iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Ath-007350

Ensembl Protein ID

AT2G17190.1

UniProt Accession

Q9SII9; Q9C5L7; DSK2A_ARATH

Genbank Protein ID

AAD25137.2; AEC06596.1; AAK25869.1; AAK68768.1; AAM10012.1; AAM44934.1; BAF00527.1

Protein Name

Ubiquitin domain-containing protein DSK2a

Genbank Nucleotide ID

AC007127; CP002685; AF360159; AY042828; AY081450; AY113886; AK228616

Gene Name

DSK2A; At2g17190; T23A1.5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT2G17190	AT2G17190.1	AT2G17190.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	20059542; 21764993
ULD/UDP/UBQ/UBQ_PIM	UBQ_PIM	20059542; 21764993

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	1.70e-11	44.8	498	533
ULD/UDP/UBQ/UBQ_PIM	1.10e-24	87.0	19	88

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 5    dkleqlveMGF.dreealqaLraannnleaAveyLl 39
            +l+ql+eMGF dr e+++aL+a+n+n++aAve+Ll
   Q: 498  TQLQQLQEMGFyDRAENIRALLATNGNVNAAVERLL 533
           68*********************************9 PP

ULD/UDP/UBQ/UBQ_PIM

   S: 2    kltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvv 71
            ++v++++g++f ++ s d+tve++Ke+ia++s+vp++qq+LIy+G+iLkDd+tL ++g++ +++vh+v 
   Q: 19   AVNVRCSNGTKFSVTTSLDSTVESFKELIAQNSDVPANQQRLIYKGRILKDDQTLLSYGLQADHTVHMVR 88
           699*****************************************************************95 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Binds and presumably selects ubiquitin-conjugates for destruction. Prefers multiubiquitin chains rather than single ubiquitins, with a binding affinity for 'Lys-48'-linked ubiquitin chains. Acts as a ubiquitin receptor that associates with the 26S proteasomal docking subunit RPN10 for the indirect recognition of ubiquitinated substrates of ubiquitin/26S proteasome-mediated proteolysis (UPP).

Protein Sequence
(Fasta)

MGGEADSRQP LTAEGVAVAV NVRCSNGTKF SVTTSLDSTV ESFKELIAQN SDVPANQQRL 60
IYKGRILKDD QTLLSYGLQA DHTVHMVRGF VPSSPSAPAA NAGNQTTAPQ AVGSNDSSNL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGAACTATA TACCAAATGC CTCAATTTAG ACCCGACCCG GCCCAATCTT ACCCAGTAAG 60
AGTCGTCGAT ACGTTCTCTG AAGCGCAAGT CATTTCTGGA TTCTCATTTA ATTGGCCGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR006636--STI1_HS-bd
IPR015940--UBA
IPR009060--UBA-like
IPR015496--Ubiquilin
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50030--UBA
PS50053--UBIQUITIN_2

Pfam

PF00627--UBA
PF00240--ubiquitin

SMART

SM00727--STI1
SM00165--UBA
SM00213--UBQ

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0031593--F:polyubiquitin binding

KEGG

ath:AT2G17190

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-004150	Anas platyrhynchos	38.46	4.00e-39	155.00
IUUC-Aly-005419	Arabidopsis lyrata	96.84	0.00e+00	798.00
IUUC-Ago-007963	Ashbya gossypii	29.52	9.00e-13	67.00
IUUC-Acl-008361	Aspergillus clavatus	28.51	1.00e-16	80.50
IUUC-Afl-008403	Aspergillus flavus	29.82	3.00e-19	89.00
IUUC-Afu-009029	Aspergillus fumigatus	28.07	1.00e-15	77.40
IUUC-Ani-009418	Aspergillus nidulans	30.25	3.00e-15	75.90
IUUC-Ang-009826	Aspergillus niger	28.02	3.00e-18	85.10
IUUC-Aor-010091	Aspergillus oryzae	29.82	3.00e-19	89.00
IUUC-Ate-010419	Aspergillus terreus	31.72	4.00e-18	85.50
IUUC-Ame-011329	Astyanax mexicanus	34.47	7.00e-53	201.00
IUUC-Bgr-012188	Blumeria graminis	25.97	2.00e-14	72.80
IUUC-Bta-013048	Bos taurus	37.12	4.00e-51	195.00
IUUC-Cja-019976	Callithrix jacchus	36.89	3.00e-51	195.00
IUUC-Cfa-020092	Canis familiaris	37.59	1.00e-51	196.00
IUUC-Cre-022634	Chlamydomonas reinhardtii	51.79	2.00e-13	69.70
IUUC-Csa-024087	Chlorocebus sabaeus	36.45	2.00e-49	189.00
IUUC-Cho-024834	Choloepus hoffmanni	37.12	3.00e-51	195.00
IUUC-Csv-026009	Ciona savignyi	37.35	1.00e-38	154.00
IUUC-Cgl-026590	Colletotrichum gloeosporioides	25.11	3.00e-10	58.90
IUUC-Cne-026833	Cryptococcus neoformans	33.19	5.00e-26	111.00
IUUC-Cme-027155	Cyanidioschyzon merolae	51.52	4.00e-36	145.00
IUUC-Dre-028009	Danio rerio	39.38	1.00e-42	167.00
IUUC-Dse-031421	Dothistroma septosporum	28.80	1.00e-15	77.00
IUUC-Ete-032273	Echinops telfairi	37.35	1.00e-50	193.00
IUUC-Eca-033667	Equus caballus	36.66	3.00e-48	185.00
IUUC-Fal-037642	Ficedula albicollis	37.10	4.00e-51	195.00
IUUC-Gmo-039317	Gadus morhua	40.61	2.00e-41	162.00
IUUC-Ggr-039961	Gaeumannomyces graminis	29.30	5.00e-13	68.20
IUUC-Gac-041826	Gasterosteus aculeatus	41.30	7.00e-44	171.00
IUUC-Ggo-044969	Gorilla gorilla	36.19	1.00e-48	186.00
IUUC-Hsa-046669	Homo sapiens	37.12	2.00e-51	196.00
IUUC-Kpa-049251	Komagataella pastoris	31.44	5.00e-18	84.70
IUUC-Lch-049480	Latimeria chalumnae	40.67	2.00e-42	166.00
IUUC-Lma-053152	Leptosphaeria maculans	27.57	3.00e-16	79.30
IUUC-Mcc-055680	Macaca mulatta	36.89	2.00e-51	196.00
IUUC-Mla-058987	Melampsora laricipopulina	65.91	5.00e-11	61.20
IUUC-Mvi-060466	Microbotryum violaceum	71.11	7.00e-14	70.90
IUUC-Mmr-061094	Microcebus murinus	37.12	9.00e-51	194.00
IUUC-Mmu-064088	Mus musculus	33.39	3.00e-56	212.00
IUUC-Nfi-068487	Neosartorya fischeri	27.19	7.00e-15	74.70
IUUC-Ncr-068732	Neurospora crassa	29.26	3.00e-11	62.40
IUUC-Nle-069321	Nomascus leucogenys	37.12	2.00e-51	196.00
IUUC-Ont-072038	Oreochromis niloticus	40.89	1.00e-42	167.00
IUUC-Oan-072808	Ornithorhynchus anatinus	36.84	6.00e-50	191.00
IUUC-Ocu-074301	Oryctolagus cuniculus	35.01	4.00e-56	211.00
IUUC-Ola-086802	Oryzias latipes	35.13	2.00e-53	202.00
IUUC-Oar-089711	Ovis aries	36.43	9.00e-50	191.00
IUUC-Ptr-091439	Pan troglodytes	37.12	8.00e-50	191.00
IUUC-Pan-092641	Papio anubis	36.89	2.00e-51	196.00
IUUC-Psi-093262	Pelodiscus sinensis	40.46	2.00e-39	156.00
IUUC-Pno-094908	Phaeosphaeria nodorum	30.00	4.00e-15	74.30
IUUC-Pfo-096638	Poecilia formosa	39.20	2.00e-46	179.00
IUUC-Pab-098699	Pongo abelii	37.44	4.00e-51	195.00
IUUC-Ptt-103817	Puccinia triticina	29.49	5.00e-13	67.80
IUUC-Pte-104090	Pyrenophora teres	29.67	4.00e-14	72.00
IUUC-Pyt-104472	Pyrenophora triticirepentis	29.67	9.00e-15	73.90
IUUC-Sce-106332	Saccharomyces cerevisiae	33.04	3.00e-19	88.60
IUUC-Sha-107346	Sarcophilus harrisii	40.30	1.00e-39	157.00
IUUC-Spo-108223	Schizosaccharomyces pombe	27.83	1.00e-17	83.20
IUUC-Sar-113022	Sorex araneus	41.36	2.00e-33	136.00
IUUC-Sre-115081	Sporisorium reilianum	29.34	9.00e-17	80.50
IUUC-Ssc-115820	Sus scrofa	37.12	7.00e-51	194.00
IUUC-Tru-118652	Takifugu rubripes	38.64	6.00e-41	161.00
IUUC-Tni-119780	Tetraodon nigroviridis	33.11	1.00e-44	173.00
IUUC-Tca-121610	Theobroma cacao	60.92	9.00e-141	493.00
IUUC-Tvi-122381	Trichoderma virens	26.43	7.00e-11	60.80
IUUC-Tae-125468	Triticum aestivum	57.65	8.00e-82	297.00
IUUC-Tur-126783	Triticum urartu	57.65	9.00e-82	296.00
IUUC-Uma-129639	Ustilago maydis	28.03	9.00e-16	77.40
IUUC-Xtr-132978	Xenopus tropicalis	36.43	2.00e-39	156.00
IUUC-Xma-134155	Xiphophorus maculatus	34.56	3.00e-49	188.00
IUUC-Yli-134630	Yarrowia lipolytica	30.43	9.00e-17	80.50

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence