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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063640
Ensembl Protein ID ENSMUSP00000075210.4
UniProt Accession Q8BVE8; B3VCH6; Q6ZPY1; Q7TSF5; Q811F0; NSD2_MOUSE
Genbank Protein ID ACE75882.1; BAC98097.1; BAC37342.1; AAH46473.1; AAH53454.1
Protein Name Histone-lysine N-methyltransferase NSD2; Multiple myeloma SET domain-containing protein; Nuclear SET domain-containing protein 2; Wolf-Hirschhorn syndrome candidate 1 protein homolog
Genbank Nucleotide ID EU733655; AK129287; AC163329; BC046473; BC053454
Gene Name Whsc1; Nsd2; Kiaa1090
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000057406.16 ENSMUST00000075812.10 ENSMUSP00000075210.4
ENSMUSG00000057406.16 ENSMUST00000114397.8 ENSMUSP00000110039.1
ENSMUSG00000057406.16 ENSMUST00000114399.7 ENSMUSP00000110041.1
ENSMUSG00000057406.16 ENSMUST00000058096.13 ENSMUSP00000058940.7
ENSMUSG00000057406.16 ENSMUST00000141416.4 ENSMUSP00000117233.1
ENSMUSG00000057406.16 ENSMUST00000142080.1 ENSMUSP00000115251.1
ENSMUSG00000057406.16 ENSMUST00000202525.3 ENSMUSP00000144255.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitecircBasemiRTarBasemicroRNA
TRANSFACRepTarmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 3.70e-15 57.0 834 874
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           +C vC +gg+    l++Ce C  +fHp+Cl+++    +p+ + w+C++Cr
   Q: 834  WCFVCSKGGS----LLCCEACPAAFHPDCLNIE----MPDGS-WFCNDCR 874
           8*********....*******************....9***8.******8 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity.
 Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity.
Protein Sequence
(Fasta)
MEFSIRKSPL SVQKVVKCMK MKQTPEILGS ANGKTQNCEV NHECSVFLSK AQLSNSLQEG 60
VMQKFNGHDA LPFLPAEKLK DLTSCVFNGE PGAHDTKLCF EAQEVKGIGT PPNTTPIKNG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063640|E3,PHD|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGAGAGCCTC GGCCTGGCCG CGCTGCGCCC GCCGCTGCCG CCGCCGCCGC CCCCTCCTGC 60
CTCCCTGCCC TCCGCGGCCT CGCGTCCGCT GTCGCCGCCG CTGCCGTCGC CGGACAGCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063640|E3,PHD|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR006560--AWS_dom
IPR009071--HMG_box_dom
IPR003616--Post-SET_dom
IPR000313--PWWP_dom
IPR001214--SET_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51215--AWS
PS50118--HMG_BOX_2
PS50868--POST_SET
PS50812--PWWP
PS50280--SET
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF00505--HMG_box
PF00855--PWWP
PF00856--SET
SMART

SM00570--AWS
SM00398--HMG
SM00249--PHD
SM00508--PostSET
SM00293--PWWP
SM00317--SET
Gene Ontology

GO:0005694--C:chromosome
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0043565--F:sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0003289--P:atrial septum primum morphogenesis
GO:0003290--P:atrial septum secundum morphogenesis
GO:0060348--P:bone development
GO:0010452--P:histone H3-K36 methylation
GO:0034770--P:histone H4-K20 methylation
GO:0003149--P:membranous septum morphogenesis
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048298--P:positive regulation of isotype switching to IgA isotypes
GO:2001032--P:regulation of double-strand break repair via nonhomologous end joining
GO:0070201--P:regulation of establishment of protein localization
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG mmu:107823
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002181 Ailuropoda melanoleuca 89.93 0.00e+00 2391.00
IUUC-Apl-003677 Anas platyrhynchos 78.97 0.00e+00 2103.00
IUUC-Aca-004278 Anolis carolinensis 75.44 0.00e+00 1412.00
IUUC-Ame-011932 Astyanax mexicanus 70.98 0.00e+00 1029.00
IUUC-Bta-012522 Bos taurus 83.72 0.00e+00 2207.00
IUUC-Cja-018908 Callithrix jacchus 90.45 0.00e+00 2309.00
IUUC-Cfa-020894 Canis familiaris 89.44 0.00e+00 2426.00
IUUC-Cpo-021982 Cavia porcellus 89.04 0.00e+00 2383.00
IUUC-Csa-023807 Chlorocebus sabaeus 90.81 0.00e+00 2342.00
IUUC-Cho-024405 Choloepus hoffmanni 70.66 0.00e+00 703.00
IUUC-Csv-026298 Ciona savignyi 37.70 1.00e-57 217.00
IUUC-Dre-027492 Danio rerio 70.68 0.00e+00 1065.00
IUUC-Dno-030020 Dasypus novemcinctus 85.84 0.00e+00 2039.00
IUUC-Dor-031103 Dipodomys ordii 85.36 0.00e+00 2204.00
IUUC-Ete-032488 Echinops telfairi 80.15 0.00e+00 2072.00
IUUC-Eca-034066 Equus caballus 90.70 0.00e+00 2441.00
IUUC-Eeu-035199 Erinaceus europaeus 70.27 0.00e+00 750.00
IUUC-Fca-035434 Felis catus 85.38 0.00e+00 1957.00
IUUC-Fal-037113 Ficedula albicollis 77.11 0.00e+00 2113.00
IUUC-Gmo-039686 Gadus morhua 70.32 0.00e+00 1011.00
IUUC-Gga-040273 Gallus gallus 77.45 0.00e+00 2078.00
IUUC-Gac-042123 Gasterosteus aculeatus 49.89 0.00e+00 1223.00
IUUC-Ggo-044643 Gorilla gorilla 90.96 0.00e+00 2368.00
IUUC-Hsa-046380 Homo sapiens 91.24 0.00e+00 2342.00
IUUC-Itr-048658 Ictidomys tridecemlineatus 92.63 0.00e+00 1458.00
IUUC-Lch-050217 Latimeria chalumnae 66.82 0.00e+00 1746.00
IUUC-Loc-052766 Lepisosteus oculatus 58.94 0.00e+00 1288.00
IUUC-Laf-053780 Loxodonta africana 87.55 0.00e+00 2384.00
IUUC-Mcc-054928 Macaca mulatta 90.89 0.00e+00 2376.00
IUUC-Meu-056184 Macropus eugenii 73.96 0.00e+00 775.00
IUUC-Mga-059576 Meleagris gallopavo 78.22 0.00e+00 2083.00
IUUC-Mmr-061045 Microcebus murinus 90.63 0.00e+00 2423.00
IUUC-Mdo-062576 Monodelphis domestica 81.85 0.00e+00 2168.00
IUUC-Mac-065303 Musa acuminata 28.04 4.00e-11 63.50
IUUC-Mpu-066512 Mustela putorius furo 89.90 0.00e+00 2367.00
IUUC-Mlu-067280 Myotis lucifugus 78.43 0.00e+00 1087.00
IUUC-Nle-069896 Nomascus leucogenys 91.22 0.00e+00 2259.00
IUUC-Ont-072197 Oreochromis niloticus 73.00 0.00e+00 1035.00
IUUC-Oan-072724 Ornithorhynchus anatinus 78.52 0.00e+00 1361.00
IUUC-Ocu-074758 Oryctolagus cuniculus 87.45 0.00e+00 2276.00
IUUC-Ogl-077641 Oryza glaberrima 29.07 2.00e-10 60.10
IUUC-Ogu-078898 Oryza glumaepatula 29.07 2.00e-10 60.10
IUUC-Oin-079557 Oryza indica 29.07 2.00e-10 60.10
IUUC-Olo-080702 Oryza longistaminata 41.94 2.00e-45 178.00
IUUC-Opu-083371 Oryza punctata 42.31 4.00e-47 183.00
IUUC-Osa-085353 Oryza sativa 29.07 2.00e-10 60.10
IUUC-Oga-088702 Otolemur garnettii 89.63 0.00e+00 2075.00
IUUC-Oar-089736 Ovis aries 79.19 0.00e+00 1960.00
IUUC-Ptr-091055 Pan troglodytes 91.09 0.00e+00 2340.00
IUUC-Pan-092752 Papio anubis 95.53 0.00e+00 1424.00
IUUC-Psi-093620 Pelodiscus sinensis 79.51 0.00e+00 2122.00
IUUC-Pma-094747 Petromyzon marinus 70.72 0.00e+00 700.00
IUUC-Pfo-097464 Poecilia formosa 64.73 0.00e+00 1055.00
IUUC-Pab-098051 Pongo abelii 91.02 0.00e+00 2373.00
IUUC-Pop-099927 Populus trichocarpa 28.93 7.00e-12 66.20
IUUC-Pca-100273 Procavia capensis 87.99 0.00e+00 2333.00
IUUC-Ppe-101635 Prunus persica 28.02 3.00e-11 64.30
IUUC-Pva-102473 Pteropus vampyrus 77.13 0.00e+00 1915.00
IUUC-Rno-105056 Rattus norvegicus 97.03 0.00e+00 2585.00
IUUC-Sha-107494 Sarcophilus harrisii 82.54 0.00e+00 2164.00
IUUC-Sar-113310 Sorex araneus 89.42 0.00e+00 1856.00
IUUC-Sbi-114581 Sorghum bicolor 35.19 5.00e-10 58.50
IUUC-Ssc-116344 Sus scrofa 83.50 0.00e+00 2211.00
IUUC-Tgu-116786 Taeniopygia guttata 78.84 0.00e+00 2108.00
IUUC-Tru-117638 Takifugu rubripes 50.37 0.00e+00 1231.00
IUUC-Tsy-118937 Tarsius syrichta 95.28 0.00e+00 1546.00
IUUC-Tni-120452 Tetraodon nigroviridis 63.93 0.00e+00 1046.00
IUUC-Tae-125237 Triticum aestivum 29.45 2.00e-07 49.70
IUUC-Tbe-127291 Tupaia belangeri 87.08 0.00e+00 1527.00
IUUC-Ttr-129017 Tursiops truncatus 81.24 0.00e+00 1716.00
IUUC-Xtr-132673 Xenopus tropicalis 67.09 0.00e+00 1771.00
IUUC-Xma-133695 Xiphophorus maculatus 69.37 0.00e+00 1014.00
Created Date 25-Jun-2017

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