iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000025878.16	ENSMUST00000127195.7	ENSMUSP00000122196.1
ENSMUSG00000025878.16	ENSMUST00000148702.7	ENSMUSP00000120935.1
ENSMUSG00000025878.16	ENSMUST00000099496.3	ENSMUSP00000097095.3
ENSMUSG00000025878.16	ENSMUST00000026997.11	ENSMUSP00000026997.5

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	circBase	microRNA	TRANSFAC
RepTar	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UIM	UIM	19015238; 19536136

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UIM	0.00013	22.7	105	123

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UIM

   S: 1    dEdeeLqlAlalSlqEeee 19
           +E+e+L++A+a+Sl+ +++
   Q: 105  KEEELLRKAIAESLNSCWS 123
           69*************9986 PP

Organism

Mus musculus

Functional Description
(View)

Ubiquitin-binding protein. Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19536136). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1 (By similarity).

Protein Sequence
(Fasta)

MPRRKKKIKE ASESQNLEKK DLETSSCVSI KKKRRLEDLL IVISDSDGEE TKEENGLQKT 60
KTKQSNRSKC LAKRKVAHMS EEEQFALALK MSEQEAREVN NQEEKEEELL RKAIAESLNS 120

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Nucleotide Sequence
(Fasta)

CTGCCGCCTC GCGCCGCCGC GCGGGCTCTC CTCTTTCTAA AGAGTTGCGG CCGCTCGCGA 60
CCCCCAGCGT TCAGGAGGCG CTGGGCGGCG CTGCCAGATC CGCGGTGAGT ACGCGTCGCC 120

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Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation

Interpro

IPR003903--UIM_dom

PROSITE

PS50330--UIM

SMART

SM00726--UIM

Gene Ontology

GO:0070531--C:BRCA1-A complex
GO:0016604--C:nuclear body
GO:0005634--C:nucleus
GO:0042393--F:histone binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:0046965--F:retinoid X receptor binding
GO:0006302--P:double-strand break repair
GO:0031572--P:G2 DNA damage checkpoint
GO:0070537--P:histone H2A K63-linked deubiquitination
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045739--P:positive regulation of DNA repair
GO:0010212--P:response to ionizing radiation
GO:0006351--P:transcription, DNA-templated

KEGG

mmu:20184

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002335	Ailuropoda melanoleuca	75.34	0.00e+00	946.00
IUUC-Apl-003971	Anas platyrhynchos	42.62	6.00e-89	321.00
IUUC-Aca-004239	Anolis carolinensis	38.58	3.00e-94	339.00
IUUC-Ame-011593	Astyanax mexicanus	61.40	5.00e-18	86.70
IUUC-Bta-012883	Bos taurus	74.39	0.00e+00	1025.00
IUUC-Cja-018904	Callithrix jacchus	73.00	0.00e+00	847.00
IUUC-Cfa-021279	Canis familiaris	76.47	0.00e+00	1041.00
IUUC-Cpo-021857	Cavia porcellus	74.76	0.00e+00	1007.00
IUUC-Csa-023278	Chlorocebus sabaeus	74.51	0.00e+00	969.00
IUUC-Cho-025002	Choloepus hoffmanni	81.51	3.00e-111	395.00
IUUC-Dre-028822	Danio rerio	61.40	7.00e-20	92.80
IUUC-Dno-029930	Dasypus novemcinctus	74.93	0.00e+00	967.00
IUUC-Dor-031008	Dipodomys ordii	68.72	3.00e-162	565.00
IUUC-Ete-032370	Echinops telfairi	65.60	0.00e+00	835.00
IUUC-Eca-033353	Equus caballus	78.94	0.00e+00	780.00
IUUC-Eeu-034724	Erinaceus europaeus	60.80	0.00e+00	693.00
IUUC-Fca-035721	Felis catus	74.20	0.00e+00	999.00
IUUC-Fal-036888	Ficedula albicollis	39.63	2.00e-97	350.00
IUUC-Gga-040932	Gallus gallus	42.62	5.00e-58	219.00
IUUC-Ggo-045465	Gorilla gorilla	75.24	0.00e+00	978.00
IUUC-Hsa-045760	Homo sapiens	75.49	0.00e+00	986.00
IUUC-Itr-048407	Ictidomys tridecemlineatus	85.03	9.00e-157	546.00
IUUC-Lch-050225	Latimeria chalumnae	39.19	1.00e-73	271.00
IUUC-Loc-052879	Lepisosteus oculatus	28.92	5.00e-39	155.00
IUUC-Laf-053871	Loxodonta africana	72.38	0.00e+00	906.00
IUUC-Mcc-055478	Macaca mulatta	74.65	0.00e+00	971.00
IUUC-Meu-056617	Macropus eugenii	45.05	8.00e-115	407.00
IUUC-Mtr-057799	Medicago truncatula	41.30	8.40e-02	33.10
IUUC-Mga-059771	Meleagris gallopavo	41.23	7.00e-84	305.00
IUUC-Mmr-061450	Microcebus murinus	75.21	0.00e+00	979.00
IUUC-Mdo-061927	Monodelphis domestica	50.07	3.00e-169	588.00
IUUC-Mpu-065921	Mustela putorius furo	75.79	0.00e+00	920.00
IUUC-Mlu-067296	Myotis lucifugus	73.78	0.00e+00	937.00
IUUC-Nle-069257	Nomascus leucogenys	74.51	0.00e+00	964.00
IUUC-Opr-071016	Ochotona princeps	67.53	0.00e+00	830.00
IUUC-Ont-071282	Oreochromis niloticus	32.46	1.00e-22	101.00
IUUC-Ocu-074580	Oryctolagus cuniculus	75.46	0.00e+00	1014.00
IUUC-Oga-088521	Otolemur garnettii	75.27	0.00e+00	988.00
IUUC-Ptr-091227	Pan troglodytes	75.56	0.00e+00	978.00
IUUC-Pan-092193	Papio anubis	71.18	0.00e+00	948.00
IUUC-Pfo-096691	Poecilia formosa	62.50	4.00e-19	90.10
IUUC-Pab-098460	Pongo abelii	73.67	0.00e+00	965.00
IUUC-Pca-100892	Procavia capensis	63.95	0.00e+00	840.00
IUUC-Pva-102816	Pteropus vampyrus	73.61	0.00e+00	875.00
IUUC-Pgr-103571	Puccinia graminis	25.60	7.00e-04	38.50
IUUC-Rno-105049	Rattus norvegicus	84.59	0.00e+00	1180.00
IUUC-Sha-106502	Sarcophilus harrisii	48.79	2.00e-132	466.00
IUUC-Sar-113108	Sorex araneus	60.52	3.00e-137	482.00
IUUC-Ssc-115306	Sus scrofa	76.05	0.00e+00	983.00
IUUC-Tgu-116746	Taeniopygia guttata	43.96	2.00e-89	323.00
IUUC-Tsy-119018	Tarsius syrichta	55.36	3.00e-140	492.00
IUUC-Tbe-127389	Tupaia belangeri	77.41	4.00e-178	618.00
IUUC-Ttr-128880	Tursiops truncatus	66.57	3.00e-111	395.00
IUUC-Xtr-132854	Xenopus tropicalis	33.33	2.00e-67	249.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence