iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000067081.12	ENSMUST00000086882.7	ENSMUSP00000084095.1
ENSMUSG00000067081.12	ENSMUST00000154228.7	ENSMUSP00000117767.1
ENSMUSG00000067081.12	ENSMUST00000151330.1	ENSMUSP00000117836.1
ENSMUSG00000067081.12	ENSMUST00000097656.9	ENSMUSP00000095261.3

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	2.10e-14	54.2	416	462

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 5    wllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyed 51
           + l   pr LqhLCR++Ir+++g++ ++++++LPLP+ L++YLl e+
   Q: 416  FALAHTPRCLQHLCRCTIRKLFGKESVHLVPQLPLPETLQNYLLLEP 462
           566778**************************************986 PP

Organism

Mus musculus

Functional Description
(View)

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MSSWDSPPDY PLSSDIVRRL KSALATGDED TVQKLICTEV EPVDAVIELA NDDWMKEPSA 60
ELPTGVLLGD LDHIRLLMDQ CFWDANAVFE ISNGEMEWQV TSLATFGLSG LWTLEYQREL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CATCTGTCCT GCTCTGGGGA CAGGGCTAAC TTTGGGCATG CATTAGAGGA AGAGAAGAAG 60
GCTGGCCCTG CACAGGGAGA GATACCACAA TGTCCAGCTG GGACTCGCCC CCAGATTACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001496--SOCS_box

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50225--SOCS

Pfam

PF00023--Ank
PF12796--Ank_2
PF07525--SOCS_box

SMART

SM00248--ANK
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0035556--P:intracellular signal transduction

KEGG

mmu:208372

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002328	Ailuropoda melanoleuca	62.69	4.00e-152	531.00
IUUC-Apl-003595	Anas platyrhynchos	42.72	8.00e-79	287.00
IUUC-Aca-005091	Anolis carolinensis	42.36	7.00e-74	271.00
IUUC-Bta-013283	Bos taurus	78.54	0.00e+00	677.00
IUUC-Cfa-020851	Canis familiaris	79.18	8.00e-172	596.00
IUUC-Dre-027748	Danio rerio	40.58	2.00e-58	219.00
IUUC-Fca-035404	Felis catus	53.97	2.00e-117	416.00
IUUC-Gga-040184	Gallus gallus	54.80	6.00e-125	440.00
IUUC-Itr-049022	Ictidomys tridecemlineatus	65.19	4.00e-161	561.00
IUUC-Lch-050513	Latimeria chalumnae	51.94	6.00e-132	464.00
IUUC-Mga-059542	Meleagris gallopavo	56.47	2.00e-118	418.00
IUUC-Ont-072370	Oreochromis niloticus	42.78	1.00e-72	266.00
IUUC-Ocu-074668	Oryctolagus cuniculus	77.04	6.00e-168	583.00
IUUC-Oga-088246	Otolemur garnettii	71.46	9.00e-159	553.00
IUUC-Oar-090260	Ovis aries	77.68	0.00e+00	659.00
IUUC-Psi-093971	Pelodiscus sinensis	55.74	2.00e-144	505.00
IUUC-Rno-105235	Rattus norvegicus	92.27	0.00e+00	716.00
IUUC-Sha-106849	Sarcophilus harrisii	58.23	1.00e-145	509.00
IUUC-Ssc-115480	Sus scrofa	65.24	2.00e-149	522.00
IUUC-Tru-118046	Takifugu rubripes	42.26	7.00e-65	241.00
IUUC-Xtr-132422	Xenopus tropicalis	50.21	9.00e-117	413.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence