iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132814

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase MARCH2; Membrane-associated RING finger protein 2; Membrane-associated RING-CH protein II; RING-type E3 ubiquitin transferase MARCH2

Genbank Nucleotide ID

CR762288

Gene Name

march2; TGas088c08.1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000021892.3	ENSXETT00000047379.3	ENSXETP00000047379.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	78.46	1.00e-108	389.00	IUUC-Hsa-046263

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Xenopus tropicalis

Functional Description
(View)

E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MTTGDCCHLP GSLCDCTGSA TFLKSLEESD LGRPQYVTQV TAKDGQLLST VIKALGTQSD 60
GPICRICHEG GNGERLLSPC DCTGTLGTVH KTCLEKWLSS SNTSYCELCH TEFAVERRPR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCTCAGTGA GGCGACATCC TCTTTTACGC AGGCCGCTGC TCCGACATCG TAAAGTTACG 60
CTCTCTACAT AGTTACGCTT TAGGCACAGC TGACAGGAGA GGAGATGGTA GTCATGGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0254--Endocytosis
KW-0256--Endoplasmic reticulum
KW-0967--Endosome
KW-0458--Lysosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR033275--MARCH-like
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51292--ZF_RING_CH

Pfam

PF12906--RINGv

SMART

SM00744--RINGv

Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0010008--C:endosome membrane
GO:0016021--C:integral component of membrane
GO:0005765--C:lysosomal membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006897--P:endocytosis
GO:0030097--P:hemopoiesis
GO:0016567--P:protein ubiquitination

KEGG

xtr:549760

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002189	Ailuropoda melanoleuca	79.67	3.00e-111	394.00
IUUC-Apl-004200	Anas platyrhynchos	89.52	1.00e-122	432.00
IUUC-Ame-010786	Astyanax mexicanus	87.80	1.00e-120	425.00
IUUC-Bta-012678	Bos taurus	78.07	4.00e-105	373.00
IUUC-Cfa-020820	Canis familiaris	78.63	1.00e-110	392.00
IUUC-Cpo-021511	Cavia porcellus	78.46	4.00e-110	390.00
IUUC-Dre-028107	Danio rerio	85.54	6.00e-117	412.00
IUUC-Dno-029379	Dasypus novemcinctus	79.67	1.00e-103	369.00
IUUC-Dor-031059	Dipodomys ordii	78.46	6.00e-110	389.00
IUUC-Eca-034013	Equus caballus	81.36	4.00e-106	376.00
IUUC-Eeu-035139	Erinaceus europaeus	74.19	1.00e-51	194.00
IUUC-Fca-035894	Felis catus	79.67	5.00e-112	396.00
IUUC-Fal-037434	Ficedula albicollis	84.15	1.00e-113	402.00
IUUC-Gmo-039276	Gadus morhua	81.30	9.00e-110	389.00
IUUC-Gga-041224	Gallus gallus	87.40	6.00e-122	429.00
IUUC-Gac-042104	Gasterosteus aculeatus	76.21	7.00e-108	382.00
IUUC-Hsa-046263	Homo sapiens	78.46	6.00e-110	389.00
IUUC-Itr-048963	Ictidomys tridecemlineatus	78.86	7.00e-111	392.00
IUUC-Lch-050103	Latimeria chalumnae	87.80	1.00e-121	428.00
IUUC-Loc-052480	Lepisosteus oculatus	78.86	8.00e-111	392.00
IUUC-Laf-054410	Loxodonta africana	78.46	5.00e-111	393.00
IUUC-Mcc-054712	Macaca mulatta	78.46	3.00e-110	390.00
IUUC-Mtr-057809	Medicago truncatula	28.32	3.00e-10	58.50
IUUC-Mga-060053	Meleagris gallopavo	86.99	4.00e-124	436.00
IUUC-Mdo-062010	Monodelphis domestica	85.77	4.00e-122	430.00
IUUC-Mmu-064040	Mus musculus	80.35	2.00e-109	388.00
IUUC-Mpu-066205	Mustela putorius furo	80.08	1.00e-112	398.00
IUUC-Mlu-067013	Myotis lucifugus	75.50	5.00e-103	366.00
IUUC-Ont-071768	Oreochromis niloticus	79.03	9.00e-111	392.00
IUUC-Oan-073269	Ornithorhynchus anatinus	66.94	7.00e-91	326.00
IUUC-Ocu-074212	Oryctolagus cuniculus	78.05	1.00e-109	388.00
IUUC-Ola-087137	Oryzias latipes	73.59	1.00e-99	355.00
IUUC-Oga-088712	Otolemur garnettii	78.86	2.00e-110	390.00
IUUC-Oar-090175	Ovis aries	77.63	7.00e-103	365.00
IUUC-Pan-092276	Papio anubis	78.46	2.00e-110	391.00
IUUC-Psi-094007	Pelodiscus sinensis	88.62	4.00e-126	443.00
IUUC-Pfo-097509	Poecilia formosa	81.70	9.00e-107	379.00
IUUC-Pca-100424	Procavia capensis	78.46	4.00e-109	387.00
IUUC-Pva-102806	Pteropus vampyrus	78.46	6.00e-111	392.00
IUUC-Rno-105029	Rattus norvegicus	78.46	1.00e-109	388.00
IUUC-Sha-106628	Sarcophilus harrisii	85.77	2.00e-121	427.00
IUUC-Ssc-115689	Sus scrofa	79.27	1.00e-110	392.00
IUUC-Tgu-116681	Taeniopygia guttata	86.99	3.00e-124	437.00
IUUC-Tru-118517	Takifugu rubripes	79.46	2.00e-103	367.00
IUUC-Tni-120353	Tetraodon nigroviridis	71.89	2.00e-100	358.00
IUUC-Ttr-128265	Tursiops truncatus	78.86	3.00e-110	390.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence