iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000015574.1	ENSLACT00000017812.1	ENSLACP00000017682.1
ENSLACG00000015574.1	ENSLACT00000017813.1	ENSLACP00000017683.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	9.10e-136	452.9	980	1310

Active Site

Position(s)	Description	Evidence
1280	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + lk+rl++ef++E+gld+gGv+re+++l+ske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+++++g+lld
   Q: 980  DLLKARLWIEFENEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMSVYHGKLLD 1066
           66899********************************************************************************** PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
            ++ ++fyk++l+k+++l+d+e+vd+e+y+slk+i+en   d ++  ldl+f ++ee +g+t+++eLk+gG++i +tn+Nk+eY++l
   Q: 1067 GFFIRPFYKMMLQKPITLNDMESVDSEYYNSLKWILEN---DPTD--LDLRFIIDEEFFGQTQQHELKTGGADIVITNKNKREYIHL 1148
           ************************************99...6666..7*************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           v+++r+ ++i++q++af+eGf+e+ip++l+++F+e+elell+cG  ++dv+d++++tkyk+ y++++p+iqwFw+++  ++se+r +
   Q: 1149 VIQWRFVDRIQKQMAAFKEGFYELIPQDLIKIFDENELELLMCGLGDVDVNDWRENTKYKNSYHANHPVIQWFWKTVLLMDSEKRIR 1235
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +LqFvTg+sr+P++Gfael     p+lf+i++++++d+lP+++TCfn+L+LP+Y+s e l+ekL +Aie+++gF+
   Q: 1236 LLQFVTGTSRVPMNGFAELYgsngPQLFTIEQWGTPDKLPRAHTCFNRLDLPPYESFEDLREKLHTAIENAQGFD 1310
           **************************************************************************8 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

MARRLHLHFA ANRSNTDPLS ETCEDGWDNI YMSFQSPSQN STQNVQMKVT PRQMTLVSQD 60
LLTSQSSSIF IPQLNNNKKS TSLQISLQSR KLRESTKPRN GISNNEDTYS NTDNEGNSSS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCATAAACCA CAGAAGTATA GTTTTGGGAA AAGAGGCAAG GAAAGAGCTC TCCACACCCT 60
TTGAATATTT CATACATGTA TATTGCAGTC TTGTGACCTG TAGACTGGAC AGGACTTCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001201	Ailuropoda melanoleuca	59.51	0.00e+00	1477.00
IUUC-Apl-003886	Anas platyrhynchos	67.75	0.00e+00	1151.00
IUUC-Ame-011138	Astyanax mexicanus	86.80	0.00e+00	880.00
IUUC-Bta-012453	Bos taurus	58.08	0.00e+00	1399.00
IUUC-Cja-019034	Callithrix jacchus	55.54	0.00e+00	1298.00
IUUC-Cfa-020258	Canis familiaris	58.91	0.00e+00	1425.00
IUUC-Cpo-021648	Cavia porcellus	71.87	0.00e+00	1191.00
IUUC-Csa-023334	Chlorocebus sabaeus	73.09	0.00e+00	1192.00
IUUC-Cin-025157	Ciona intestinalis	66.73	0.00e+00	798.00
IUUC-Csv-026098	Ciona savignyi	58.01	0.00e+00	656.00
IUUC-Dno-029159	Dasypus novemcinctus	69.89	0.00e+00	1048.00
IUUC-Dme-032166	Drosophila melanogaster	70.02	0.00e+00	738.00
IUUC-Ete-032409	Echinops telfairi	68.11	0.00e+00	962.00
IUUC-Eca-033441	Equus caballus	72.47	0.00e+00	1157.00
IUUC-Fca-036384	Felis catus	58.89	0.00e+00	1441.00
IUUC-Fal-037547	Ficedula albicollis	73.33	0.00e+00	1192.00
IUUC-Gmo-039679	Gadus morhua	70.42	0.00e+00	1139.00
IUUC-Ggr-040107	Gaeumannomyces graminis	47.38	4.00e-154	538.00
IUUC-Gga-040524	Gallus gallus	73.21	0.00e+00	1187.00
IUUC-Gac-042607	Gasterosteus aculeatus	69.77	0.00e+00	1154.00
IUUC-Hsa-046479	Homo sapiens	59.54	0.00e+00	1461.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	65.48	0.00e+00	971.00
IUUC-Loc-052645	Lepisosteus oculatus	77.93	0.00e+00	1277.00
IUUC-Laf-053638	Loxodonta africana	67.49	0.00e+00	1109.00
IUUC-Mcc-055585	Macaca mulatta	59.68	0.00e+00	1450.00
IUUC-Meu-056897	Macropus eugenii	88.15	2.00e-161	563.00
IUUC-Mga-059362	Meleagris gallopavo	68.08	0.00e+00	1152.00
IUUC-Mmr-061061	Microcebus murinus	59.28	0.00e+00	1474.00
IUUC-Mdo-062178	Monodelphis domestica	51.06	0.00e+00	1290.00
IUUC-Mpu-066567	Mustela putorius furo	73.19	0.00e+00	1216.00
IUUC-Mlu-068148	Myotis lucifugus	58.87	0.00e+00	1418.00
IUUC-Nle-069225	Nomascus leucogenys	59.63	0.00e+00	1454.00
IUUC-Ont-071664	Oreochromis niloticus	69.47	0.00e+00	1105.00
IUUC-Oan-073019	Ornithorhynchus anatinus	74.41	0.00e+00	1204.00
IUUC-Ocu-074409	Oryctolagus cuniculus	58.89	0.00e+00	1449.00
IUUC-Oga-088241	Otolemur garnettii	55.69	0.00e+00	1288.00
IUUC-Oar-089797	Ovis aries	72.35	0.00e+00	1185.00
IUUC-Ptr-091629	Pan troglodytes	71.84	0.00e+00	1098.00
IUUC-Psi-093618	Pelodiscus sinensis	60.47	0.00e+00	1429.00
IUUC-Pfo-097145	Poecilia formosa	69.59	0.00e+00	1090.00
IUUC-Pab-098394	Pongo abelii	72.09	0.00e+00	1190.00
IUUC-Pca-100568	Procavia capensis	53.79	0.00e+00	1037.00
IUUC-Sha-107370	Sarcophilus harrisii	53.67	0.00e+00	1328.00
IUUC-Tgu-117474	Taeniopygia guttata	73.83	0.00e+00	1193.00
IUUC-Tru-117675	Takifugu rubripes	66.83	0.00e+00	1099.00
IUUC-Tni-119993	Tetraodon nigroviridis	65.23	0.00e+00	1071.00
IUUC-Tre-122203	Trichoderma reesei	45.75	2.00e-152	533.00
IUUC-Tbe-127408	Tupaia belangeri	69.84	0.00e+00	942.00
IUUC-Ttr-128437	Tursiops truncatus	64.58	0.00e+00	934.00
IUUC-Vpa-130503	Vicugna pacos	53.72	0.00e+00	1245.00
IUUC-Xtr-132431	Xenopus tropicalis	65.48	0.00e+00	1123.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence