iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ate-010523

Ensembl Protein ID

CADATEAP00008073

UniProt Accession

Q0D0X6; LIS1_ASPTN

Genbank Protein ID

EAU39054.1

Protein Name

Nuclear distribution protein nudF; Lissencephaly-1 homolog

Genbank Nucleotide ID

CH476594

Gene Name

ATEG_00408; nudF; lis1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADATEAG00008073	CADATEAT00008073	CADATEAP00008073

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.70e-49	162.7	114	149
UBD/Beta-Prp	5.30e-62	208.8	110	446

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvl 35
           H d +t++af +  t l+sGs D+tik+WD+  g l
   Q: 114  HRDAITSIAFhPVfTSLASGSEDCTIKIWDWELGEL 149
           99********988899**************876665 PP

UBD/Beta-Prp

   S: 5    lkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk..ilvtgseDrtikvwdls.tgkcvhtlkghe 94
            +++h + it+++f+p  + la+gs+d tik+wd++ g l r+l+gh  +v+ ++f  ++   +l+++s D tik+wd+s ++  ++tl+gh+
   Q: 110  TFESHRDAITSIAFHPVFTSLASGSEDCTIKIWDWELGELERTLKGHMRGVSGLDFGGQKGhtLLASCSGDLTIKLWDPSkDYANIRTLHGHD 202
           56788999************************************************9887788**************9886899********* PP
   S: 95   dsvlslsfspsg.dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysl 186
           +sv +++f  s+ + lvs+s+d  ir+wd++tg+c++ t + ++ +   v+ + dg+ lv+G+ D++v +W +++++    l g h+++v++ 
   Q: 203  HSVSAVRFLTSTeNLLVSASRDASIRIWDVSTGYCVR-TITSNSIWFLDVSPSFDGKWLVAGGRDQAVTVWEVSSAEPRAALLG-HDNDVQCC 293
           **********666************************.888888888888888889***************************9.******** PP
   S: 187  sfdsng.....................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdl.rsgdll 257
            f +                       +++++gs+d+t+klw+  +g+ ++tl gh+++++ + f+p +++l s+s+D++ir+Wdl + g l+
   Q: 294  VFAPPAsyeylatlaghkkaplassssEFIATGSRDKTIKLWEA-RGRLIKTLVGHDNWIRGLVFHPSGKYLFSVSDDKTIRCWDLsQEGRLV 385
           *66655566666666666666666666****************9.7889***********************************9736799** PP
   S: 258  ktlqlhnssvisvavlsfg.dnvl........................vlgsedskvniwk 293
           kt+++ + ++is+  + +  +n                          ++gs+ds+v+++k
   Q: 386  KTISNAHGHFISCIRWAPPpRNAAaeasettngvskkaptkpafqcviATGSADSCVRVFK 446
           *******6666666633331333355555566666777777777777799999*****997 PP

Organism

Aspergillus terreus

Functional Description
(View)

Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.

Protein Sequence
(Fasta)

MSQILTASQA EELHKSMVAY LSSIKASQSS NTLREELGIG DNFDEATCKK YEGLLEKKWT 60
GIARLQRKIL DLESKITSLQ AELDSVPSMA RSKQHQDPDN WLPAQSSAHT FESHRDAITS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGCCAGA TATTAACCGC TAGCCAGGCA GAAGAGCTGT ATGTGTTTAC ACTCCGCGGC 60
CCAACGACCC GCCCACTCAC TGATAAACAA AAACAAACTA GGCACAAGTC TATGGTCGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0000922--C:spindle pole
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0006810--P:transport

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001589	Ailuropoda melanoleuca	41.86	3.00e-88	317.00
IUUC-Apl-004024	Anas platyrhynchos	42.11	3.00e-91	326.00
IUUC-Aca-004564	Anolis carolinensis	41.56	4.00e-89	319.00
IUUC-Ago-007862	Ashbya gossypii	27.52	1.00e-36	145.00
IUUC-Acl-008360	Aspergillus clavatus	58.06	1.00e-154	537.00
IUUC-Afl-008502	Aspergillus flavus	53.41	1.00e-140	491.00
IUUC-Afu-008848	Aspergillus fumigatus	58.71	8.00e-164	568.00
IUUC-Ani-009173	Aspergillus nidulans	75.34	0.00e+00	698.00
IUUC-Ang-009873	Aspergillus niger	74.16	0.00e+00	674.00
IUUC-Aor-009973	Aspergillus oryzae	51.75	1.00e-137	481.00
IUUC-Ame-011154	Astyanax mexicanus	41.56	1.00e-90	324.00
IUUC-Bgr-011972	Blumeria graminis	61.66	1.00e-169	587.00
IUUC-Bta-013106	Bos taurus	41.81	4.00e-91	326.00
IUUC-Bci-013615	Botrytis cinerea	62.26	5.00e-176	608.00
IUUC-Cel-018459	Caenorhabditis elegans	40.45	4.00e-81	293.00
IUUC-Cja-018755	Callithrix jacchus	41.35	1.00e-88	318.00
IUUC-Cfa-020749	Canis familiaris	41.81	4.00e-91	326.00
IUUC-Cpo-022371	Cavia porcellus	41.81	4.00e-91	326.00
IUUC-Csa-023524	Chlorocebus sabaeus	42.90	8.00e-77	278.00
IUUC-Cho-024764	Choloepus hoffmanni	39.61	5.00e-75	272.00
IUUC-Cin-025753	Ciona intestinalis	38.43	1.00e-81	295.00
IUUC-Csv-025817	Ciona savignyi	37.81	1.00e-83	301.00
IUUC-Cgl-026529	Colletotrichum gloeosporioides	59.91	7.00e-157	545.00
IUUC-Cne-027087	Cryptococcus neoformans	49.37	2.00e-100	357.00
IUUC-Dre-028314	Danio rerio	41.85	4.00e-90	323.00
IUUC-Dno-029050	Dasypus novemcinctus	41.81	4.00e-91	326.00
IUUC-Dor-030222	Dipodomys ordii	38.64	3.00e-82	296.00
IUUC-Dse-031164	Dothistroma septosporum	57.52	4.00e-152	529.00
IUUC-Dme-031745	Drosophila melanogaster	42.61	3.00e-82	296.00
IUUC-Ete-032508	Echinops telfairi	44.23	6.00e-61	226.00
IUUC-Eca-034288	Equus caballus	41.86	4.00e-88	316.00
IUUC-Eeu-034984	Erinaceus europaeus	38.38	5.00e-81	292.00
IUUC-Fca-036498	Felis catus	41.81	4.00e-91	326.00
IUUC-Fal-036920	Ficedula albicollis	42.11	3.00e-91	326.00
IUUC-Fox-037996	Fusarium oxysporum	59.78	1.00e-163	567.00
IUUC-Fso-038160	Fusarium solani	57.21	8.00e-156	541.00
IUUC-Gmo-038983	Gadus morhua	42.07	1.00e-90	324.00
IUUC-Ggr-040051	Gaeumannomyces graminis	55.65	6.00e-151	525.00
IUUC-Gga-040623	Gallus gallus	42.11	3.00e-91	326.00
IUUC-Gac-041613	Gasterosteus aculeatus	41.56	7.00e-90	322.00
IUUC-Ggo-045410	Gorilla gorilla	41.43	2.00e-74	270.00
IUUC-Hsa-046358	Homo sapiens	41.81	5.00e-91	325.00
IUUC-Itr-047890	Ictidomys tridecemlineatus	41.81	4.00e-91	326.00
IUUC-Kpa-049351	Komagataella pastoris	27.80	6.00e-43	166.00
IUUC-Lch-049936	Latimeria chalumnae	42.46	7.00e-91	325.00
IUUC-Loc-052476	Lepisosteus oculatus	42.38	2.00e-88	317.00
IUUC-Lma-053170	Leptosphaeria maculans	60.78	2.00e-159	553.00
IUUC-Laf-053713	Loxodonta africana	41.21	2.00e-89	321.00
IUUC-Mcc-054628	Macaca mulatta	41.81	7.00e-91	325.00
IUUC-Meu-055927	Macropus eugenii	37.98	5.00e-45	172.00
IUUC-Mor-056962	Magnaporthe oryzae	57.95	6.00e-158	548.00
IUUC-Mpo-057583	Magnaporthe poae	56.52	4.00e-145	506.00
IUUC-Mla-058819	Melampsora laricipopulina	43.36	2.00e-98	351.00
IUUC-Mga-059945	Meleagris gallopavo	42.11	4.00e-91	326.00
IUUC-Mvi-060403	Microbotryum violaceum	44.74	5.00e-111	392.00
IUUC-Mmr-061289	Microcebus murinus	41.86	2.00e-88	317.00
IUUC-Mdo-061912	Monodelphis domestica	41.81	1.00e-90	325.00
IUUC-Mmu-063253	Mus musculus	41.81	4.00e-91	326.00
IUUC-Mpu-066638	Mustela putorius furo	41.81	4.00e-91	326.00
IUUC-Mlu-067267	Myotis lucifugus	41.16	1.00e-88	318.00
IUUC-Nfi-068571	Neosartorya fischeri	54.84	1.00e-148	517.00
IUUC-Ncr-068895	Neurospora crassa	59.69	3.00e-156	542.00
IUUC-Nle-069087	Nomascus leucogenys	40.12	8.00e-73	265.00
IUUC-Opr-070579	Ochotona princeps	41.81	4.00e-91	326.00
IUUC-Ont-072432	Oreochromis niloticus	42.61	1.00e-91	328.00
IUUC-Oan-073072	Ornithorhynchus anatinus	41.81	4.00e-91	326.00
IUUC-Ocu-074180	Oryctolagus cuniculus	41.81	4.00e-91	326.00
IUUC-Ola-086815	Oryzias latipes	42.32	7.00e-91	325.00
IUUC-Oga-088219	Otolemur garnettii	40.95	2.00e-89	320.00
IUUC-Oar-090394	Ovis aries	41.81	4.00e-91	326.00
IUUC-Ptr-091517	Pan troglodytes	41.81	4.00e-91	326.00
IUUC-Pan-092421	Papio anubis	41.81	7.00e-91	325.00
IUUC-Psi-093370	Pelodiscus sinensis	41.81	8.00e-91	325.00
IUUC-Pma-094319	Petromyzon marinus	41.14	3.00e-74	270.00
IUUC-Pno-094815	Phaeosphaeria nodorum	59.35	4.00e-163	565.00
IUUC-Pfo-097089	Poecilia formosa	42.32	2.00e-91	327.00
IUUC-Pab-098421	Pongo abelii	41.81	4.00e-91	326.00
IUUC-Pca-100120	Procavia capensis	33.14	3.00e-49	187.00
IUUC-Pva-102960	Pteropus vampyrus	41.56	9.00e-90	322.00
IUUC-Pgr-103538	Puccinia graminis	43.48	1.00e-104	371.00
IUUC-Ptt-103990	Puccinia triticina	38.77	4.00e-38	151.00
IUUC-Pte-104261	Pyrenophora teres	60.87	1.00e-165	574.00
IUUC-Pyt-104780	Pyrenophora triticirepentis	60.43	4.00e-165	572.00
IUUC-Rno-105123	Rattus norvegicus	41.81	4.00e-91	326.00
IUUC-Sce-106208	Saccharomyces cerevisiae	24.21	8.00e-32	129.00
IUUC-Sha-107010	Sarcophilus harrisii	41.81	7.00e-91	325.00
IUUC-Sja-107899	Schizosaccharomyces japonicus	36.60	3.00e-68	250.00
IUUC-Ssl-108571	Sclerotinia sclerotiorum	62.67	1.00e-169	587.00
IUUC-Sar-113309	Sorex araneus	41.09	9.00e-86	308.00
IUUC-Sre-115003	Sporisorium reilianum	47.45	2.00e-114	403.00
IUUC-Ssc-116148	Sus scrofa	41.81	4.00e-91	326.00
IUUC-Tgu-117299	Taeniopygia guttata	42.11	4.00e-91	326.00
IUUC-Tru-118179	Takifugu rubripes	41.31	3.00e-89	320.00
IUUC-Tsy-119493	Tarsius syrichta	42.32	6.00e-90	322.00
IUUC-Tni-120355	Tetraodon nigroviridis	41.06	1.00e-88	318.00
IUUC-Tre-121977	Trichoderma reesei	54.32	3.00e-143	499.00
IUUC-Tvi-122661	Trichoderma virens	54.62	8.00e-144	501.00
IUUC-Tme-127031	Tuber melanosporum	61.17	1.00e-159	554.00
IUUC-Tbe-127492	Tupaia belangeri	36.92	6.00e-41	159.00
IUUC-Ttr-128929	Tursiops truncatus	41.81	6.00e-91	325.00
IUUC-Uma-129347	Ustilago maydis	46.88	3.00e-112	396.00
IUUC-Vda-129837	Verticillium dahliae	56.93	8.00e-147	511.00
IUUC-Vpa-130532	Vicugna pacos	35.86	5.00e-72	262.00
IUUC-Xtr-131985	Xenopus tropicalis	42.07	2.00e-91	327.00
IUUC-Xma-133314	Xiphophorus maculatus	42.32	3.00e-91	326.00
IUUC-Yli-134403	Yarrowia lipolytica	37.23	5.00e-85	306.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence