iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Rno-105424

Ensembl Protein ID

ENSRNOP00000065635.1

UniProt Accession

Q7TPL3; BACD3_RAT

Genbank Protein ID

AAP79438.1

Protein Name

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3; BTB/POZ domain-containing protein KCTD10

Genbank Nucleotide ID

AY318756

Gene Name

Kctd10

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000047896.2	ENSRNOT00000073019.2	ENSRNOP00000065635.1

Annotation

mRNA Expression
GEO
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
IID	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	1.00e-08	35.8	34	100

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 3    vilvvggeeffahkivLaasSsvFyalflmele.esksklmveikdvqpevfrallkFlYtgkldene 69
           v l+vgg  + ++  +L+ +  +++a+f++ +e  ++s++ + i+ +  ++f ++l++l+ g ++++e
   Q: 34   VKLNVGGALYYTTMQTLTKQDTMLKAMFSGRMEvLTDSEGWILID-RCGKHFGTILNYLRDGAVPLPE 100
           99*******************************************.******************9986 PP

Organism

Rattus norvegicus

Functional Description
(View)

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).

Protein Sequence
(Fasta)

MEEMSGESVV TSAVPAAATR TTSFKGASPS SKYVKLNVGG ALYYTTMQTL TKQDTMLKAM 60
FSGRMEVLTD SEGWILIDRC GKHFGTILNY LRDGAVPLPE SRREIEELLA EAKYYLVQGL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCCGGCCCC GCCTCCGCCC CCTGCCTTGA GTGAGCTGGG TGTTTCCTGC CTCTCAGTCC 60
GGATTTGGAG ACTCCGGCGT CCTCCGACTT TTCATGGTGA GGGCGGTGGC CGCCGTCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR003131--T1-type_BTB

PROSITE

PS50097--BTB

Pfam

PF02214--BTB_2

SMART

SM00225--BTB

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051260--P:protein homooligomerization
GO:0016567--P:protein ubiquitination

KEGG

rno:494521

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001542	Ailuropoda melanoleuca	98.10	5.00e-164	570.00
IUUC-Bta-013372	Bos taurus	98.63	5.00e-163	566.00
IUUC-Cel-018444	Caenorhabditis elegans	35.82	7.00e-29	120.00
IUUC-Cja-019804	Callithrix jacchus	98.40	3.00e-164	570.00
IUUC-Cfa-020438	Canis familiaris	97.12	6.00e-163	566.00
IUUC-Cpo-022204	Cavia porcellus	98.41	2.00e-165	574.00
IUUC-Csa-024214	Chlorocebus sabaeus	98.63	5.00e-163	566.00
IUUC-Cin-025494	Ciona intestinalis	73.75	7.00e-108	383.00
IUUC-Csv-026325	Ciona savignyi	72.09	2.00e-109	388.00
IUUC-Dre-027582	Danio rerio	92.74	1.00e-158	551.00
IUUC-Dno-029910	Dasypus novemcinctus	97.95	6.00e-161	559.00
IUUC-Dor-030244	Dipodomys ordii	99.32	8.00e-164	569.00
IUUC-Dme-031829	Drosophila melanogaster	70.00	6.00e-104	370.00
IUUC-Eca-033705	Equus caballus	98.09	7.00e-165	572.00
IUUC-Fca-035701	Felis catus	98.63	5.00e-163	566.00
IUUC-Fal-036623	Ficedula albicollis	94.55	3.00e-159	553.00
IUUC-Gmo-039520	Gadus morhua	92.41	6.00e-156	543.00
IUUC-Gga-040287	Gallus gallus	86.54	5.00e-140	489.00
IUUC-Gac-041695	Gasterosteus aculeatus	91.42	2.00e-154	538.00
IUUC-Gma-043357	Glycine max	46.49	4.00e-20	91.30
IUUC-Hsa-046604	Homo sapiens	97.26	9.00e-162	562.00
IUUC-Itr-048792	Ictidomys tridecemlineatus	97.26	7.00e-155	539.00
IUUC-Lch-050521	Latimeria chalumnae	96.15	2.00e-171	594.00
IUUC-Loc-052261	Lepisosteus oculatus	93.95	2.00e-169	588.00
IUUC-Laf-054190	Loxodonta africana	97.78	4.00e-163	566.00
IUUC-Mcc-054717	Macaca mulatta	98.10	1.00e-163	568.00
IUUC-Meu-056301	Macropus eugenii	95.54	4.00e-162	563.00
IUUC-Mga-060191	Meleagris gallopavo	93.65	5.00e-158	550.00
IUUC-Mmr-060849	Microcebus murinus	98.10	6.00e-164	569.00
IUUC-Mmu-063684	Mus musculus	98.42	8.00e-165	572.00
IUUC-Mpu-066892	Mustela putorius furo	98.63	5.00e-163	566.00
IUUC-Mlu-067537	Myotis lucifugus	97.88	7.00e-154	536.00
IUUC-Nle-069770	Nomascus leucogenys	98.63	5.00e-163	566.00
IUUC-Opr-070517	Ochotona princeps	98.97	2.00e-163	568.00
IUUC-Ont-071872	Oreochromis niloticus	91.43	4.00e-150	523.00
IUUC-Ocu-074821	Oryctolagus cuniculus	98.63	4.00e-163	566.00
IUUC-Ola-086732	Oryzias latipes	90.13	5.00e-162	563.00
IUUC-Oga-088014	Otolemur garnettii	98.29	1.00e-161	561.00
IUUC-Oar-089713	Ovis aries	96.47	2.00e-153	534.00
IUUC-Pan-092149	Papio anubis	98.63	5.00e-163	566.00
IUUC-Psi-093600	Pelodiscus sinensis	96.23	1.00e-153	535.00
IUUC-Pma-094524	Petromyzon marinus	84.49	2.00e-112	397.00
IUUC-Pfo-096431	Poecilia formosa	89.52	8.00e-165	572.00
IUUC-Pab-098442	Pongo abelii	98.63	5.00e-163	566.00
IUUC-Pva-102644	Pteropus vampyrus	98.09	3.00e-165	573.00
IUUC-Ptt-103832	Puccinia triticina	23.81	4.60e-01	29.60
IUUC-Sha-107257	Sarcophilus harrisii	93.65	7.00e-158	549.00
IUUC-Sar-113351	Sorex araneus	93.63	4.00e-154	537.00
IUUC-Ssc-116078	Sus scrofa	98.29	1.00e-161	561.00
IUUC-Tgu-116771	Taeniopygia guttata	94.27	8.00e-160	555.00
IUUC-Tru-117556	Takifugu rubripes	92.33	5.00e-164	570.00
IUUC-Tni-120749	Tetraodon nigroviridis	92.04	2.00e-165	575.00
IUUC-Xtr-131958	Xenopus tropicalis	93.99	5.00e-160	556.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence