iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aml-001380

Ensembl Protein ID

ENSAMEP00000016241.1

UniProt Accession

D2HNY3; FAN1_AILME

Genbank Protein ID

EFB17558.1

Protein Name

Fanconi-associated nuclease 1; FANCD2/FANCI-associated nuclease 1; Myotubularin-related protein 15

Genbank Nucleotide ID

GL193105

Gene Name

FAN1; MTMR15; PANDA_013441

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000015396.1	ENSAMET00000016915.1	ENSAMEP00000016241.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/ZnF/UBZ	1.40e-07	31.7	41	64

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/UBZ

   S: 1    llvCPvCqkmvdqtdfeeHlDe.C 23
           +l CP+C+kmv+++d++ HlDe C
   Q: 41   KLACPICSKMVPRYDLNWHLDEkC 64
           689******************988 PP

Organism

Ailuropoda melanoleuca

Functional Description
(View)

Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL. Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap. Also has endonuclease activity toward 5'-flaps.

Protein Sequence
(Fasta)

IMSEGKSPAK KRARRSLSIS KTKKNECNSI ISFFNNVPPA KLACPICSKM VPRYDLNWHL 60
DEKCANNDNI TPVDLRHVGF TDSSGSTVNL TNTVLENVTP GKLSPSKASL TPDPSDSAKM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTATGTCAG AAGGGAAATC TCCTGCAAAA AAAAGAGCTC GTAGAAGTTT ATCAATCAGT 60
AAAACTAAAA AAAATGAGTG TAACTCTATT ATTTCATTTT TTAACAATGT ACCACCTGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0255--Endonuclease
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0460--Magnesium
KW-0464--Manganese
KW-0479--Metal-binding
KW-0540--Nuclease
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR033315--Fan1-like
IPR011990--TPR-like_helical_dom
IPR014883--VRR_NUC
IPR006642--Znf_Rad18_put

Pfam

PF08774--VRR_NUC

SMART

SM00990--VRR_NUC
SM00734--ZnF_Rad18

Gene Ontology

GO:0005634--C:nucleus
GO:0008409--F:5'-3' exonuclease activity
GO:0017108--F:5'-flap endonuclease activity
GO:0070336--F:flap-structured DNA binding
GO:0046872--F:metal ion binding
GO:0004528--F:phosphodiesterase I activity
GO:0043130--F:ubiquitin binding
GO:0006281--P:DNA repair
GO:0000724--P:double-strand break repair via homologous recombination
GO:0036297--P:interstrand cross-link repair
GO:0006289--P:nucleotide-excision repair
GO:0033683--P:nucleotide-excision repair, DNA incision

KEGG

aml:100481860

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000306	Aegilops tauschii	35.14	9.00e-58	217.00
IUUC-Atr-002873	Amborella trichopoda	29.70	1.00e-76	281.00
IUUC-Apl-003430	Anas platyrhynchos	53.89	0.00e+00	939.00
IUUC-Aca-005376	Anolis carolinensis	50.25	0.00e+00	849.00
IUUC-Aly-005463	Arabidopsis lyrata	28.57	2.00e-70	260.00
IUUC-Ath-007392	Arabidopsis thaliana	30.59	4.00e-70	259.00
IUUC-Acl-008285	Aspergillus clavatus	25.21	4.00e-57	216.00
IUUC-Afl-008680	Aspergillus flavus	28.01	6.00e-64	239.00
IUUC-Afu-008795	Aspergillus fumigatus	25.91	3.00e-56	213.00
IUUC-Ani-009329	Aspergillus nidulans	26.53	7.00e-52	198.00
IUUC-Ang-009526	Aspergillus niger	25.10	4.00e-46	179.00
IUUC-Aor-009880	Aspergillus oryzae	27.76	3.00e-63	236.00
IUUC-Ate-010269	Aspergillus terreus	27.45	2.00e-62	234.00
IUUC-Ame-011630	Astyanax mexicanus	60.99	5.00e-173	601.00
IUUC-Bgr-012168	Blumeria graminis	24.67	2.00e-36	147.00
IUUC-Bta-013504	Bos taurus	74.22	0.00e+00	1391.00
IUUC-Bci-013838	Botrytis cinerea	25.65	2.00e-53	204.00
IUUC-Bdi-014522	Brachypodium distachyon	30.40	1.00e-65	244.00
IUUC-Bol-016153	Brassica oleracea	30.70	8.00e-72	265.00
IUUC-Bra-017548	Brassica rapa	29.28	6.00e-61	229.00
IUUC-Cel-018711	Caenorhabditis elegans	31.34	5.00e-64	239.00
IUUC-Cja-018810	Callithrix jacchus	76.68	0.00e+00	1437.00
IUUC-Cfa-020147	Canis familiaris	89.70	0.00e+00	1826.00
IUUC-Cpo-021787	Cavia porcellus	72.51	0.00e+00	1399.00
IUUC-Cre-022863	Chlamydomonas reinhardtii	45.45	2.00e-03	33.90
IUUC-Csa-023730	Chlorocebus sabaeus	78.97	0.00e+00	1519.00
IUUC-Cho-024754	Choloepus hoffmanni	74.26	5.00e-131	461.00
IUUC-Cin-025459	Ciona intestinalis	49.70	7.00e-40	155.00
IUUC-Cgl-026724	Colletotrichum gloeosporioides	26.66	2.00e-44	174.00
IUUC-Cne-026815	Cryptococcus neoformans	36.00	6.00e-32	132.00
IUUC-Cme-027208	Cyanidioschyzon merolae	31.19	3.00e-23	103.00
IUUC-Dre-027725	Danio rerio	60.15	0.00e+00	747.00
IUUC-Dno-029713	Dasypus novemcinctus	74.83	0.00e+00	1506.00
IUUC-Dse-031534	Dothistroma septosporum	26.08	3.00e-41	163.00
IUUC-Ete-033004	Echinops telfairi	63.49	0.00e+00	928.00
IUUC-Eca-034119	Equus caballus	84.24	0.00e+00	1635.00
IUUC-Eeu-034618	Erinaceus europaeus	66.60	0.00e+00	1217.00
IUUC-Fca-035411	Felis catus	89.48	0.00e+00	1826.00
IUUC-Fal-037505	Ficedula albicollis	52.29	0.00e+00	877.00
IUUC-Fox-038070	Fusarium oxysporum	25.91	4.00e-53	202.00
IUUC-Fso-038376	Fusarium solani	26.93	5.00e-53	202.00
IUUC-Gmo-039093	Gadus morhua	61.12	0.00e+00	754.00
IUUC-Ggr-040081	Gaeumannomyces graminis	25.96	2.00e-49	191.00
IUUC-Gac-041973	Gasterosteus aculeatus	47.89	0.00e+00	832.00
IUUC-Gma-043421	Glycine max	30.42	5.00e-73	269.00
IUUC-Ggo-044431	Gorilla gorilla	78.79	0.00e+00	1516.00
IUUC-Hsa-046520	Homo sapiens	78.70	0.00e+00	1513.00
IUUC-Hvu-047632	Hordeum vulgare	31.65	5.00e-75	275.00
IUUC-Itr-048263	Ictidomys tridecemlineatus	77.14	0.00e+00	1509.00
IUUC-Lch-049799	Latimeria chalumnae	66.92	0.00e+00	917.00
IUUC-Lpe-051149	Leersia perrieri	32.57	6.00e-79	289.00
IUUC-Loc-051964	Lepisosteus oculatus	49.53	0.00e+00	852.00
IUUC-Lma-053161	Leptosphaeria maculans	27.13	2.00e-55	211.00
IUUC-Laf-054446	Loxodonta africana	75.65	0.00e+00	1468.00
IUUC-Mcc-055087	Macaca mulatta	78.29	0.00e+00	1501.00
IUUC-Meu-055930	Macropus eugenii	59.24	0.00e+00	744.00
IUUC-Mor-056966	Magnaporthe oryzae	29.43	4.00e-52	199.00
IUUC-Mpo-057393	Magnaporthe poae	28.27	1.00e-43	171.00
IUUC-Mtr-058315	Medicago truncatula	31.15	8.00e-75	275.00
IUUC-Mla-058859	Melampsora laricipopulina	25.55	2.00e-38	154.00
IUUC-Mga-059870	Meleagris gallopavo	68.87	0.00e+00	875.00
IUUC-Mvi-060226	Microbotryum violaceum	27.04	1.00e-48	187.00
IUUC-Mmr-060892	Microcebus murinus	80.82	0.00e+00	1551.00
IUUC-Mdo-062896	Monodelphis domestica	59.87	0.00e+00	1196.00
IUUC-Mmu-064276	Mus musculus	70.16	0.00e+00	1392.00
IUUC-Mac-064503	Musa acuminata	30.43	1.00e-67	251.00
IUUC-Mpu-066820	Mustela putorius furo	90.64	0.00e+00	1851.00
IUUC-Mlu-068131	Myotis lucifugus	70.34	0.00e+00	1303.00
IUUC-Nfi-068480	Neosartorya fischeri	25.87	3.00e-55	209.00
IUUC-Ncr-068646	Neurospora crassa	26.91	2.00e-58	221.00
IUUC-Nle-069545	Nomascus leucogenys	76.24	0.00e+00	1467.00
IUUC-Opr-070722	Ochotona princeps	84.25	0.00e+00	858.00
IUUC-Ont-072561	Oreochromis niloticus	49.04	0.00e+00	867.00
IUUC-Oan-072811	Ornithorhynchus anatinus	58.22	0.00e+00	1129.00
IUUC-Ocu-073884	Oryctolagus cuniculus	71.93	0.00e+00	1417.00
IUUC-Oba-075112	Oryza barthii	31.97	1.00e-60	228.00
IUUC-Obr-076057	Oryza brachyantha	32.01	3.00e-78	286.00
IUUC-Ogl-077002	Oryza glaberrima	31.96	1.00e-71	265.00
IUUC-Ogu-078683	Oryza glumaepatula	31.48	5.00e-58	219.00
IUUC-Oin-079952	Oryza indica	31.13	5.00e-59	223.00
IUUC-Olo-080278	Oryza longistaminata	31.76	6.00e-59	222.00
IUUC-Ome-081094	Oryza meridionalis	32.03	4.00e-59	223.00
IUUC-Oni-083059	Oryza nivara	32.51	5.00e-60	226.00
IUUC-Opu-084144	Oryza punctata	31.88	4.00e-74	273.00
IUUC-Oru-084897	Oryza rufipogon	32.08	2.00e-59	224.00
IUUC-Osa-085924	Oryza sativa	31.96	6.00e-72	265.00
IUUC-Oga-088979	Otolemur garnettii	77.82	0.00e+00	1509.00
IUUC-Oar-090362	Ovis aries	73.99	0.00e+00	1440.00
IUUC-Ptr-090823	Pan troglodytes	78.89	0.00e+00	1519.00
IUUC-Pan-092863	Papio anubis	78.50	0.00e+00	1516.00
IUUC-Psi-093006	Pelodiscus sinensis	55.83	0.00e+00	990.00
IUUC-Pma-094523	Petromyzon marinus	49.90	1.00e-130	459.00
IUUC-Pno-094770	Phaeosphaeria nodorum	27.89	2.00e-47	184.00
IUUC-Ppa-095372	Physcomitrella patens	31.85	2.00e-70	261.00
IUUC-Pfo-096875	Poecilia formosa	60.03	0.00e+00	780.00
IUUC-Pab-097665	Pongo abelii	78.55	0.00e+00	1486.00
IUUC-Pop-099082	Populus trichocarpa	31.26	1.00e-77	284.00
IUUC-Pca-100138	Procavia capensis	66.77	1.00e-122	434.00
IUUC-Ppe-101167	Prunus persica	27.79	5.00e-31	129.00
IUUC-Pva-103199	Pteropus vampyrus	64.71	4.00e-118	418.00
IUUC-Pgr-103480	Puccinia graminis	27.59	1.00e-44	175.00
IUUC-Ptt-103783	Puccinia triticina	29.52	1.00e-44	175.00
IUUC-Pte-104357	Pyrenophora teres	25.78	2.00e-46	181.00
IUUC-Pyt-104788	Pyrenophora triticirepentis	28.20	4.00e-50	193.00
IUUC-Rno-104958	Rattus norvegicus	70.62	0.00e+00	1369.00
IUUC-Sha-106828	Sarcophilus harrisii	59.85	0.00e+00	1213.00
IUUC-Sja-107731	Schizosaccharomyces japonicus	28.80	6.00e-53	202.00
IUUC-Spo-108086	Schizosaccharomyces pombe	24.58	5.00e-44	172.00
IUUC-Ssl-108610	Sclerotinia sclerotiorum	25.90	9.00e-49	188.00
IUUC-Smo-108690	Selaginella moellendorffii	33.70	8.00e-75	275.00
IUUC-Sit-110385	Setaria italica	36.47	5.00e-48	186.00
IUUC-Sly-111187	Solanum lycopersicum	31.80	3.00e-75	276.00
IUUC-Stu-112673	Solanum tuberosum	43.29	2.00e-31	127.00
IUUC-Sar-113548	Sorex araneus	55.54	0.00e+00	663.00
IUUC-Sbi-114131	Sorghum bicolor	34.44	3.00e-57	216.00
IUUC-Sre-114921	Sporisorium reilianum	38.46	5.00e-35	143.00
IUUC-Ssc-115484	Sus scrofa	80.18	0.00e+00	1546.00
IUUC-Tgu-116749	Taeniopygia guttata	67.17	0.00e+00	842.00
IUUC-Tru-118772	Takifugu rubripes	60.68	0.00e+00	744.00
IUUC-Tsy-119359	Tarsius syrichta	78.30	0.00e+00	1232.00
IUUC-Tni-120878	Tetraodon nigroviridis	60.82	0.00e+00	746.00
IUUC-Tca-120912	Theobroma cacao	31.29	2.00e-78	287.00
IUUC-Tre-122171	Trichoderma reesei	26.39	3.00e-58	220.00
IUUC-Tvi-122483	Trichoderma virens	27.07	2.00e-57	217.00
IUUC-Tae-125125	Triticum aestivum	32.17	1.00e-73	271.00
IUUC-Tur-126497	Triticum urartu	32.16	5.00e-73	269.00
IUUC-Tbe-127473	Tupaia belangeri	61.13	3.00e-88	319.00
IUUC-Ttr-128458	Tursiops truncatus	75.50	0.00e+00	1427.00
IUUC-Uma-129558	Ustilago maydis	40.10	1.00e-34	142.00
IUUC-Vda-129683	Verticillium dahliae	25.06	8.00e-51	195.00
IUUC-Vpa-130201	Vicugna pacos	70.34	0.00e+00	636.00
IUUC-Vvi-131226	Vitis vinifera	34.64	8.00e-62	231.00
IUUC-Xtr-132517	Xenopus tropicalis	54.64	0.00e+00	709.00
IUUC-Xma-133763	Xiphophorus maculatus	60.77	0.00e+00	776.00
IUUC-Zma-135455	Zea mays	32.11	2.00e-78	287.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence