iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-005388

UUCD1 version

UUC-AnC-00678

Ensembl Protein ID

ENSACAP00000009558.2

UniProt Accession

G1KJA9; G1KJA9_ANOCA

Protein Name

E3 ubiquitin-protein ligase

Gene Name

WWP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000009554.2	ENSACAT00000009755.2	ENSACAP00000009558.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.30e-134	448.8	594	926

Active Site

Position(s)	Description	Evidence
895	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f+gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl++F f+Gr++++al++g+++d+
   Q: 594  PYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKSNYCLQINPASTI-NPDHLSYFCFIGRFIAMALFHGKFIDT 681
           6799*******************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+kkl+++dle++d e+y+sl +i++n   +iee++l++ f+v+ e+lg+++++eLkpgG+n  Vt+eNkeeY+ l++e
   Q: 682  GFSLPFYKRMLNKKLTIKDLESIDTEFYNSLIWIRDN---NIEECNLEMYFCVDMELLGKVTSHELKPGGSNLLVTEENKEEYIGLMAE 767
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +g++eq++af +Gfnev+pl++l++F+e+ele+++cG++e+d+ d++++t y++ yt++s++i+wFw++++e ++e r +++qFv
   Q: 768  WRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRH-YTRNSKQIIWFWQFIKEADNEVRMRLMQFV 855
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlPlgGfael+    p++f+++k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 856  TGTCRLPLGGFAELMgsngPQKFCVEKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 926
           *********************************************************************96 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MATASPRTGS SNNYNGRLQM QVTICSAKLK RKKNWFGGTA IYTEVVADSE IKKTSKSNSS 60
SNPKWDEQLT VNVTPQTTLE FRVWSHHTLK ADALLGKATV DLRHALEIHN RRLEGVKEQL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCACAG CTTCTCCACG GACTGGAAGC AGTAATAACT ACAATGGGAG ATTACAAATG 60
CAAGTAACTA GTAAGTAAAA ATCTGTCCAA TTATGCACAT AATCATTTTT TTTGTTTTTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0061630--F:ubiquitin protein ligase activity
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001213	Ailuropoda melanoleuca	80.45	0.00e+00	1456.00
IUUC-Apl-003310	Anas platyrhynchos	84.26	0.00e+00	1526.00
IUUC-Ame-010992	Astyanax mexicanus	92.42	0.00e+00	853.00
IUUC-Bta-012857	Bos taurus	80.54	0.00e+00	1454.00
IUUC-Cel-018299	Caenorhabditis elegans	67.36	0.00e+00	840.00
IUUC-Cja-019448	Callithrix jacchus	81.42	0.00e+00	1479.00
IUUC-Cfa-020728	Canis familiaris	80.67	0.00e+00	1450.00
IUUC-Cpo-021635	Cavia porcellus	77.15	0.00e+00	1426.00
IUUC-Csa-023805	Chlorocebus sabaeus	84.77	0.00e+00	1170.00
IUUC-Cho-024943	Choloepus hoffmanni	70.41	0.00e+00	965.00
IUUC-Cin-025212	Ciona intestinalis	73.75	0.00e+00	905.00
IUUC-Csv-026256	Ciona savignyi	73.01	0.00e+00	901.00
IUUC-Dre-028245	Danio rerio	71.02	0.00e+00	1216.00
IUUC-Dno-029618	Dasypus novemcinctus	80.56	0.00e+00	1458.00
IUUC-Dme-032041	Drosophila melanogaster	69.74	0.00e+00	890.00
IUUC-Ete-032779	Echinops telfairi	90.85	0.00e+00	1066.00
IUUC-Eca-033313	Equus caballus	79.78	0.00e+00	1428.00
IUUC-Eeu-035259	Erinaceus europaeus	73.55	0.00e+00	1295.00
IUUC-Fca-035420	Felis catus	79.19	0.00e+00	1436.00
IUUC-Fal-037335	Ficedula albicollis	84.15	0.00e+00	1523.00
IUUC-Gmo-039172	Gadus morhua	87.65	0.00e+00	1062.00
IUUC-Gga-040246	Gallus gallus	83.53	0.00e+00	1504.00
IUUC-Gac-042211	Gasterosteus aculeatus	92.31	0.00e+00	1177.00
IUUC-Ggo-045001	Gorilla gorilla	80.10	0.00e+00	1304.00
IUUC-Hsa-046544	Homo sapiens	80.34	0.00e+00	1469.00
IUUC-Itr-048860	Ictidomys tridecemlineatus	80.00	0.00e+00	1415.00
IUUC-Lch-050398	Latimeria chalumnae	76.02	0.00e+00	1354.00
IUUC-Loc-052116	Lepisosteus oculatus	93.90	0.00e+00	1187.00
IUUC-Laf-053551	Loxodonta africana	79.48	0.00e+00	1426.00
IUUC-Mga-059986	Meleagris gallopavo	83.82	0.00e+00	1519.00
IUUC-Mmr-060945	Microcebus murinus	78.09	0.00e+00	1405.00
IUUC-Mdo-063024	Monodelphis domestica	80.09	0.00e+00	1412.00
IUUC-Mmu-063202	Mus musculus	79.03	0.00e+00	1400.00
IUUC-Mpu-065773	Mustela putorius furo	80.71	0.00e+00	1446.00
IUUC-Nle-069188	Nomascus leucogenys	80.88	0.00e+00	1479.00
IUUC-Opr-070965	Ochotona princeps	78.52	0.00e+00	1405.00
IUUC-Ont-072226	Oreochromis niloticus	90.85	0.00e+00	1183.00
IUUC-Oan-073497	Ornithorhynchus anatinus	82.37	0.00e+00	1475.00
IUUC-Ocu-073891	Oryctolagus cuniculus	77.79	0.00e+00	1373.00
IUUC-Ola-087438	Oryzias latipes	89.92	0.00e+00	1174.00
IUUC-Oga-087922	Otolemur garnettii	80.79	0.00e+00	1467.00
IUUC-Oar-089317	Ovis aries	79.68	0.00e+00	1435.00
IUUC-Ptr-090484	Pan troglodytes	80.34	0.00e+00	1468.00
IUUC-Pan-092117	Papio anubis	80.67	0.00e+00	1474.00
IUUC-Psi-093338	Pelodiscus sinensis	85.68	0.00e+00	1560.00
IUUC-Pma-094279	Petromyzon marinus	72.25	0.00e+00	833.00
IUUC-Pfo-096171	Poecilia formosa	92.67	0.00e+00	1178.00
IUUC-Pab-098654	Pongo abelii	82.53	0.00e+00	1133.00
IUUC-Pva-102811	Pteropus vampyrus	71.29	0.00e+00	1268.00
IUUC-Rno-106125	Rattus norvegicus	79.68	0.00e+00	1432.00
IUUC-Sha-107243	Sarcophilus harrisii	81.07	0.00e+00	1445.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	48.21	9.00e-151	527.00
IUUC-Sre-114929	Sporisorium reilianum	45.42	2.00e-152	532.00
IUUC-Ssc-115368	Sus scrofa	80.26	0.00e+00	1444.00
IUUC-Tgu-117079	Taeniopygia guttata	83.40	0.00e+00	1499.00
IUUC-Tru-118062	Takifugu rubripes	70.64	0.00e+00	1320.00
IUUC-Tsy-119507	Tarsius syrichta	75.94	0.00e+00	1349.00
IUUC-Tni-120151	Tetraodon nigroviridis	90.97	0.00e+00	1169.00
IUUC-Ttr-129260	Tursiops truncatus	70.57	0.00e+00	1213.00
IUUC-Uma-129332	Ustilago maydis	45.25	8.00e-145	507.00
IUUC-Xtr-132877	Xenopus tropicalis	69.39	0.00e+00	1190.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence