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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Dme-031777
UUCD1 version UUC-DrM-00023
Ensembl Protein ID FBpp0073787
UniProt Accession Q9NB71; Q8MZ36; Q9VXZ5; HIW_DROME
Genbank Protein ID AAF76150.1; AAF48411.2; AAM29381.1
Protein Name E3 ubiquitin-protein ligase highwire; Protein pam/highwire/rpm-1; RING-type E3 ubiquitin transferase highwire
Genbank Nucleotide ID AF262977; AE014298; AY113376
Gene Name hiw; CG32592
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0030600 FBtr0073970 FBpp0073787
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
RAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Post-translational Modifications (PTMs)
dbPAFdbPTMPhospho.ELMUniProt
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 20009548
Reviewed
Classification
Family Identity E-value Score Source Orthology
E3 activity/RING/RING 38.91 2.00e-120 432.00 IUUC-Cel-018686
E3 activity/RING/RING 62.38 0.00e+00 725.00 IUUC-Hsa-046977
E3 activity/RING/RING 62.57 0.00e+00 725.00 IUUC-Mmu-063569
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligases mediate ubiquitination and subsequent proteasomal degradation of target proteins. Has a role during synaptogenesis; negative regulator of synaptic growth.
 E3 ubiquitin-protein ligases mediate ubiquitination and subsequent proteasomal degradation of target proteins. Has a role during synaptogenesis; negative regulator of synaptic growth.
Protein Sequence
(Fasta)
MVGLLNPLKY GDHFYELYTN STRRKMQHDR KVLTKRKSRK DKSAAAMAAA AAAAVLEGNA 60
GAGGLVNPLD PPLVKEQLMI LPSFPVAHIE LDPNASKFAV FSAIRSTVLE AETRYSLFQE 120
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Protein Fasta Sequence


>IUUC-Dme-031777|E3,RING|Drosophila melanogaster
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Nucleotide Sequence
(Fasta)
AGTTCCCTCG TTCCCATTGT ACCGTTGCGT TGTCGCTCGG TGTGTGTTTC CTTTTTTTTG 60
GGTGAAAGTG ACAAAAGGCA AATGGCGAAA ACAAAGGGCA CTCAAATTGC CAGACGATGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-031777|E3,RING|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR004939--APC_su10/DOC_dom
IPR017868--Filamin/ABP280_repeat-like
IPR008979--Galactose-bd-like
IPR013783--Ig-like_fold
IPR014756--Ig_E-set
IPR012983--PHR
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51284--DOC
PS50194--FILAMIN_REPEAT
PS00626--RCC1_2
PS50012--RCC1_3
PS50089--ZF_RING_2
Pfam

PF08005--PHR
PF00415--RCC1
PRINTS

PR00633--RCCNDNSATION
SMART

SM01337--APC10
SM00184--RING
Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007628--P:adult walking behavior
GO:0006914--P:autophagy
GO:0030509--P:BMP signaling pathway
GO:0050965--P:detection of temperature stimulus involved in sensory perception of pain
GO:0040011--P:locomotion
GO:0007616--P:long-term memory
GO:0030514--P:negative regulation of BMP signaling pathway
GO:0045886--P:negative regulation of synaptic growth at neuromuscular junction
GO:0016567--P:protein ubiquitination
GO:0008582--P:regulation of synaptic growth at neuromuscular junction
GO:2000331--P:regulation of terminal button organization
GO:0048678--P:response to axon injury
GO:0050808--P:synapse organization
GO:0006351--P:transcription, DNA-templated
KEGG dme:Dmel_CG32592
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001951 Ailuropoda melanoleuca 62.57 0.00e+00 727.00
IUUC-Apl-003625 Anas platyrhynchos 60.97 0.00e+00 663.00
IUUC-Aca-005207 Anolis carolinensis 62.76 0.00e+00 690.00
IUUC-Ame-010649 Astyanax mexicanus 49.07 0.00e+00 1111.00
IUUC-Bta-012670 Bos taurus 62.57 0.00e+00 727.00
IUUC-Cel-018686 Caenorhabditis elegans 28.79 8.00e-148 519.00
IUUC-Cja-019910 Callithrix jacchus 62.76 0.00e+00 728.00
IUUC-Cfa-020184 Canis familiaris 62.57 0.00e+00 727.00
IUUC-Cpo-021334 Cavia porcellus 62.76 0.00e+00 727.00
IUUC-Csa-023291 Chlorocebus sabaeus 62.76 0.00e+00 728.00
IUUC-Cho-024927 Choloepus hoffmanni 36.79 2.00e-105 379.00
IUUC-Cin-025345 Ciona intestinalis 58.03 0.00e+00 654.00
IUUC-Csv-026264 Ciona savignyi 56.02 0.00e+00 628.00
IUUC-Dre-028645 Danio rerio 49.76 0.00e+00 1126.00
IUUC-Dno-029670 Dasypus novemcinctus 62.76 0.00e+00 729.00
IUUC-Dor-030993 Dipodomys ordii 57.91 0.00e+00 642.00
IUUC-Ete-032613 Echinops telfairi 58.47 0.00e+00 660.00
IUUC-Eca-034364 Equus caballus 62.76 0.00e+00 728.00
IUUC-Eeu-035200 Erinaceus europaeus 61.91 0.00e+00 713.00
IUUC-Fca-036054 Felis catus 62.76 0.00e+00 728.00
IUUC-Fal-036991 Ficedula albicollis 62.76 0.00e+00 694.00
IUUC-Gmo-038487 Gadus morhua 48.33 0.00e+00 1154.00
IUUC-Gga-041035 Gallus gallus 62.76 0.00e+00 694.00
IUUC-Gac-041637 Gasterosteus aculeatus 61.64 0.00e+00 681.00
IUUC-Ggo-045091 Gorilla gorilla 41.30 7.00e-114 406.00
IUUC-Hsa-046977 Homo sapiens 62.57 0.00e+00 728.00
IUUC-Itr-048995 Ictidomys tridecemlineatus 40.99 9.00e-113 401.00
IUUC-Lch-050171 Latimeria chalumnae 37.43 0.00e+00 1088.00
IUUC-Loc-052822 Lepisosteus oculatus 62.01 0.00e+00 686.00
IUUC-Laf-054065 Loxodonta africana 62.57 0.00e+00 726.00
IUUC-Mcc-054947 Macaca mulatta 62.76 0.00e+00 728.00
IUUC-Meu-056600 Macropus eugenii 58.78 6.00e-171 596.00
IUUC-Mga-059559 Meleagris gallopavo 61.82 0.00e+00 682.00
IUUC-Mmr-060973 Microcebus murinus 62.76 0.00e+00 728.00
IUUC-Mdo-061938 Monodelphis domestica 62.57 0.00e+00 691.00
IUUC-Mmu-063569 Mus musculus 62.76 0.00e+00 727.00
IUUC-Mpu-066457 Mustela putorius furo 60.80 0.00e+00 654.00
IUUC-Mlu-067165 Myotis lucifugus 41.80 1.00e-132 469.00
IUUC-Nle-069042 Nomascus leucogenys 62.20 0.00e+00 712.00
IUUC-Opr-070201 Ochotona princeps 43.07 1.00e-106 382.00
IUUC-Ont-072263 Oreochromis niloticus 49.72 0.00e+00 1129.00
IUUC-Oan-073108 Ornithorhynchus anatinus 41.08 2.00e-133 471.00
IUUC-Ocu-074359 Oryctolagus cuniculus 62.94 0.00e+00 730.00
IUUC-Ola-087074 Oryzias latipes 35.51 9.00e-109 389.00
IUUC-Oga-088322 Otolemur garnettii 62.76 0.00e+00 728.00
IUUC-Oar-089244 Ovis aries 62.57 0.00e+00 726.00
IUUC-Ptr-091449 Pan troglodytes 62.57 0.00e+00 727.00
IUUC-Pan-091756 Papio anubis 62.76 0.00e+00 728.00
IUUC-Psi-093387 Pelodiscus sinensis 62.38 0.00e+00 693.00
IUUC-Pma-094327 Petromyzon marinus 46.35 7.00e-66 243.00
IUUC-Ppa-095276 Physcomitrella patens 39.18 5.00e-51 195.00
IUUC-Pfo-097372 Poecilia formosa 61.64 0.00e+00 682.00
IUUC-Pab-097572 Pongo abelii 62.57 0.00e+00 729.00
IUUC-Pca-101007 Procavia capensis 55.12 4.00e-174 607.00
IUUC-Pva-102217 Pteropus vampyrus 63.91 0.00e+00 695.00
IUUC-Rno-105422 Rattus norvegicus 62.76 0.00e+00 727.00
IUUC-Sce-106318 Saccharomyces cerevisiae 31.48 2.60e-02 33.90
IUUC-Sha-107119 Sarcophilus harrisii 62.34 0.00e+00 687.00
IUUC-Smo-108712 Selaginella moellendorffii 42.12 5.00e-65 239.00
IUUC-Sar-113595 Sorex araneus 57.91 0.00e+00 645.00
IUUC-Ssc-115690 Sus scrofa 57.66 4.00e-153 537.00
IUUC-Tgu-116555 Taeniopygia guttata 62.76 0.00e+00 694.00
IUUC-Tru-117796 Takifugu rubripes 49.48 0.00e+00 1122.00
IUUC-Tsy-118924 Tarsius syrichta 60.15 0.00e+00 692.00
IUUC-Tni-120759 Tetraodon nigroviridis 49.80 0.00e+00 1117.00
IUUC-Tme-127029 Tuber melanosporum 37.72 1.00e-07 52.40
IUUC-Ttr-128814 Tursiops truncatus 62.57 0.00e+00 728.00
IUUC-Vpa-130430 Vicugna pacos 60.72 0.00e+00 650.00
IUUC-Xtr-131898 Xenopus tropicalis 46.86 8.00e-73 268.00
Created Date 25-Jun-2017

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