iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Spo-108284

Ensembl Protein ID

SPAC16E8.09.1:pep

UniProt Accession

P40995; SCD1_SCHPO

Genbank Protein ID

AAA50556.2; CAB11037.1

Protein Name

Rho guanine nucleotide exchange factor scd1

Genbank Nucleotide ID

U12538; CU329670

Gene Name

scd1; ral1; SPAC16E8.09

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPAC16E8.09	SPAC16E8.09.1	SPAC16E8.09.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	UniProt
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UDP/UFD/PB1	33.07	4.00e-51	198.00	IUUC-Sce-106197

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Required for mating and morphogenesis. May contain a cryptic binding site for cdc42 that is enhanced by binding Ras. Interacts directly with scd2. Promotes the exchange of cdc42-bound GDP by GTP. Involved in septation and stimulates the elongation of conjugation tubes.

Protein Sequence
(Fasta)

MAYFQDRKTS SRSLPSYINH STQNLVGPRK DETNLSEYMK LRLLQSPSQV IYNLENTVSL 60
YRRCLNLRKR LMDISELAAF FDSIHREALN SSFKILEFKD IEFDDPVTEI WLFCRLGYPL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTATATTTA ATTCCAAAGA AACTTCAGGC TTTTTTATGT TTAAGAAATC TTGAAATTGG 60
GTTGTTGGTT TGAATTTCCA TTAATTGTTC AAGCATTGGA CTACATGCGA GTACTTATAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0344--Guanine-nucleotide releasing factor
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0717--Septation

Interpro

IPR010481--Cdc24/Scd1_N
IPR033511--Cdc24/Scd1_PH_dom
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR000270--PB1_dom
IPR011993--PH_dom-like
IPR001849--PH_domain

PROSITE

PS00741--DH_1
PS50010--DH_2
PS51745--PB1
PS50003--PH_DOMAIN

Pfam

PF06395--CDC24
PF00564--PB1
PF00621--RhoGEF

SMART

SM00666--PB1
SM00233--PH
SM00325--RhoGEF

Gene Ontology

GO:0071521--C:Cdc42 GTPase complex
GO:0051285--C:cell cortex of cell tip
GO:1902716--C:cell cortex of growing cell tip
GO:0032153--C:cell division site
GO:0051286--C:cell tip
GO:0005829--C:cytosol
GO:0005622--C:intracellular
GO:0043332--C:mating projection tip
GO:0072686--C:mitotic spindle
GO:0005634--C:nucleus
GO:0030427--C:site of polarized growth
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0000917--P:barrier septum assembly
GO:0000747--P:conjugation with cellular fusion
GO:0035556--P:intracellular signal transduction
GO:0031139--P:positive regulation of conjugation with cellular fusion
GO:0032955--P:regulation of barrier septum assembly
GO:0030100--P:regulation of endocytosis
GO:2000769--P:regulation of establishment or maintenance of cell polarity regulating cell shape
GO:0043087--P:regulation of GTPase activity
GO:0035023--P:regulation of Rho protein signal transduction
GO:0032887--P:regulation of spindle elongation
GO:0032005--P:signal transduction involved in conjugation with cellular fusion

KEGG

spo:SPAC16E8.09

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002073	Ailuropoda melanoleuca	26.72	3.00e-19	89.40
IUUC-Apl-004117	Anas platyrhynchos	27.13	2.00e-19	89.00
IUUC-Aca-004793	Anolis carolinensis	26.72	5.00e-19	88.60
IUUC-Aly-006318	Arabidopsis lyrata	34.69	5.90e-01	27.30
IUUC-Ago-008003	Ashbya gossypii	32.09	2.00e-63	235.00
IUUC-Acl-008142	Aspergillus clavatus	30.56	9.00e-63	233.00
IUUC-Afl-008481	Aspergillus flavus	29.66	8.00e-63	233.00
IUUC-Afu-009099	Aspergillus fumigatus	28.32	3.00e-55	208.00
IUUC-Ani-009276	Aspergillus nidulans	30.25	3.00e-66	244.00
IUUC-Ang-009549	Aspergillus niger	31.10	4.00e-63	234.00
IUUC-Aor-010216	Aspergillus oryzae	29.66	8.00e-63	233.00
IUUC-Ate-010338	Aspergillus terreus	32.15	1.00e-64	239.00
IUUC-Ame-010682	Astyanax mexicanus	26.52	2.00e-21	96.30
IUUC-Bgr-012058	Blumeria graminis	31.19	1.00e-60	226.00
IUUC-Bta-012674	Bos taurus	25.14	2.00e-17	83.60
IUUC-Bci-013634	Botrytis cinerea	32.09	7.00e-71	260.00
IUUC-Cel-018578	Caenorhabditis elegans	25.19	3.00e-14	72.40
IUUC-Cja-019555	Callithrix jacchus	27.13	2.00e-19	88.20
IUUC-Cfa-020578	Canis familiaris	26.72	2.00e-19	89.40
IUUC-Cpo-021726	Cavia porcellus	23.88	3.00e-15	75.90
IUUC-Csa-023331	Chlorocebus sabaeus	26.06	2.00e-18	85.50
IUUC-Cho-025069	Choloepus hoffmanni	24.56	2.00e-22	100.00
IUUC-Cin-025453	Ciona intestinalis	28.64	4.00e-21	94.00
IUUC-Csv-025922	Ciona savignyi	29.61	2.00e-23	102.00
IUUC-Cgl-026579	Colletotrichum gloeosporioides	33.13	6.00e-64	237.00
IUUC-Cne-027023	Cryptococcus neoformans	35.62	1.00e-49	190.00
IUUC-Cme-027247	Cyanidioschyzon merolae	23.77	1.00e-03	36.60
IUUC-Dre-028197	Danio rerio	26.32	1.00e-19	91.70
IUUC-Dno-029679	Dasypus novemcinctus	26.32	3.00e-19	89.40
IUUC-Dor-030739	Dipodomys ordii	26.67	1.00e-18	85.90
IUUC-Dse-031545	Dothistroma septosporum	33.07	5.00e-64	237.00
IUUC-Dme-031672	Drosophila melanogaster	24.92	5.00e-17	81.30
IUUC-Ete-032545	Echinops telfairi	28.57	5.00e-23	102.00
IUUC-Eca-034299	Equus caballus	26.72	5.00e-19	87.40
IUUC-Eeu-034720	Erinaceus europaeus	24.26	9.00e-23	101.00
IUUC-Fca-036416	Felis catus	26.72	7.00e-19	87.00
IUUC-Fal-037035	Ficedula albicollis	27.13	2.00e-20	93.20
IUUC-Fox-037710	Fusarium oxysporum	27.52	1.00e-49	189.00
IUUC-Fso-038080	Fusarium solani	32.26	1.00e-65	243.00
IUUC-Gmo-039587	Gadus morhua	28.92	1.00e-19	89.00
IUUC-Ggr-039728	Gaeumannomyces graminis	31.02	3.00e-59	221.00
IUUC-Gga-040841	Gallus gallus	24.72	1.00e-18	85.90
IUUC-Gac-042498	Gasterosteus aculeatus	31.07	2.00e-21	94.70
IUUC-Ggo-044700	Gorilla gorilla	24.26	1.00e-22	100.00
IUUC-Hsa-045681	Homo sapiens	26.72	2.00e-19	89.70
IUUC-Hvu-047138	Hordeum vulgare	28.24	6.00e-03	33.90
IUUC-Itr-048380	Ictidomys tridecemlineatus	26.53	7.00e-19	86.70
IUUC-Kpa-049278	Komagataella pastoris	31.37	3.00e-64	238.00
IUUC-Lch-049639	Latimeria chalumnae	28.43	5.00e-19	87.40
IUUC-Loc-051994	Lepisosteus oculatus	25.70	6.00e-20	90.50
IUUC-Lma-052955	Leptosphaeria maculans	32.70	4.00e-69	254.00
IUUC-Laf-054307	Loxodonta africana	26.72	6.00e-19	87.00
IUUC-Mcc-055305	Macaca mulatta	28.37	2.00e-17	81.30
IUUC-Meu-056376	Macropus eugenii	25.72	3.00e-18	85.10
IUUC-Mor-057139	Magnaporthe oryzae	32.73	3.00e-62	231.00
IUUC-Mpo-057433	Magnaporthe poae	31.90	3.00e-57	215.00
IUUC-Mla-059044	Melampsora laricipopulina	37.11	7.00e-81	293.00
IUUC-Mga-059644	Meleagris gallopavo	27.13	3.00e-20	92.40
IUUC-Mvi-060486	Microbotryum violaceum	38.63	4.00e-91	327.00
IUUC-Mmr-061664	Microcebus murinus	27.13	1.00e-19	90.90
IUUC-Mdo-062404	Monodelphis domestica	24.33	5.00e-24	105.00
IUUC-Mmu-063143	Mus musculus	24.85	8.00e-24	104.00
IUUC-Mpu-066851	Mustela putorius furo	26.72	3.00e-19	89.00
IUUC-Mlu-066956	Myotis lucifugus	26.83	2.00e-19	89.70
IUUC-Nfi-068331	Neosartorya fischeri	30.22	2.00e-62	232.00
IUUC-Ncr-068819	Neurospora crassa	32.38	4.00e-60	224.00
IUUC-Nle-069174	Nomascus leucogenys	28.84	3.00e-22	97.10
IUUC-Opr-070209	Ochotona princeps	27.17	5.00e-19	87.40
IUUC-Ont-072091	Oreochromis niloticus	29.80	1.00e-23	103.00
IUUC-Oan-073722	Ornithorhynchus anatinus	25.18	1.00e-17	82.40
IUUC-Ocu-074885	Oryctolagus cuniculus	27.17	3.00e-19	89.40
IUUC-Ola-087155	Oryzias latipes	25.60	6.00e-24	105.00
IUUC-Oga-088758	Otolemur garnettii	27.13	6.00e-20	91.30
IUUC-Oar-090384	Ovis aries	24.86	5.00e-14	72.00
IUUC-Ptr-091555	Pan troglodytes	26.72	6.00e-19	87.00
IUUC-Pan-092037	Papio anubis	26.72	4.00e-19	88.60
IUUC-Psi-093865	Pelodiscus sinensis	26.72	5.00e-19	88.20
IUUC-Pma-094503	Petromyzon marinus	30.66	1.00e-25	110.00
IUUC-Pno-095127	Phaeosphaeria nodorum	30.88	2.00e-56	211.00
IUUC-Pfo-096918	Poecilia formosa	25.60	3.00e-25	109.00
IUUC-Pab-097910	Pongo abelii	26.72	3.00e-19	89.40
IUUC-Pca-100891	Procavia capensis	26.50	1.00e-22	100.00
IUUC-Pva-102967	Pteropus vampyrus	25.91	4.00e-18	84.30
IUUC-Pgr-103400	Puccinia graminis	36.94	2.00e-90	325.00
IUUC-Ptt-103822	Puccinia triticina	35.96	7.00e-56	210.00
IUUC-Pte-104293	Pyrenophora teres	32.13	1.00e-64	239.00
IUUC-Pyt-104722	Pyrenophora triticirepentis	32.32	1.00e-64	239.00
IUUC-Rno-105479	Rattus norvegicus	26.33	1.00e-23	104.00
IUUC-Sce-106197	Saccharomyces cerevisiae	32.89	2.00e-51	195.00
IUUC-Sha-107592	Sarcophilus harrisii	27.13	4.00e-19	89.00
IUUC-Sja-107728	Schizosaccharomyces japonicus	48.52	7.00e-136	476.00
IUUC-Ssl-108541	Sclerotinia sclerotiorum	31.46	3.00e-70	258.00
IUUC-Sar-113369	Sorex araneus	29.06	1.00e-16	79.30
IUUC-Sre-115126	Sporisorium reilianum	39.51	1.00e-103	369.00
IUUC-Ssc-115967	Sus scrofa	23.60	6.00e-13	68.60
IUUC-Tgu-117088	Taeniopygia guttata	25.10	2.00e-18	85.10
IUUC-Tru-118716	Takifugu rubripes	26.79	4.00e-25	108.00
IUUC-Tsy-118846	Tarsius syrichta	27.27	8.00e-19	85.90
IUUC-Tni-120887	Tetraodon nigroviridis	26.19	2.00e-24	107.00
IUUC-Tre-121935	Trichoderma reesei	32.44	2.00e-71	261.00
IUUC-Tvi-122300	Trichoderma virens	32.82	1.00e-71	262.00
IUUC-Tme-127216	Tuber melanosporum	37.65	7.00e-91	326.00
IUUC-Tbe-127248	Tupaia belangeri	26.50	7.00e-23	101.00
IUUC-Ttr-128429	Tursiops truncatus	28.57	9.00e-14	71.20
IUUC-Uma-129594	Ustilago maydis	38.20	3.00e-99	354.00
IUUC-Vda-129831	Verticillium dahliae	30.58	1.00e-50	193.00
IUUC-Vpa-130750	Vicugna pacos	24.33	1.00e-21	97.40
IUUC-Xtr-132676	Xenopus tropicalis	28.57	9.00e-20	89.70
IUUC-Xma-133871	Xiphophorus maculatus	25.60	2.00e-25	110.00
IUUC-Yli-134423	Yarrowia lipolytica	37.35	7.00e-91	326.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence