iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	11683918

Classification

Family	E-value	Score	Start	End
DUB/USP	1.60e-92	310.6	570	1175

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp..kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEfla 97
           +Gl N gN CY N+ +QcL+ +++l++++l++++ +  ++ +   ++ +e + +++kl++e+w  kkk+++p+++ +a++  + +f+ +eq+D+qEf+a
   Q: 570  VGLVNYGNFCYRNAGIQCLARVSPLTQYFLDEDNLDAIKRGNlrRGDAAETTIEYAKLLREMWAAKKKNIAPNDFNDAIRLSSDMFECSEQHDCQEFVA 668
           6******************************555554444333378899************************************************** PP
   S: 98   flldqleeelkk...eknkpkeeeeeedkselsde..................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslp 175
           flldql++++ +   + + + ee+e++d+++lsd+                  ++ + +k+n+sl+++lF gql+s+++c +c+++ss +epf++lslp
   Q: 669  FLLDQLHTSMYEsnkSLHPSPEESEGTDSNKLSDSskkkeadkeeadeekaerSWTEYEKQNESLVTQLFTGQLRSRLICRTCQSSSSVFEPFTSLSLP 767
           **********6656644445555555555555555566666666666667777********************************************** PP
   S: 176  vpgkeetkke......................................................................................... 185
           +  ++    +                                                                                         
   Q: 768  IGFEDVDLYQvivvhrdgriprrygfrlsrdskvgnlrevvavssgismshltiqcmsskgtlmsrspnhrssnlrdelplssfpsgarlyalelpest 866
           **999887779**************************************************************************************** PP
   S: 186  ................................................................................................... 185
                                                                                                              
   Q: 867  gedqwrvamhrklqynhepyilgstagfivsrfglplivgldeevtgkklyedvmyqmhrfmehsvnssssrahdpcedensgypftlclvdpnyewcg 965
           *************************************************************************************************** PP
   S: 186  ..................................................................slqdcLesftkeeelegenkyycekckkkqeae 218
                                                                             sl++c+e+f+ +e+l+   +++c++c+kk+   
   Q: 966  qcpalrfcrgcpirpdeskvfipancpiavdwlpialylrynhsqeqaceddpsvaetwsrhfapsSLEHCIEKFSCPETLDA--AIQCDRCEKKTMRD 1062
           *********************************************************************************85..8************* PP
   S: 219  kklklkklPevLilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVte 316
           k ++++klP++Li+hLkRf+f +eq++  k+++ v+fpl+ +d +pf+ +p+      ++Ye ia  +H+G+ls+GH++ay+k++++kWll++D +V+e
   Q: 1063 KVMTIWKLPKYLIIHLKRFEFLREQGRMGKCKRTVNFPLKhFDPAPFVDKPD-----GNTYECIALANHYGQLSCGHFIAYAKSNEDKWLLLNDCSVRE 1156
           **************************************************98.....679*************************************** PP
   S: 317  vkeeevleetgstaYvlfYkrr 338
           v+eeev +   + aY+lfY+r+
   Q: 1157 VSEEEVDK---QGAYLLFYERK 1175
           ********...********985 PP

Organism

Caenorhabditis elegans

Protein Sequence
(Fasta)

MGNTLTGRSN AIAPIISAED AKTYISDEEY RRIRQAFQRF KNGCINYDEF CYHVLGGAQI 60
PEEKRRLLFS FFSHGAETIS FDNLLSSLVG LCRVEEVQSR FIEEYHEFAS WGLSPPKLTI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTCGGCAAG AAAATCTGGT TCAGATGCTC AAATGCCATA ATCCGAAATG GGTAACACGT 60
TAACTGGACG TTCGAACGCT ATCGCACCGA TTATCAGTGC GGAAGATGCT AAAACTTATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0106--Calcium
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR002048--EF_hand_dom
IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS00018--EF_HAND_1
PS50222--EF_HAND_2
PS50235--USP_3

Pfam

PF06337--DUSP
PF00443--UCH

SMART

SM00695--DUSP
SM00054--EFh

Gene Ontology

GO:0005509--F:calcium ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination

KEGG

cel:CELE_ZK328.1

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cho-024603	Choloepus hoffmanni	37.37	3.00e-28	120.00
IUUC-Csv-026344	Ciona savignyi	28.37	2.00e-68	253.00
IUUC-Dme-032094	Drosophila melanogaster	29.55	2.00e-48	187.00
IUUC-Fal-036985	Ficedula albicollis	29.21	1.00e-84	307.00
IUUC-Gmo-039479	Gadus morhua	25.53	5.00e-45	175.00
IUUC-Gga-040509	Gallus gallus	28.38	3.00e-106	379.00
IUUC-Gac-041757	Gasterosteus aculeatus	29.11	2.00e-84	306.00
IUUC-Ggo-044956	Gorilla gorilla	29.76	3.00e-77	283.00
IUUC-Hvu-047686	Hordeum vulgare	28.32	7.00e-33	133.00
IUUC-Itr-048865	Ictidomys tridecemlineatus	37.45	3.00e-37	148.00
IUUC-Lch-050332	Latimeria chalumnae	23.31	5.00e-37	149.00
IUUC-Laf-054033	Loxodonta africana	26.89	8.00e-48	184.00
IUUC-Mga-059892	Meleagris gallopavo	29.13	1.00e-81	297.00
IUUC-Obr-076301	Oryza brachyantha	24.52	5.00e-52	198.00
IUUC-Oin-080145	Oryza indica	23.79	2.00e-50	192.00
IUUC-Opu-083518	Oryza punctata	26.39	3.00e-50	192.00
IUUC-Ola-087303	Oryzias latipes	26.29	4.00e-46	179.00
IUUC-Rno-105113	Rattus norvegicus	30.07	4.00e-84	305.00
IUUC-Sha-106558	Sarcophilus harrisii	25.91	2.00e-46	179.00
IUUC-Sar-113201	Sorex araneus	37.01	4.00e-37	149.00
IUUC-Ssc-115312	Sus scrofa	25.48	1.00e-44	174.00
IUUC-Tru-118705	Takifugu rubripes	27.31	3.00e-76	278.00
IUUC-Tae-125515	Triticum aestivum	24.81	3.00e-56	212.00
IUUC-Tur-126392	Triticum urartu	24.67	4.00e-53	202.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence