iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-071628

Ensembl Protein ID

ENSONIP00000023110.1

UniProt Accession

I3KPR5; I3KPR5_ORENI

Genbank Protein ID

ENSONIP00000023110

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AERX01019660

Gene Name

hectd3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000018354.1	ENSONIT00000023130.1	ENSONIP00000023110.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.20e-73	248.8	523	847

Active Site

Position(s)	Description	Evidence
817	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 8    rlevefvgEegldlgGvtreflallskelqnpd......lglflysendketlqpnpdsglknp..ehlklFeflGrllgkalqdgrll 88
            +e++f  E  +d+gG +r+ la +s+el+ ++      l++f +++n+      ++d ++ +p  +++  +e++G+l+g al+ + +l
   Q: 523  WWECKFIAEGIIDQGGGFRDSLADMSEELCPSSsecpmpLPFFSRTSNQGDF--EARDYYVPTPscKEFHKYEWIGQLMGAALRGKDFL 609
           356****************************999999888888777764443..455555555555999******************** PP
   S: 89   dlplsksfyklllgkklsl.edleevdpelykslkeikenaesdieelgldltfs...vseeilgetkeeeLkpgGenipVtneNkeeY 173
            l l+  ++k+l+g+++s+ +d+++vd+ l++ l+ ++++     ++++++++f    v +++l + + +eL+pgG+n++V +e+++e+
   Q: 610  VLALPGLVWKQLIGESVSWsKDFAAVDSVLVNLLEAMENM-----DQETFEFRFGeelVYTTLLTDGSMVELIPGGSNVSVHYEDRSEF 693
           **************************************55.....66667788775566777799************************ PP
   S: 174  vklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           ++lv ++r++e  k+q++a++ G+ +v+p+ +l+l+t++e+e  icG++ei+ve+lk+ t+y++ +++++  +q++we+l +f++e+r+
   Q: 694  IRLVQKARMEE-SKQQIAAIQTGLLKVVPQAVLDLLTWQEVEKKICGDPEITVEALKRLTRYED-LEQSDVRVQYLWEALTNFTNEDRS 780
           **********9.9*************************************************76.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirk..dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +fL+FvTg+srlP+       p  +   k  ++++d lP+s+TC ++L LP+Y+s ++++ekL+yA  ++ +++
   Q: 781  RFLRFVTGRSRLPA-------PIYVFPDKqgSETTDALPQSSTCSSTLYLPNYPSAKVCEEKLRYAAYNCVAID 847
           *************5.......44355556788888*********************************998776 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MGDNPHLLLG RIRFLNRCIE TFRRSEPVPE CLCYVPKEVC YKICKDSSSS SSASSSGASV 60
GGSTVGKTIV SVFESPHQTA HSKKACKYNI EPKKGTCIRT TGEEYCNSQG LWVKINKEQL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGCGACGGA AGGCCGGAAG GATCAGAAGA GTCTCTGCTC TTCCGTGTTG TCAGAAAACC 60
ATAGAATCTG TAACAGGGTG CGGGACACTA GTCAGCAGGT ACGTTGGTAT CTACTGTTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR004939--APC_su10/DOC_dom
IPR008979--Galactose-bd-like
IPR000569--HECT_dom

PROSITE

PS51284--DOC
PS50237--HECT

Pfam

PF03256--ANAPC10
PF00632--HECT

SMART

SM01337--APC10
SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001229	Ailuropoda melanoleuca	69.01	0.00e+00	1217.00
IUUC-Apl-003715	Anas platyrhynchos	79.08	0.00e+00	1211.00
IUUC-Aca-004377	Anolis carolinensis	72.85	0.00e+00	1285.00
IUUC-Ame-011918	Astyanax mexicanus	78.57	0.00e+00	1360.00
IUUC-Bta-012736	Bos taurus	69.59	0.00e+00	1231.00
IUUC-Cja-019926	Callithrix jacchus	69.82	0.00e+00	1229.00
IUUC-Cfa-020753	Canis familiaris	77.99	0.00e+00	964.00
IUUC-Cpo-021415	Cavia porcellus	69.59	0.00e+00	1226.00
IUUC-Csa-023096	Chlorocebus sabaeus	69.36	0.00e+00	1225.00
IUUC-Dre-028746	Danio rerio	86.64	0.00e+00	1459.00
IUUC-Dno-029293	Dasypus novemcinctus	78.34	0.00e+00	887.00
IUUC-Dor-031113	Dipodomys ordii	78.31	0.00e+00	1012.00
IUUC-Ete-032601	Echinops telfairi	68.09	0.00e+00	1073.00
IUUC-Eca-034198	Equus caballus	68.77	0.00e+00	1217.00
IUUC-Eeu-034708	Erinaceus europaeus	78.57	0.00e+00	747.00
IUUC-Fca-035478	Felis catus	70.16	0.00e+00	1220.00
IUUC-Fal-037366	Ficedula albicollis	71.99	0.00e+00	1253.00
IUUC-Gmo-039020	Gadus morhua	88.99	0.00e+00	1216.00
IUUC-Gga-040332	Gallus gallus	75.12	0.00e+00	1318.00
IUUC-Gac-042336	Gasterosteus aculeatus	89.85	0.00e+00	1592.00
IUUC-Ggo-045382	Gorilla gorilla	69.36	0.00e+00	1225.00
IUUC-Hsa-046562	Homo sapiens	69.36	0.00e+00	1225.00
IUUC-Itr-048208	Ictidomys tridecemlineatus	69.36	0.00e+00	1225.00
IUUC-Lch-049606	Latimeria chalumnae	63.30	0.00e+00	794.00
IUUC-Loc-052448	Lepisosteus oculatus	73.22	0.00e+00	1248.00
IUUC-Laf-054507	Loxodonta africana	69.16	0.00e+00	1238.00
IUUC-Mcc-055690	Macaca mulatta	69.36	0.00e+00	1224.00
IUUC-Meu-055970	Macropus eugenii	68.56	0.00e+00	1197.00
IUUC-Mga-059654	Meleagris gallopavo	79.45	0.00e+00	1202.00
IUUC-Mmr-061069	Microcebus murinus	69.36	0.00e+00	1225.00
IUUC-Mdo-062547	Monodelphis domestica	79.67	0.00e+00	697.00
IUUC-Mmu-063096	Mus musculus	69.24	0.00e+00	1225.00
IUUC-Mpu-065846	Mustela putorius furo	69.59	0.00e+00	1229.00
IUUC-Mlu-067992	Myotis lucifugus	73.73	0.00e+00	1199.00
IUUC-Nle-069565	Nomascus leucogenys	68.03	0.00e+00	1129.00
IUUC-Opr-070853	Ochotona princeps	65.22	0.00e+00	807.00
IUUC-Ocu-074094	Oryctolagus cuniculus	69.24	0.00e+00	1226.00
IUUC-Ola-087384	Oryzias latipes	89.51	0.00e+00	1587.00
IUUC-Oga-088224	Otolemur garnettii	69.01	0.00e+00	1227.00
IUUC-Oar-090043	Ovis aries	67.49	0.00e+00	1166.00
IUUC-Ptr-090852	Pan troglodytes	69.12	0.00e+00	1216.00
IUUC-Pan-092787	Papio anubis	69.36	0.00e+00	1225.00
IUUC-Psi-092986	Pelodiscus sinensis	68.02	0.00e+00	914.00
IUUC-Pma-094416	Petromyzon marinus	39.37	9.00e-175	607.00
IUUC-Pfo-096720	Poecilia formosa	91.11	0.00e+00	1616.00
IUUC-Pab-098325	Pongo abelii	66.22	0.00e+00	910.00
IUUC-Pca-100885	Procavia capensis	63.59	0.00e+00	932.00
IUUC-Pva-102829	Pteropus vampyrus	57.44	0.00e+00	948.00
IUUC-Rno-104882	Rattus norvegicus	69.47	0.00e+00	1227.00
IUUC-Sha-106811	Sarcophilus harrisii	77.83	1.00e-100	360.00
IUUC-Sar-113020	Sorex araneus	68.81	3.00e-170	592.00
IUUC-Ssc-115436	Sus scrofa	69.85	1.00e-113	403.00
IUUC-Tgu-117042	Taeniopygia guttata	74.68	0.00e+00	1306.00
IUUC-Tru-118419	Takifugu rubripes	86.67	0.00e+00	1458.00
IUUC-Tsy-118829	Tarsius syrichta	70.43	0.00e+00	743.00
IUUC-Tni-120410	Tetraodon nigroviridis	75.35	0.00e+00	1206.00
IUUC-Tbe-128113	Tupaia belangeri	78.53	0.00e+00	639.00
IUUC-Ttr-128167	Tursiops truncatus	65.77	0.00e+00	1137.00
IUUC-Xtr-132910	Xenopus tropicalis	63.28	0.00e+00	1053.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence