM2_HUMAN
Genbank Protein ID AAG53472.1; BAA25443.1; EAX04960.1; EAX04962.1; AAH05016.1; AAH11052.1; CAB53687.2
Protein Name Tripartite motif-containing protein 2; E3 ubiquitin-protein ligase TRIM2; RING finger protein 86; RING-type E3 ubiquitin transferase TRIM2
Genbank Nucleotide ID AF220018; AB011089; AC013477; CH471056; BC005016; BC011052; AL110234
Gene Name TRIM2; KIAA0517; RNF86
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000109654.14 ENST00000494872.5 ENSP00000488229.1
ENSG00000109654.14 ENST00000338700.9 ENSP00000339659.5
ENSG00000109654.14 ENST00000632856.1 ENSP00000487836.1
ENSG00000109654.14 ENST00000460908.1 ENSP00000488751.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanmiRecordsRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18687884; 23562820
Classification
Family E-value Score Start End
E3 activity/RING/RING 4.50e-08 35.2 50 91
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCle++k+ p+vlpC H+f++ Clq++       s + +CP+Cr
   Q: 50   CSICLERYKN-PKVLPCLHTFCERCLQNY---IPAHSLTLSCPVCR 91
           **********.******************...44578999*****8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance.
 UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance.
Protein Sequence
(Fasta)
MHRSGRYGTQ QQRAGSKTAG PPCQWSRMAS EGTNIPSPVV RQIDKQFLIC SICLERYKNP 60
KVLPCLHTFC ERCLQNYIPA HSLTLSCPVC RQTSILPEKG VAALQNNFFI TNLMDVLQRT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046365|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCTGGGGCGT GGTCGCCGGG CTGCCGTGCG CTCGGGATCA GTCTTTTTAT ACATATATAT 60
ATGTGTGTAT ATATATATAT ATATATATAC ACACATATAT ATATGTTATA AAATTCTAAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046365|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0144--Charcot-Marie-Tooth disease
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0479--Metal-binding
KW-0523--Neurodegeneration
KW-0622--Neuropathy
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR003649--Bbox_C
IPR017868--Filamin/ABP280_repeat-like
IPR001298--Filamin/ABP280_rpt
IPR013783--Ig-like_fold
IPR014756--Ig_E-set
IPR001258--NHL_repeat
IPR013017--NHL_repeat_subgr
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50194--FILAMIN_REPEAT
PS51125--NHL
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00630--Filamin
PF01436--NHL
PF00643--zf-B_box
PF13445--zf-RING_UBOX
SMART

SM00502--BBC
SM00336--BBOX
SM00557--IG_FLMN
SM00184--RING
Gene Ontology

GO:0005737--C:cytoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0043523--P:regulation of neuron apoptotic process
KEGG hsa:23321
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002127 Ailuropoda melanoleuca 98.57 0.00e+00 1584.00
IUUC-Apl-003865 Anas platyrhynchos 96.30 0.00e+00 1518.00
IUUC-Aca-004825 Anolis carolinensis 95.44 0.00e+00 1309.00
IUUC-Ame-011612 Astyanax mexicanus 81.12 0.00e+00 1280.00
IUUC-Bta-012548 Bos taurus 98.92 0.00e+00 1531.00
IUUC-Cja-019580 Callithrix jacchus 99.60 0.00e+00 1537.00
IUUC-Cpo-022342 Cavia porcellus 95.66 0.00e+00 1511.00
IUUC-Csa-023735 Chlorocebus sabaeus 99.47 0.00e+00 1574.00
IUUC-Cho-025025 Choloepus hoffmanni 87.85 0.00e+00 812.00
IUUC-Csv-026112 Ciona savignyi 27.85 1.00e-83 304.00
IUUC-Dre-028599 Danio rerio 79.73 0.00e+00 1211.00
IUUC-Dno-029768 Dasypus novemcinctus 99.08 0.00e+00 1569.00
IUUC-Dor-030841 Dipodomys ordii 90.99 0.00e+00 1382.00
IUUC-Eca-033960 Equus caballus 98.95 0.00e+00 1566.00
IUUC-Eeu-035207 Erinaceus europaeus 89.18 0.00e+00 1168.00
IUUC-Fca-035695 Felis catus 98.82 0.00e+00 1565.00
IUUC-Fal-037000 Ficedula albicollis 97.04 0.00e+00 1509.00
IUUC-Gmo-038767 Gadus morhua 78.63 0.00e+00 1206.00
IUUC-Gga-041007 Gallus gallus 96.64 0.00e+00 1505.00
IUUC-Gac-042586 Gasterosteus aculeatus 84.54 0.00e+00 1334.00
IUUC-Ggo-045221 Gorilla gorilla 99.87 0.00e+00 1602.00
IUUC-Lch-050198 Latimeria chalumnae 85.00 0.00e+00 1335.00
IUUC-Loc-052583 Lepisosteus oculatus 89.35 0.00e+00 1376.00
IUUC-Laf-054233 Loxodonta africana 98.95 0.00e+00 1569.00
IUUC-Mcc-055569 Macaca mulatta 99.72 0.00e+00 1479.00
IUUC-Mga-059355 Meleagris gallopavo 95.51 0.00e+00 1512.00
IUUC-Mmr-061171 Microcebus murinus 99.09 0.00e+00 1590.00
IUUC-Mdo-062885 Monodelphis domestica 97.98 0.00e+00 1517.00
IUUC-Mmu-063562 Mus musculus 98.83 0.00e+00 1581.00
IUUC-Mpu-066097 Mustela putorius furo 98.69 0.00e+00 1564.00
IUUC-Mlu-068044 Myotis lucifugus 98.95 0.00e+00 1567.00
IUUC-Nle-069532 Nomascus leucogenys 99.74 0.00e+00 1600.00
IUUC-Opr-070346 Ochotona princeps 98.25 0.00e+00 1518.00
IUUC-Ont-071572 Oreochromis niloticus 84.81 0.00e+00 1337.00
IUUC-Oan-072836 Ornithorhynchus anatinus 97.84 0.00e+00 1420.00
IUUC-Ocu-074750 Oryctolagus cuniculus 98.95 0.00e+00 1571.00
IUUC-Ola-087547 Oryzias latipes 82.24 0.00e+00 1314.00
IUUC-Oga-088484 Otolemur garnettii 99.47 0.00e+00 1575.00
IUUC-Oar-089231 Ovis aries 97.28 0.00e+00 1560.00
IUUC-Ptr-091007 Pan troglodytes 98.31 0.00e+00 1569.00
IUUC-Pan-092589 Papio anubis 99.74 0.00e+00 1600.00
IUUC-Psi-093880 Pelodiscus sinensis 97.04 0.00e+00 1507.00
IUUC-Pma-094132 Petromyzon marinus 86.57 1.00e-132 465.00
IUUC-Pfo-096688 Poecilia formosa 80.98 0.00e+00 1164.00
IUUC-Pab-098260 Pongo abelii 99.87 0.00e+00 1540.00
IUUC-Pca-100644 Procavia capensis 99.58 0.00e+00 978.00
IUUC-Pva-102141 Pteropus vampyrus 99.06 0.00e+00 1533.00
IUUC-Rno-105358 Rattus norvegicus 95.93 0.00e+00 1502.00
IUUC-Sha-106703 Sarcophilus harrisii 97.62 0.00e+00 1531.00
IUUC-Sar-113100 Sorex araneus 98.74 0.00e+00 972.00
IUUC-Ssc-116118 Sus scrofa 98.82 0.00e+00 1563.00
IUUC-Tgu-117257 Taeniopygia guttata 96.56 0.00e+00 1524.00
IUUC-Tru-118683 Takifugu rubripes 82.75 0.00e+00 1306.00
IUUC-Tni-120534 Tetraodon nigroviridis 82.49 0.00e+00 1293.00
IUUC-Tbe-127438 Tupaia belangeri 90.80 0.00e+00 934.00
IUUC-Ttr-128897 Tursiops truncatus 98.12 0.00e+00 1515.00
IUUC-Vpa-130582 Vicugna pacos 98.88 2.00e-159 556.00
Created Date 25-Jun-2017

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