iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074409

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAGW02024906

Gene Name

NEDD4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000006856.3	ENSOCUT00000006858.3	ENSOCUP00000005929.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.20e-135	450.9	983	1312

Active Site

Position(s)	Description	Evidence
1282	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
            lk+rl++ef gE+gld+gGv+re+++l+ske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 983  FLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDG 1069
           5899*********************************************************************************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           ++ ++fyk++l+k+++l+d+e+vd+e+y+sl +i+en   d +e  ldl+f ++ee++g+t+++eLk gG++i Vtn+Nk+eY+ lv
   Q: 1070 FFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILEN---DPTE--LDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLV 1151
           ***********************************99...6666..7**************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           +++r+ ++i++q++af+eGf e+ip++l+++F+e+elell+cG  ++dv+d++++tkyk+gy++++++iqwFw+++ +++se+r ++
   Q: 1152 IQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSSSHQVIQWFWKAVLMMDSEKRIRL 1238
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           LqFvTg+sr+P++Gfael     p++f++++++++++lP+++TCfn+L+LP+Y+s e+l +kL++Aie+t+gF+
   Q: 1239 LQFVTGTSRVPMNGFAELYgsngPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFD 1312
           *************************************************************************8 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MAQSLRLHFA ARRSNTYPLS ETSGDDLDSH VHMCFKKPTR ISASNVVQMK LTPRQTALAP 60
LIKESVKAQE RSSVPASENV NKKSSCLQIS LQPTRYSGCL PSCSVLADGD DVSSFARVLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCTTAACAT GTTTGGAAAT GAGAACAAAT GGCACAAAGC TTACGATTGC ACTTTGCAGC 60
CAGAAGAAGT AATACTTACC CTTTGTCAGA GACCTCCGGA GATGATTTGG ATAGCCATGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0000785--C:chromatin
GO:0005829--C:cytosol
GO:0043197--C:dendritic spine
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0019871--F:sodium channel inhibitor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0002250--P:adaptive immune response
GO:0048514--P:blood vessel morphogenesis
GO:0044111--P:development involved in symbiotic interaction
GO:0003197--P:endocardial cushion development
GO:0042921--P:glucocorticoid receptor signaling pathway
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:0010768--P:negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0030948--P:negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0007528--P:neuromuscular junction development
GO:0031175--P:neuron projection development
GO:0003151--P:outflow tract morphogenesis
GO:0046824--P:positive regulation of nucleocytoplasmic transport
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0045732--P:positive regulation of protein catabolic process
GO:0050847--P:progesterone receptor signaling pathway
GO:0006513--P:protein monoubiquitination
GO:0006622--P:protein targeting to lysosome
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0031623--P:receptor internalization
GO:0048814--P:regulation of dendrite morphogenesis
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity
GO:0050807--P:regulation of synapse organization
GO:0042110--P:T cell activation
GO:0019089--P:transmission of virus
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

KEGG

ocu:100009418

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001201	Ailuropoda melanoleuca	87.02	0.00e+00	2253.00
IUUC-Apl-003886	Anas platyrhynchos	74.68	0.00e+00	1251.00
IUUC-Ame-011138	Astyanax mexicanus	83.54	0.00e+00	854.00
IUUC-Bta-012453	Bos taurus	86.26	0.00e+00	2204.00
IUUC-Bci-013785	Botrytis cinerea	47.42	9.00e-160	557.00
IUUC-Cja-019034	Callithrix jacchus	91.32	0.00e+00	1395.00
IUUC-Cfa-020258	Canis familiaris	87.62	0.00e+00	2204.00
IUUC-Cpo-021648	Cavia porcellus	90.05	0.00e+00	1477.00
IUUC-Csa-023334	Chlorocebus sabaeus	93.16	0.00e+00	1483.00
IUUC-Cho-024672	Choloepus hoffmanni	78.53	0.00e+00	652.00
IUUC-Cin-025157	Ciona intestinalis	56.26	0.00e+00	884.00
IUUC-Dre-027924	Danio rerio	67.82	0.00e+00	909.00
IUUC-Dno-029159	Dasypus novemcinctus	87.96	0.00e+00	1308.00
IUUC-Dor-030729	Dipodomys ordii	78.11	0.00e+00	1019.00
IUUC-Ete-032409	Echinops telfairi	84.72	0.00e+00	1178.00
IUUC-Eca-033441	Equus caballus	93.66	0.00e+00	1429.00
IUUC-Eeu-034546	Erinaceus europaeus	74.07	0.00e+00	1177.00
IUUC-Fca-036384	Felis catus	87.42	0.00e+00	2243.00
IUUC-Fal-037547	Ficedula albicollis	80.65	0.00e+00	1306.00
IUUC-Gga-040524	Gallus gallus	81.27	0.00e+00	1306.00
IUUC-Hsa-046479	Homo sapiens	89.02	0.00e+00	2287.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	81.96	0.00e+00	1206.00
IUUC-Lch-050445	Latimeria chalumnae	59.40	0.00e+00	1459.00
IUUC-Loc-052645	Lepisosteus oculatus	73.47	0.00e+00	1203.00
IUUC-Lma-052980	Leptosphaeria maculans	45.87	4.00e-91	328.00
IUUC-Laf-053638	Loxodonta africana	84.06	0.00e+00	1350.00
IUUC-Mcc-055585	Macaca mulatta	89.48	0.00e+00	2269.00
IUUC-Meu-056897	Macropus eugenii	95.82	4.00e-172	598.00
IUUC-Mga-059362	Meleagris gallopavo	74.86	0.00e+00	1273.00
IUUC-Mvi-060395	Microbotryum violaceum	54.02	5.00e-151	528.00
IUUC-Mmr-061061	Microcebus murinus	88.95	0.00e+00	2285.00
IUUC-Mmu-063318	Mus musculus	80.22	0.00e+00	1281.00
IUUC-Mpu-066567	Mustela putorius furo	92.69	0.00e+00	1508.00
IUUC-Mlu-068148	Myotis lucifugus	86.42	0.00e+00	2200.00
IUUC-Nle-069225	Nomascus leucogenys	88.72	0.00e+00	2275.00
IUUC-Oan-073019	Ornithorhynchus anatinus	84.60	0.00e+00	1370.00
IUUC-Oga-088241	Otolemur garnettii	83.82	0.00e+00	2043.00
IUUC-Oar-089797	Ovis aries	93.91	0.00e+00	1497.00
IUUC-Ptr-091629	Pan troglodytes	91.46	0.00e+00	1362.00
IUUC-Psi-093618	Pelodiscus sinensis	67.00	0.00e+00	1618.00
IUUC-Pno-095118	Phaeosphaeria nodorum	48.20	6.00e-163	568.00
IUUC-Pab-098394	Pongo abelii	93.03	0.00e+00	1489.00
IUUC-Pca-100568	Procavia capensis	77.63	0.00e+00	1151.00
IUUC-Pva-102303	Pteropus vampyrus	77.29	0.00e+00	1718.00
IUUC-Rno-106095	Rattus norvegicus	79.04	0.00e+00	1276.00
IUUC-Sha-107370	Sarcophilus harrisii	65.31	0.00e+00	1708.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	50.81	2.00e-156	545.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	47.50	2.00e-160	559.00
IUUC-Sre-114929	Sporisorium reilianum	47.35	4.00e-156	545.00
IUUC-Tgu-117474	Taeniopygia guttata	81.02	0.00e+00	1311.00
IUUC-Tru-117675	Takifugu rubripes	81.33	0.00e+00	845.00
IUUC-Tbe-127408	Tupaia belangeri	86.38	0.00e+00	1163.00
IUUC-Ttr-128437	Tursiops truncatus	83.83	0.00e+00	1169.00
IUUC-Vpa-130503	Vicugna pacos	88.74	0.00e+00	1301.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence