iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	1.90e-08	34.9	30	105
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	5.30e-08	32.1	138	168

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalf......lmele.esksklmveikdvqpevfrallkFlYtgkldene 69
           +D  lv++gee++++k +Laa+S+ F          + + + +  s+ ++e+++++ + +r++l+++ +g++++ne
   Q: 30   CDAHLVLDGEEIPVQKNILAAASPHFTFFPflrtklNYNPPkDDGSTYKIELEGISVTIMREILDYIFSGQIRLNE 105
           8999*******************9885321232322333332445566666667*******************997 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 2    eNclgilrfAdlydcpdLkdaaldfilkhFk 32
           eNc+gi++fA +y++++++  a +++++hF+
   Q: 138  ENCIGIRDFALHYCLHHVHYLATEYLETHFR 168
           9*****************************7 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MAEGSAVSDP QHAARLLRAL SSFREEARFC DAHLVLDGEE IPVQKNILAA ASPHFTFFPF 60
LRTKLNYNPP KDDGSTYKIE LEGISVTIMR EILDYIFSGQ IRLNEDTIQD VVQAADLLLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGGGACGCG CGCGGGATTC GGGCAAGCGG GCGGGCGGGC GGGCGGGCGG GTCGGTGGCG 60
GCGGAGGAGC GGGAGGCGCG ATGGCCGAGG GCAGCGCTGT GTCCGACCCT CAGCACGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030579--KLHL16
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0007010--P:cytoskeleton organization
GO:0016567--P:protein ubiquitination

KEGG

rno:307893

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002164	Ailuropoda melanoleuca	97.61	0.00e+00	1070.00
IUUC-Apl-004132	Anas platyrhynchos	92.08	0.00e+00	1013.00
IUUC-Aca-005264	Anolis carolinensis	89.35	0.00e+00	1083.00
IUUC-Ame-011222	Astyanax mexicanus	68.50	0.00e+00	694.00
IUUC-Bta-012855	Bos taurus	96.02	0.00e+00	1156.00
IUUC-Bol-015268	Brassica oleracea	26.05	7.00e-08	52.00
IUUC-Cja-019865	Callithrix jacchus	96.52	0.00e+00	1160.00
IUUC-Cfa-020864	Canis familiaris	96.52	0.00e+00	1165.00
IUUC-Cpo-021500	Cavia porcellus	96.19	0.00e+00	1157.00
IUUC-Csa-023114	Chlorocebus sabaeus	96.85	0.00e+00	1168.00
IUUC-Cho-024996	Choloepus hoffmanni	97.23	0.00e+00	1052.00
IUUC-Dre-028758	Danio rerio	67.39	2.00e-178	618.00
IUUC-Dno-029380	Dasypus novemcinctus	96.15	0.00e+00	1146.00
IUUC-Dor-030704	Dipodomys ordii	97.93	0.00e+00	771.00
IUUC-Ete-032632	Echinops telfairi	95.69	0.00e+00	1149.00
IUUC-Eca-034092	Equus caballus	97.61	0.00e+00	1066.00
IUUC-Eeu-034482	Erinaceus europaeus	90.58	0.00e+00	1069.00
IUUC-Fca-035706	Felis catus	97.80	0.00e+00	1066.00
IUUC-Fal-037414	Ficedula albicollis	91.84	0.00e+00	956.00
IUUC-Gmo-039716	Gadus morhua	67.00	0.00e+00	848.00
IUUC-Gga-040801	Gallus gallus	90.55	0.00e+00	1100.00
IUUC-Gac-042023	Gasterosteus aculeatus	66.94	0.00e+00	856.00
IUUC-Ggo-045209	Gorilla gorilla	98.17	0.00e+00	1073.00
IUUC-Hsa-046018	Homo sapiens	96.85	0.00e+00	1168.00
IUUC-Itr-048003	Ictidomys tridecemlineatus	97.76	0.00e+00	894.00
IUUC-Lch-050253	Latimeria chalumnae	81.20	0.00e+00	983.00
IUUC-Loc-052224	Lepisosteus oculatus	79.03	0.00e+00	959.00
IUUC-Laf-054497	Loxodonta africana	95.17	0.00e+00	1144.00
IUUC-Mcc-055363	Macaca mulatta	96.85	0.00e+00	1168.00
IUUC-Meu-056415	Macropus eugenii	86.24	0.00e+00	1019.00
IUUC-Mga-059506	Meleagris gallopavo	92.08	0.00e+00	1011.00
IUUC-Mmr-060695	Microcebus murinus	96.35	0.00e+00	1162.00
IUUC-Mdo-062539	Monodelphis domestica	93.70	0.00e+00	1134.00
IUUC-Mmu-063833	Mus musculus	98.18	0.00e+00	1177.00
IUUC-Mpu-066163	Mustela putorius furo	96.19	0.00e+00	1159.00
IUUC-Mlu-067351	Myotis lucifugus	97.01	0.00e+00	1168.00
IUUC-Nle-069432	Nomascus leucogenys	96.68	0.00e+00	1166.00
IUUC-Opr-070941	Ochotona princeps	87.43	0.00e+00	919.00
IUUC-Ont-072620	Oreochromis niloticus	68.67	0.00e+00	880.00
IUUC-Oan-073408	Ornithorhynchus anatinus	93.84	1.00e-147	515.00
IUUC-Ocu-074067	Oryctolagus cuniculus	96.35	0.00e+00	1159.00
IUUC-Ola-087263	Oryzias latipes	66.83	0.00e+00	848.00
IUUC-Oga-088387	Otolemur garnettii	96.04	0.00e+00	1159.00
IUUC-Oar-089890	Ovis aries	97.07	0.00e+00	1054.00
IUUC-Ptr-090867	Pan troglodytes	98.15	0.00e+00	1064.00
IUUC-Pan-092790	Papio anubis	98.17	0.00e+00	1073.00
IUUC-Psi-093381	Pelodiscus sinensis	92.23	0.00e+00	923.00
IUUC-Pma-094681	Petromyzon marinus	67.26	2.00e-157	548.00
IUUC-Ppa-095543	Physcomitrella patens	27.81	4.00e-15	75.90
IUUC-Pfo-096446	Poecilia formosa	67.00	0.00e+00	867.00
IUUC-Pab-097839	Pongo abelii	96.85	0.00e+00	1169.00
IUUC-Pca-101042	Procavia capensis	77.66	5.00e-117	414.00
IUUC-Pva-102911	Pteropus vampyrus	96.52	0.00e+00	1162.00
IUUC-Sha-107321	Sarcophilus harrisii	92.21	0.00e+00	1146.00
IUUC-Sar-113417	Sorex araneus	87.62	0.00e+00	919.00
IUUC-Ssc-115450	Sus scrofa	96.19	0.00e+00	1162.00
IUUC-Tgu-117089	Taeniopygia guttata	90.33	0.00e+00	1082.00
IUUC-Tru-118452	Takifugu rubripes	64.32	0.00e+00	815.00
IUUC-Tsy-119125	Tarsius syrichta	92.54	0.00e+00	884.00
IUUC-Tni-120845	Tetraodon nigroviridis	63.58	0.00e+00	807.00
IUUC-Tbe-127688	Tupaia belangeri	68.24	1.00e-112	399.00
IUUC-Ttr-128621	Tursiops truncatus	95.27	0.00e+00	903.00
IUUC-Vpa-130159	Vicugna pacos	98.70	5.00e-180	624.00
IUUC-Xtr-132635	Xenopus tropicalis	82.85	0.00e+00	994.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence