iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-069927

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADFV01185722

Gene Name

MDM2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000003757.1	ENSNLET00000004788.1	ENSNLEP00000004551.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	99.20	0.00e+00	871.00	IUUC-Hsa-046376
E3 activity/RING/RING	80.24	0.00e+00	660.00	IUUC-Mmu-063207
E3 activity/RING/RING	83.47	0.00e+00	691.00	IUUC-Rno-105641

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MVRSRQMCNT NMSVPTDGAV TTSQIPASEQ ETLVRPKPLL LKLLKSVGAQ KDTYTMKEVL 60
FYLGQYIMTK RLYDEKQQHI VYCSNDLLGD LFGVPSFSVK EHRKIYTMIY RNLVVVNQQE 120

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Nucleotide Sequence
(Fasta)

CTGTGCGGCC CTGTGTGTCG GGAAGATGGA GCAAGAAGCC GAGCCCGAGG GGTGGCCCCG 60
ACCCCTCTGA CCGAGATCCT GCTGCTTTCG CAGCCAGGAG CACCGTCCCT CCCCGGATTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome

Interpro

IPR028340--Mdm2
IPR015459--MDM2_E3_ligase
IPR016495--p53_neg-reg_MDM_2/4
IPR003121--SWIB_MDM2_domain
IPR001876--Znf_RanBP2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
PS50089--ZF_RING_2

Pfam

PF02201--SWIB
PF00641--zf-RanBP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016604--C:nuclear body
GO:0005730--C:nucleolus
GO:0043234--C:protein complex
GO:0016874--F:ligase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0071456--P:cellular response to hypoxia
GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0045184--P:establishment of protein localization
GO:0043066--P:negative regulation of apoptotic process
GO:0071157--P:negative regulation of cell cycle arrest
GO:0043518--P:negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0018205--P:peptidyl-lysine modification
GO:0045931--P:positive regulation of mitotic cell cycle
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0006461--P:protein complex assembly
GO:0031648--P:protein destabilization
GO:0034504--P:protein localization to nucleus
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0046677--P:response to antibiotic

KEGG

nle:100601465

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002039	Ailuropoda melanoleuca	94.52	0.00e+00	825.00
IUUC-Apl-003193	Anas platyrhynchos	65.19	7.00e-158	550.00
IUUC-Aca-004305	Anolis carolinensis	59.13	1.00e-117	417.00
IUUC-Ame-010675	Astyanax mexicanus	45.33	1.00e-84	306.00
IUUC-Bta-013270	Bos taurus	93.90	0.00e+00	791.00
IUUC-Cja-019744	Callithrix jacchus	96.35	0.00e+00	822.00
IUUC-Cfa-020807	Canis familiaris	92.23	0.00e+00	754.00
IUUC-Cpo-022182	Cavia porcellus	89.63	0.00e+00	751.00
IUUC-Csa-023541	Chlorocebus sabaeus	99.19	0.00e+00	856.00
IUUC-Cho-024831	Choloepus hoffmanni	74.64	2.00e-90	325.00
IUUC-Cin-025448	Ciona intestinalis	28.77	5.00e-21	94.40
IUUC-Csv-026151	Ciona savignyi	31.17	3.00e-11	61.60
IUUC-Dre-028419	Danio rerio	43.54	1.00e-50	194.00
IUUC-Dno-028950	Dasypus novemcinctus	92.89	0.00e+00	817.00
IUUC-Dor-031048	Dipodomys ordii	72.38	7.00e-173	600.00
IUUC-Ete-032264	Echinops telfairi	69.17	3.00e-173	601.00
IUUC-Eca-033301	Equus caballus	83.57	0.00e+00	730.00
IUUC-Eeu-035005	Erinaceus europaeus	81.06	0.00e+00	645.00
IUUC-Fca-035454	Felis catus	94.30	0.00e+00	812.00
IUUC-Fal-036720	Ficedula albicollis	61.79	2.00e-74	272.00
IUUC-Gmo-039296	Gadus morhua	41.42	1.00e-44	173.00
IUUC-Gga-040251	Gallus gallus	66.73	1.00e-152	532.00
IUUC-Ggo-044948	Gorilla gorilla	90.43	0.00e+00	772.00
IUUC-Hsa-046376	Homo sapiens	99.20	0.00e+00	871.00
IUUC-Itr-048328	Ictidomys tridecemlineatus	92.91	0.00e+00	766.00
IUUC-Lch-050037	Latimeria chalumnae	57.64	6.00e-116	410.00
IUUC-Loc-051837	Lepisosteus oculatus	50.91	2.00e-112	399.00
IUUC-Laf-053483	Loxodonta africana	85.57	0.00e+00	736.00
IUUC-Mcc-055294	Macaca mulatta	99.40	0.00e+00	872.00
IUUC-Mga-060007	Meleagris gallopavo	65.56	6.00e-145	507.00
IUUC-Mmr-060673	Microcebus murinus	94.91	0.00e+00	826.00
IUUC-Mdo-063057	Monodelphis domestica	74.39	0.00e+00	664.00
IUUC-Mmu-063207	Mus musculus	80.24	0.00e+00	639.00
IUUC-Mpu-065836	Mustela putorius furo	92.87	0.00e+00	816.00
IUUC-Mlu-068193	Myotis lucifugus	88.69	0.00e+00	780.00
IUUC-Opr-070590	Ochotona princeps	85.66	0.00e+00	710.00
IUUC-Ont-071984	Oreochromis niloticus	40.24	7.00e-73	267.00
IUUC-Oan-072744	Ornithorhynchus anatinus	72.62	3.00e-162	564.00
IUUC-Ocu-074071	Oryctolagus cuniculus	93.54	0.00e+00	790.00
IUUC-Ola-087329	Oryzias latipes	41.70	9.00e-72	264.00
IUUC-Oga-088135	Otolemur garnettii	85.05	0.00e+00	743.00
IUUC-Oar-089726	Ovis aries	93.33	0.00e+00	825.00
IUUC-Ptr-091399	Pan troglodytes	99.60	0.00e+00	875.00
IUUC-Pan-092720	Papio anubis	99.40	0.00e+00	872.00
IUUC-Psi-093591	Pelodiscus sinensis	66.96	2.00e-131	461.00
IUUC-Pma-094500	Petromyzon marinus	62.50	7.00e-19	86.70
IUUC-Pfo-096316	Poecilia formosa	41.41	5.00e-72	265.00
IUUC-Pab-097696	Pongo abelii	99.20	0.00e+00	865.00
IUUC-Pca-100974	Procavia capensis	83.33	0.00e+00	767.00
IUUC-Pva-102488	Pteropus vampyrus	87.12	0.00e+00	720.00
IUUC-Rno-105641	Rattus norvegicus	83.47	0.00e+00	672.00
IUUC-Sha-107314	Sarcophilus harrisii	73.94	0.00e+00	684.00
IUUC-Sar-112938	Sorex araneus	86.12	0.00e+00	749.00
IUUC-Ssc-115495	Sus scrofa	93.28	0.00e+00	778.00
IUUC-Tgu-116623	Taeniopygia guttata	64.89	6.00e-151	526.00
IUUC-Tru-117820	Takifugu rubripes	39.65	1.00e-71	263.00
IUUC-Tsy-119162	Tarsius syrichta	68.21	7.00e-91	327.00
IUUC-Tbe-127816	Tupaia belangeri	92.07	5.00e-119	421.00
IUUC-Ttr-129194	Tursiops truncatus	83.19	0.00e+00	672.00
IUUC-Vpa-130326	Vicugna pacos	87.50	0.00e+00	731.00
IUUC-Xtr-132216	Xenopus tropicalis	56.63	4.00e-120	424.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence