iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-011777

Ensembl Protein ID

ENSAMXP00000012820.1

UniProt Accession

W5KZ08; W5KZ08_ASTMX

Genbank Protein ID

ENSAMXP00000012820

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

APWO01108814

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000012425.1	ENSAMXT00000012820.1	ENSAMXP00000012820.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	7.70e-110	367.5	148	691

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tG+kN+gN+CYmN++LQ+Lsn+p+l++++l+     ++   ++++k +l+ks+qkl++elw k++ ++v p++l++ +k ++++f+gy+
   Q: 148  TGMKNIGNSCYMNAALQALSNCPPLTQFFLD-----CSGLVRTDKKPALCKSYQKLISELWhKKRPSYVVPTSLFHGIKLVNPMFRGYA 231
           7******************************.....9999999******************99999*********************** PP
   S: 89   qqDaqEflaflldqleeelkk.............eknkpkeeeeeedkselsde................................... 129
           qqD+qEfl++l+dql+eelk+             e+                 +                                   
   Q: 232  QQDTQEFLRCLMDQLHEELKEpfadcsssadsgpER-----------------Nldnrnhsngdcspseddflscdsgsgsergdgerg 303
           *******************88777665544433322.................1222233344556667779***************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 304  sgtgggdaelliqdecvgprstggisekerqkerrkedkgeertqemdedadvdtaaqeepaerageqagpprtgqtqgntepdneatm 392
           ***************************************************************************************** PP
   S: 130  ...............................................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfld 171
                                                          a++kk+++ +s+isd+F+g++ s ++cl+cd+vs++ e+f+d
   Q: 393  hrpasrpcspthsvqelhsklssspprssplraspiyafkkaqmllgAKKKKQSRFRSVISDIFDGSILSLVQCLTCDRVSTTVETFQD 481
           ***************************************************************************************** PP
   S: 172  lslpvpgkeetkke.................................................slqdcLesftkeeelegenkyycekc 211
           lslp+pgke+ +k+                                                 +l+dcL++f++++el+g+n+y+ce+c
   Q: 482  LSLPIPGKEDLAKLhssihqsapaktgvctdtyasqgwisyimdsirrfvvscipswfwgpmvTLEDCLAAFFAADELKGDNMYSCERC 570
           *********99888*************************************************************************** PP
   S: 212  kkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayv 299
           kk+++ +k +k+ +lPe+L++hLkRf  ++e + + ki+++v+fple Ldl+pf+++++ +q   ++Y+L++v++H+G+++sGHY+ay 
   Q: 571  KKLRNGVKYCKVLRLPEILCIHLKRF--RHEVMYSFKISSHVSFPLEgLDLKPFLAKESPSQ--ITTYDLLSVICHHGTAGSGHYIAYS 655
           **************************..9999*************************88887..9************************ PP
   S: 300  kn.ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           +n  +g+W++fdD++Vtev+e+ v++   ++aYvlfY++
   Q: 656  QNvINGQWYEFDDQYVTEVHETVVQN---AEAYVLFYRK 691
           **78999*******************...********98 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

MTDSRDVCPH LDSIGEVTKE ELLHKSKGTC QSCGVGGPNL WACLQCDCPY VGCGESYSDH 60
STTHAQAKKH NLTVNLTTFR VWCYVCEREV FLEQRPVVPV AGTHRYKPLD QDALLQSACH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGGCGGAGC TGCCTGGCTC TGCTCTGTGC TCTCTGTGCT AGTCTCTGTT ATTCTGCTGG 60
CTAGCGCAGT GAGATCCTCA GGAGATCGGG AGATTTTCAT TTAGACGGAA AATGAACACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002209	Ailuropoda melanoleuca	75.43	0.00e+00	1333.00
IUUC-Apl-003351	Anas platyrhynchos	76.12	0.00e+00	1380.00
IUUC-Aca-005077	Anolis carolinensis	69.72	0.00e+00	990.00
IUUC-Bta-013063	Bos taurus	75.57	0.00e+00	1346.00
IUUC-Cja-019868	Callithrix jacchus	75.49	0.00e+00	1365.00
IUUC-Cfa-020761	Canis familiaris	75.27	0.00e+00	1348.00
IUUC-Cpo-022267	Cavia porcellus	73.01	0.00e+00	1327.00
IUUC-Csa-024251	Chlorocebus sabaeus	76.08	0.00e+00	1375.00
IUUC-Cho-024483	Choloepus hoffmanni	91.51	3.00e-118	419.00
IUUC-Dre-028061	Danio rerio	79.80	0.00e+00	1426.00
IUUC-Dno-029423	Dasypus novemcinctus	75.35	0.00e+00	1352.00
IUUC-Dor-030877	Dipodomys ordii	76.92	0.00e+00	907.00
IUUC-Dme-031837	Drosophila melanogaster	49.36	9.00e-138	484.00
IUUC-Ete-032802	Echinops telfairi	63.03	2.00e-111	397.00
IUUC-Eca-034283	Equus caballus	74.43	0.00e+00	1336.00
IUUC-Eeu-034620	Erinaceus europaeus	72.23	0.00e+00	912.00
IUUC-Fca-036357	Felis catus	75.92	0.00e+00	1341.00
IUUC-Fal-037411	Ficedula albicollis	75.97	0.00e+00	1375.00
IUUC-Gmo-038944	Gadus morhua	59.03	0.00e+00	1031.00
IUUC-Gga-041101	Gallus gallus	76.71	0.00e+00	1384.00
IUUC-Gac-041315	Gasterosteus aculeatus	80.82	0.00e+00	1427.00
IUUC-Ggo-045600	Gorilla gorilla	75.81	0.00e+00	1346.00
IUUC-Hsa-045825	Homo sapiens	76.11	0.00e+00	1363.00
IUUC-Itr-048549	Ictidomys tridecemlineatus	66.77	0.00e+00	1128.00
IUUC-Lch-050002	Latimeria chalumnae	73.31	0.00e+00	1271.00
IUUC-Loc-052574	Lepisosteus oculatus	80.65	0.00e+00	1444.00
IUUC-Laf-054428	Loxodonta africana	75.57	0.00e+00	1348.00
IUUC-Mcc-055736	Macaca mulatta	76.08	0.00e+00	1377.00
IUUC-Meu-056645	Macropus eugenii	52.39	0.00e+00	879.00
IUUC-Mga-059781	Meleagris gallopavo	76.56	0.00e+00	1378.00
IUUC-Mmr-061241	Microcebus murinus	56.12	0.00e+00	1009.00
IUUC-Mdo-063048	Monodelphis domestica	77.37	0.00e+00	1355.00
IUUC-Mmu-064079	Mus musculus	74.95	0.00e+00	1338.00
IUUC-Mpu-066616	Mustela putorius furo	75.27	0.00e+00	1368.00
IUUC-Mlu-067294	Myotis lucifugus	75.89	0.00e+00	1336.00
IUUC-Nle-070015	Nomascus leucogenys	75.89	0.00e+00	1351.00
IUUC-Opr-070328	Ochotona princeps	75.35	0.00e+00	1348.00
IUUC-Ont-071464	Oreochromis niloticus	81.76	0.00e+00	1419.00
IUUC-Oan-073259	Ornithorhynchus anatinus	68.38	0.00e+00	1169.00
IUUC-Ocu-074630	Oryctolagus cuniculus	72.90	0.00e+00	1287.00
IUUC-Ola-087240	Oryzias latipes	80.24	0.00e+00	1409.00
IUUC-Oga-088761	Otolemur garnettii	75.05	0.00e+00	1360.00
IUUC-Oar-089490	Ovis aries	72.28	0.00e+00	1234.00
IUUC-Ptr-091662	Pan troglodytes	76.22	0.00e+00	1361.00
IUUC-Pan-092199	Papio anubis	75.81	0.00e+00	1362.00
IUUC-Psi-093726	Pelodiscus sinensis	76.27	0.00e+00	1374.00
IUUC-Pma-094389	Petromyzon marinus	62.79	2.00e-100	358.00
IUUC-Pfo-096522	Poecilia formosa	77.70	0.00e+00	1028.00
IUUC-Pab-098632	Pongo abelii	75.89	0.00e+00	1361.00
IUUC-Pca-100614	Procavia capensis	69.80	0.00e+00	1051.00
IUUC-Pva-102820	Pteropus vampyrus	56.24	0.00e+00	868.00
IUUC-Rno-105215	Rattus norvegicus	74.62	0.00e+00	1334.00
IUUC-Sha-106601	Sarcophilus harrisii	76.07	0.00e+00	1339.00
IUUC-Sar-113665	Sorex araneus	58.02	0.00e+00	1047.00
IUUC-Ssc-115533	Sus scrofa	74.87	0.00e+00	1343.00
IUUC-Tgu-117364	Taeniopygia guttata	76.00	0.00e+00	1365.00
IUUC-Tru-117770	Takifugu rubripes	77.59	0.00e+00	1402.00
IUUC-Tsy-119598	Tarsius syrichta	51.75	0.00e+00	867.00
IUUC-Tni-120001	Tetraodon nigroviridis	80.17	0.00e+00	1373.00
IUUC-Ttr-128732	Tursiops truncatus	75.70	0.00e+00	1346.00
IUUC-Vpa-130598	Vicugna pacos	57.05	0.00e+00	1024.00
IUUC-Xtr-132157	Xenopus tropicalis	72.07	0.00e+00	1282.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence