iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.80e-98	330.2	250	654

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle........kkkeklneenp....................................... 42
           tGl+NlgNtCYmNS+LQ+Ls+++++re++l+         +++++n +++                                       
   Q: 250  TGLRNLGNTCYMNSILQVLSHLQKFRECFLNldpstsehLFPQATNGKAQipsrpasstaagfsvrsdraqgfepqgfcwssgasisrs 338
           7******************************6665555555555555555999999***************************999999 PP
   S: 43   .........kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeed 122
                    ++++ +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ ll+++++el         e+e+++
   Q: 339  leliqnkepSSKHISLCHELHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQEL---------ESEGST 418
           99999999999999************************************************************.........678899 PP
   S: 123  kselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke..........slqdcLesftkeeele 201
           ++ l   +++k +k+  ++++++F+gql sq++c +c+ +s++ epf+dlsl++p++ ++ ++           l+++L++ft++e le
   Q: 419  RRILIPFSQRKLTKQVLKVVNTIFHGQLLSQVTCVSCNYKSNTIEPFWDLSLEFPERYHCVEKgfvplnqtecLLTEMLAKFTETEALE 507
           9999999***************************************************99888************************** PP
   S: 202  genkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke..kkk 277
           g+  y c++c++k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c+ +  ++ +  +  
   Q: 508  GRI-YACDQCNSKRRksnpkplvlseARKQLMIYRLPQVLRLHLKRFRWSGR-NHREKIGVHVVFDQVLTMEPYCCGDMLSSLDkdTFA 594
           965.*******9999999*******************************997.8889********************877765544899 PP
   S: 278  YeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkrr 338
           Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk  +++ eev++   ++aY+lfY+rr
   Q: 595  YDLSAVVMHHGkGFGSGHYTAYCYNTEGGfWVHCNDSKLDVCSVEEVCK---TQAYILFYTRR 654
           *************************9999********************...********985 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MDRCKHVGRL RLAQDHSILN PQKWCCLECA TTESAWACLK CSHVACGRYI EDHALKHFEE 60
TGHPLAMEVR DLYVFCYLCK DYVLNDNPEG DLKLLRSSLL AVRGQKQDLP ARRGRTLRST 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTGCAAGGG AGCCTTTCTG TTTCAGAATG GACTTTATCC CTCTCGGAAG TCCTTGAGGC 60
CACTGCCACC TAGGTCTGAT TTATTTCCCA GTCCCTATTT GGGGAGCGAT GAACCTTTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0035616--P:histone H2B conserved C-terminal lysine deubiquitination
GO:0000398--P:mRNA splicing, via spliceosome
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

rno:316211

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002395	Ailuropoda melanoleuca	88.99	0.00e+00	799.00
IUUC-Apl-003658	Anas platyrhynchos	77.19	0.00e+00	1043.00
IUUC-Aca-005278	Anolis carolinensis	77.04	0.00e+00	1056.00
IUUC-Bta-012911	Bos taurus	86.88	0.00e+00	1102.00
IUUC-Cja-019171	Callithrix jacchus	90.98	0.00e+00	1210.00
IUUC-Cfa-020408	Canis familiaris	87.72	0.00e+00	1135.00
IUUC-Cpo-022233	Cavia porcellus	81.77	0.00e+00	1049.00
IUUC-Csa-024272	Chlorocebus sabaeus	91.16	0.00e+00	997.00
IUUC-Cho-025051	Choloepus hoffmanni	86.86	0.00e+00	637.00
IUUC-Cin-025587	Ciona intestinalis	46.98	2.00e-106	380.00
IUUC-Dre-027878	Danio rerio	60.37	0.00e+00	756.00
IUUC-Dno-029856	Dasypus novemcinctus	86.92	0.00e+00	1147.00
IUUC-Ete-032761	Echinops telfairi	74.40	0.00e+00	846.00
IUUC-Eca-033851	Equus caballus	82.42	0.00e+00	1008.00
IUUC-Fal-037290	Ficedula albicollis	75.91	0.00e+00	935.00
IUUC-Gmo-039249	Gadus morhua	77.04	2.00e-145	509.00
IUUC-Gac-042595	Gasterosteus aculeatus	60.11	0.00e+00	759.00
IUUC-Ggo-044979	Gorilla gorilla	89.81	0.00e+00	1200.00
IUUC-Hsa-046743	Homo sapiens	89.67	0.00e+00	1194.00
IUUC-Itr-048251	Ictidomys tridecemlineatus	90.80	0.00e+00	1206.00
IUUC-Lch-050294	Latimeria chalumnae	74.50	0.00e+00	938.00
IUUC-Loc-051961	Lepisosteus oculatus	67.47	0.00e+00	806.00
IUUC-Laf-053819	Loxodonta africana	88.32	0.00e+00	802.00
IUUC-Mcc-055048	Macaca mulatta	90.39	0.00e+00	1204.00
IUUC-Meu-055971	Macropus eugenii	65.71	1.00e-147	516.00
IUUC-Mmr-061253	Microcebus murinus	81.90	2.00e-148	519.00
IUUC-Mdo-062073	Monodelphis domestica	78.97	0.00e+00	1074.00
IUUC-Mmu-064095	Mus musculus	96.64	0.00e+00	1269.00
IUUC-Mpu-066318	Mustela putorius furo	88.61	0.00e+00	817.00
IUUC-Mlu-067090	Myotis lucifugus	86.57	0.00e+00	1125.00
IUUC-Nle-069486	Nomascus leucogenys	90.25	0.00e+00	1204.00
IUUC-Opr-070563	Ochotona princeps	87.98	0.00e+00	1166.00
IUUC-Ont-071637	Oreochromis niloticus	59.45	0.00e+00	778.00
IUUC-Oan-073245	Ornithorhynchus anatinus	88.57	8.00e-180	622.00
IUUC-Ocu-074851	Oryctolagus cuniculus	90.24	0.00e+00	946.00
IUUC-Ola-086413	Oryzias latipes	57.93	0.00e+00	743.00
IUUC-Oga-088862	Otolemur garnettii	88.95	0.00e+00	1165.00
IUUC-Ptr-091525	Pan troglodytes	91.05	0.00e+00	1095.00
IUUC-Pan-092363	Papio anubis	90.90	0.00e+00	1176.00
IUUC-Psi-093353	Pelodiscus sinensis	78.51	0.00e+00	1046.00
IUUC-Pma-094155	Petromyzon marinus	59.73	2.00e-83	302.00
IUUC-Pfo-096413	Poecilia formosa	61.14	0.00e+00	790.00
IUUC-Pab-098592	Pongo abelii	90.64	0.00e+00	991.00
IUUC-Pca-100449	Procavia capensis	86.54	0.00e+00	1146.00
IUUC-Pva-102868	Pteropus vampyrus	87.45	0.00e+00	1135.00
IUUC-Sha-107337	Sarcophilus harrisii	79.80	0.00e+00	1063.00
IUUC-Sar-113561	Sorex araneus	89.22	2.00e-88	319.00
IUUC-Ssc-115735	Sus scrofa	87.45	0.00e+00	1122.00
IUUC-Tgu-117025	Taeniopygia guttata	71.64	0.00e+00	867.00
IUUC-Tru-117585	Takifugu rubripes	61.67	0.00e+00	764.00
IUUC-Tsy-118814	Tarsius syrichta	90.70	0.00e+00	1191.00
IUUC-Tni-120600	Tetraodon nigroviridis	61.18	0.00e+00	741.00
IUUC-Xtr-132090	Xenopus tropicalis	69.92	0.00e+00	923.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence