iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-091062

UUCD1 version

UUC-PaT-00813

Ensembl Protein ID

ENSPTRP00000042795.2

UniProt Accession

H2R1S6; H2R1S6_PANTR

Genbank Protein ID

JAA27285.1; JAA27286.1

Protein Name

Apoptotic protease-activating factor 1

Genbank Nucleotide ID

AACZ03085161; GABD01005814

Gene Name

APAF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000005335.5	ENSPTRT00000048551.2	ENSPTRP00000042795.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.00e-61	201.1	741	775
UBD/Beta-Prp	1.10e-89	300.5	614	776

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtg 33
           gHt+sv+ ++f +d +ll+s+s Dgt+k+WD ++ 
   Q: 741  GHTNSVNHCRFsPDdKLLASCSADGTLKLWDATSA 775
           8***********777****************8776 PP

UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
           h++ ++  +fs+d++ +a+ ++d+t++v++++tg +l +++ he+ev ++ fs d+ +++t+s D+ +k+w+  tg+ vht+ +h+++v
   Q: 614  HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQV 702
           33334445555555555555555555555555555555555555555555555555555555555555555555555555555555555 PP
   S: 98   lslsfspsg..dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvy 184
            +++f  s+    l++Gs+d  +++wdl++++c + t  gh+ +vn+ +++pd++ll+s+s+D+t++lWd                   
   Q: 703  NCCHFTNSShhLLLATGSSDCFLKLWDLNQKECRN-TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDA------------------ 772
           55555552211233445555555555555555554.55555555555555555555555555555555554.................. PP
   S: 185  slsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgd 255
                                                                              +s +
   Q: 773  -------------------------------------------------------------------TSAN 776
           ...................................................................4444 PP

Organism

Pan troglodytes

Functional Description
(View)

Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

Protein Sequence
(Fasta)

MDAKARNCLL QHREALEKDI KTSYIMDHMI SDGFLTISEE EKVRNEPTQQ QRAAMLIKMI 60
LKKDNDSYVS FYNALLHEGY KDLAALLHDG IPVVSSSSGK DSVSGITSYV RTVLCEGGVP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGAAGAGGT AGCGAGTGGA CGTGACTGCT CTATCCCGGG CAAAAGGGAT AGAACCAGAG 60
GTGGGGAGTC TGGGCAGTCG GCGACCCGCG AAGACTTGAG GTGCCGCAGC GGCATCCGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR017251--Apaf-1
IPR001315--CARD
IPR003143--Cyt_cd1_C
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50209--CARD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00619--CARD
PF00931--NB-ARC
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0043293--C:apoptosome
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0043531--F:ADP binding
GO:0005524--F:ATP binding
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008635--P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0030900--P:forebrain development
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0001843--P:neural tube closure
GO:0051402--P:neuron apoptotic process
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:1902510--P:regulation of apoptotic DNA fragmentation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001432	Ailuropoda melanoleuca	91.13	0.00e+00	2313.00
IUUC-Apl-004201	Anas platyrhynchos	70.82	0.00e+00	1831.00
IUUC-Aca-004638	Anolis carolinensis	69.03	0.00e+00	1813.00
IUUC-Ani-009285	Aspergillus nidulans	25.88	4.00e-67	250.00
IUUC-Ame-011062	Astyanax mexicanus	54.83	0.00e+00	1377.00
IUUC-Bta-012865	Bos taurus	90.47	0.00e+00	2333.00
IUUC-Cel-018376	Caenorhabditis elegans	21.72	5.00e-31	130.00
IUUC-Cja-018815	Callithrix jacchus	84.66	0.00e+00	2132.00
IUUC-Cfa-020222	Canis familiaris	86.69	0.00e+00	2178.00
IUUC-Cpo-021524	Cavia porcellus	88.15	0.00e+00	2270.00
IUUC-Csa-023861	Chlorocebus sabaeus	97.36	0.00e+00	2498.00
IUUC-Cho-024484	Choloepus hoffmanni	79.21	0.00e+00	1209.00
IUUC-Dre-028006	Danio rerio	53.50	0.00e+00	1270.00
IUUC-Dno-029591	Dasypus novemcinctus	90.39	0.00e+00	2336.00
IUUC-Dor-030237	Dipodomys ordii	75.67	0.00e+00	1087.00
IUUC-Ete-032620	Echinops telfairi	85.16	0.00e+00	1092.00
IUUC-Eca-033569	Equus caballus	90.39	0.00e+00	2314.00
IUUC-Eeu-035354	Erinaceus europaeus	64.17	4.00e-176	612.00
IUUC-Fca-036337	Felis catus	91.20	0.00e+00	2347.00
IUUC-Fal-037077	Ficedula albicollis	71.18	0.00e+00	1832.00
IUUC-Gmo-039687	Gadus morhua	51.01	0.00e+00	939.00
IUUC-Ggr-039828	Gaeumannomyces graminis	23.78	2.00e-41	165.00
IUUC-Gga-040299	Gallus gallus	69.78	0.00e+00	1846.00
IUUC-Gac-041762	Gasterosteus aculeatus	52.15	0.00e+00	1281.00
IUUC-Ggo-045563	Gorilla gorilla	99.52	0.00e+00	2557.00
IUUC-Hsa-046771	Homo sapiens	99.44	0.00e+00	2554.00
IUUC-Lch-050200	Latimeria chalumnae	65.17	0.00e+00	1637.00
IUUC-Loc-052090	Lepisosteus oculatus	59.56	0.00e+00	1517.00
IUUC-Laf-053861	Loxodonta africana	90.79	0.00e+00	2328.00
IUUC-Mcc-055543	Macaca mulatta	97.76	0.00e+00	2505.00
IUUC-Meu-056688	Macropus eugenii	80.19	0.00e+00	2043.00
IUUC-Mga-059243	Meleagris gallopavo	70.31	0.00e+00	1855.00
IUUC-Mmr-061134	Microcebus murinus	86.54	0.00e+00	2023.00
IUUC-Mdo-062913	Monodelphis domestica	78.99	0.00e+00	2056.00
IUUC-Mmu-063811	Mus musculus	87.59	0.00e+00	2279.00
IUUC-Mpu-066780	Mustela putorius furo	91.04	0.00e+00	2310.00
IUUC-Mlu-067276	Myotis lucifugus	90.24	0.00e+00	2320.00
IUUC-Nle-069129	Nomascus leucogenys	98.16	0.00e+00	2511.00
IUUC-Opr-071007	Ochotona princeps	66.90	0.00e+00	1119.00
IUUC-Ont-071348	Oreochromis niloticus	55.09	0.00e+00	1410.00
IUUC-Oan-072717	Ornithorhynchus anatinus	80.98	0.00e+00	2109.00
IUUC-Ocu-074286	Oryctolagus cuniculus	90.98	0.00e+00	1994.00
IUUC-Ola-086895	Oryzias latipes	50.66	0.00e+00	1196.00
IUUC-Oga-088678	Otolemur garnettii	91.35	0.00e+00	2347.00
IUUC-Oar-089359	Ovis aries	90.15	0.00e+00	2330.00
IUUC-Pan-092528	Papio anubis	98.90	0.00e+00	1460.00
IUUC-Psi-093430	Pelodiscus sinensis	73.68	0.00e+00	1916.00
IUUC-Pma-094690	Petromyzon marinus	38.82	3.00e-152	532.00
IUUC-Pfo-097204	Poecilia formosa	54.88	0.00e+00	1386.00
IUUC-Pab-097690	Pongo abelii	99.12	0.00e+00	2545.00
IUUC-Pca-100778	Procavia capensis	70.69	0.00e+00	1181.00
IUUC-Pva-102870	Pteropus vampyrus	88.24	0.00e+00	2102.00
IUUC-Rno-104889	Rattus norvegicus	87.59	0.00e+00	2245.00
IUUC-Sha-107465	Sarcophilus harrisii	79.28	0.00e+00	2092.00
IUUC-Sar-113268	Sorex araneus	90.88	0.00e+00	675.00
IUUC-Ssc-115654	Sus scrofa	89.83	0.00e+00	2321.00
IUUC-Tgu-117302	Taeniopygia guttata	71.10	0.00e+00	1843.00
IUUC-Tru-118363	Takifugu rubripes	54.69	0.00e+00	1390.00
IUUC-Tsy-119007	Tarsius syrichta	88.14	0.00e+00	2243.00
IUUC-Tni-120910	Tetraodon nigroviridis	53.12	0.00e+00	1337.00
IUUC-Tbe-127413	Tupaia belangeri	77.45	0.00e+00	1408.00
IUUC-Ttr-129213	Tursiops truncatus	84.70	0.00e+00	2133.00
IUUC-Vpa-130146	Vicugna pacos	85.16	0.00e+00	1620.00
IUUC-Xtr-132559	Xenopus tropicalis	61.42	0.00e+00	1550.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence