iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053722

UUCD1 version

UUC-LoA-00919

Ensembl Protein ID

ENSLAFP00000027451.1

UniProt Accession

G3UHZ3; G3UHZ3_LOXAF

Protein Name

Uncharacterized protein

Gene Name

TNFAIP3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000011428.3	ENSLAFT00000027333.1	ENSLAFP00000027451.1
ENSLAFG00000011428.3	ENSLAFT00000011423.3	ENSLAFP00000009541.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	2.10e-40	138.7	93	262
UBD/ZnF/ZnF_A20	8.90e-23	80.3	758	790

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseyl....qkesdffsefieek........edekefcqklvepeakg 77
           ++lkt+gDGnCL++Avsq+++gv+d+d+ l++al++aL+e+ ++++    q es + +ef+e++        +de++++ k++++++ g
   Q: 93   VALKTNGDGNCLMHAVSQYMWGVQDTDLvLRKALFSALKETDTRNFkfrwQLESLKSQEFVETGlcydtrnwNDEWDNLIKMASTDTPG 181
           789**********************************************9************************************665 PP
   S: 78   ..........eeihifaLaqiLsrpiivvdvdsles..........kvggillpllfpeek.lkkpivLlYrsgHYdaLva 137
                     eeihif+L++iL+rp+iv+++++l+s          kvggi+lpl++p+++ +++pivL+Y+s H+ +Lv+
   Q: 182  arvgfqyhslEEIHIFVLCNILRRPVIVISDKMLRSlesgsnfapvKVGGIYLPLHWPAKEcYRYPIVLGYDSQHFVPLVT 262
           6777***************************************************************************97 PP

UBD/ZnF/ZnF_A20

   S: 3    skllCkk.gCgfYGnpetngyCSkCyreelrrr 34
           +k++C++ +C ++Gn+++ gyC++C++++++++
   Q: 758  PKQRCRApACEHFGNAKCSGYCNECFQFKQMYG 790
           79*****************************96 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MAEQLLPLAL YLSNMRKAVK IRERTPEDIF KPTNGIIHHF KTMHRYTLEM FRTCQFCPQF 60
REIIHKALID RNTQASLESQ RKLNWCREVR KLVALKTNGD GNCLMHAVSQ YMWGVQDTDL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTGAAC AACTCCTTCC CCTGGCTTTG TATTTGAGCA ATATGCGGAA AGCTGTGAAG 60
ATAAGAGAGA GAACGCCAGA AGATATTTTT AAACCTACCA ATGGGATAAT TCATCATTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR033478--A20
IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0001922--P:B-1 B cell homeostasis
GO:0070301--P:cellular response to hydrogen peroxide
GO:0072666--P:establishment of protein localization to vacuole
GO:0050869--P:negative regulation of B cell activation
GO:2000349--P:negative regulation of CD40 signaling pathway
GO:0002677--P:negative regulation of chronic inflammatory response
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:2000352--P:negative regulation of endothelial cell apoptotic process
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045824--P:negative regulation of innate immune response
GO:0032691--P:negative regulation of interleukin-1 beta production
GO:0032703--P:negative regulation of interleukin-2 production
GO:0032715--P:negative regulation of interleukin-6 production
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0070429--P:negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070433--P:negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0031397--P:negative regulation of protein ubiquitination
GO:0048662--P:negative regulation of smooth muscle cell proliferation
GO:0034140--P:negative regulation of toll-like receptor 3 signaling pathway
GO:0034148--P:negative regulation of toll-like receptor 5 signaling pathway
GO:0032720--P:negative regulation of tumor necrosis factor production
GO:1903364--P:positive regulation of cellular protein catabolic process
GO:2000347--P:positive regulation of hepatocyte proliferation
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0002634--P:regulation of germinal center formation
GO:0032495--P:response to muramyl dipeptide
GO:0072573--P:tolerance induction to lipopolysaccharide

KEGG

lav:100670852

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001825	Ailuropoda melanoleuca	88.86	0.00e+00	1460.00
IUUC-Apl-003501	Anas platyrhynchos	67.34	0.00e+00	1058.00
IUUC-Aca-004245	Anolis carolinensis	64.30	0.00e+00	1062.00
IUUC-Ame-011789	Astyanax mexicanus	45.44	0.00e+00	686.00
IUUC-Bta-012664	Bos taurus	84.18	0.00e+00	1352.00
IUUC-Cja-019895	Callithrix jacchus	90.00	0.00e+00	1462.00
IUUC-Cfa-020754	Canis familiaris	88.48	0.00e+00	1455.00
IUUC-Cpo-021780	Cavia porcellus	88.01	0.00e+00	1426.00
IUUC-Csa-023568	Chlorocebus sabaeus	89.87	0.00e+00	1477.00
IUUC-Cho-024300	Choloepus hoffmanni	88.63	0.00e+00	641.00
IUUC-Dre-028577	Danio rerio	47.71	0.00e+00	675.00
IUUC-Dno-029382	Dasypus novemcinctus	82.78	0.00e+00	1330.00
IUUC-Dor-030874	Dipodomys ordii	85.19	0.00e+00	1375.00
IUUC-Ete-032721	Echinops telfairi	91.13	0.00e+00	802.00
IUUC-Eca-033596	Equus caballus	85.95	0.00e+00	1394.00
IUUC-Eeu-035159	Erinaceus europaeus	84.24	0.00e+00	1090.00
IUUC-Fca-035847	Felis catus	89.24	0.00e+00	1459.00
IUUC-Fal-036681	Ficedula albicollis	65.55	0.00e+00	1052.00
IUUC-Gmo-038521	Gadus morhua	57.99	4.00e-144	505.00
IUUC-Gga-040975	Gallus gallus	65.18	0.00e+00	1060.00
IUUC-Gac-042216	Gasterosteus aculeatus	59.56	1.00e-149	523.00
IUUC-Ggo-045258	Gorilla gorilla	89.37	0.00e+00	1467.00
IUUC-Hsa-046071	Homo sapiens	89.62	0.00e+00	1472.00
IUUC-Itr-048386	Ictidomys tridecemlineatus	88.99	0.00e+00	1449.00
IUUC-Lch-050326	Latimeria chalumnae	57.82	0.00e+00	920.00
IUUC-Loc-051945	Lepisosteus oculatus	46.16	1.00e-174	606.00
IUUC-Mcc-055503	Macaca mulatta	89.62	0.00e+00	1471.00
IUUC-Meu-056481	Macropus eugenii	74.30	0.00e+00	1171.00
IUUC-Mga-059690	Meleagris gallopavo	63.10	0.00e+00	982.00
IUUC-Mmr-061233	Microcebus murinus	87.50	0.00e+00	1412.00
IUUC-Mdo-062446	Monodelphis domestica	78.92	0.00e+00	1278.00
IUUC-Mmu-063436	Mus musculus	85.82	0.00e+00	1365.00
IUUC-Mpu-066808	Mustela putorius furo	89.11	0.00e+00	1464.00
IUUC-Mlu-067339	Myotis lucifugus	86.96	0.00e+00	1415.00
IUUC-Nle-069888	Nomascus leucogenys	89.49	0.00e+00	1470.00
IUUC-Opr-070303	Ochotona princeps	86.63	0.00e+00	1411.00
IUUC-Ont-072283	Oreochromis niloticus	57.97	4.00e-144	505.00
IUUC-Oan-072925	Ornithorhynchus anatinus	75.69	0.00e+00	1229.00
IUUC-Ocu-073889	Oryctolagus cuniculus	87.48	0.00e+00	1397.00
IUUC-Ola-087417	Oryzias latipes	57.87	2.00e-143	503.00
IUUC-Oga-088708	Otolemur garnettii	85.70	0.00e+00	1349.00
IUUC-Oar-089271	Ovis aries	84.30	0.00e+00	1365.00
IUUC-Ptr-091296	Pan troglodytes	89.62	0.00e+00	1471.00
IUUC-Pan-092474	Papio anubis	89.75	0.00e+00	1474.00
IUUC-Psi-093447	Pelodiscus sinensis	68.38	0.00e+00	1102.00
IUUC-Pfo-096511	Poecilia formosa	58.11	7.00e-145	508.00
IUUC-Pab-098700	Pongo abelii	89.49	0.00e+00	1470.00
IUUC-Pca-100246	Procavia capensis	79.49	0.00e+00	1254.00
IUUC-Pva-102606	Pteropus vampyrus	77.92	8.00e-180	624.00
IUUC-Rno-105818	Rattus norvegicus	85.46	0.00e+00	1394.00
IUUC-Sha-106559	Sarcophilus harrisii	78.29	0.00e+00	1274.00
IUUC-Spo-108099	Schizosaccharomyces pombe	33.93	1.20e-01	31.60
IUUC-Sar-113454	Sorex araneus	92.68	0.00e+00	642.00
IUUC-Ssc-116064	Sus scrofa	86.58	0.00e+00	1395.00
IUUC-Tgu-117212	Taeniopygia guttata	65.23	0.00e+00	1045.00
IUUC-Tru-118230	Takifugu rubripes	58.60	5.00e-148	518.00
IUUC-Tsy-119066	Tarsius syrichta	86.08	0.00e+00	1402.00
IUUC-Tni-119825	Tetraodon nigroviridis	46.12	0.00e+00	675.00
IUUC-Tbe-127601	Tupaia belangeri	94.51	0.00e+00	659.00
IUUC-Ttr-128930	Tursiops truncatus	84.81	0.00e+00	1381.00
IUUC-Vpa-130450	Vicugna pacos	94.01	0.00e+00	800.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence