iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-063557

Ensembl Protein ID

ENSMUSP00000046532.7

UniProt Accession

O89100; GRAP2_MOUSE

Genbank Protein ID

AAD08803.1; AAC98669.1; AAD41783.1; AAF60318.1; CAA09756.1; AAH52496.1

Protein Name

GRB2-related adaptor protein 2; Adapter protein GRID; GADS protein; GRB-2-like protein; GRB-2-related monocytic adapter protein; GRBLG; Growth factor receptor-binding protein; Hematopoietic cell-associated adaptor protein GrpL

Genbank Nucleotide ID

AF055465; AF053405; AF129477; AF236118; AJ011735; BC052496

Gene Name

Grap2; Gads; Grb2l; Grid; Mona

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000042351.8	ENSMUST00000043149.7	ENSMUSP00000046532.7

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	4.60e-30	104.5	269	319

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++lyd+ea ++deL +++G+vv+v+  ++ +  W+ g   l++k GlfP+n+v+ 
   Q: 269  RALYDFEALEEDELGFRSGEVVEVL--DSSNPSWWTG--RLHNKLGLFPANYVAP 319
           79***********************..999*******..8*************86 PP

Organism

Mus musculus

Functional Description
(View)

Interacts with phosphorylated LAT and LAX1 upon TCR activation. Interacts with SHB. Interacts with PTPN23 (By similarity). Interacts with phosphorylated LIME1 upon TCR activation.

Protein Sequence
(Fasta)

MEATAKFDFM ASGEDELSFR TGDILKILSN QEEWLKAELG SQEGYVPKNF IDIEFPEWFH 60
EGLSRHQAEN LLMGKDIGFF IIRASQSSPG DFSISVRHED DVQHFKVMRD TKGNYFLWTE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATTTGGGGA AGCAGATCTG GAAGGCTGCA GCAGCTCTTG TTGCAAACAT GAGCTCTGGC 60
CTCGCACAGC CTTCTCCACC GCCTGAGCCT AGCTCTCCAG CCTGCAGACA TCCACTGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain

Interpro

IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005768--C:endosome
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005634--C:nucleus
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

mmu:17444

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001994	Ailuropoda melanoleuca	84.71	3.00e-154	537.00
IUUC-Apl-003684	Anas platyrhynchos	58.66	5.00e-101	360.00
IUUC-Aca-005371	Anolis carolinensis	56.44	1.00e-94	339.00
IUUC-Ame-011392	Astyanax mexicanus	45.17	1.00e-70	259.00
IUUC-Bta-013508	Bos taurus	79.51	3.00e-144	504.00
IUUC-Cja-019613	Callithrix jacchus	77.11	8.00e-62	229.00
IUUC-Cfa-020290	Canis familiaris	83.18	4.00e-152	530.00
IUUC-Cpo-022534	Cavia porcellus	85.93	7.00e-151	526.00
IUUC-Csa-023438	Chlorocebus sabaeus	82.73	5.00e-152	530.00
IUUC-Cho-024466	Choloepus hoffmanni	57.14	7.00e-73	266.00
IUUC-Dre-027927	Danio rerio	46.69	2.00e-76	278.00
IUUC-Dno-029894	Dasypus novemcinctus	81.35	3.00e-146	511.00
IUUC-Dor-030493	Dipodomys ordii	91.39	3.00e-80	291.00
IUUC-Ete-032335	Echinops telfairi	70.03	4.00e-120	424.00
IUUC-Eca-033750	Equus caballus	82.15	2.00e-150	525.00
IUUC-Eeu-034884	Erinaceus europaeus	67.58	2.00e-104	371.00
IUUC-Fca-036001	Felis catus	84.71	3.00e-154	537.00
IUUC-Fal-036692	Ficedula albicollis	59.34	9.00e-104	370.00
IUUC-Gmo-039524	Gadus morhua	61.33	4.00e-53	201.00
IUUC-Gac-041301	Gasterosteus aculeatus	59.51	1.00e-56	213.00
IUUC-Ggo-045424	Gorilla gorilla	82.12	2.00e-150	525.00
IUUC-Hsa-045808	Homo sapiens	82.12	9.00e-151	526.00
IUUC-Itr-048000	Ictidomys tridecemlineatus	83.95	3.00e-149	521.00
IUUC-Lch-049610	Latimeria chalumnae	49.54	6.00e-76	277.00
IUUC-Loc-052925	Lepisosteus oculatus	48.17	1.00e-78	286.00
IUUC-Laf-054004	Loxodonta africana	86.54	2.00e-155	541.00
IUUC-Mcc-055020	Macaca mulatta	82.42	2.00e-151	528.00
IUUC-Meu-056169	Macropus eugenii	69.25	9.00e-122	429.00
IUUC-Mga-059483	Meleagris gallopavo	59.10	8.00e-103	366.00
IUUC-Mmr-061755	Microcebus murinus	85.32	4.00e-154	537.00
IUUC-Mdo-062504	Monodelphis domestica	69.70	2.00e-126	445.00
IUUC-Mpu-066852	Mustela putorius furo	83.49	1.00e-153	535.00
IUUC-Mlu-067510	Myotis lucifugus	83.28	4.00e-152	530.00
IUUC-Nle-069691	Nomascus leucogenys	82.12	6.00e-151	526.00
IUUC-Opr-070271	Ochotona princeps	80.31	2.00e-141	494.00
IUUC-Ont-072651	Oreochromis niloticus	43.37	6.00e-70	257.00
IUUC-Oan-073183	Ornithorhynchus anatinus	70.86	4.00e-121	427.00
IUUC-Ocu-074899	Oryctolagus cuniculus	73.70	2.00e-126	444.00
IUUC-Ola-086462	Oryzias latipes	47.01	9.00e-74	270.00
IUUC-Oga-088553	Otolemur garnettii	83.23	3.00e-155	540.00
IUUC-Oar-089572	Ovis aries	80.31	5.00e-148	516.00
IUUC-Ptr-090582	Pan troglodytes	82.42	3.00e-151	527.00
IUUC-Pan-092063	Papio anubis	82.42	2.00e-151	528.00
IUUC-Psi-094056	Pelodiscus sinensis	62.35	4.00e-109	387.00
IUUC-Pfo-096115	Poecilia formosa	44.69	6.00e-72	263.00
IUUC-Pab-098217	Pongo abelii	82.42	3.00e-151	527.00
IUUC-Pca-100838	Procavia capensis	83.69	8.00e-148	516.00
IUUC-Pva-102559	Pteropus vampyrus	81.18	2.00e-118	418.00
IUUC-Rno-105926	Rattus norvegicus	81.65	6.00e-140	489.00
IUUC-Sha-106948	Sarcophilus harrisii	70.15	7.00e-121	426.00
IUUC-Ssc-115605	Sus scrofa	82.77	3.00e-147	514.00
IUUC-Tgu-117211	Taeniopygia guttata	58.18	1.00e-101	362.00
IUUC-Tru-118347	Takifugu rubripes	54.74	3.00e-57	214.00
IUUC-Tsy-119441	Tarsius syrichta	82.57	7.00e-149	519.00
IUUC-Tni-119732	Tetraodon nigroviridis	46.65	2.00e-72	265.00
IUUC-Tbe-127289	Tupaia belangeri	79.06	3.00e-127	447.00
IUUC-Ttr-128961	Tursiops truncatus	86.86	2.00e-86	312.00
IUUC-Vpa-130320	Vicugna pacos	73.94	3.00e-74	271.00
IUUC-Xtr-131814	Xenopus tropicalis	46.15	4.00e-77	281.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence