iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-050185

Ensembl Protein ID

ENSLACP00000005071.1

UniProt Accession

H3A600; H3A600_LATCH

Genbank Protein ID

ENSLACP00000005071

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AFYH01203118

Gene Name

HECW1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000004512.1	ENSLACT00000005117.1	ENSLACP00000005071.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.50e-72	245.0	1252	1549

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGr...llgkalqdgr 86
           + ++++l+++fvgEegld++G++ref++lls+el+np++glf+ys+nd++t+q++p s +  ++hl++Fe +     ll + l ++ 
   Q: 1252 ELQRNKLYITFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENHLECFEKAQSsssLLLILLLHS- 1336
           567899****************************************************985.5******98644111444444444. PP
   S: 87   lldlplsksfyklllgk..klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNke 171
              +++   f+k + +    l+   l  ++ ++++  +e k+n    i++  +dl f+  ++i+ +++e+eLk+gG+ni+Vt++Nk+
   Q: 1337 ---YTFFFLFLKIVPDAilALDSTSLWLLNLTFHNREEEGKKN---FISQR-VDLDFKLYKSIFIKVTERELKSGGANIQVTEKNKK 1416
           ...4444455555544422245567777888888887777777...77775.99999999*************************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefss 258
           eY++++v++r+++g+ +q+ea+ +Gf+ev++ +l+s+F+++elel+i G++eid+ d++++t+y+ggy++ + +i+wFw ++e+f++
   Q: 1417 EYIERMVKWRVERGMVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLIDWRNNTEYRGGYHDGHIVIRWFWAAVERFNN 1503
           *************************************************************************************** PP
   S: 259  eerkafLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPs 300
           e+r ++LqFvTg+s++P +Gf +l+     r+f+i+k+++ ++lP+
   Q: 1504 EQRLRLLQFVTGTSSIPYEGFVALRgsngLRRFCIEKWGKITSLPR 1549
           *****************************999************96 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

FSSHLFFQNL YQNRLLGLAA MASPSRSSQN RRRCKEPLRY SYNPEQFHNM DIENRPHGTL 60
NIPRSTSDTD LVTSDSRSTL MVSSSYYTIG QSQDLVICWD IKEEVDAGDW IGMYLIDEAL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCTCTTCTC ACCTGTTCTT TCAGAATTTG TATCAGAACA GACTTCTAGG CCTGGCAGCC 60
ATGGCCTCCC CATCTAGGAG TTCTCAGAAC AGGCGCCGTT GCAAGGAACC CCTCAGATAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001636	Ailuropoda melanoleuca	73.67	0.00e+00	1364.00
IUUC-Apl-003299	Anas platyrhynchos	74.24	0.00e+00	2119.00
IUUC-Aca-005024	Anolis carolinensis	73.85	0.00e+00	2094.00
IUUC-Bta-012604	Bos taurus	69.84	0.00e+00	1981.00
IUUC-Cja-019880	Callithrix jacchus	64.62	0.00e+00	1622.00
IUUC-Cfa-021216	Canis familiaris	72.77	0.00e+00	1390.00
IUUC-Cpo-021466	Cavia porcellus	80.19	0.00e+00	1331.00
IUUC-Csa-023080	Chlorocebus sabaeus	69.98	0.00e+00	2013.00
IUUC-Dre-028750	Danio rerio	67.44	0.00e+00	1340.00
IUUC-Dno-030019	Dasypus novemcinctus	73.22	0.00e+00	1402.00
IUUC-Dor-031030	Dipodomys ordii	60.16	0.00e+00	838.00
IUUC-Eca-033948	Equus caballus	70.22	0.00e+00	1973.00
IUUC-Fca-036148	Felis catus	73.91	0.00e+00	1395.00
IUUC-Fal-036957	Ficedula albicollis	73.94	0.00e+00	2112.00
IUUC-Gga-041194	Gallus gallus	74.02	0.00e+00	2127.00
IUUC-Gac-041366	Gasterosteus aculeatus	66.06	0.00e+00	1224.00
IUUC-Ggo-045442	Gorilla gorilla	68.43	0.00e+00	1190.00
IUUC-Hsa-045730	Homo sapiens	69.82	0.00e+00	2010.00
IUUC-Itr-048439	Ictidomys tridecemlineatus	74.67	0.00e+00	1436.00
IUUC-Loc-052744	Lepisosteus oculatus	72.70	0.00e+00	2004.00
IUUC-Mga-059545	Meleagris gallopavo	74.00	0.00e+00	2123.00
IUUC-Mmr-061078	Microcebus murinus	72.08	0.00e+00	1349.00
IUUC-Mdo-062176	Monodelphis domestica	72.80	0.00e+00	1363.00
IUUC-Mmu-063513	Mus musculus	70.06	0.00e+00	1962.00
IUUC-Mpu-065786	Mustela putorius furo	71.88	0.00e+00	1416.00
IUUC-Mlu-067780	Myotis lucifugus	71.63	0.00e+00	1340.00
IUUC-Nle-069213	Nomascus leucogenys	72.14	0.00e+00	1418.00
IUUC-Ont-072132	Oreochromis niloticus	64.33	0.00e+00	1206.00
IUUC-Oan-072807	Ornithorhynchus anatinus	74.84	0.00e+00	1418.00
IUUC-Ocu-074745	Oryctolagus cuniculus	73.18	0.00e+00	1405.00
IUUC-Ola-086981	Oryzias latipes	68.83	0.00e+00	1267.00
IUUC-Oga-087965	Otolemur garnettii	74.22	0.00e+00	1380.00
IUUC-Oar-089749	Ovis aries	73.04	0.00e+00	1394.00
IUUC-Ptr-091243	Pan troglodytes	69.90	0.00e+00	2011.00
IUUC-Pan-092201	Papio anubis	69.61	0.00e+00	2000.00
IUUC-Psi-093511	Pelodiscus sinensis	72.50	0.00e+00	2081.00
IUUC-Pfo-097001	Poecilia formosa	60.82	0.00e+00	1372.00
IUUC-Pab-098728	Pongo abelii	67.96	0.00e+00	1910.00
IUUC-Pca-100129	Procavia capensis	70.96	0.00e+00	942.00
IUUC-Pva-102250	Pteropus vampyrus	68.92	0.00e+00	1311.00
IUUC-Rno-105031	Rattus norvegicus	70.00	0.00e+00	1962.00
IUUC-Tgu-117515	Taeniopygia guttata	73.56	0.00e+00	2116.00
IUUC-Tni-120178	Tetraodon nigroviridis	63.06	0.00e+00	1221.00
IUUC-Tbe-127762	Tupaia belangeri	69.84	0.00e+00	1273.00
IUUC-Ttr-128806	Tursiops truncatus	76.77	0.00e+00	1324.00
IUUC-Vpa-130812	Vicugna pacos	77.36	7.00e-168	585.00
IUUC-Xtr-132903	Xenopus tropicalis	69.98	0.00e+00	1599.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence