iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089567

Ensembl Protein ID

ENSOARP00000004966.1

UniProt Accession

W5P3G6; W5P3G6_SHEEP

Genbank Protein ID

ENSOARP00000004966

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01100069

Gene Name

KLHL8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000004639.1	ENSOART00000005051.1	ENSOARP00000004966.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	2.10e-15	57.0	64	129
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	7.40e-09	34.8	163	194

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           +Dv+l+vg + +++hk+ La   ++F+a+fl+e+ e k +   ei+d + +++++l+kF+Y+++l++
   Q: 64   CDVTLKVGSKLISCHKLALACVIPYFKAMFLSEMAEAK-QTLNEIRDFDGDAVEDLVKFVYSSRLTL 129
           9************************************9.999**********************986 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           ++Ncl++++fA+ ++  dL+d a+ +++ hF+
   Q: 163  PSNCLAVRAFAESHNRIDLMDMADQYACEHFT 194
           89*****************************7 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MASEAVNAKQ ARNRFTKGKR QQQIKNRSSL GDGDGEDSFL FEANEAWKDF HGSLLQFYEN 60
GELCDVTLKV GSKLISCHKL ALACVIPYFK AMFLSEMAEA KQTLNEIRDF DGDAVEDLVK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTGCGGCGG GGGGGCTGGC GTTGGGGGGA GGCTGTGGGG GGGGGGGGGG GTGGGTCGAA 60
GAGTGCCTCT GAGTTTGAGA GCAGAAACTG CAGCCTCTTT CAAAACACGC CTCTGCTCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030605--KLHL8
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005654--C:nucleoplasm
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001443	Ailuropoda melanoleuca	95.80	0.00e+00	1204.00
IUUC-Apl-003978	Anas platyrhynchos	88.33	0.00e+00	1132.00
IUUC-Aca-004958	Anolis carolinensis	85.44	0.00e+00	1071.00
IUUC-Ame-011139	Astyanax mexicanus	83.14	0.00e+00	1051.00
IUUC-Bta-013142	Bos taurus	98.38	0.00e+00	1234.00
IUUC-Cel-018551	Caenorhabditis elegans	39.41	3.00e-125	442.00
IUUC-Cja-019650	Callithrix jacchus	94.35	0.00e+00	1217.00
IUUC-Cfa-021046	Canis familiaris	96.28	0.00e+00	1209.00
IUUC-Cpo-022445	Cavia porcellus	93.21	0.00e+00	1144.00
IUUC-Csa-023642	Chlorocebus sabaeus	95.32	0.00e+00	1228.00
IUUC-Cho-025012	Choloepus hoffmanni	77.99	0.00e+00	863.00
IUUC-Dre-027723	Danio rerio	80.94	0.00e+00	1035.00
IUUC-Dno-028964	Dasypus novemcinctus	93.92	0.00e+00	998.00
IUUC-Dor-030899	Dipodomys ordii	82.12	8.00e-131	460.00
IUUC-Ete-032815	Echinops telfairi	92.25	0.00e+00	1184.00
IUUC-Eca-034162	Equus caballus	95.15	0.00e+00	1179.00
IUUC-Eeu-034660	Erinaceus europaeus	93.53	0.00e+00	1176.00
IUUC-Fca-035659	Felis catus	96.12	0.00e+00	1209.00
IUUC-Fal-037619	Ficedula albicollis	88.98	0.00e+00	1145.00
IUUC-Gmo-038546	Gadus morhua	83.90	0.00e+00	1035.00
IUUC-Gga-040770	Gallus gallus	88.83	0.00e+00	1109.00
IUUC-Gac-042557	Gasterosteus aculeatus	79.77	0.00e+00	1014.00
IUUC-Ggo-044741	Gorilla gorilla	95.00	0.00e+00	1226.00
IUUC-Hsa-046025	Homo sapiens	94.84	0.00e+00	1224.00
IUUC-Itr-048541	Ictidomys tridecemlineatus	96.54	0.00e+00	1081.00
IUUC-Loc-052834	Lepisosteus oculatus	82.66	0.00e+00	992.00
IUUC-Laf-054513	Loxodonta africana	95.15	0.00e+00	1199.00
IUUC-Mcc-054707	Macaca mulatta	95.16	0.00e+00	1223.00
IUUC-Meu-056779	Macropus eugenii	88.26	0.00e+00	1132.00
IUUC-Mga-059676	Meleagris gallopavo	88.67	0.00e+00	1108.00
IUUC-Mmr-061359	Microcebus murinus	94.03	0.00e+00	1177.00
IUUC-Mdo-062527	Monodelphis domestica	87.64	0.00e+00	1126.00
IUUC-Mmu-063112	Mus musculus	91.10	0.00e+00	1186.00
IUUC-Mac-064682	Musa acuminata	36.36	5.00e-40	159.00
IUUC-Mpu-065800	Mustela putorius furo	95.32	0.00e+00	1199.00
IUUC-Mlu-067536	Myotis lucifugus	93.65	0.00e+00	1139.00
IUUC-Nle-069397	Nomascus leucogenys	95.00	0.00e+00	1224.00
IUUC-Opr-070599	Ochotona princeps	93.54	0.00e+00	989.00
IUUC-Ont-072580	Oreochromis niloticus	79.74	0.00e+00	1032.00
IUUC-Oan-073180	Ornithorhynchus anatinus	89.35	0.00e+00	1138.00
IUUC-Ocu-074026	Oryctolagus cuniculus	95.15	0.00e+00	1182.00
IUUC-Ola-086776	Oryzias latipes	79.58	0.00e+00	996.00
IUUC-Oga-088651	Otolemur garnettii	94.69	0.00e+00	1189.00
IUUC-Ptr-091564	Pan troglodytes	95.00	0.00e+00	1226.00
IUUC-Pan-092578	Papio anubis	95.32	0.00e+00	1228.00
IUUC-Psi-093635	Pelodiscus sinensis	88.22	0.00e+00	1078.00
IUUC-Pma-094660	Petromyzon marinus	61.30	0.00e+00	740.00
IUUC-Pfo-097507	Poecilia formosa	79.07	0.00e+00	961.00
IUUC-Pab-098025	Pongo abelii	95.00	0.00e+00	1226.00
IUUC-Pca-101046	Procavia capensis	86.58	1.00e-177	616.00
IUUC-Ppe-101154	Prunus persica	32.68	2.00e-36	147.00
IUUC-Pva-102359	Pteropus vampyrus	95.68	0.00e+00	877.00
IUUC-Rno-105750	Rattus norvegicus	91.63	0.00e+00	1169.00
IUUC-Sha-107513	Sarcophilus harrisii	90.65	0.00e+00	1163.00
IUUC-Stu-112032	Solanum tuberosum	33.46	2.00e-40	160.00
IUUC-Sar-113616	Sorex araneus	69.28	4.00e-115	408.00
IUUC-Ssc-116205	Sus scrofa	95.70	0.00e+00	1013.00
IUUC-Tgu-117435	Taeniopygia guttata	88.83	0.00e+00	1134.00
IUUC-Tru-118709	Takifugu rubripes	80.43	0.00e+00	1028.00
IUUC-Tsy-119466	Tarsius syrichta	97.26	0.00e+00	1082.00
IUUC-Tni-119988	Tetraodon nigroviridis	80.30	0.00e+00	1020.00
IUUC-Tbe-127704	Tupaia belangeri	94.89	0.00e+00	1038.00
IUUC-Ttr-128892	Tursiops truncatus	97.19	0.00e+00	906.00
IUUC-Vpa-130545	Vicugna pacos	95.89	0.00e+00	1015.00
IUUC-Xtr-132289	Xenopus tropicalis	82.56	0.00e+00	1005.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence