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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063933
UUCD1 version UUC-MuM-00035
Ensembl Protein ID ENSMUSP00000134380.1
UniProt Accession Q80U04; Q3TH95; Q810E3; Q91W46; Q99KC0; PJA2_MOUSE
Genbank Protein ID AAO85470.1; BAC65564.1; BAE25949.1; BAE40303.1; AAH04742.1; AAH17130.1
Protein Name E3 ubiquitin-protein ligase Praja-2; RING finger protein 131; RING-type E3 ubiquitin transferase Praja-2
Genbank Nucleotide ID AF493070; AK122282; AK144586; AK168371; BC004742; BC017130
Gene Name Pja2; Kiaa0438; Rnf131
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000024083.15 ENSMUST00000172818.7 ENSMUSP00000134380.1
ENSMUSG00000024083.15 ENSMUST00000172733.1 ENSMUSP00000133730.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
PHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 16247473
Classification
Family E-value Score Start End
E3 activity/RING/RING 4.60e-06 28.2 633 674
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC++++  +d    lpC H+fh+ C+  w       +k+ +CP+Cr
   Q: 633  CPICCSEYikDDIATELPCHHFFHKPCVSIW------LQKSGTCPVCR 674
           ******99753324449**************......**********8 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes (By similarity).
 Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes (By similarity).
Protein Sequence
(Fasta)
MSQYTEKEPS VMDQESSKAA WPKPAGGYQT ITGRRYGRRH AYVSFKPCMT RHERSLGRAG 60
DDYEVLELDD VPKENTSGSS SLDQVHPALP NEPTVEKSET EISTCGPALN QSTESSPSIA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063933|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
CGCCGCCGCC GCTGCAGCCG CTGCGCGTTC GGCGGGGGAG GAGTCGGAGG CGGAGAAGAA 60
GGCGGTGGTG GCGGGTGGAG GATCGAGCGC TGTTCTCGCT CTGGAGCCGC TGCACATCTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063933|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0628--Postsynaptic cell membrane
KW-1185--Reference proteome
KW-0770--Synapse
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR030639--Praja-2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0030054--C:cell junction
GO:0005737--C:cytoplasm
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0045111--C:intermediate filament cytoskeleton
GO:0005886--C:plasma membrane
GO:0014069--C:postsynaptic density
GO:0045211--C:postsynaptic membrane
GO:0034236--F:protein kinase A catalytic subunit binding
GO:0034237--F:protein kinase A regulatory subunit binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0035329--P:hippo signaling
GO:0007616--P:long-term memory
GO:0016567--P:protein ubiquitination
GO:0010738--P:regulation of protein kinase A signaling
KEGG mmu:224938
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001388 Ailuropoda melanoleuca 79.21 0.00e+00 1100.00
IUUC-Aca-004858 Anolis carolinensis 45.77 2.00e-144 505.00
IUUC-Ago-007872 Ashbya gossypii 41.54 5.00e-09 53.50
IUUC-Ame-010842 Astyanax mexicanus 60.00 8.00e-63 234.00
IUUC-Bta-013122 Bos taurus 79.18 0.00e+00 1103.00
IUUC-Cja-019345 Callithrix jacchus 76.87 0.00e+00 808.00
IUUC-Cfa-021193 Canis familiaris 82.53 0.00e+00 1099.00
IUUC-Cpo-021991 Cavia porcellus 79.35 0.00e+00 1092.00
IUUC-Csa-024052 Chlorocebus sabaeus 83.73 0.00e+00 1096.00
IUUC-Cho-024680 Choloepus hoffmanni 80.03 0.00e+00 1097.00
IUUC-Dre-027662 Danio rerio 46.15 3.00e-63 236.00
IUUC-Dno-028851 Dasypus novemcinctus 81.14 0.00e+00 1108.00
IUUC-Dor-031005 Dipodomys ordii 76.77 0.00e+00 867.00
IUUC-Ete-032637 Echinops telfairi 66.37 2.00e-121 429.00
IUUC-Eca-034011 Equus caballus 81.05 0.00e+00 920.00
IUUC-Eeu-034596 Erinaceus europaeus 77.37 0.00e+00 998.00
IUUC-Fca-036523 Felis catus 81.36 0.00e+00 1080.00
IUUC-Fal-037255 Ficedula albicollis 40.81 2.00e-108 386.00
IUUC-Gga-040434 Gallus gallus 45.19 2.00e-129 456.00
IUUC-Hsa-046514 Homo sapiens 83.26 0.00e+00 1108.00
IUUC-Itr-047883 Ictidomys tridecemlineatus 82.70 0.00e+00 1087.00
IUUC-Lch-050133 Latimeria chalumnae 32.48 2.00e-48 187.00
IUUC-Loc-051901 Lepisosteus oculatus 39.11 2.00e-106 379.00
IUUC-Laf-054289 Loxodonta africana 80.20 0.00e+00 1067.00
IUUC-Mcc-055552 Macaca mulatta 83.85 0.00e+00 1120.00
IUUC-Meu-056394 Macropus eugenii 74.73 6.00e-108 385.00
IUUC-Mga-059909 Meleagris gallopavo 75.51 2.00e-23 100.00
IUUC-Mmr-060712 Microcebus murinus 80.75 0.00e+00 1048.00
IUUC-Mdo-062457 Monodelphis domestica 54.19 0.00e+00 672.00
IUUC-Mpu-065994 Mustela putorius furo 82.88 0.00e+00 1127.00
IUUC-Mlu-067843 Myotis lucifugus 78.49 0.00e+00 1055.00
IUUC-Nle-069787 Nomascus leucogenys 83.11 0.00e+00 1103.00
IUUC-Opr-071190 Ochotona princeps 67.06 8.00e-118 417.00
IUUC-Oan-072728 Ornithorhynchus anatinus 30.40 4.00e-59 223.00
IUUC-Ocu-074152 Oryctolagus cuniculus 82.99 0.00e+00 1082.00
IUUC-Oga-088608 Otolemur garnettii 81.63 0.00e+00 1080.00
IUUC-Oar-090415 Ovis aries 77.16 0.00e+00 1033.00
IUUC-Ptr-091211 Pan troglodytes 83.11 0.00e+00 1102.00
IUUC-Pan-091698 Papio anubis 78.71 0.00e+00 1023.00
IUUC-Psi-093139 Pelodiscus sinensis 49.78 3.00e-138 485.00
IUUC-Pab-097745 Pongo abelii 82.97 0.00e+00 1102.00
IUUC-Pca-100681 Procavia capensis 74.16 0.00e+00 955.00
IUUC-Pva-102525 Pteropus vampyrus 81.13 0.00e+00 1107.00
IUUC-Rno-105620 Rattus norvegicus 92.08 0.00e+00 1287.00
IUUC-Sce-106223 Saccharomyces cerevisiae 48.89 9.00e-09 53.10
IUUC-Sha-106812 Sarcophilus harrisii 49.75 2.00e-120 426.00
IUUC-Sar-113270 Sorex araneus 84.73 1.00e-162 566.00
IUUC-Ssc-115913 Sus scrofa 72.49 2.00e-178 618.00
IUUC-Tgu-117101 Taeniopygia guttata 58.63 2.00e-68 252.00
IUUC-Tsy-119078 Tarsius syrichta 78.98 0.00e+00 899.00
IUUC-Tbe-127715 Tupaia belangeri 77.49 0.00e+00 1023.00
IUUC-Ttr-129003 Tursiops truncatus 83.12 0.00e+00 1161.00
IUUC-Vpa-130373 Vicugna pacos 83.11 0.00e+00 1120.00
Created Date 25-Jun-2017

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