iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-091460

UUCD1 version

UUC-PaT-00391

Ensembl Protein ID

ENSPTRP00000017850.4

UniProt Accession

H2QFB9; H2QFB9_PANTR

Genbank Protein ID

JAA05525.1; JAA19225.1; JAA24389.1; JAA24390.1; JAA40050.1

Protein Name

Kelch-like ECH-associated protein 1

Genbank Nucleotide ID

AACZ03117969; GABF01002920; GABD01008711; GABD01008710; GABE01004689

Gene Name

KEAP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000010473.4	ENSPTRT00000019286.4	ENSPTRP00000017850.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	5.30e-17	62.0	77	148
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	3.30e-09	35.9	181	211

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvv....g.geeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           +Dv+l+v    +   +f ahk+vLa+sS+vF+a+f+++l+e+   + v i+++ p+v++ l++F Yt ++++ 
   Q: 77   CDVTLQVkyqdApAAQFMAHKVVLASSSPVFKAMFTNGLREQG-MEVVSIEGIHPKVMERLIEFAYTASISMG 148
           8******77552699**************************98.***********************998875 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           ++N++gi  fA++ +c +L+++a+++i  hF
   Q: 181  PSNAIGIANFAEQIGCVELHQRAREYIYMHF 211
           89****************************9 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MQPDPRPSGA GACCRFLPLQ SQCPEGAGDA VMYASTECKA EVTPSQHGNR TFSYTLEDHT 60
KQAFGIMNEL RLSQQLCDVT LQVKYQDAPA AQFMAHKVVL ASSSPVFKAM FTNGLREQGM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCTGCTTAGT CATGGTGACC TGCGCGCGCT CCGCGCCTCC CCCACGCGCA GCGATGGAGG 60
CGCCGGGGCT CGGGCGGTGG AGGCGGAGCC GGAGCGCGGC CATGGCGGGG TGAGTGAGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR030563--KEAP1
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0005884--C:actin filament
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005815--C:microtubule organizing center
GO:0030496--C:midbody
GO:0005654--C:nucleoplasm
GO:0008134--F:transcription factor binding
GO:0071353--P:cellular response to interleukin-4
GO:0042994--P:cytoplasmic sequestering of transcription factor
GO:0001701--P:in utero embryonic development
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0010499--P:proteasomal ubiquitin-independent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0045604--P:regulation of epidermal cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001377	Ailuropoda melanoleuca	97.60	0.00e+00	1277.00
IUUC-Aca-005389	Anolis carolinensis	86.00	0.00e+00	1083.00
IUUC-Ame-010749	Astyanax mexicanus	78.74	0.00e+00	974.00
IUUC-Bta-013505	Bos taurus	97.60	0.00e+00	1276.00
IUUC-Cja-018823	Callithrix jacchus	98.24	0.00e+00	1288.00
IUUC-Cfa-021202	Canis familiaris	97.60	0.00e+00	1276.00
IUUC-Cpo-021830	Cavia porcellus	96.12	0.00e+00	840.00
IUUC-Csa-023728	Chlorocebus sabaeus	99.04	0.00e+00	1297.00
IUUC-Cin-025195	Ciona intestinalis	55.00	0.00e+00	677.00
IUUC-Csv-026155	Ciona savignyi	53.59	1.00e-180	625.00
IUUC-Dre-027388	Danio rerio	77.25	0.00e+00	948.00
IUUC-Dno-029066	Dasypus novemcinctus	85.28	0.00e+00	1086.00
IUUC-Dor-030674	Dipodomys ordii	94.89	0.00e+00	831.00
IUUC-Dme-032165	Drosophila melanogaster	49.73	2.00e-161	562.00
IUUC-Ete-032255	Echinops telfairi	93.96	2.00e-98	352.00
IUUC-Eca-034381	Equus caballus	93.76	0.00e+00	1208.00
IUUC-Eeu-034791	Erinaceus europaeus	92.36	0.00e+00	821.00
IUUC-Fca-036067	Felis catus	97.76	0.00e+00	1280.00
IUUC-Gmo-039691	Gadus morhua	77.21	0.00e+00	953.00
IUUC-Gga-040266	Gallus gallus	79.53	0.00e+00	999.00
IUUC-Gac-041866	Gasterosteus aculeatus	77.46	0.00e+00	957.00
IUUC-Ggo-044719	Gorilla gorilla	100.00	0.00e+00	1310.00
IUUC-Hsa-046255	Homo sapiens	100.00	0.00e+00	1310.00
IUUC-Itr-048457	Ictidomys tridecemlineatus	97.28	0.00e+00	1273.00
IUUC-Lch-049646	Latimeria chalumnae	82.88	0.00e+00	1041.00
IUUC-Loc-052296	Lepisosteus oculatus	56.79	0.00e+00	641.00
IUUC-Laf-054579	Loxodonta africana	97.12	0.00e+00	1275.00
IUUC-Mcc-055315	Macaca mulatta	99.04	0.00e+00	1297.00
IUUC-Meu-056288	Macropus eugenii	87.82	0.00e+00	1119.00
IUUC-Mmr-061639	Microcebus murinus	96.96	0.00e+00	1276.00
IUUC-Mdo-062072	Monodelphis domestica	94.07	0.00e+00	1222.00
IUUC-Mmu-063622	Mus musculus	94.07	0.00e+00	1239.00
IUUC-Mpu-066737	Mustela putorius furo	95.03	0.00e+00	1236.00
IUUC-Mlu-068173	Myotis lucifugus	97.12	0.00e+00	1270.00
IUUC-Nle-069336	Nomascus leucogenys	63.81	0.00e+00	734.00
IUUC-Opr-070432	Ochotona princeps	96.66	0.00e+00	1224.00
IUUC-Ont-072160	Oreochromis niloticus	77.31	0.00e+00	947.00
IUUC-Oan-072691	Ornithorhynchus anatinus	80.50	0.00e+00	976.00
IUUC-Ocu-073798	Oryctolagus cuniculus	96.15	0.00e+00	1267.00
IUUC-Ola-086367	Oryzias latipes	74.70	0.00e+00	917.00
IUUC-Oga-088231	Otolemur garnettii	97.28	0.00e+00	1276.00
IUUC-Oar-089227	Ovis aries	96.31	0.00e+00	1252.00
IUUC-Pan-092713	Papio anubis	99.04	0.00e+00	1297.00
IUUC-Pfo-096468	Poecilia formosa	78.10	0.00e+00	954.00
IUUC-Pab-098357	Pongo abelii	99.68	0.00e+00	1304.00
IUUC-Pca-100837	Procavia capensis	95.51	0.00e+00	1249.00
IUUC-Pva-103249	Pteropus vampyrus	94.87	0.00e+00	1210.00
IUUC-Rno-106086	Rattus norvegicus	93.59	0.00e+00	1226.00
IUUC-Sha-107245	Sarcophilus harrisii	93.91	0.00e+00	1221.00
IUUC-Sar-112985	Sorex araneus	95.67	0.00e+00	1256.00
IUUC-Ssc-115756	Sus scrofa	98.08	0.00e+00	1284.00
IUUC-Tgu-116838	Taeniopygia guttata	53.93	2.00e-119	422.00
IUUC-Tru-117644	Takifugu rubripes	77.82	0.00e+00	976.00
IUUC-Tni-120245	Tetraodon nigroviridis	78.19	0.00e+00	963.00
IUUC-Tbe-127472	Tupaia belangeri	98.78	2.00e-149	522.00
IUUC-Ttr-128953	Tursiops truncatus	96.09	0.00e+00	707.00
IUUC-Vpa-130683	Vicugna pacos	94.38	0.00e+00	1104.00
IUUC-Xtr-132827	Xenopus tropicalis	76.28	0.00e+00	952.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence