iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053705

UUCD1 version

UUC-LoA-01047

Ensembl Protein ID

ENSLAFP00000016578.2

UniProt Accession

G3TN23; G3TN23_LOXAF

Protein Name

Ubiquitin thioesterase

Gene Name

OTUB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000021422.2	ENSLAFT00000022412.2	ENSLAFP00000016578.2
ENSLAFG00000021422.2	ENSLAFT00000027123.1	ENSLAFP00000018730.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	3.00e-51	173.8	81	271

Active Site

Position(s)	Description	Evidence
88	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
91	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
265		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs..........................................................llgvfdddslsd 32
           +i+kt++DGnC++rA+++s                                                          ll++f+d+s+sd
   Q: 81   YIRKTRPDGNCFYRAFGFShleallddskelqrfkavsakskedlvsqgfteftiedfhntfmdlieqvekqtsvadLLASFNDQSTSD 169
           89*************************************************************************************** PP
   S: 33   alveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklk 120
           +lv++Lr+lts ylq+es+ff++fie+++++kefcq++vep++k +++ihi+aLaq+Ls++i+v+++d++e   gg+++p++fpe + +
   Q: 170  YLVVYLRLLTSGYLQRESKFFEHFIEGGRTVKEFCQQEVEPMCKeSDHIHIIALAQALSVSIQVEYMDRGE---GGTTNPHVFPEGS-E 254
           **********************************************************************9...9************.* PP
   S: 121  kpivLlYrsgHYdaLva 137
           ++++LlYr+gHYd+L++
   Q: 255  PKVYLLYRPGHYDILYK 271
           ***************96 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MAAEEPQQQK QEPLGSDSEG VNCLAYDEAI MAQQDRIQQE IAVQNPLVSE RLELSVLYKE 60
YAEDDNIYQQ KIKDLHKKYS YIRKTRPDGN CFYRAFGFSH LEALLDDSKE LQRFKAVSAK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACAGGCCTC TTCTCGGTCC TCCTCTGGAC AGGCTTTTTC TCGGCCTCCT CAGGACAAGC 60
CTCTTCTCGG CCTTAGAGTT ACTGCCTCAG CACAGCTGGG GCATCTTCTG TTGCCAAAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003323--OTU_dom
IPR030298--OTUB1
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0071108--P:protein K48-linked deubiquitination

KEGG

lav:100670750

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001871	Ailuropoda melanoleuca	97.80	8.00e-156	542.00
IUUC-Apl-003233	Anas platyrhynchos	58.46	5.00e-19	85.10
IUUC-Aca-004648	Anolis carolinensis	85.77	1.00e-137	481.00
IUUC-Aly-005710	Arabidopsis lyrata	42.12	5.00e-52	197.00
IUUC-Ath-007112	Arabidopsis thaliana	41.97	5.00e-51	194.00
IUUC-Afl-008439	Aspergillus flavus	34.18	2.00e-08	52.40
IUUC-Ame-010662	Astyanax mexicanus	83.27	2.00e-130	457.00
IUUC-Bta-013533	Bos taurus	99.26	5.00e-153	533.00
IUUC-Bol-016100	Brassica oleracea	42.05	2.00e-50	192.00
IUUC-Bra-017705	Brassica rapa	39.15	3.00e-45	175.00
IUUC-Cel-018295	Caenorhabditis elegans	34.42	6.00e-42	164.00
IUUC-Cja-019190	Callithrix jacchus	99.63	4.00e-154	536.00
IUUC-Cfa-020430	Canis familiaris	99.60	1.00e-149	521.00
IUUC-Cpo-022355	Cavia porcellus	100.00	3.00e-154	537.00
IUUC-Cre-022997	Chlamydomonas reinhardtii	38.80	7.00e-47	180.00
IUUC-Csa-023286	Chlorocebus sabaeus	96.43	1.00e-151	528.00
IUUC-Cin-025507	Ciona intestinalis	43.33	1.00e-44	172.00
IUUC-Csv-026273	Ciona savignyi	49.80	4.00e-69	254.00
IUUC-Dre-027843	Danio rerio	78.95	1.00e-126	445.00
IUUC-Dno-029165	Dasypus novemcinctus	98.50	1.00e-117	415.00
IUUC-Dor-030943	Dipodomys ordii	100.00	3.00e-154	537.00
IUUC-Dme-031922	Drosophila melanogaster	56.40	2.00e-78	285.00
IUUC-Ete-032296	Echinops telfairi	96.86	8.00e-90	323.00
IUUC-Eca-033695	Equus caballus	98.41	4.00e-148	516.00
IUUC-Fca-036441	Felis catus	99.60	1.00e-149	521.00
IUUC-Gmo-038908	Gadus morhua	80.68	8.00e-127	446.00
IUUC-Ggr-040020	Gaeumannomyces graminis	31.41	9.00e-33	135.00
IUUC-Gga-040460	Gallus gallus	81.92	4.00e-134	470.00
IUUC-Gac-042417	Gasterosteus aculeatus	81.60	8.00e-123	432.00
IUUC-Gma-043712	Glycine max	41.13	1.00e-51	196.00
IUUC-Ggo-044552	Gorilla gorilla	99.37	1.00e-92	332.00
IUUC-Hsa-046766	Homo sapiens	99.63	4.00e-154	536.00
IUUC-Itr-048312	Ictidomys tridecemlineatus	100.00	3.00e-154	537.00
IUUC-Lch-050602	Latimeria chalumnae	80.95	4.00e-119	420.00
IUUC-Mcc-055745	Macaca mulatta	93.43	1.00e-150	525.00
IUUC-Meu-056569	Macropus eugenii	85.98	1.00e-135	474.00
IUUC-Mtr-057712	Medicago truncatula	43.49	9.00e-47	180.00
IUUC-Mvi-060358	Microbotryum violaceum	33.94	2.00e-15	75.90
IUUC-Mmr-061123	Microcebus murinus	99.57	6.00e-128	449.00
IUUC-Mdo-062613	Monodelphis domestica	87.45	8.00e-124	436.00
IUUC-Mmu-063658	Mus musculus	100.00	3.00e-154	537.00
IUUC-Mac-065274	Musa acuminata	38.00	1.00e-39	156.00
IUUC-Mpu-066172	Mustela putorius furo	99.63	4.00e-154	536.00
IUUC-Mlu-066966	Myotis lucifugus	98.89	3.00e-153	533.00
IUUC-Nle-069519	Nomascus leucogenys	87.63	2.00e-93	335.00
IUUC-Ont-071901	Oreochromis niloticus	82.87	2.00e-125	441.00
IUUC-Ola-087331	Oryzias latipes	81.46	3.00e-86	310.00
IUUC-Oga-088064	Otolemur garnettii	99.63	4.00e-154	536.00
IUUC-Oar-089251	Ovis aries	98.43	6.00e-148	516.00
IUUC-Ptr-091430	Pan troglodytes	99.63	5.00e-154	536.00
IUUC-Psi-093823	Pelodiscus sinensis	88.12	2.00e-134	470.00
IUUC-Pma-094366	Petromyzon marinus	72.01	3.00e-103	367.00
IUUC-Pfo-096734	Poecilia formosa	80.48	5.00e-114	403.00
IUUC-Pab-097919	Pongo abelii	100.00	3.00e-127	447.00
IUUC-Pop-099401	Populus trichocarpa	41.24	1.00e-48	186.00
IUUC-Ppe-101977	Prunus persica	42.38	1.00e-51	196.00
IUUC-Pva-102499	Pteropus vampyrus	99.60	4.00e-149	520.00
IUUC-Rno-105233	Rattus norvegicus	100.00	3.00e-154	537.00
IUUC-Sha-107081	Sarcophilus harrisii	96.90	9.00e-149	519.00
IUUC-Sly-111640	Solanum lycopersicum	42.01	3.00e-49	188.00
IUUC-Ssc-116202	Sus scrofa	99.63	4.00e-154	536.00
IUUC-Tru-117664	Takifugu rubripes	77.70	5.00e-123	433.00
IUUC-Tca-121467	Theobroma cacao	41.54	2.00e-50	192.00
IUUC-Tbe-128116	Tupaia belangeri	98.14	2.00e-93	335.00
IUUC-Ttr-128622	Tursiops truncatus	98.89	1.00e-151	528.00
IUUC-Vvi-131389	Vitis vinifera	43.75	4.00e-53	201.00
IUUC-Xma-134191	Xiphophorus maculatus	80.88	4.00e-115	407.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence