iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fca-035852

Ensembl Protein ID

ENSFCAP00000003613.3

UniProt Accession

M3W172; M3W172_FELCA

Genbank Protein ID

ENSFCAP00000003613

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AANG02070392

Gene Name

OPTN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000003917.3	ENSFCAT00000003918.3	ENSFCAP00000003613.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/UBAN	1.40e-24	85.8	460	516

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBAN

   S: 1    keelletvevLkqQveiYkeDFqaERadRErlneekeeLqeqveklqkqvsklndsl 57
           +ee+let++vL++Q+e+Y++DF+aERa+RE+++eeke+L+ q++ l+k+++ ++d++
   Q: 460  QEEDLETMTVLRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAILLKENNVFEDGG 516
           79****************************************************986 PP

Organism

Felis catus

Protein Sequence
(Fasta)

MSHQPLSCLT EKGDSPSETT GNGPPNLAHP NLDTFTPEEL LQQMKELLTE NHQLKEAMKL 60
NNQAMKGRFE ELSAWTEKQK EERLFFEIQS KEAKERLVAL SHENEKLKEE LRKLKGKTES 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCCCACC AACCACTTAG CTGCCTGACT GAAAAGGGGG ACAGCCCCAG TGAGACCACA 60
GGAAATGGAC CCCCCAACCT GGCCCACCCA AATCTGGACA CGTTCACACC AGAGGAACTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR032419--CC2-LZ_dom
IPR021063--NEMO_N
IPR032939--Optineurin
IPR034735--ZF_CCHC_NOA

PROSITE

PS51801--ZF_CCHC_NOA

Pfam

PF16516--CC2-LZ
PF11577--NEMO

Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005802--C:trans-Golgi network
GO:0070530--F:K63-linked polyubiquitin binding
GO:0050829--P:defense response to Gram-negative bacterium
GO:0090161--P:Golgi ribbon formation
GO:0043001--P:Golgi to plasma membrane protein transport
GO:0016236--P:macroautophagy
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0001920--P:negative regulation of receptor recycling
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1904417--P:positive regulation of xenophagy
GO:0000042--P:protein targeting to Golgi
GO:0043122--P:regulation of I-kappaB kinase/NF-kappaB signaling

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002037	Ailuropoda melanoleuca	88.51	0.00e+00	871.00
IUUC-Apl-003812	Anas platyrhynchos	55.18	3.00e-148	518.00
IUUC-Aca-004625	Anolis carolinensis	55.05	1.00e-146	512.00
IUUC-Aly-005781	Arabidopsis lyrata	55.00	2.30e-02	33.50
IUUC-Ame-011116	Astyanax mexicanus	47.40	1.00e-55	211.00
IUUC-Bta-013240	Bos taurus	86.18	0.00e+00	947.00
IUUC-Cja-019911	Callithrix jacchus	83.28	0.00e+00	857.00
IUUC-Cfa-020330	Canis familiaris	89.59	0.00e+00	922.00
IUUC-Cpo-021753	Cavia porcellus	80.10	0.00e+00	832.00
IUUC-Csa-023662	Chlorocebus sabaeus	84.80	0.00e+00	872.00
IUUC-Cho-024574	Choloepus hoffmanni	67.93	4.00e-130	457.00
IUUC-Cme-027299	Cyanidioschyzon merolae	35.96	5.00e-03	35.80
IUUC-Dre-027720	Danio rerio	40.66	2.00e-94	339.00
IUUC-Dno-029079	Dasypus novemcinctus	80.20	0.00e+00	790.00
IUUC-Dor-030890	Dipodomys ordii	79.53	0.00e+00	836.00
IUUC-Dme-032072	Drosophila melanogaster	28.57	6.00e-03	35.00
IUUC-Ete-032568	Echinops telfairi	79.00	0.00e+00	727.00
IUUC-Eca-033528	Equus caballus	88.91	0.00e+00	926.00
IUUC-Eeu-035219	Erinaceus europaeus	76.23	0.00e+00	823.00
IUUC-Fal-036862	Ficedula albicollis	58.02	1.00e-142	499.00
IUUC-Gmo-038735	Gadus morhua	38.52	2.00e-73	270.00
IUUC-Gga-040939	Gallus gallus	56.39	2.00e-145	509.00
IUUC-Gac-041580	Gasterosteus aculeatus	42.71	6.00e-97	347.00
IUUC-Ggo-045034	Gorilla gorilla	76.11	0.00e+00	788.00
IUUC-Hsa-046624	Homo sapiens	84.12	0.00e+00	877.00
IUUC-Itr-048288	Ictidomys tridecemlineatus	76.73	0.00e+00	819.00
IUUC-Lch-049720	Latimeria chalumnae	48.33	3.00e-82	298.00
IUUC-Loc-052185	Lepisosteus oculatus	44.54	9.00e-106	377.00
IUUC-Laf-054079	Loxodonta africana	84.52	0.00e+00	861.00
IUUC-Mcc-055674	Macaca mulatta	86.01	0.00e+00	871.00
IUUC-Meu-056769	Macropus eugenii	83.43	2.00e-70	259.00
IUUC-Mga-060203	Meleagris gallopavo	56.88	2.00e-137	482.00
IUUC-Mmr-061492	Microcebus murinus	84.64	0.00e+00	858.00
IUUC-Mdo-063051	Monodelphis domestica	74.87	0.00e+00	792.00
IUUC-Mmu-063409	Mus musculus	77.39	0.00e+00	874.00
IUUC-Mpu-065907	Mustela putorius furo	85.20	0.00e+00	905.00
IUUC-Mlu-066957	Myotis lucifugus	84.47	0.00e+00	832.00
IUUC-Ncr-068766	Neurospora crassa	33.33	1.20e-01	31.60
IUUC-Nle-069973	Nomascus leucogenys	84.12	0.00e+00	875.00
IUUC-Opr-071049	Ochotona princeps	76.65	0.00e+00	733.00
IUUC-Ont-071915	Oreochromis niloticus	42.88	2.00e-92	332.00
IUUC-Oan-072965	Ornithorhynchus anatinus	72.67	0.00e+00	759.00
IUUC-Ocu-074029	Oryctolagus cuniculus	74.31	0.00e+00	679.00
IUUC-Ola-087019	Oryzias latipes	41.81	2.00e-89	323.00
IUUC-Oga-088613	Otolemur garnettii	82.97	0.00e+00	868.00
IUUC-Oar-090386	Ovis aries	86.01	0.00e+00	946.00
IUUC-Ptr-091619	Pan troglodytes	83.95	0.00e+00	874.00
IUUC-Pan-092178	Papio anubis	84.03	0.00e+00	857.00
IUUC-Psi-093214	Pelodiscus sinensis	62.29	1.00e-163	569.00
IUUC-Pfo-096901	Poecilia formosa	40.65	6.00e-84	304.00
IUUC-Pab-097560	Pongo abelii	76.69	0.00e+00	754.00
IUUC-Pca-100853	Procavia capensis	72.67	5.00e-122	431.00
IUUC-Pva-102255	Pteropus vampyrus	85.37	0.00e+00	825.00
IUUC-Rno-105812	Rattus norvegicus	79.90	0.00e+00	864.00
IUUC-Sha-107225	Sarcophilus harrisii	80.32	1.00e-155	542.00
IUUC-Sit-110549	Setaria italica	29.09	8.80e-02	31.20
IUUC-Sar-113736	Sorex araneus	72.26	4.00e-131	461.00
IUUC-Ssc-115422	Sus scrofa	86.35	0.00e+00	931.00
IUUC-Tgu-116924	Taeniopygia guttata	55.52	1.00e-143	503.00
IUUC-Tru-117695	Takifugu rubripes	38.70	7.00e-86	311.00
IUUC-Tsy-119090	Tarsius syrichta	78.32	3.00e-149	521.00
IUUC-Tni-120645	Tetraodon nigroviridis	42.86	8.00e-90	324.00
IUUC-Tbe-127970	Tupaia belangeri	71.39	2.00e-139	489.00
IUUC-Ttr-129244	Tursiops truncatus	85.54	0.00e+00	868.00
IUUC-Vpa-130313	Vicugna pacos	83.84	0.00e+00	820.00
IUUC-Xtr-132115	Xenopus tropicalis	44.11	2.00e-96	346.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence