iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	miRNAMap	RAID2
Protein-protein Interaction
iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	3.00e-07	31.1	592	630

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           CaiC+ ++k++ +++pC+H fh  Cl kw         +  CPlC
   Q: 592  CAICFIEMKEEARITPCKHYFHGPCLRKW------LAVKMVCPLC 630
           *****************************......9999****** PP

Organism

Caenorhabditis elegans

Protein Sequence
(Fasta)

MEGVMENVGG LMQNIRRRHM SITEMTEESV RLGVAQMDTG FKKIKEMSIM VLETGLRLPG 60
LLFIELLWRY QGFSFEDISD DMMKQTPLSY FDIPTMLDFV HRRNFDHHAA IILSYFVIFI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCAAAAATT CCGTCAAACA ACTAAGAATG GAGGGAGTGA TGGAGAATGT GGGTGGTTTG 60
ATGCAGAATA TACGGAGAAG ACATATGAGT ATTACGGAAA TGACTGAAGA ATCTGTACGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR025754--TRC8_N_dom
IPR001841--Znf_RING
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13705--TRC8_N

SMART

SM00184--RING
SM00744--RINGv

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

cel:CELE_Y119C1B.5

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002354	Ailuropoda melanoleuca	27.50	7.00e-56	210.00
IUUC-Apl-003823	Anas platyrhynchos	27.59	2.00e-56	212.00
IUUC-Aca-004944	Anolis carolinensis	27.59	3.00e-56	212.00
IUUC-Aly-005840	Arabidopsis lyrata	31.91	9.00e-09	53.10
IUUC-Ame-011578	Astyanax mexicanus	29.75	2.00e-64	239.00
IUUC-Bta-012560	Bos taurus	26.36	5.00e-56	211.00
IUUC-Cja-018929	Callithrix jacchus	27.00	3.00e-52	198.00
IUUC-Cfa-021110	Canis familiaris	27.50	7.00e-56	211.00
IUUC-Cpo-022452	Cavia porcellus	27.67	3.00e-55	208.00
IUUC-Csa-024116	Chlorocebus sabaeus	27.50	2.00e-55	209.00
IUUC-Cho-024285	Choloepus hoffmanni	24.16	1.00e-28	119.00
IUUC-Cin-025223	Ciona intestinalis	27.44	2.00e-29	121.00
IUUC-Csv-026018	Ciona savignyi	27.14	2.00e-24	105.00
IUUC-Dre-027493	Danio rerio	29.55	4.00e-64	237.00
IUUC-Dno-029615	Dasypus novemcinctus	27.71	3.00e-56	211.00
IUUC-Dor-030728	Dipodomys ordii	24.45	6.00e-38	150.00
IUUC-Dme-032186	Drosophila melanogaster	29.89	5.00e-29	121.00
IUUC-Ete-032551	Echinops telfairi	29.21	2.00e-38	152.00
IUUC-Eca-033349	Equus caballus	27.50	2.00e-55	209.00
IUUC-Eeu-035349	Erinaceus europaeus	25.29	1.00e-20	93.20
IUUC-Fca-035696	Felis catus	27.55	6.00e-56	210.00
IUUC-Fal-037495	Ficedula albicollis	27.59	3.00e-56	211.00
IUUC-Gmo-039374	Gadus morhua	29.35	6.00e-62	230.00
IUUC-Gga-040146	Gallus gallus	27.67	2.00e-56	212.00
IUUC-Gac-041731	Gasterosteus aculeatus	28.52	9.00e-62	229.00
IUUC-Gma-043316	Glycine max	44.23	3.00e-10	57.40
IUUC-Ggo-045158	Gorilla gorilla	27.44	4.00e-55	207.00
IUUC-Hsa-045787	Homo sapiens	27.50	1.00e-55	209.00
IUUC-Itr-048928	Ictidomys tridecemlineatus	31.59	2.00e-53	202.00
IUUC-Lch-050499	Latimeria chalumnae	27.83	3.00e-58	218.00
IUUC-Loc-052482	Lepisosteus oculatus	29.04	1.00e-60	226.00
IUUC-Laf-053362	Loxodonta africana	27.50	9.00e-56	210.00
IUUC-Mcc-055779	Macaca mulatta	27.44	2.00e-55	209.00
IUUC-Meu-056130	Macropus eugenii	31.37	1.00e-28	120.00
IUUC-Mga-059742	Meleagris gallopavo	27.67	4.00e-56	211.00
IUUC-Mmr-060812	Microcebus murinus	27.07	4.00e-57	214.00
IUUC-Mdo-063045	Monodelphis domestica	27.15	6.00e-55	207.00
IUUC-Mmu-064377	Mus musculus	27.17	4.00e-60	224.00
IUUC-Mpu-066637	Mustela putorius furo	27.55	7.00e-56	210.00
IUUC-Mlu-066985	Myotis lucifugus	27.33	8.00e-56	210.00
IUUC-Nle-069833	Nomascus leucogenys	27.44	2.00e-55	209.00
IUUC-Opr-070461	Ochotona princeps	24.70	2.00e-37	149.00
IUUC-Ont-072116	Oreochromis niloticus	28.41	1.00e-62	233.00
IUUC-Oan-073730	Ornithorhynchus anatinus	27.26	1.00e-55	209.00
IUUC-Ocu-074958	Oryctolagus cuniculus	27.67	7.00e-56	210.00
IUUC-Oin-079826	Oryza indica	46.00	2.00e-10	57.00
IUUC-Ola-087368	Oryzias latipes	28.90	6.00e-64	237.00
IUUC-Oga-088301	Otolemur garnettii	27.27	8.00e-55	207.00
IUUC-Oar-089745	Ovis aries	27.55	5.00e-56	211.00
IUUC-Ptr-091397	Pan troglodytes	27.50	1.00e-55	209.00
IUUC-Pan-092817	Papio anubis	27.50	2.00e-55	209.00
IUUC-Psi-093820	Pelodiscus sinensis	26.92	8.00e-51	194.00
IUUC-Pma-094527	Petromyzon marinus	26.91	1.00e-45	176.00
IUUC-Pfo-097173	Poecilia formosa	28.57	4.00e-63	234.00
IUUC-Pab-097630	Pongo abelii	27.50	2.00e-55	209.00
IUUC-Pca-100472	Procavia capensis	31.51	1.00e-53	202.00
IUUC-Pva-102485	Pteropus vampyrus	26.94	9.00e-53	200.00
IUUC-Rno-106029	Rattus norvegicus	27.50	1.00e-55	209.00
IUUC-Sha-106580	Sarcophilus harrisii	27.41	1.00e-55	210.00
IUUC-Stu-112267	Solanum tuberosum	38.24	1.00e-11	61.20
IUUC-Ssc-116438	Sus scrofa	31.59	2.00e-53	202.00
IUUC-Tgu-116638	Taeniopygia guttata	27.59	2.00e-56	212.00
IUUC-Tru-117779	Takifugu rubripes	28.41	2.00e-63	235.00
IUUC-Tsy-119541	Tarsius syrichta	27.29	2.00e-54	205.00
IUUC-Tni-119862	Tetraodon nigroviridis	28.41	2.00e-63	235.00
IUUC-Tca-121120	Theobroma cacao	46.30	7.00e-12	61.20
IUUC-Tre-121878	Trichoderma reesei	37.93	6.00e-07	48.50
IUUC-Tbe-127328	Tupaia belangeri	24.58	3.00e-36	145.00
IUUC-Ttr-129144	Tursiops truncatus	23.48	3.00e-36	145.00
IUUC-Vpa-130226	Vicugna pacos	23.84	6.00e-36	144.00
IUUC-Xtr-132826	Xenopus tropicalis	27.42	7.00e-61	227.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence