iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-091836

Ensembl Protein ID

ENSPANP00000013900.1

UniProt Accession

A0A096NLP2; A0A096NLP2_PAPAN

Genbank Protein ID

ENSPANP00000013900

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHZZ01051067

Gene Name

SOCS1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000000526.1	ENSPANT00000012316.1	ENSPANP00000013900.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.80e-13	50.2	145	192

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
            ++l+++++r+Lq+LCR +I+ ++g+++l    ++PL+++L+dYL+++++q
   Q: 145  GTPLRQRRVRPLQELCRQRIVATVGRENL---ARIPLNPVLRDYLSSFPFQ 192
           57899************************...***************9986 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

MVAHNQVAAD NAVSTAAEPR RRPEPSSSSS SSPDTHFRTF RSHADYRRIT RASALLDACG 60
FYWGPLSVHG AHERLRAEPV GTFLVRDSRQ RNCFFALSVK MASGPTSIRV HFQAGRFHLD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTAGCAC ACAACCAGGT GGCAGCCGAC AATGCAGTCT CCACAGCAGC AGAGCCCCGA 60
CGGCGGCCAG AGCCTTCCTC CTCTTCCTCC TCCTCGCCCG CGGCCCCCGC GCGCCCGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028411--SOCS1
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0000932--C:P-body
GO:0019210--F:kinase inhibitor activity
GO:0071230--P:cellular response to amino acid stimulus
GO:0019221--P:cytokine-mediated signaling pathway
GO:0045444--P:fat cell differentiation
GO:0007259--P:JAK-STAT cascade
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0042512--P:negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518--P:negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0016567--P:protein ubiquitination
GO:0010534--P:regulation of activation of JAK2 kinase activity
GO:0050707--P:regulation of cytokine secretion
GO:0060334--P:regulation of interferon-gamma-mediated signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001204	Ailuropoda melanoleuca	91.25	2.00e-79	288.00
IUUC-Apl-003313	Anas platyrhynchos	62.32	1.00e-74	272.00
IUUC-Aca-005109	Anolis carolinensis	59.28	1.00e-63	235.00
IUUC-Ame-011550	Astyanax mexicanus	45.88	4.00e-49	187.00
IUUC-Bta-013411	Bos taurus	84.30	6.00e-93	333.00
IUUC-Cja-019595	Callithrix jacchus	90.52	6.00e-95	339.00
IUUC-Cfa-020563	Canis familiaris	96.88	2.00e-89	320.00
IUUC-Cpo-021374	Cavia porcellus	87.10	3.00e-94	337.00
IUUC-Csa-023333	Chlorocebus sabaeus	90.61	3.00e-95	340.00
IUUC-Dre-028507	Danio rerio	43.43	3.00e-45	174.00
IUUC-Dno-029406	Dasypus novemcinctus	90.38	2.00e-94	337.00
IUUC-Ete-032399	Echinops telfairi	89.95	2.00e-92	331.00
IUUC-Eca-033519	Equus caballus	80.57	9.00e-90	322.00
IUUC-Fal-036726	Ficedula albicollis	61.84	7.00e-75	272.00
IUUC-Gmo-039667	Gadus morhua	49.56	2.00e-26	112.00
IUUC-Gga-040970	Gallus gallus	62.32	1.00e-74	272.00
IUUC-Gac-041838	Gasterosteus aculeatus	45.00	1.00e-35	142.00
IUUC-Ggo-045569	Gorilla gorilla	98.45	2.00e-98	350.00
IUUC-Hsa-046010	Homo sapiens	91.00	1.00e-93	335.00
IUUC-Itr-047995	Ictidomys tridecemlineatus	99.38	1.00e-91	328.00
IUUC-Lch-050219	Latimeria chalumnae	62.66	2.00e-62	231.00
IUUC-Loc-052494	Lepisosteus oculatus	57.86	1.00e-54	205.00
IUUC-Laf-054219	Loxodonta africana	95.59	5.00e-72	262.00
IUUC-Mcc-054830	Macaca mulatta	89.77	5.00e-95	340.00
IUUC-Meu-056565	Macropus eugenii	67.77	3.00e-80	290.00
IUUC-Mga-060153	Meleagris gallopavo	61.84	1.00e-73	269.00
IUUC-Mmr-061365	Microcebus murinus	85.39	3.00e-92	330.00
IUUC-Mdo-062824	Monodelphis domestica	67.29	4.00e-79	286.00
IUUC-Mmu-064120	Mus musculus	86.32	6.00e-91	326.00
IUUC-Mpu-066839	Mustela putorius furo	87.50	3.00e-94	337.00
IUUC-Mlu-067829	Myotis lucifugus	87.14	9.00e-91	325.00
IUUC-Nle-069592	Nomascus leucogenys	87.98	4.00e-90	323.00
IUUC-Ont-072173	Oreochromis niloticus	45.00	8.00e-38	149.00
IUUC-Oan-073586	Ornithorhynchus anatinus	54.21	3.00e-26	110.00
IUUC-Ocu-073996	Oryctolagus cuniculus	98.12	8.00e-91	325.00
IUUC-Oba-075150	Oryza barthii	30.59	3.70e-02	31.20
IUUC-Ola-087158	Oryzias latipes	46.25	2.00e-39	155.00
IUUC-Oga-088076	Otolemur garnettii	87.74	4.00e-93	333.00
IUUC-Ptr-091241	Pan troglodytes	90.52	6.00e-95	339.00
IUUC-Psi-093628	Pelodiscus sinensis	65.22	5.00e-76	276.00
IUUC-Pfo-097501	Poecilia formosa	45.28	7.00e-37	146.00
IUUC-Pab-098170	Pongo abelii	90.14	2.00e-93	334.00
IUUC-Pop-100072	Populus trichocarpa	32.69	9.00e-03	34.30
IUUC-Pva-102796	Pteropus vampyrus	89.20	7.00e-93	332.00
IUUC-Rno-105319	Rattus norvegicus	86.32	6.00e-91	326.00
IUUC-Sha-107201	Sarcophilus harrisii	81.82	7.00e-75	272.00
IUUC-Ssc-116004	Sus scrofa	81.82	1.00e-94	338.00
IUUC-Tgu-116836	Taeniopygia guttata	61.35	2.00e-73	267.00
IUUC-Tru-118090	Takifugu rubripes	43.12	4.00e-36	144.00
IUUC-Tni-120719	Tetraodon nigroviridis	43.12	1.00e-31	129.00
IUUC-Vpa-130235	Vicugna pacos	87.91	4.00e-93	333.00
IUUC-Xtr-132610	Xenopus tropicalis	54.98	2.00e-66	244.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence