iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000156831.7	ENST00000519010.5	ENSP00000481615.1
ENSG00000156831.7	ENST00000287437.7	ENSP00000287437.3
ENSG00000156831.7	ENST00000518146.5	ENSP00000430313.1
ENSG00000156831.7	ENST00000519712.1	ENSP00000429014.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	16055714; 19793919

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	5.70e-09	37.6	166	240
E3 activity/RING/RING	0.00012	24.2	169	211

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 5    eflCpIslelMrdPvvlp.sGitydrssIekwlasggk.....tcPv...trqplteedlvPnltlrrliqawce 70
            f CpI++e M+ Pv  + +G+ty+  +I + ++s +k      cP     ++ ++++dl+   +lrr i+++ +
   Q: 166  NFTCPITKEEMKKPVKNKvCGHTYEEDAIVRMIESRQKrkkkaYCPQigcSHTDIRKSDLIQDEALRRAIENHNK 240
           79*******************************777777788988861115566699*************98765 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCP 43
           C+i +e++k++++   CgH++ +d + ++  + ++ +k+++CP
   Q: 169  CPITKEEMKKPVKNKVCGHTYEEDAIVRMIESRQKRKKKAYCP 211
           **********555555**********888899999******** PP

Organism

Homo sapiens

Functional Description
(View)

E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines. Required for sister chromatid cohesion during prometaphase and mitotic progression.

Protein Sequence
(Fasta)

MPGRSSSNSG STGFISFSGV ESALSSLKNF QACINSGMDT ASSVALDLVE SQTEVSSEYS 60
MDKAMVEFAT LDRQLNHYVK AVQSTINHVK EERPEKIPDL KLLVEKKFLA LQSKNSDADF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTTTCCACC CCTCCCTCAA GGCGGCGGTC CTCTTCTATC CGCAGTCCCG GACCTGGAGC 60
GGGTCAGACC CCGACTTCCG CCCCTGACTC CCCAGGCGGT CACATGACCG AAGCGGCTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0131--Cell cycle
KW-0132--Cell division
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0233--DNA recombination
KW-0234--DNA repair
KW-0242--Dwarfism
KW-0436--Ligase
KW-0991--Mental retardation
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0779--Telomere
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR026846--Nse2(Mms21)
IPR004181--Znf_MIZ
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51044--ZF_SP_RING

Pfam

PF11789--zf-Nse

Gene Ontology

GO:0000781--C:chromosome, telomeric region
GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0030915--C:Smc5-Smc6 complex
GO:0016874--F:ligase activity
GO:0019789--F:SUMO transferase activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0090398--P:cellular senescence
GO:0000724--P:double-strand break repair via homologous recombination
GO:0007067--P:mitotic nuclear division
GO:0034184--P:positive regulation of maintenance of mitotic sister chromatid cohesion
GO:0045842--P:positive regulation of mitotic metaphase/anaphase transition
GO:0000722--P:telomere maintenance via recombination

KEGG

hsa:286053

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001627	Ailuropoda melanoleuca	85.83	7.00e-104	369.00
IUUC-Atr-002438	Amborella trichopoda	32.67	5.00e-07	48.10
IUUC-Apl-004091	Anas platyrhynchos	64.52	4.00e-30	122.00
IUUC-Aca-004433	Anolis carolinensis	48.93	9.00e-67	246.00
IUUC-Aly-006133	Arabidopsis lyrata	26.92	5.00e-09	54.70
IUUC-Ath-007424	Arabidopsis thaliana	28.02	5.00e-11	61.20
IUUC-Ago-007852	Ashbya gossypii	29.73	3.00e-07	48.50
IUUC-Acl-008011	Aspergillus clavatus	32.56	1.40e-02	34.70
IUUC-Afu-008893	Aspergillus fumigatus	30.23	7.00e-03	35.40
IUUC-Ani-009414	Aspergillus nidulans	29.55	3.00e-03	36.60
IUUC-Ang-009587	Aspergillus niger	25.81	7.00e-03	35.80
IUUC-Ate-010326	Aspergillus terreus	32.56	3.90e-02	34.30
IUUC-Ame-010902	Astyanax mexicanus	42.36	1.00e-45	176.00
IUUC-Bgr-012088	Blumeria graminis	26.88	1.00e-06	47.40
IUUC-Bta-013397	Bos taurus	86.63	2.00e-69	254.00
IUUC-Bci-013738	Botrytis cinerea	26.88	7.00e-06	45.40
IUUC-Cja-019246	Callithrix jacchus	91.67	1.00e-111	395.00
IUUC-Cpo-021670	Cavia porcellus	86.03	2.00e-98	352.00
IUUC-Csa-023982	Chlorocebus sabaeus	90.79	7.00e-109	386.00
IUUC-Cin-025127	Ciona intestinalis	24.77	3.00e-16	78.60
IUUC-Cgl-026430	Colletotrichum gloeosporioides	33.90	1.00e-07	50.80
IUUC-Cne-026806	Cryptococcus neoformans	39.02	3.00e-09	55.80
IUUC-Cme-027175	Cyanidioschyzon merolae	29.31	2.00e-04	40.00
IUUC-Dre-028325	Danio rerio	35.05	2.00e-32	132.00
IUUC-Dno-029735	Dasypus novemcinctus	87.04	4.00e-118	417.00
IUUC-Dor-030454	Dipodomys ordii	73.25	8.00e-77	280.00
IUUC-Dme-031971	Drosophila melanogaster	29.51	1.00e-11	63.50
IUUC-Ete-032838	Echinops telfairi	62.58	1.00e-50	191.00
IUUC-Eca-034371	Equus caballus	86.23	3.00e-116	410.00
IUUC-Eeu-035258	Erinaceus europaeus	86.02	6.00e-82	296.00
IUUC-Fca-035576	Felis catus	86.64	5.00e-104	370.00
IUUC-Fal-037038	Ficedula albicollis	55.95	3.00e-74	271.00
IUUC-Fox-037843	Fusarium oxysporum	32.93	5.00e-08	52.40
IUUC-Fso-038272	Fusarium solani	31.87	5.00e-08	52.40
IUUC-Ggr-040059	Gaeumannomyces graminis	28.57	4.00e-06	46.20
IUUC-Gga-040737	Gallus gallus	44.40	3.00e-57	215.00
IUUC-Gac-042591	Gasterosteus aculeatus	44.64	2.00e-46	179.00
IUUC-Gma-043177	Glycine max	26.34	9.00e-09	54.30
IUUC-Ggo-045206	Gorilla gorilla	99.56	9.00e-123	432.00
IUUC-Hvu-047252	Hordeum vulgare	26.39	1.00e-05	43.50
IUUC-Itr-048972	Ictidomys tridecemlineatus	86.05	3.00e-46	176.00
IUUC-Kpa-049181	Komagataella pastoris	29.36	3.00e-12	65.50
IUUC-Lpe-051150	Leersia perrieri	32.18	5.00e-06	45.10
IUUC-Loc-052687	Lepisosteus oculatus	41.67	4.00e-42	164.00
IUUC-Lma-053255	Leptosphaeria maculans	29.63	6.00e-07	49.30
IUUC-Laf-054270	Loxodonta africana	83.40	3.00e-116	410.00
IUUC-Mcc-054757	Macaca mulatta	89.30	2.00e-85	307.00
IUUC-Mor-057028	Magnaporthe oryzae	22.76	1.00e-05	44.70
IUUC-Mpo-057462	Magnaporthe poae	28.57	4.00e-07	49.30
IUUC-Mtr-058011	Medicago truncatula	27.42	1.00e-10	60.50
IUUC-Mga-059215	Meleagris gallopavo	65.48	3.00e-32	129.00
IUUC-Mvi-060511	Microbotryum violaceum	29.87	1.00e-05	44.70
IUUC-Mmr-061584	Microcebus murinus	89.07	1.00e-112	399.00
IUUC-Mdo-061863	Monodelphis domestica	53.19	2.00e-70	258.00
IUUC-Mmu-064413	Mus musculus	84.21	3.00e-112	397.00
IUUC-Mpu-066092	Mustela putorius furo	73.45	2.00e-101	362.00
IUUC-Mlu-068198	Myotis lucifugus	88.52	5.00e-117	413.00
IUUC-Ncr-068773	Neurospora crassa	32.18	1.00e-06	47.40
IUUC-Nle-070109	Nomascus leucogenys	96.93	3.00e-119	420.00
IUUC-Opr-070540	Ochotona princeps	62.30	1.00e-65	243.00
IUUC-Ont-071575	Oreochromis niloticus	41.48	3.00e-44	171.00
IUUC-Oan-072777	Ornithorhynchus anatinus	66.67	4.00e-20	89.00
IUUC-Ocu-074730	Oryctolagus cuniculus	89.78	2.00e-108	384.00
IUUC-Obr-076506	Oryza brachyantha	27.78	9.00e-07	47.00
IUUC-Olu-087903	Ostreococcus lucimarinus	39.71	3.00e-05	42.40
IUUC-Oga-087925	Otolemur garnettii	90.35	9.00e-105	372.00
IUUC-Oar-090138	Ovis aries	72.10	1.00e-96	345.00
IUUC-Ptr-091582	Pan troglodytes	100.00	1.00e-123	435.00
IUUC-Pan-092890	Papio anubis	90.79	1.00e-108	385.00
IUUC-Psi-093714	Pelodiscus sinensis	56.61	4.00e-77	281.00
IUUC-Pma-094198	Petromyzon marinus	33.33	4.00e-22	97.10
IUUC-Pno-094931	Phaeosphaeria nodorum	32.93	4.00e-05	43.10
IUUC-Pab-098005	Pongo abelii	98.68	7.00e-123	432.00
IUUC-Pop-099559	Populus trichocarpa	25.13	6.00e-09	54.70
IUUC-Pca-100368	Procavia capensis	66.67	2.00e-64	238.00
IUUC-Ppe-101873	Prunus persica	25.27	3.00e-09	55.50
IUUC-Pva-102951	Pteropus vampyrus	87.85	4.00e-110	390.00
IUUC-Pte-104390	Pyrenophora teres	40.00	5.00e-07	48.90
IUUC-Pyt-104633	Pyrenophora triticirepentis	40.00	1.00e-06	47.80
IUUC-Rno-105346	Rattus norvegicus	84.62	9.00e-119	419.00
IUUC-Sce-106198	Saccharomyces cerevisiae	24.68	9.00e-05	40.80
IUUC-Sha-107586	Sarcophilus harrisii	64.34	6.00e-41	159.00
IUUC-Sja-107983	Schizosaccharomyces japonicus	33.33	2.00e-11	62.40
IUUC-Spo-108327	Schizosaccharomyces pombe	29.21	7.00e-07	47.80
IUUC-Ssl-108555	Sclerotinia sclerotiorum	25.27	2.00e-04	40.80
IUUC-Smo-109219	Selaginella moellendorffii	36.00	2.00e-05	45.10
IUUC-Sar-113609	Sorex araneus	85.90	2.00e-100	358.00
IUUC-Sbi-113916	Sorghum bicolor	30.56	4.00e-09	55.10
IUUC-Sre-115187	Sporisorium reilianum	35.94	9.00e-06	44.30
IUUC-Tgu-116472	Taeniopygia guttata	54.63	7.00e-72	263.00
IUUC-Tru-117771	Takifugu rubripes	40.42	3.00e-41	161.00
IUUC-Tni-119821	Tetraodon nigroviridis	38.30	3.00e-44	171.00
IUUC-Tca-121272	Theobroma cacao	27.59	3.00e-07	48.90
IUUC-Tre-122049	Trichoderma reesei	34.15	2.00e-09	56.60
IUUC-Tvi-122642	Trichoderma virens	31.71	4.00e-08	52.40
IUUC-Tur-126346	Triticum urartu	29.75	4.00e-06	44.70
IUUC-Tme-126988	Tuber melanosporum	30.00	9.00e-08	51.20
IUUC-Tbe-127676	Tupaia belangeri	91.37	1.00e-93	335.00
IUUC-Ttr-128602	Tursiops truncatus	86.78	6.00e-105	373.00
IUUC-Vpa-130510	Vicugna pacos	88.26	2.00e-107	382.00
IUUC-Vvi-131486	Vitis vinifera	28.90	3.00e-10	58.90

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence