iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ola-086895

Ensembl Protein ID

ENSORLP00000019346.2

UniProt Accession

H2MKX5; H2MKX5_ORYLA

Genbank Protein ID

ENSORLP00000019346

Protein Name

Apoptotic protease-activating factor 1

Genbank Nucleotide ID

BAAF04007134

Gene Name

apaf1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSORLG00000015449.2	ENSORLT00000019347.2	ENSORLP00000019346.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.10e-51	169.9	1044	1085
UBD/Beta-Prp	1.70e-83	280.5	960	1203

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.....sdtllvsGsdDgtikvWDlrtgvllk 37
           gH++ v+c+a+     +d +l+s s Dgt+kvW++ +g +l+
   Q: 1044 GHKEQVRCFALlspssNDSRLLSWSFDGTVKVWNTESGQKLQ 1085
           8*********99**966699***************9998876 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkgh 93
           +++ s+i+c +  +d s++a g +dgt++v  v + k l++l gh+++v  ++f + g++l+t+seD ti+vw+l +g+c  +l+gh
   Q: 960  EKKPSRIRCTCLLRDLSVVALGQEDGTVQVLAVPSAKPLATLLGHTKTVLHCQFTHYGQTLITSSEDCTIRVWNLPSGECK-VLQGH 1045
           56678999999999******************************************************************6.699** PP
   S: 94   edsvlslsfsp...sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltg 177
           +++v++ ++     ++++l+s s d t++vw++e+gq+l+   + h g++ + +v+pdg+l++++s+Drt +lW  +  ++  tltg
   Q: 1046 KEQVRCFALLSpssNDSRLLSWSFDGTVKVWNTESGQKLQ-DIDAHGGAILSCHVSPDGRLFATSSADRTAKLWHCEAWQCTFTLTG 1131
           ******8877667688************************.56679999999999*******************************9 PP
   S: 178  ghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnght.........dnvksvrfspnderlvsgs 241
            h++ v+s  f+ ++++l++g+++g ++lw++  g+ +r++              +v++++fsp++ +lvs++
   Q: 1132 -HQECVRSCRFSWDSECLATGDDNGEIRLWNVNDGSLLRICSREVkdsmdsfhgGWVTDLHFSPDNSLLVSAG 1203
           .********************************888877776666666777777****************987 PP

Organism

Oryzias latipes

Functional Description
(View)

Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

Protein Sequence
(Fasta)

LDERARACLL KSRHKLEEIM KPAYLMDHMI SDEAITVEEE DMIANQNTKR EQAAALVDLL 60
LKKDNYSFRS FYNALLKEEY DELANLLKED LPLTQFTSSS QCPGEKCLGA VVQTVLSEGG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGGATGAGA GAGCACGGGC TTGTCTGCTG AAGTCCCGCC ACAAACTGGA GGAGATCATG 60
AAGCCGGCCT ACCTGATGGA CCACATGATC AGTGATGAAG CCATCACAGT CGAGGAAGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR017251--Apaf-1
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR027295--Quinoprotein_ADH-like_fam
IPR000772--Ricin_B_lectin
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50209--CARD
PS50231--RICIN_B_LECTIN
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00619--CARD
PF00931--NB-ARC
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0043293--C:apoptosome
GO:0043531--F:ADP binding
GO:0005524--F:ATP binding
GO:0097190--P:apoptotic signaling pathway
GO:0042981--P:regulation of apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001432	Ailuropoda melanoleuca	49.71	0.00e+00	1183.00
IUUC-Apl-004201	Anas platyrhynchos	50.12	0.00e+00	1198.00
IUUC-Aca-004638	Anolis carolinensis	49.59	0.00e+00	1201.00
IUUC-Ame-011062	Astyanax mexicanus	62.50	0.00e+00	1530.00
IUUC-Bta-012865	Bos taurus	49.92	0.00e+00	1204.00
IUUC-Cja-018815	Callithrix jacchus	45.45	0.00e+00	1041.00
IUUC-Cfa-020222	Canis familiaris	47.91	0.00e+00	1109.00
IUUC-Cpo-021524	Cavia porcellus	50.17	0.00e+00	1212.00
IUUC-Csa-023861	Chlorocebus sabaeus	50.25	0.00e+00	1204.00
IUUC-Cho-024484	Choloepus hoffmanni	42.64	9.00e-161	561.00
IUUC-Dre-028006	Danio rerio	58.65	0.00e+00	1381.00
IUUC-Dno-029591	Dasypus novemcinctus	50.74	0.00e+00	1233.00
IUUC-Dor-030237	Dipodomys ordii	41.42	4.00e-136	479.00
IUUC-Ete-032620	Echinops telfairi	46.23	6.00e-163	568.00
IUUC-Eca-033569	Equus caballus	49.59	0.00e+00	1186.00
IUUC-Eeu-035354	Erinaceus europaeus	48.00	3.00e-78	287.00
IUUC-Fca-036337	Felis catus	49.55	0.00e+00	1205.00
IUUC-Fal-037077	Ficedula albicollis	50.33	0.00e+00	1196.00
IUUC-Gmo-039687	Gadus morhua	55.11	0.00e+00	1029.00
IUUC-Gga-040299	Gallus gallus	48.48	0.00e+00	1197.00
IUUC-Gac-041762	Gasterosteus aculeatus	65.44	0.00e+00	1593.00
IUUC-Ggo-045563	Gorilla gorilla	50.58	0.00e+00	1215.00
IUUC-Hsa-046771	Homo sapiens	50.58	0.00e+00	1215.00
IUUC-Lch-050200	Latimeria chalumnae	52.84	0.00e+00	1315.00
IUUC-Loc-052090	Lepisosteus oculatus	59.75	0.00e+00	1431.00
IUUC-Laf-053861	Loxodonta africana	50.41	0.00e+00	1206.00
IUUC-Mcc-055543	Macaca mulatta	50.41	0.00e+00	1209.00
IUUC-Meu-056688	Macropus eugenii	51.60	0.00e+00	1214.00
IUUC-Mga-059243	Meleagris gallopavo	49.01	0.00e+00	1203.00
IUUC-Mmr-061134	Microcebus murinus	47.95	0.00e+00	1024.00
IUUC-Mdo-062913	Monodelphis domestica	51.28	0.00e+00	1220.00
IUUC-Mmu-063811	Mus musculus	50.91	0.00e+00	1231.00
IUUC-Mpu-066780	Mustela putorius furo	49.42	0.00e+00	1187.00
IUUC-Mlu-067276	Myotis lucifugus	50.45	0.00e+00	1207.00
IUUC-Nle-069129	Nomascus leucogenys	50.25	0.00e+00	1207.00
IUUC-Opr-071007	Ochotona princeps	39.82	5.00e-151	528.00
IUUC-Ont-071348	Oreochromis niloticus	70.37	0.00e+00	1780.00
IUUC-Oan-072717	Ornithorhynchus anatinus	52.13	0.00e+00	1264.00
IUUC-Ocu-074286	Oryctolagus cuniculus	50.54	0.00e+00	1018.00
IUUC-Oga-088678	Otolemur garnettii	51.16	0.00e+00	1228.00
IUUC-Oar-089359	Ovis aries	50.17	0.00e+00	1211.00
IUUC-Ptr-091062	Pan troglodytes	50.66	0.00e+00	1216.00
IUUC-Pan-092528	Papio anubis	51.44	0.00e+00	751.00
IUUC-Psi-093430	Pelodiscus sinensis	51.52	0.00e+00	1223.00
IUUC-Pma-094690	Petromyzon marinus	37.11	3.00e-120	426.00
IUUC-Pfo-097204	Poecilia formosa	67.60	0.00e+00	1704.00
IUUC-Pab-097690	Pongo abelii	50.41	0.00e+00	1210.00
IUUC-Pca-100778	Procavia capensis	39.24	7.00e-159	555.00
IUUC-Pva-102870	Pteropus vampyrus	49.55	0.00e+00	1086.00
IUUC-Rno-104889	Rattus norvegicus	49.92	0.00e+00	1194.00
IUUC-Sha-107465	Sarcophilus harrisii	51.23	0.00e+00	1230.00
IUUC-Sar-113268	Sorex araneus	47.46	1.00e-95	344.00
IUUC-Ssc-115654	Sus scrofa	49.83	0.00e+00	1209.00
IUUC-Tgu-117302	Taeniopygia guttata	50.00	0.00e+00	1204.00
IUUC-Tru-118363	Takifugu rubripes	69.14	0.00e+00	1724.00
IUUC-Tsy-119007	Tarsius syrichta	50.00	0.00e+00	1200.00
IUUC-Tni-120910	Tetraodon nigroviridis	68.36	0.00e+00	1729.00
IUUC-Tbe-127413	Tupaia belangeri	41.39	0.00e+00	671.00
IUUC-Ttr-129213	Tursiops truncatus	48.41	0.00e+00	1095.00
IUUC-Vpa-130146	Vicugna pacos	45.78	0.00e+00	786.00
IUUC-Xtr-132559	Xenopus tropicalis	47.57	0.00e+00	1138.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence