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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046864
UUCD1 version UUC-HoS-00736
Ensembl Protein ID ENSP00000269439.6
UniProt Accession Q6ZSG1; B3KVD1; RN165_HUMAN
Genbank Protein ID BAC86992.1; BAG53743.1; ENSP00000269439
Protein Name E3 ubiquitin-protein ligase RNF165; RING finger protein 165
Genbank Nucleotide ID AK127467; AK122819; AC015959
Gene Name RNF165
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000141622.13 ENST00000587853.1 ENSP00000466208.1
ENSG00000141622.13 ENST00000588679.1 ENSP00000467609.1
ENSG00000141622.13 ENST00000586604.5 ENSP00000468365.1
ENSG00000141622.13 ENST00000269439.11 ENSP00000269439.6
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
dbPTM
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 4.40e-07 32.0 294 335
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdg..plvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iCl++++dg  ++ lpC H+fh+ C+ +w         + +CP+Cr
   Q: 294  CTICLSMLEDGedVRRLPCMHLFHQLCVDQW------LAMSKKCPICR 335
           ********66555******************......999999****8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL.
 E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL.
Protein Sequence
(Fasta)
MVLVHVGYLV LPVFGSVRNR GAPFQRSQHP HATSCRHFHL GPPQPQQLAP DFPLAHPVQS 60
QPGLSAHMAP AHQHSGALHQ SLTPLPTLQF QDVTGPSFLP QALHQQYLLQ QQLLEAQHRR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046864|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGAGACCGT CCAAGGAGGG CTTCAGCGGC AGAGGGGAGA CCGTCCAAGG AGGGCTTCAG 60
CGGCAGAGGG GAGACCATCC AAGGGAGTGA GTGGGGACTA AAATTCAGCC TGAAGTTCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046864|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
SM00744--RINGv
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0035136--P:forelimb morphogenesis
GO:0060384--P:innervation
GO:0008045--P:motor neuron axon guidance
GO:0010259--P:multicellular organism aging
GO:0061061--P:muscle structure development
GO:0030513--P:positive regulation of BMP signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG hsa:494470
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000618 Aegilops tauschii 37.96 3.00e-15 77.00
IUUC-Aml-001791 Ailuropoda melanoleuca 99.42 1.00e-179 622.00
IUUC-Atr-003149 Amborella trichopoda 52.54 4.00e-16 76.30
IUUC-Apl-003783 Anas platyrhynchos 69.28 2.00e-120 425.00
IUUC-Aca-005299 Anolis carolinensis 84.94 2.00e-138 484.00
IUUC-Ame-011948 Astyanax mexicanus 70.90 1.00e-129 455.00
IUUC-Bta-012470 Bos taurus 96.14 5.00e-166 577.00
IUUC-Bdi-014014 Brachypodium distachyon 37.93 3.00e-16 79.70
IUUC-Bol-016013 Brassica oleracea 37.27 2.00e-13 69.30
IUUC-Cel-018118 Caenorhabditis elegans 41.18 1.00e-15 78.20
IUUC-Cja-019798 Callithrix jacchus 95.66 1.00e-178 618.00
IUUC-Cfa-020297 Canis familiaris 97.98 8.00e-178 615.00
IUUC-Cpo-022225 Cavia porcellus 97.94 2.00e-179 621.00
IUUC-Csa-024018 Chlorocebus sabaeus 100.00 1.00e-177 615.00
IUUC-Cme-027312 Cyanidioschyzon merolae 49.23 7.00e-13 68.20
IUUC-Dre-028365 Danio rerio 68.39 2.00e-104 372.00
IUUC-Dno-029962 Dasypus novemcinctus 94.93 1.00e-153 535.00
IUUC-Dor-030727 Dipodomys ordii 97.69 5.00e-180 623.00
IUUC-Eca-033911 Equus caballus 99.08 3.00e-168 584.00
IUUC-Fca-035641 Felis catus 98.54 6.00e-177 613.00
IUUC-Fal-037200 Ficedula albicollis 85.84 1.00e-142 499.00
IUUC-Fox-037754 Fusarium oxysporum 38.27 1.00e-11 63.20
IUUC-Gmo-039613 Gadus morhua 74.57 2.00e-86 311.00
IUUC-Gga-040277 Gallus gallus 87.02 5.00e-124 437.00
IUUC-Gac-042544 Gasterosteus aculeatus 63.20 4.00e-115 407.00
IUUC-Gma-044396 Glycine max 39.39 2.00e-15 77.80
IUUC-Ggo-044631 Gorilla gorilla 89.60 1.00e-179 622.00
IUUC-Hvu-047447 Hordeum vulgare 37.04 4.00e-15 75.90
IUUC-Itr-048602 Ictidomys tridecemlineatus 99.39 7.00e-176 609.00
IUUC-Lch-049656 Latimeria chalumnae 72.80 3.00e-108 384.00
IUUC-Lpe-050720 Leersia perrieri 35.35 1.00e-15 77.40
IUUC-Loc-052046 Lepisosteus oculatus 78.41 2.00e-143 501.00
IUUC-Laf-053554 Loxodonta africana 98.70 1.00e-83 301.00
IUUC-Mcc-055198 Macaca mulatta 100.00 1.00e-177 615.00
IUUC-Meu-055988 Macropus eugenii 83.44 1.00e-121 429.00
IUUC-Mtr-057649 Medicago truncatula 37.37 9.00e-15 75.50
IUUC-Mga-059245 Meleagris gallopavo 88.96 1.00e-75 274.00
IUUC-Mmr-061389 Microcebus murinus 98.85 4.00e-175 607.00
IUUC-Mdo-062317 Monodelphis domestica 94.80 2.00e-149 521.00
IUUC-Mmu-063102 Mus musculus 98.56 0.00e+00 645.00
IUUC-Mac-064633 Musa acuminata 40.82 6.00e-15 75.50
IUUC-Mpu-066793 Mustela putorius furo 96.72 1.00e-163 568.00
IUUC-Nle-069235 Nomascus leucogenys 100.00 0.00e+00 653.00
IUUC-Opr-070646 Ochotona princeps 98.47 3.00e-161 560.00
IUUC-Ont-072005 Oreochromis niloticus 72.32 1.00e-119 423.00
IUUC-Oan-072924 Ornithorhynchus anatinus 74.63 8.00e-115 406.00
IUUC-Ocu-074718 Oryctolagus cuniculus 98.27 0.00e+00 640.00
IUUC-Oba-075466 Oryza barthii 34.29 8.00e-16 78.20
IUUC-Obr-076189 Oryza brachyantha 38.46 4.00e-15 75.90
IUUC-Ogl-076994 Oryza glaberrima 34.29 8.00e-16 78.20
IUUC-Ogu-078200 Oryza glumaepatula 34.29 8.00e-16 78.20
IUUC-Oin-079508 Oryza indica 34.29 8.00e-16 78.20
IUUC-Olo-080855 Oryza longistaminata 35.35 8.00e-16 78.60
IUUC-Ome-081841 Oryza meridionalis 34.29 8.00e-16 78.20
IUUC-Oni-082470 Oryza nivara 34.29 9.00e-16 78.20
IUUC-Oru-085181 Oryza rufipogon 34.29 8.00e-16 78.20
IUUC-Osa-086143 Oryza sativa 34.29 8.00e-16 78.20
IUUC-Ola-087143 Oryzias latipes 72.07 2.00e-120 425.00
IUUC-Olu-087774 Ostreococcus lucimarinus 42.59 6.00e-13 66.20
IUUC-Oga-087993 Otolemur garnettii 99.42 0.00e+00 649.00
IUUC-Oar-089588 Ovis aries 96.64 2.00e-162 565.00
IUUC-Ptr-091341 Pan troglodytes 100.00 0.00e+00 655.00
IUUC-Pan-091775 Papio anubis 100.00 0.00e+00 655.00
IUUC-Psi-092966 Pelodiscus sinensis 85.51 9.00e-137 479.00
IUUC-Ppa-095313 Physcomitrella patens 32.32 6.00e-14 73.60
IUUC-Pfo-096103 Poecilia formosa 69.41 8.00e-111 393.00
IUUC-Pop-099945 Populus trichocarpa 42.42 9.00e-15 75.90
IUUC-Ppe-101513 Prunus persica 41.41 6.00e-15 76.30
IUUC-Pva-102801 Pteropus vampyrus 94.22 4.00e-174 603.00
IUUC-Rno-105973 Rattus norvegicus 96.45 1.00e-174 605.00
IUUC-Sha-107027 Sarcophilus harrisii 91.28 1.00e-151 528.00
IUUC-Sja-107932 Schizosaccharomyces japonicus 50.98 4.00e-12 66.60
IUUC-Spo-108030 Schizosaccharomyces pombe 50.98 5.00e-11 63.20
IUUC-Sit-110501 Setaria italica 35.24 3.00e-16 79.30
IUUC-Sly-111039 Solanum lycopersicum 41.41 7.00e-16 79.30
IUUC-Stu-112006 Solanum tuberosum 37.08 3.00e-11 63.90
IUUC-Sar-113383 Sorex araneus 96.63 6.00e-159 553.00
IUUC-Sbi-113906 Sorghum bicolor 58.33 9.00e-16 77.00
IUUC-Ssc-116357 Sus scrofa 89.76 2.00e-148 518.00
IUUC-Tgu-117345 Taeniopygia guttata 85.54 3.00e-142 497.00
IUUC-Tru-118756 Takifugu rubripes 70.59 4.00e-121 427.00
IUUC-Tni-120423 Tetraodon nigroviridis 69.38 7.00e-113 400.00
IUUC-Tca-121441 Theobroma cacao 37.25 2.00e-15 77.40
IUUC-Tur-126401 Triticum urartu 34.78 4.00e-14 73.20
IUUC-Vpa-130177 Vicugna pacos 98.91 2.00e-101 361.00
IUUC-Vvi-130983 Vitis vinifera 35.64 6.00e-08 50.80
IUUC-Xtr-132317 Xenopus tropicalis 76.56 4.00e-114 404.00
IUUC-Xma-133967 Xiphophorus maculatus 70.06 5.00e-110 390.00
Created Date 25-Jun-2017

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