iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-090605

UUCD1 version

UUC-PaT-01079

Ensembl Protein ID

ENSPTRP00000016094.2

UniProt Accession

H2QDL0; H2QDL0_PANTR

Genbank Protein ID

JAA19127.1; JAA19128.1; JAA25959.1; JAA25960.1; JAA25961.1; JAA40366.1; JAA40367.1; JAA40368.1; JAA40369.1

Protein Name

Ubiquitin specific peptidase 32

Genbank Nucleotide ID

AACZ03108796; GABF01003017; GABD01007141; GABD01007140; GABD01007139; GABE01004373; GABE01004372; GABE01004371; GABE01004370

Gene Name

USP32

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000009483.6	ENSPTRT00000017384.2	ENSPTRP00000016094.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.30e-107	357.6	734	1567

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl+NlgNtC+mNS +Qc sn+++l++++ + ++  +ln++np ++kg+++k++ +l++elw++++k+v+p +l  +++k+a++f+g
   Q: 734  TGLSNLGNTCFMNSSIQCVSNTQPLTQYFISgRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKNVAPLKLRWTIAKYAPRFNG 820
           7******************************9******************************************************* PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           ++qqD+qE+laflld+l+e+l++ ++kp+ e++++d   ++d+     a++++ ++n+s+++dlF+gql+sq+kc++c+++s+r++p
   Q: 821  FQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSD--GRPDWevaaeAWDNHLRRNRSIVVDLFHGQLRSQVKCKTCGHISVRFDP 905
           ********************************9999..6666666777*************************************** PP
   S: 169  fldlslpvpgkeetkke...................................................................... 185
           f+ lslp+p+++ +++e                                                                      
   Q: 906  FNFLSLPLPMDSYMHLEitvikldgttpvryglrlnmdekytglkkqlsdlcglnseqillaevhgsniknfpqdnqkvrlsvsgfl 992
           *************9999********************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 993  cafeipvpvspisassptqtdfssspstngmftlttngdlprpifipngmpntvvpcgteknftngmvnghmpslpdspftgyiiav 1079
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 1080 hrkmmrtelyflssqknrpslfgmplivpctvhtrkkdlydavwiqvsrlasplppqeasnhaqdcddsmgyqypftlrvvqkdgns 1166
           *************************************************************************************** PP
   S: 186  ...................................................................slqdcLesftkeeelegenk 205
                                                                              +l++cL++ft+eeel ++++
   Q: 1167 cawcpwyrfcrgckidcgedrafignayiavdwdptalhlryqtsqervvdehesveqsrraqaepiNLDSCLRAFTSEEELGENEM 1253
           *************************************************************************************** PP
   S: 206  yycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.Ldlspfcts........................ 267
           yyc+kck ++ a+kkl+l++lP++Li+hLkRf+f +   + +k +k v+fp+e +d s f++                         
   Q: 1254 YYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNG--RWIKSQKIVKFPREsFDPSAFLVPrdpalcqrkpltpqgdelsepril 1338
           ********************************99775..5569******************99999999999999999999999999 PP
   S: 268  ....................................................................................... 267
                                                                                                  
   Q: 1339 arevkkvdaqssageedvllskspsslsaniisspkgspsssrksgtscpssknsspnssprtlgrskgrlrlpqigsknklssske 1425
           999999999999888888888888888888888888888888888887777777666666666666666666666666665555555 PP
   S: 268  ..peekqke.............................................................................k 275
             +                                                                                   k
   Q: 1426 nlD-----AskengagqiceladalsrghvlggsqpelvtpqdhevalangflyeheacgngysngqlgnhseedstddqredtriK 1507
           550.....055555555555666666666666666666666666666666666666666666666666666666667777788888* PP
   S: 276  kkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkrr 338
            +Y+L+a+ +HsG l++GHYv+y+kn + kW++++Ds+++e++ +e+ +   ++aY+lfY+++
   Q: 1508 PIYNLYAISCHSGILGGGHYVTYAKNPNCKWYCYNDSSCKELHPDEIDT---DSAYILFYEQQ 1567
           *************************************************...********985 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MGAKESRIGF LSYEEALRRV TDVELKRLKD AFKRTCGLSY YMGQHCFIRE VLGDGVPPKV 60
AEVIYCSFGG TSKGLHFNNL IVGLVLLTRG KDEEKAKYIF SLFSSESGNY VIREEMERML 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGAGGGAAG GAGAGGGAGG AGAGAGAAGG GCGGAGTAGG AGGCAGGGGA AGGGGGCGGG 60
GCGGAAGAGT CACGTGATCC GGCATGGAGG CGGTGGCGGC GACCGGGAGG AGCCGCCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0106--Calcium
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR002048--EF_hand_dom
IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR028135--Ub_USP-typ
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS00018--EF_HAND_1
PS50222--EF_HAND_2
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF06337--DUSP
PF13202--EF-hand_5
PF14836--Ubiquitin_3
PF00443--UCH

SMART

SM00695--DUSP
SM00054--EFh

Gene Ontology

GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005509--F:calcium ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001611	Ailuropoda melanoleuca	96.72	0.00e+00	2622.00
IUUC-Apl-003272	Anas platyrhynchos	83.62	0.00e+00	2659.00
IUUC-Aca-005057	Anolis carolinensis	83.60	0.00e+00	2305.00
IUUC-Ame-010781	Astyanax mexicanus	74.60	0.00e+00	2401.00
IUUC-Bta-013502	Bos taurus	92.68	0.00e+00	2820.00
IUUC-Cja-018754	Callithrix jacchus	98.57	0.00e+00	3141.00
IUUC-Cfa-020526	Canis familiaris	96.97	0.00e+00	3050.00
IUUC-Cpo-021568	Cavia porcellus	91.47	0.00e+00	2770.00
IUUC-Csa-023143	Chlorocebus sabaeus	98.69	0.00e+00	3108.00
IUUC-Cho-024603	Choloepus hoffmanni	62.92	0.00e+00	699.00
IUUC-Cin-025583	Ciona intestinalis	50.60	0.00e+00	1281.00
IUUC-Csv-026344	Ciona savignyi	46.88	0.00e+00	1174.00
IUUC-Dre-028121	Danio rerio	82.76	0.00e+00	2180.00
IUUC-Dno-029911	Dasypus novemcinctus	95.41	0.00e+00	2980.00
IUUC-Dor-030608	Dipodomys ordii	59.76	0.00e+00	1098.00
IUUC-Dme-032094	Drosophila melanogaster	45.21	4.00e-123	436.00
IUUC-Ete-032639	Echinops telfairi	93.61	0.00e+00	1579.00
IUUC-Eca-034253	Equus caballus	96.74	0.00e+00	3024.00
IUUC-Eeu-035084	Erinaceus europaeus	80.14	0.00e+00	1578.00
IUUC-Fca-035474	Felis catus	96.42	0.00e+00	2510.00
IUUC-Fal-036985	Ficedula albicollis	84.56	0.00e+00	2613.00
IUUC-Gmo-039568	Gadus morhua	80.83	0.00e+00	2140.00
IUUC-Gga-040509	Gallus gallus	83.50	0.00e+00	2745.00
IUUC-Gac-041757	Gasterosteus aculeatus	80.56	0.00e+00	2186.00
IUUC-Ggo-044956	Gorilla gorilla	90.18	0.00e+00	1874.00
IUUC-Hsa-046107	Homo sapiens	99.81	0.00e+00	3162.00
IUUC-Itr-048865	Ictidomys tridecemlineatus	96.08	0.00e+00	1198.00
IUUC-Lch-050681	Latimeria chalumnae	78.13	0.00e+00	2408.00
IUUC-Loc-052474	Lepisosteus oculatus	77.87	0.00e+00	2481.00
IUUC-Laf-054273	Loxodonta africana	96.01	0.00e+00	3058.00
IUUC-Mcc-054718	Macaca mulatta	98.88	0.00e+00	3143.00
IUUC-Meu-056558	Macropus eugenii	71.92	0.00e+00	1410.00
IUUC-Mga-059892	Meleagris gallopavo	84.99	0.00e+00	2661.00
IUUC-Mmr-060866	Microcebus murinus	96.91	0.00e+00	3137.00
IUUC-Mdo-062607	Monodelphis domestica	92.47	0.00e+00	2980.00
IUUC-Mmu-063797	Mus musculus	95.70	0.00e+00	3110.00
IUUC-Mpu-066121	Mustela putorius furo	97.26	0.00e+00	3111.00
IUUC-Mlu-067581	Myotis lucifugus	95.04	0.00e+00	3044.00
IUUC-Nle-069916	Nomascus leucogenys	96.85	0.00e+00	3011.00
IUUC-Opr-071073	Ochotona princeps	85.41	0.00e+00	1207.00
IUUC-Ont-071310	Oreochromis niloticus	81.21	0.00e+00	2157.00
IUUC-Oan-073356	Ornithorhynchus anatinus	89.85	0.00e+00	2877.00
IUUC-Ocu-074216	Oryctolagus cuniculus	96.57	0.00e+00	3078.00
IUUC-Ola-087434	Oryzias latipes	80.55	0.00e+00	2090.00
IUUC-Oga-089034	Otolemur garnettii	95.97	0.00e+00	2999.00
IUUC-Oar-090369	Ovis aries	96.80	0.00e+00	3045.00
IUUC-Pan-092381	Papio anubis	98.85	0.00e+00	3061.00
IUUC-Psi-093819	Pelodiscus sinensis	87.20	0.00e+00	2757.00
IUUC-Pma-094480	Petromyzon marinus	64.11	0.00e+00	1476.00
IUUC-Pfo-096561	Poecilia formosa	80.00	0.00e+00	2122.00
IUUC-Pab-097643	Pongo abelii	96.57	0.00e+00	3029.00
IUUC-Pca-100944	Procavia capensis	78.29	0.00e+00	1030.00
IUUC-Pva-102732	Pteropus vampyrus	86.73	0.00e+00	2684.00
IUUC-Rno-105113	Rattus norvegicus	95.65	0.00e+00	3045.00
IUUC-Sha-107608	Sarcophilus harrisii	84.40	2.00e-172	597.00
IUUC-Sar-113201	Sorex araneus	83.99	0.00e+00	1694.00
IUUC-Ssc-115469	Sus scrofa	94.60	0.00e+00	659.00
IUUC-Tgu-117322	Taeniopygia guttata	85.94	0.00e+00	2760.00
IUUC-Tru-118705	Takifugu rubripes	68.60	0.00e+00	674.00
IUUC-Tsy-119433	Tarsius syrichta	81.76	0.00e+00	2126.00
IUUC-Tni-120631	Tetraodon nigroviridis	80.59	0.00e+00	2103.00
IUUC-Tbe-127553	Tupaia belangeri	88.02	0.00e+00	704.00
IUUC-Ttr-128260	Tursiops truncatus	95.90	0.00e+00	3050.00
IUUC-Vpa-130479	Vicugna pacos	91.80	0.00e+00	2850.00
IUUC-Xtr-132686	Xenopus tropicalis	82.71	0.00e+00	2608.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence