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Tag Content
UUCD2 ID IUUC-Dre-028230
UUCD1 version UUC-DaR-01461
Ensembl Protein ID ENSDARP00000116502.1
UniProt Accession A5WWB0; UBP46_DANRE
Genbank Protein ID CAN88313.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 46; Deubiquitinating enzyme 46; Ubiquitin thioesterase 46; Ubiquitin-specific-processing protease 46
Genbank Nucleotide ID CT827859
Gene Name usp46; ch73-16a12.1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSDARG00000045343.7 ENSDART00000132093.1 ENSDARP00000116502.1
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 1.20e-97 328.1 35 368
Active Site
Position(s) Description Evidence
44 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
317 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgy 87
           +Gl N+gNtCY+NSvLQ+L++++++re++l     k++    +++k++ll++l++lf+++   k+k +++ p+++++ l+ke+  f++y
   Q: 35   FGLVNFGNTCYCNSVLQALYFCRPFRENVLA---YKVQ----QKKKENLLTCLADLFHSIAtqKKKVGVIPPKKFISRLRKENDLFDNY 116
           6******************************...5665....45789*************976777779******************** PP
   S: 88   eqqDaqEflaflldqleeelkkeknkpkeeeeeedk.selsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslp 175
           +qqDa+Efl++ll+++ + l++e++++k++ + +++ ++   + e +++k  +++++++Fqg+l+++++cl+c++vss++e+fldls++
   Q: 117  MQQDAHEFLNYLLNTVADILQEERKQEKQNGRLKNNgTAIATDTEPEQNKIDPTWVHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVD 205
           ********************774444444443333303444446667777777************************************ PP
   S: 176  vpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspf 264
           v++++     s+++cL++f+++e+l++e kyyce c++kqea+k++++kklP +L lhLkRf++ e+ ++ +k++ +v fpleL l  f
   Q: 206  VEQNT-----SITHCLRDFSNTETLCSEYKYYCEMCCSKQEAQKRMRVKKLPMILALHLKRFKYMEQLHRYTKLSYRVVFPLELRL--F 287
           *****.....9**********************************************************************55555..7 PP
   S: 265  ctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetg.........staYvlfYkr 337
           +ts  ++++ ++ Y+L+avvvH G +++ GHY+++vk+ +g WllfdD+ V++++ + ++e+ g         +++Y+lfY++
   Q: 288  NTSG-DAVNLDRMYDLVAVVVHCGsGPNRGHYITIVKS-HGFWLLFDDDIVEKIDAQAIEEFYGltsdisknsESGYILFYQS 368
           7774.45556****************************.888*******************999*****************97 PP
   
Organism Danio rerio
Functional Description
(View)

Functional Description


     Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with wdr48 to have a high activity (By similarity).
 Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with wdr48 to have a high activity (By similarity).
Protein Sequence
(Fasta)
MTVRNIASIC NMGTNASALE KDIGPEQFPI NEHYFGLVNF GNTCYCNSVL QALYFCRPFR 60
ENVLAYKVQQ KKKENLLTCL ADLFHSIATQ KKKVGVIPPK KFISRLRKEN DLFDNYMQQD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dre-028230|DUB,USP|Danio rerio
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGCGGGGTT TGACCGCTAA TCCAGGATGT GAATGTTTCG TTTAGGACGT GCAACTGGCA 60
AAGATGTTTA CAATAAGTTT ATCCAGCATT TTTATTCTCA TTTGCAGTGG CCATGAAGAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dre-028230|DUB,USP|Danio rerio
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0085--Behavior
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF00443--UCH
Gene Ontology

GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007610--P:behavior
GO:0016579--P:protein deubiquitination
GO:0032228--P:regulation of synaptic transmission, GABAergic
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG dre:100148916
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002353 Ailuropoda melanoleuca 91.03 0.00e+00 667.00
IUUC-Atr-002650 Amborella trichopoda 59.29 1.00e-124 439.00
IUUC-Apl-003380 Anas platyrhynchos 89.73 0.00e+00 665.00
IUUC-Aca-005031 Anolis carolinensis 94.86 0.00e+00 726.00
IUUC-Ath-006663 Arabidopsis thaliana 59.34 2.00e-125 442.00
IUUC-Ago-007871 Ashbya gossypii 38.72 4.00e-48 186.00
IUUC-Ame-010862 Astyanax mexicanus 96.22 0.00e+00 745.00
IUUC-Bta-013023 Bos taurus 91.23 0.00e+00 665.00
IUUC-Bdi-014008 Brachypodium distachyon 60.00 3.00e-125 441.00
IUUC-Cel-018379 Caenorhabditis elegans 62.16 8.00e-142 496.00
IUUC-Cja-018956 Callithrix jacchus 90.30 0.00e+00 662.00
IUUC-Cfa-021064 Canis familiaris 91.90 0.00e+00 654.00
IUUC-Cpo-022443 Cavia porcellus 92.24 0.00e+00 667.00
IUUC-Csa-023841 Chlorocebus sabaeus 92.70 0.00e+00 687.00
IUUC-Csv-025828 Ciona savignyi 53.76 7.00e-125 440.00
IUUC-Cne-026900 Cryptococcus neoformans 42.03 4.00e-60 226.00
IUUC-Dno-029209 Dasypus novemcinctus 90.24 0.00e+00 665.00
IUUC-Dme-032038 Drosophila melanogaster 81.28 3.00e-100 358.00
IUUC-Eca-033721 Equus caballus 92.46 0.00e+00 662.00
IUUC-Eeu-034916 Erinaceus europaeus 91.97 1.00e-151 529.00
IUUC-Fca-036299 Felis catus 90.27 0.00e+00 664.00
IUUC-Gmo-038611 Gadus morhua 93.58 0.00e+00 701.00
IUUC-Ggr-039806 Gaeumannomyces graminis 43.17 7.00e-77 281.00
IUUC-Gga-041157 Gallus gallus 92.70 0.00e+00 689.00
IUUC-Gac-041764 Gasterosteus aculeatus 93.19 0.00e+00 716.00
IUUC-Gma-043828 Glycine max 59.57 2.00e-125 442.00
IUUC-Ggo-044659 Gorilla gorilla 90.57 0.00e+00 666.00
IUUC-Hsa-046156 Homo sapiens 92.70 0.00e+00 687.00
IUUC-Itr-048157 Ictidomys tridecemlineatus 92.70 0.00e+00 687.00
IUUC-Kpa-049250 Komagataella pastoris 43.54 1.00e-67 251.00
IUUC-Lch-049969 Latimeria chalumnae 93.26 0.00e+00 680.00
IUUC-Loc-052479 Lepisosteus oculatus 90.27 0.00e+00 696.00
IUUC-Lma-053300 Leptosphaeria maculans 45.37 1.00e-80 295.00
IUUC-Laf-054085 Loxodonta africana 92.70 0.00e+00 687.00
IUUC-Mcc-055566 Macaca mulatta 90.79 0.00e+00 665.00
IUUC-Mpo-057424 Magnaporthe poae 43.79 4.00e-76 279.00
IUUC-Mtr-057715 Medicago truncatula 59.56 6.00e-125 440.00
IUUC-Mla-059142 Melampsora laricipopulina 54.92 3.00e-95 343.00
IUUC-Mga-059575 Meleagris gallopavo 92.46 0.00e+00 662.00
IUUC-Mvi-060357 Microbotryum violaceum 51.92 2.00e-76 281.00
IUUC-Mdo-062579 Monodelphis domestica 94.34 0.00e+00 687.00
IUUC-Mmu-063611 Mus musculus 92.70 0.00e+00 687.00
IUUC-Mac-065323 Musa acuminata 59.17 1.00e-121 429.00
IUUC-Mpu-066038 Mustela putorius furo 92.46 0.00e+00 662.00
IUUC-Mlu-068183 Myotis lucifugus 90.76 0.00e+00 670.00
IUUC-Nle-069330 Nomascus leucogenys 92.70 0.00e+00 687.00
IUUC-Opr-070980 Ochotona princeps 93.87 0.00e+00 660.00
IUUC-Ont-072134 Oreochromis niloticus 96.49 0.00e+00 749.00
IUUC-Ocu-074923 Oryctolagus cuniculus 92.46 0.00e+00 663.00
IUUC-Oba-075220 Oryza barthii 58.90 2.00e-122 432.00
IUUC-Ogl-077216 Oryza glaberrima 58.90 2.00e-122 432.00
IUUC-Ogu-078836 Oryza glumaepatula 58.90 2.00e-122 432.00
IUUC-Oin-079522 Oryza indica 58.90 2.00e-122 432.00
IUUC-Olo-080882 Oryza longistaminata 58.90 2.00e-122 432.00
IUUC-Ome-081549 Oryza meridionalis 58.90 2.00e-122 432.00
IUUC-Oni-082982 Oryza nivara 58.90 2.00e-122 432.00
IUUC-Opu-083532 Oryza punctata 58.90 8.00e-123 433.00
IUUC-Oru-084568 Oryza rufipogon 58.90 2.00e-122 432.00
IUUC-Osa-085299 Oryza sativa 58.90 2.00e-122 432.00
IUUC-Ola-086546 Oryzias latipes 94.78 0.00e+00 722.00
IUUC-Oga-088073 Otolemur garnettii 92.46 0.00e+00 662.00
IUUC-Oar-089248 Ovis aries 92.46 0.00e+00 662.00
IUUC-Ptr-090814 Pan troglodytes 92.70 0.00e+00 687.00
IUUC-Pan-091753 Papio anubis 92.70 0.00e+00 687.00
IUUC-Psi-094012 Pelodiscus sinensis 92.46 0.00e+00 662.00
IUUC-Pma-094388 Petromyzon marinus 89.81 0.00e+00 694.00
IUUC-Pno-095044 Phaeosphaeria nodorum 45.48 1.00e-78 288.00
IUUC-Ppa-095275 Physcomitrella patens 59.41 1.00e-127 449.00
IUUC-Pfo-097369 Poecilia formosa 96.49 0.00e+00 749.00
IUUC-Pab-098594 Pongo abelii 92.48 0.00e+00 664.00
IUUC-Pca-100913 Procavia capensis 78.06 5.00e-149 520.00
IUUC-Pva-102892 Pteropus vampyrus 92.46 0.00e+00 662.00
IUUC-Rno-104909 Rattus norvegicus 94.07 0.00e+00 686.00
IUUC-Sce-106367 Saccharomyces cerevisiae 36.69 5.00e-56 212.00
IUUC-Sha-107400 Sarcophilus harrisii 94.15 0.00e+00 662.00
IUUC-Ssc-115550 Sus scrofa 92.46 0.00e+00 662.00
IUUC-Tgu-116800 Taeniopygia guttata 92.70 0.00e+00 689.00
IUUC-Tru-118212 Takifugu rubripes 96.49 0.00e+00 745.00
IUUC-Tni-120071 Tetraodon nigroviridis 96.49 0.00e+00 748.00
IUUC-Vpa-130590 Vicugna pacos 89.72 1.00e-178 619.00
IUUC-Xma-133111 Xiphophorus maculatus 96.22 0.00e+00 747.00
Created Date 25-Jun-2017

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