iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18698375

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	8.20e-06	26.3	45	103

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiC...................ledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiC                   + + ++ ++ + C+H fh+ C   w       +++ rCPlC+
   Q: 45   CAICrvqvmdsclrcqadnkrdvMGRQDCVVVWGECNHSFHHCCMSLW------VKQNNRCPLCQ 103
           99995555444444444444333333355577799*************......**********7 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MADDPENSVD RPTDDGDAGK PEKMFTLKKW NAVAMWSWDV ECDICAICRV QVMDSCLRCQ 60
ADNKRDVMGR QDCVVVWGEC NHSFHHCCMS LWVKQNNRCP LCQQEWSIQR MGK 113

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATAGTTTTCC CTTGTTTTGG TGTGGCCACA CTGACTTTTG GCTTGCTATT GTTTACATTC 60
AATTATTTCG ACTTCTTATT TGTTGGTAAG TCAAACCGGC GGTTCCTTAT CATTTGCCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR024766--Znf_RING_H2

PROSITE

PS50089--ZF_RING_2

Pfam

PF12678--zf-rbx1

Gene Ontology

GO:0031466--C:Cul5-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0097602--F:cullin family protein binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0016567--P:protein ubiquitination

KEGG

dme:Dmel_CG8998

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001959	Ailuropoda melanoleuca	81.52	1.00e-40	156.00
IUUC-Apl-003554	Anas platyrhynchos	74.19	1.00e-23	99.80
IUUC-Aca-004651	Anolis carolinensis	81.52	9.00e-41	157.00
IUUC-Ame-010935	Astyanax mexicanus	81.52	1.00e-40	156.00
IUUC-Bta-013315	Bos taurus	81.52	1.00e-40	157.00
IUUC-Cel-018286	Caenorhabditis elegans	52.68	9.00e-33	130.00
IUUC-Cja-019230	Callithrix jacchus	81.52	1.00e-40	156.00
IUUC-Cfa-020188	Canis familiaris	81.52	1.00e-40	156.00
IUUC-Cpo-021681	Cavia porcellus	81.52	1.00e-40	157.00
IUUC-Csa-023305	Chlorocebus sabaeus	81.52	7.00e-41	157.00
IUUC-Cho-024539	Choloepus hoffmanni	81.52	1.00e-40	157.00
IUUC-Cin-025216	Ciona intestinalis	68.14	1.00e-39	153.00
IUUC-Csv-026356	Ciona savignyi	73.33	3.00e-36	141.00
IUUC-Dre-027952	Danio rerio	69.64	1.00e-40	157.00
IUUC-Dno-029920	Dasypus novemcinctus	81.52	1.00e-40	157.00
IUUC-Ete-033111	Echinops telfairi	65.22	1.00e-29	120.00
IUUC-Eca-034329	Equus caballus	79.12	8.00e-39	150.00
IUUC-Fal-037052	Ficedula albicollis	81.25	1.00e-42	163.00
IUUC-Gmo-038573	Gadus morhua	81.52	9.00e-41	157.00
IUUC-Gga-040409	Gallus gallus	71.68	2.00e-43	166.00
IUUC-Gac-041808	Gasterosteus aculeatus	69.64	8.00e-41	157.00
IUUC-Ggo-045314	Gorilla gorilla	81.52	7.00e-41	157.00
IUUC-Hsa-045901	Homo sapiens	81.52	7.00e-41	157.00
IUUC-Itr-048540	Ictidomys tridecemlineatus	81.52	1.00e-40	157.00
IUUC-Lch-049958	Latimeria chalumnae	81.52	8.00e-41	157.00
IUUC-Loc-052481	Lepisosteus oculatus	81.52	1.00e-40	156.00
IUUC-Laf-054260	Loxodonta africana	81.52	1.00e-40	157.00
IUUC-Mcc-055092	Macaca mulatta	68.48	2.00e-31	125.00
IUUC-Meu-056081	Macropus eugenii	58.90	5.00e-20	87.80
IUUC-Mmr-061775	Microcebus murinus	68.48	4.00e-31	124.00
IUUC-Mdo-062083	Monodelphis domestica	81.52	1.00e-40	157.00
IUUC-Mmu-063421	Mus musculus	81.52	1.00e-40	156.00
IUUC-Mpu-066010	Mustela putorius furo	81.52	1.00e-40	157.00
IUUC-Nle-069723	Nomascus leucogenys	81.52	7.00e-41	157.00
IUUC-Opr-070339	Ochotona princeps	69.57	2.00e-42	162.00
IUUC-Ont-072072	Oreochromis niloticus	70.54	3.00e-43	165.00
IUUC-Oan-073574	Ornithorhynchus anatinus	80.43	5.00e-40	155.00
IUUC-Ola-087260	Oryzias latipes	71.82	2.00e-42	162.00
IUUC-Oga-089038	Otolemur garnettii	81.52	1.00e-40	156.00
IUUC-Oar-089945	Ovis aries	81.52	1.00e-40	157.00
IUUC-Ptr-091040	Pan troglodytes	81.52	7.00e-41	157.00
IUUC-Pan-092693	Papio anubis	81.52	7.00e-41	157.00
IUUC-Psi-093633	Pelodiscus sinensis	81.52	2.00e-40	156.00
IUUC-Pfo-096440	Poecilia formosa	70.54	8.00e-41	157.00
IUUC-Pab-098277	Pongo abelii	81.52	7.00e-41	157.00
IUUC-Pva-102548	Pteropus vampyrus	81.52	1.00e-40	157.00
IUUC-Rno-105855	Rattus norvegicus	81.52	1.00e-40	156.00
IUUC-Sha-107430	Sarcophilus harrisii	81.52	1.00e-40	157.00
IUUC-Sar-112957	Sorex araneus	79.35	1.00e-39	153.00
IUUC-Ssc-115606	Sus scrofa	59.65	2.00e-12	62.80
IUUC-Tgu-116519	Taeniopygia guttata	70.15	3.00e-24	101.00
IUUC-Tru-117658	Takifugu rubripes	70.09	8.00e-42	160.00
IUUC-Tsy-119251	Tarsius syrichta	81.52	1.00e-40	156.00
IUUC-Tni-120364	Tetraodon nigroviridis	70.69	8.00e-42	160.00
IUUC-Tbe-127256	Tupaia belangeri	66.30	9.00e-28	114.00
IUUC-Ttr-129140	Tursiops truncatus	81.52	1.00e-40	157.00
IUUC-Vpa-130670	Vicugna pacos	79.35	4.00e-38	147.00
IUUC-Xtr-132382	Xenopus tropicalis	82.22	4.00e-40	154.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence