iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCJAG00000018204.3	ENSCJAT00000056416.1	ENSCJAP00000048762.1
ENSCJAG00000018204.3	ENSCJAT00000000601.2	ENSCJAP00000000557.2
ENSCJAG00000018204.3	ENSCJAT00000035742.2	ENSCJAP00000033832.2
ENSCJAG00000018204.3	ENSCJAT00000035775.1	ENSCJAP00000033864.1
ENSCJAG00000018204.3	ENSCJAT00000021613.2	ENSCJAP00000020455.2
ENSCJAG00000018204.3	ENSCJAT00000000604.2	ENSCJAP00000000560.2
ENSCJAG00000018204.3	ENSCJAT00000010931.2	ENSCJAP00000010342.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.10e-136	454.4	554	886

Active Site

Position(s)	Description	Evidence
855	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f gEegld+gGv+re+++lls+e+ np+++lf+y  +d+++lq+np+s++ np+hlk+F+f+Gr++++al++g+++d+
   Q: 554  PQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDT 641
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k++ l+dle++dpe+y+sl ++ken   +iee+gl++ fsv++eilge+k+++Lkp+G ni Vt+eNkeeY++ v+e
   Q: 642  GFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKEN---NIEECGLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAE 727
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +rl +g++eq++af eGfne++p++ l++F+++ele+l+cG++eid++d+++++ y++ yt++s++i wFw++++e+++e+r ++LqFv
   Q: 728  WRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRH-YTRTSKQIMWFWQFVKEIDNEKRMRLLQFV 815
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfa+l+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 816  TGTCRLPVGGFADLMgingPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 886
           *********************************************************************96 PP

Organism

Callithrix jacchus

Protein Sequence
(Fasta)

MKSQLQITVI SAKLKENKKN WFGPSPYVEV TVDGQSKKTE KCNNTNSPKW KQPLTVIVTP 60
VSKLHFRVWS HQTLKSDVLL GTAALDIYET LKSNNMKLEE VVVTLQLGGD KEPTETIGDL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTGCTAACT CGCTCTGGTA GCTGTGGTCG GGGCTCGAGA CCGGCTGCCA TCTTAGTCTA 60
GGGACTGAGG AGACGCCGCC GCCCCGAGTC CCGGTAAACA CCCGTGGGCG AACTCGGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0031410--C:cytoplasmic vesicle
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0016874--F:ligase activity
GO:0043021--F:ribonucleoprotein complex binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0046642--P:negative regulation of alpha-beta T cell proliferation
GO:0043066--P:negative regulation of apoptotic process
GO:0050687--P:negative regulation of defense response to virus
GO:0046329--P:negative regulation of JNK cascade
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045732--P:positive regulation of protein catabolic process
GO:0002669--P:positive regulation of T cell anergy
GO:0035519--P:protein K29-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0090085--P:regulation of protein deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002302	Ailuropoda melanoleuca	92.45	0.00e+00	1591.00
IUUC-Apl-003752	Anas platyrhynchos	80.44	0.00e+00	1428.00
IUUC-Aca-005338	Anolis carolinensis	78.52	0.00e+00	1400.00
IUUC-Ago-007742	Ashbya gossypii	48.88	2.00e-161	563.00
IUUC-Ame-010601	Astyanax mexicanus	87.73	0.00e+00	1113.00
IUUC-Bta-012782	Bos taurus	92.57	0.00e+00	1539.00
IUUC-Cfa-020648	Canis familiaris	91.47	0.00e+00	1556.00
IUUC-Cpo-022073	Cavia porcellus	93.13	0.00e+00	1595.00
IUUC-Csa-023252	Chlorocebus sabaeus	92.91	0.00e+00	1599.00
IUUC-Cho-024695	Choloepus hoffmanni	89.98	0.00e+00	1587.00
IUUC-Dre-028809	Danio rerio	88.30	0.00e+00	1107.00
IUUC-Dno-029884	Dasypus novemcinctus	92.34	0.00e+00	1618.00
IUUC-Eca-033793	Equus caballus	93.47	0.00e+00	1603.00
IUUC-Eeu-034716	Erinaceus europaeus	93.01	0.00e+00	884.00
IUUC-Fca-035605	Felis catus	92.34	0.00e+00	1618.00
IUUC-Fal-037126	Ficedula albicollis	80.40	0.00e+00	1414.00
IUUC-Gmo-038596	Gadus morhua	80.38	0.00e+00	1005.00
IUUC-Gga-040832	Gallus gallus	81.37	0.00e+00	1435.00
IUUC-Gac-041520	Gasterosteus aculeatus	87.99	0.00e+00	1112.00
IUUC-Ggo-044535	Gorilla gorilla	90.43	0.00e+00	1569.00
IUUC-Hsa-046564	Homo sapiens	97.41	0.00e+00	1694.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	93.24	0.00e+00	1551.00
IUUC-Kpa-049273	Komagataella pastoris	49.23	1.00e-162	566.00
IUUC-Lch-050454	Latimeria chalumnae	74.97	0.00e+00	1369.00
IUUC-Loc-052647	Lepisosteus oculatus	75.50	0.00e+00	1359.00
IUUC-Laf-054383	Loxodonta africana	93.13	0.00e+00	1598.00
IUUC-Mcc-055532	Macaca mulatta	92.91	0.00e+00	1601.00
IUUC-Mga-059661	Meleagris gallopavo	81.26	0.00e+00	1429.00
IUUC-Mmr-061135	Microcebus murinus	93.24	0.00e+00	1618.00
IUUC-Mdo-062505	Monodelphis domestica	83.78	0.00e+00	1480.00
IUUC-Mmu-063375	Mus musculus	91.69	0.00e+00	1553.00
IUUC-Mpu-066203	Mustela putorius furo	92.79	0.00e+00	1592.00
IUUC-Mlu-067837	Myotis lucifugus	92.57	0.00e+00	1589.00
IUUC-Nle-069244	Nomascus leucogenys	92.13	0.00e+00	1581.00
IUUC-Opr-070585	Ochotona princeps	90.99	0.00e+00	1556.00
IUUC-Ont-071798	Oreochromis niloticus	87.60	0.00e+00	1136.00
IUUC-Ocu-074298	Oryctolagus cuniculus	93.03	0.00e+00	1585.00
IUUC-Ola-086526	Oryzias latipes	70.58	0.00e+00	1294.00
IUUC-Oga-088167	Otolemur garnettii	87.26	0.00e+00	1499.00
IUUC-Oar-090316	Ovis aries	76.77	0.00e+00	1170.00
IUUC-Ptr-090819	Pan troglodytes	96.40	0.00e+00	1648.00
IUUC-Pan-092454	Papio anubis	92.91	0.00e+00	1600.00
IUUC-Psi-093319	Pelodiscus sinensis	78.29	0.00e+00	1402.00
IUUC-Pfo-096937	Poecilia formosa	89.04	0.00e+00	1124.00
IUUC-Pab-097580	Pongo abelii	90.54	0.00e+00	1536.00
IUUC-Pca-100923	Procavia capensis	79.21	0.00e+00	1313.00
IUUC-Pva-103209	Pteropus vampyrus	91.67	0.00e+00	1540.00
IUUC-Rno-104924	Rattus norvegicus	91.57	0.00e+00	1565.00
IUUC-Sha-107175	Sarcophilus harrisii	84.56	0.00e+00	1478.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	46.86	3.00e-159	555.00
IUUC-Sar-113761	Sorex araneus	86.92	0.00e+00	1497.00
IUUC-Tgu-116632	Taeniopygia guttata	77.53	0.00e+00	1317.00
IUUC-Tru-118442	Takifugu rubripes	88.75	0.00e+00	1113.00
IUUC-Tsy-119198	Tarsius syrichta	86.49	0.00e+00	1479.00
IUUC-Tni-120168	Tetraodon nigroviridis	86.52	0.00e+00	1052.00
IUUC-Tbe-127756	Tupaia belangeri	77.82	0.00e+00	1285.00
IUUC-Ttr-128504	Tursiops truncatus	84.23	0.00e+00	1112.00
IUUC-Vpa-130103	Vicugna pacos	82.34	0.00e+00	1368.00
IUUC-Xtr-132885	Xenopus tropicalis	78.34	0.00e+00	1400.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence