iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-013240

Ensembl Protein ID

ENSBTAP00000021808.3

UniProt Accession

Q3ZC32; Q3ZC32_BOVIN

Genbank Protein ID

AAI02938.1

Protein Name

Optineurin

Genbank Nucleotide ID

DAAA02035514

Gene Name

OPTN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000016401.3	ENSBTAT00000021808.3	ENSBTAP00000021808.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/UBAN	2.30e-24	85.2	448	504

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBAN

   S: 1    keelletvevLkqQveiYkeDFqaERadRErlneekeeLqeqveklqkqvsklndsl 57
           +e++let+ vL++Q+e+Y++DF+aERa+RE+++eeke+L+ q+++l+k++++++d++
   Q: 448  QEKDLETMAVLRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAVLLKENNAFEDGG 504
           6899**************************************************986 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

MSHQPLSCLT EKGDSPSETT GNGPPNLAHP NLDTFTPHEL LQQMRELLIE NHQLKEAMKL 60
NNQAMKGRFE ELSAWTEKQK EERLYFETQS KEAKERLTAL SLENEKLKQE LGTLTGKTER 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCCCAACCC CCGCCGCTGC CCCAGCGGGT CTCCTGCTTG GCGTCTGCCT CTGGGTCCGG 60
AGCCCTCTCC CAGCGGGCAT CATGCCGAGG AAGCAGTGAC CCGAGGGAGG CTGGAGCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR032419--CC2-LZ_dom
IPR021063--NEMO_N
IPR032939--Optineurin
IPR034735--ZF_CCHC_NOA

PROSITE

PS51801--ZF_CCHC_NOA

Pfam

PF16516--CC2-LZ
PF11577--NEMO

Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005802--C:trans-Golgi network
GO:0070530--F:K63-linked polyubiquitin binding
GO:0050829--P:defense response to Gram-negative bacterium
GO:0090161--P:Golgi ribbon formation
GO:0043001--P:Golgi to plasma membrane protein transport
GO:0016236--P:macroautophagy
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0001920--P:negative regulation of receptor recycling
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1904417--P:positive regulation of xenophagy
GO:0000042--P:protein targeting to Golgi
GO:0043122--P:regulation of I-kappaB kinase/NF-kappaB signaling

KEGG

bta:534150

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002037	Ailuropoda melanoleuca	81.96	0.00e+00	815.00
IUUC-Apl-003812	Anas platyrhynchos	56.38	4.00e-144	504.00
IUUC-Aca-004625	Anolis carolinensis	53.53	7.00e-143	500.00
IUUC-Ame-011116	Astyanax mexicanus	46.53	3.00e-54	206.00
IUUC-Cja-019911	Callithrix jacchus	83.07	0.00e+00	833.00
IUUC-Cfa-020330	Canis familiaris	85.89	0.00e+00	865.00
IUUC-Cpo-021753	Cavia porcellus	79.34	0.00e+00	801.00
IUUC-Csa-023662	Chlorocebus sabaeus	84.11	0.00e+00	846.00
IUUC-Cho-024574	Choloepus hoffmanni	67.17	5.00e-123	434.00
IUUC-Cme-027299	Cyanidioschyzon merolae	36.99	1.50e-02	34.30
IUUC-Dre-027720	Danio rerio	40.71	3.00e-90	325.00
IUUC-Dno-029079	Dasypus novemcinctus	79.97	0.00e+00	775.00
IUUC-Dor-030890	Dipodomys ordii	80.48	0.00e+00	820.00
IUUC-Ete-032568	Echinops telfairi	78.67	0.00e+00	689.00
IUUC-Eca-033528	Equus caballus	85.98	0.00e+00	876.00
IUUC-Eeu-035219	Erinaceus europaeus	75.39	0.00e+00	791.00
IUUC-Fca-035852	Felis catus	83.96	0.00e+00	877.00
IUUC-Fal-036862	Ficedula albicollis	58.05	2.00e-141	495.00
IUUC-Gmo-038735	Gadus morhua	38.11	3.00e-72	265.00
IUUC-Gga-040939	Gallus gallus	56.27	3.00e-142	498.00
IUUC-Gac-041580	Gasterosteus aculeatus	42.76	7.00e-93	334.00
IUUC-Ggo-045034	Gorilla gorilla	75.39	0.00e+00	758.00
IUUC-Hsa-046624	Homo sapiens	83.25	0.00e+00	837.00
IUUC-Itr-048288	Ictidomys tridecemlineatus	75.43	0.00e+00	784.00
IUUC-Lch-049720	Latimeria chalumnae	49.26	2.00e-77	282.00
IUUC-Loc-052185	Lepisosteus oculatus	43.62	2.00e-99	356.00
IUUC-Laf-054079	Loxodonta africana	81.97	0.00e+00	820.00
IUUC-Mcc-055674	Macaca mulatta	84.99	0.00e+00	846.00
IUUC-Meu-056769	Macropus eugenii	54.82	2.00e-70	259.00
IUUC-Mga-060203	Meleagris gallopavo	56.94	1.00e-134	473.00
IUUC-Mmr-061492	Microcebus murinus	82.40	0.00e+00	818.00
IUUC-Mdo-063051	Monodelphis domestica	74.19	0.00e+00	774.00
IUUC-Mmu-063409	Mus musculus	77.61	0.00e+00	854.00
IUUC-Mpu-065907	Mustela putorius furo	78.91	0.00e+00	843.00
IUUC-Mlu-066957	Myotis lucifugus	82.40	0.00e+00	784.00
IUUC-Ncr-068766	Neurospora crassa	33.33	3.50e-02	33.10
IUUC-Nle-069973	Nomascus leucogenys	82.76	0.00e+00	827.00
IUUC-Opr-071049	Ochotona princeps	75.30	0.00e+00	704.00
IUUC-Ont-071915	Oreochromis niloticus	43.17	2.00e-88	319.00
IUUC-Oan-072965	Ornithorhynchus anatinus	71.92	0.00e+00	755.00
IUUC-Ocu-074029	Oryctolagus cuniculus	72.98	0.00e+00	637.00
IUUC-Ola-087019	Oryzias latipes	41.59	1.00e-84	306.00
IUUC-Oga-088613	Otolemur garnettii	82.79	0.00e+00	835.00
IUUC-Oar-090386	Ovis aries	97.91	0.00e+00	1061.00
IUUC-Ptr-091619	Pan troglodytes	82.90	0.00e+00	833.00
IUUC-Pan-092178	Papio anubis	83.33	0.00e+00	829.00
IUUC-Psi-093214	Pelodiscus sinensis	60.54	2.00e-156	545.00
IUUC-Pfo-096901	Poecilia formosa	39.75	2.00e-81	296.00
IUUC-Pab-097560	Pongo abelii	75.30	0.00e+00	717.00
IUUC-Pca-100853	Procavia capensis	73.19	2.00e-121	429.00
IUUC-Pva-102255	Pteropus vampyrus	82.47	0.00e+00	773.00
IUUC-Rno-105812	Rattus norvegicus	79.01	0.00e+00	838.00
IUUC-Sha-107225	Sarcophilus harrisii	77.21	4.00e-149	520.00
IUUC-Sar-113736	Sorex araneus	65.45	2.00e-176	612.00
IUUC-Ssc-115422	Sus scrofa	92.16	0.00e+00	967.00
IUUC-Tgu-116924	Taeniopygia guttata	56.83	9.00e-142	496.00
IUUC-Tru-117695	Takifugu rubripes	38.31	9.00e-83	300.00
IUUC-Tsy-119090	Tarsius syrichta	80.11	5.00e-147	514.00
IUUC-Tni-120645	Tetraodon nigroviridis	41.03	5.00e-85	308.00
IUUC-Tbe-127970	Tupaia belangeri	86.67	1.00e-122	433.00
IUUC-Ttr-129244	Tursiops truncatus	91.32	0.00e+00	924.00
IUUC-Vpa-130313	Vicugna pacos	89.24	0.00e+00	861.00
IUUC-Xtr-132115	Xenopus tropicalis	44.04	1.00e-93	337.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence