iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012774

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

DAAA02012807

Gene Name

USP44

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000019946.4	ENSBTAT00000026571.2	ENSBTAP00000026571.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.30e-97	326.4	270	674

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...........kkkeklneenp.................................... 42
           tGl+NlgNtCYmNSvLQ+Ls++  +r+++l+           ++        +                                    
   Q: 270  TGLRNLGNTCYMNSVLQVLSHLLIFRQCFLKldlnqwlavtaSD--------Ktrssykhppvtdtvyqmnecqekepysvcfrhpsls 350
           7******************************8877666665522........1334444557888888888888888899999999999 PP
   S: 43   .....................kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkke 110
                                +++  +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy qqDaqEfl+ lld+++ el   
   Q: 351  sglsggaptsskmeliqprepSSQYISLCHELHTLFQVMWSGKWALVSPFAMLHSVWRLIPAFRGYGQQDAQEFLCELLDKIQHEL--- 436
           99999999888888888877777777************************************************************... PP
   S: 111  knkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.......slqdcLe 192
                 e++++++ +l   +++k  k+  ++++++F+gql sq++cl+cd++s++ epf+dlsl++p++ +++ +        ++++L+
   Q: 437  ------ETTGTRSPALIPTSQRKLIKQVLNVVNNIFHGQLLSQVTCLACDSKSNTIEPFWDLSLEFPERYQCSGKdsasqpcLVTEMLA 519
           ......7899999999***************************************************777776667777777******* PP
   S: 193  sftkeeelegenkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspee 270
           +ft++e leg+  y c++c++k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c++++ 
   Q: 520  KFTETEALEGKI-YVCDQCNSKRRrfsskpvllteAQKQLMICHLPQVLRLHLKRFRWSGR-NNREKIGVHVGFEEILNMEPYCCRESL 606
           *********965.*******999999999****99***********************998.7778********************998 PP
   S: 271  kqke..kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           k+ +  +  Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk + ++++ev++   ++aY+lfY++
   Q: 607  KSLRpeCFLYDLSAVVMHHGkGFGSGHYTAYCYNSEGGfWVHCNDSKLSMCTMDEVCK---AQAYILFYTQ 674
           8876779***************************9999********************...********98 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

MLTMDKCQHI GQLRLAQDHP ILNPQKWHCV DCNTTESIWA CLSCSHVACG RYIEEHALGH 60
FQESSHPVAL EVNEMYVFCY LCDDYVLNDN ATGDLKLLRS TLSAIKNQNY HCTTRSGRVL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCTAACAA TGGATAAGTG CCAACACATT GGGCAGTTGC GGCTTGCTCA GGACCATCCC 60
ATCCTCAACC CGCAGAAATG GCATTGTGTG GACTGCAATA CAACTGAGTC GATTTGGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:1904667--P:negative regulation of ubiquitin protein ligase activity
GO:0016579--P:protein deubiquitination
GO:0090231--P:regulation of spindle checkpoint
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

bta:517022

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001220	Ailuropoda melanoleuca	92.28	0.00e+00	1320.00
IUUC-Apl-003673	Anas platyrhynchos	75.04	0.00e+00	1062.00
IUUC-Aca-004434	Anolis carolinensis	72.20	0.00e+00	1043.00
IUUC-Ame-010986	Astyanax mexicanus	64.14	0.00e+00	879.00
IUUC-Cja-019619	Callithrix jacchus	89.06	0.00e+00	1271.00
IUUC-Cfa-020957	Canis familiaris	91.01	0.00e+00	1327.00
IUUC-Csa-023177	Chlorocebus sabaeus	89.20	0.00e+00	1270.00
IUUC-Cho-024877	Choloepus hoffmanni	88.26	0.00e+00	830.00
IUUC-Cin-025587	Ciona intestinalis	48.97	6.00e-109	388.00
IUUC-Csv-025814	Ciona savignyi	45.23	1.00e-155	543.00
IUUC-Dre-027878	Danio rerio	72.60	2.00e-180	625.00
IUUC-Dno-029832	Dasypus novemcinctus	90.73	0.00e+00	1307.00
IUUC-Ete-032627	Echinops telfairi	86.55	0.00e+00	1239.00
IUUC-Eca-033863	Equus caballus	86.99	0.00e+00	1222.00
IUUC-Eeu-035225	Erinaceus europaeus	84.27	0.00e+00	1202.00
IUUC-Fca-036288	Felis catus	91.99	0.00e+00	1320.00
IUUC-Fal-037207	Ficedula albicollis	74.64	0.00e+00	1023.00
IUUC-Gga-040457	Gallus gallus	74.51	0.00e+00	1026.00
IUUC-Ggo-044926	Gorilla gorilla	88.92	0.00e+00	1264.00
IUUC-Hsa-046079	Homo sapiens	88.64	0.00e+00	1266.00
IUUC-Itr-048737	Ictidomys tridecemlineatus	89.61	0.00e+00	1276.00
IUUC-Lch-050260	Latimeria chalumnae	67.51	0.00e+00	938.00
IUUC-Loc-051981	Lepisosteus oculatus	76.74	0.00e+00	671.00
IUUC-Laf-054491	Loxodonta africana	87.66	0.00e+00	1217.00
IUUC-Mcc-055694	Macaca mulatta	89.48	0.00e+00	1269.00
IUUC-Mga-059523	Meleagris gallopavo	74.47	0.00e+00	1038.00
IUUC-Mmr-060885	Microcebus murinus	91.46	0.00e+00	1305.00
IUUC-Mdo-063018	Monodelphis domestica	78.90	0.00e+00	1122.00
IUUC-Mmu-064012	Mus musculus	77.81	0.00e+00	1084.00
IUUC-Mpu-066207	Mustela putorius furo	90.59	0.00e+00	1325.00
IUUC-Mlu-066929	Myotis lucifugus	87.82	0.00e+00	1198.00
IUUC-Nle-069313	Nomascus leucogenys	78.78	0.00e+00	1088.00
IUUC-Opr-070375	Ochotona princeps	79.41	0.00e+00	1107.00
IUUC-Ont-071637	Oreochromis niloticus	70.74	1.00e-178	619.00
IUUC-Oan-073030	Ornithorhynchus anatinus	77.89	0.00e+00	859.00
IUUC-Ocu-074836	Oryctolagus cuniculus	86.22	0.00e+00	1211.00
IUUC-Oga-088367	Otolemur garnettii	90.88	0.00e+00	1282.00
IUUC-Oar-089953	Ovis aries	97.46	0.00e+00	1421.00
IUUC-Ptr-090980	Pan troglodytes	88.78	0.00e+00	1267.00
IUUC-Pan-092748	Papio anubis	89.89	0.00e+00	1280.00
IUUC-Psi-094078	Pelodiscus sinensis	75.69	0.00e+00	852.00
IUUC-Pab-098514	Pongo abelii	88.64	0.00e+00	1266.00
IUUC-Pva-102984	Pteropus vampyrus	89.59	0.00e+00	1277.00
IUUC-Rno-106019	Rattus norvegicus	78.74	0.00e+00	1132.00
IUUC-Sha-106965	Sarcophilus harrisii	77.72	0.00e+00	1118.00
IUUC-Ssc-115299	Sus scrofa	91.99	0.00e+00	1332.00
IUUC-Tgu-117160	Taeniopygia guttata	74.19	0.00e+00	1024.00
IUUC-Tru-118156	Takifugu rubripes	61.51	0.00e+00	835.00
IUUC-Tni-119733	Tetraodon nigroviridis	62.68	0.00e+00	860.00
IUUC-Tbe-128084	Tupaia belangeri	84.29	0.00e+00	1209.00
IUUC-Ttr-128928	Tursiops truncatus	93.95	0.00e+00	1359.00
IUUC-Vpa-130706	Vicugna pacos	92.28	0.00e+00	1323.00
IUUC-Xtr-132061	Xenopus tropicalis	70.80	0.00e+00	945.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence