iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gac-042211

UUCD1 version

UUC-GaA-00092

Ensembl Protein ID

ENSGACP00000002420.1

UniProt Accession

G3NAS4; G3NAS4_GASAC

Protein Name

E3 ubiquitin-protein ligase

Gene Name

wwp1; WWP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGACG00000001862.1	ENSGACT00000002428.1	ENSGACP00000002420.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.10e-132	443.0	605	937

Active Site

Position(s)	Description	Evidence
906	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f+gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl++F f+Gr++++al++g+++d+
   Q: 605  PYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKSNYCLQINPASAI-NPDHLSYFCFIGRFIAMALFHGKFIDT 692
           6799*******************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+kkl l+dle++d+e+y+sl +i++n   +iee++l++ fsv+ eilg++++++Lkp+G n+ Vt+eNkeeY++l++e
   Q: 693  GFSLPFYKRMLNKKLILKDLESIDSEFYNSLIWIRDN---NIEECSLEMYFSVDMEILGKITSHDLKPDGTNVLVTEENKEEYISLMAE 778
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +g++ q++af +Gfnev+pl++l++F+e+ele+++cG++e+d++d++++t y++ yt++s++i+wFw+ ++e+++e r +++qFv
   Q: 779  WRFSRGVEGQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLQDWQRNTVYRH-YTRNSKQIIWFWQLVKEVDNEVRLRLMQFV 866
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlPlgGfael+    p++f+i+k ++d++lP+s+TCfn+L+LP+Y+s ++lkekLl+Aieet+gF++
   Q: 867  TGTCRLPLGGFAELMgsngPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSFDQLKEKLLFAIEETEGFGQ 937
           *********************************************************************96 PP

Organism

Gasterosteus aculeatus

Protein Sequence
(Fasta)

MATAPSRAES SHNHRGSSQL HAIVSCAKIK RKKNRFVTAI YVEVTADGES RRTTKSHSSS 60
SPKWDETLTL NVTPHTQVDF KVWSHNTLKA DTLMGKATLD LIQALEQHDR KLENVKEVLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCACGG CTCCTTCCAG AGCCGAGTCC AGCCATAACC ACAGAGGATC ATCACAGCTC 60
CATGCCATCG GTGAGTGACG GCACACTAGG CTATAATGCA CGAGAGTGGC AGTTCGCCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001213	Ailuropoda melanoleuca	71.14	0.00e+00	1314.00
IUUC-Apl-003310	Anas platyrhynchos	92.32	0.00e+00	1153.00
IUUC-Aca-005388	Anolis carolinensis	71.26	0.00e+00	1294.00
IUUC-Bta-012857	Bos taurus	71.13	0.00e+00	1302.00
IUUC-Cel-018299	Caenorhabditis elegans	67.94	0.00e+00	847.00
IUUC-Cja-019448	Callithrix jacchus	71.19	0.00e+00	1323.00
IUUC-Cfa-020728	Canis familiaris	71.29	0.00e+00	1322.00
IUUC-Cpo-021635	Cavia porcellus	69.00	0.00e+00	1294.00
IUUC-Csa-023805	Chlorocebus sabaeus	90.56	0.00e+00	1122.00
IUUC-Cin-025212	Ciona intestinalis	72.71	0.00e+00	905.00
IUUC-Csv-026256	Ciona savignyi	71.97	0.00e+00	899.00
IUUC-Dre-028245	Danio rerio	95.23	0.00e+00	1197.00
IUUC-Dno-029618	Dasypus novemcinctus	72.54	0.00e+00	1320.00
IUUC-Dme-032041	Drosophila melanogaster	71.07	0.00e+00	895.00
IUUC-Ete-032779	Echinops telfairi	88.91	0.00e+00	1055.00
IUUC-Eca-033313	Equus caballus	90.52	0.00e+00	1128.00
IUUC-Eeu-035259	Erinaceus europaeus	64.53	0.00e+00	1139.00
IUUC-Fca-035420	Felis catus	70.40	0.00e+00	1319.00
IUUC-Fal-037335	Ficedula albicollis	71.66	0.00e+00	1340.00
IUUC-Gmo-039172	Gadus morhua	90.48	0.00e+00	1092.00
IUUC-Gga-040246	Gallus gallus	93.30	0.00e+00	1154.00
IUUC-Ggo-045001	Gorilla gorilla	71.31	0.00e+00	1174.00
IUUC-Hsa-046544	Homo sapiens	70.56	0.00e+00	1317.00
IUUC-Itr-048860	Ictidomys tridecemlineatus	91.94	0.00e+00	1134.00
IUUC-Lch-050398	Latimeria chalumnae	93.34	0.00e+00	1159.00
IUUC-Loc-052116	Lepisosteus oculatus	95.43	0.00e+00	1202.00
IUUC-Laf-053551	Loxodonta africana	91.48	0.00e+00	1137.00
IUUC-Mla-058996	Melampsora laricipopulina	44.75	3.00e-150	526.00
IUUC-Mga-059986	Meleagris gallopavo	72.16	0.00e+00	1345.00
IUUC-Mmr-060945	Microcebus murinus	68.95	0.00e+00	1248.00
IUUC-Mdo-063024	Monodelphis domestica	91.86	0.00e+00	1081.00
IUUC-Mmu-063202	Mus musculus	92.52	0.00e+00	1126.00
IUUC-Mpu-065773	Mustela putorius furo	71.85	0.00e+00	1317.00
IUUC-Nle-069188	Nomascus leucogenys	72.12	0.00e+00	1324.00
IUUC-Opr-070965	Ochotona princeps	91.25	0.00e+00	1111.00
IUUC-Ont-072226	Oreochromis niloticus	85.28	0.00e+00	1596.00
IUUC-Oan-073497	Ornithorhynchus anatinus	72.64	0.00e+00	1330.00
IUUC-Ocu-073891	Oryctolagus cuniculus	85.30	0.00e+00	1040.00
IUUC-Ola-087438	Oryzias latipes	95.78	0.00e+00	1225.00
IUUC-Oga-087922	Otolemur garnettii	71.22	0.00e+00	1315.00
IUUC-Oar-089317	Ovis aries	90.54	0.00e+00	1128.00
IUUC-Ptr-090484	Pan troglodytes	70.56	0.00e+00	1316.00
IUUC-Pan-092117	Papio anubis	70.77	0.00e+00	1318.00
IUUC-Psi-093338	Pelodiscus sinensis	72.66	0.00e+00	1360.00
IUUC-Pma-094279	Petromyzon marinus	70.88	0.00e+00	832.00
IUUC-Pfo-096171	Poecilia formosa	97.79	0.00e+00	1239.00
IUUC-Pab-098654	Pongo abelii	87.99	0.00e+00	1083.00
IUUC-Pva-102811	Pteropus vampyrus	90.69	0.00e+00	1125.00
IUUC-Rno-106125	Rattus norvegicus	93.01	0.00e+00	1124.00
IUUC-Sha-107243	Sarcophilus harrisii	91.34	0.00e+00	1134.00
IUUC-Ssc-115368	Sus scrofa	90.39	0.00e+00	1128.00
IUUC-Tgu-117079	Taeniopygia guttata	71.22	0.00e+00	1325.00
IUUC-Tru-118062	Takifugu rubripes	97.79	0.00e+00	1238.00
IUUC-Tsy-119507	Tarsius syrichta	66.25	0.00e+00	1196.00
IUUC-Tni-120151	Tetraodon nigroviridis	97.45	0.00e+00	1221.00
IUUC-Xtr-132877	Xenopus tropicalis	78.88	0.00e+00	967.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence