iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ocu-074830

Ensembl Protein ID

ENSOCUP00000022704.2

UniProt Accession

G1U027; G1U027_RABIT

Protein Name

Uncharacterized protein

Gene Name

VAV1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000022946.2	ENSOCUT00000024643.2	ENSOCUP00000022704.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.40e-13	49.9	724	775

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ yd+ a +  eL+lk+Gd+v+++ +++  +gW++g  e  g+ G fP+n+ve+
   Q: 724  KARYDFCARDRSELSLKEGDIVKIL-NKKGQQGWWRG--EIYGRIGWFPSNYVEE 775
           788**********************.89999******..9*************85 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

FLCLKNIRTF LSTCCEKFGL KRSDLFEAFD LFDVQDFGKV IYTLSALSWT EIAQNKGIMP 60
FPIDEDSMGD EDIYSGLSDQ IDDTVEEDED LYDCVENEEA EGDEIYEDLM RTDPVPTPHK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGGGCTCT GTCACGTGCC ACCCCTGCCC CCCCATACCT GTAAGGGGGG AGCTCTGTCA 60
CATGCCACCC CCTGTCCCCC AACACCTGTA AGGAGGGGGG CTCTGTCACG TGCCGCCCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR000980--SH2
IPR001452--SH3_domain
IPR028530--Vav

PROSITE

PS00741--DH_1
PS50010--DH_2
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF00307--CH
PF00621--RhoGEF
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00109--C1
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005622--C:intracellular
GO:0046872--F:metal ion binding
GO:0030676--F:Rac guanyl-nucleotide exchange factor activity
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0006955--P:immune response
GO:0007229--P:integrin-mediated signaling pathway
GO:0030593--P:neutrophil chemotaxis
GO:0006909--P:phagocytosis
GO:0045785--P:positive regulation of cell adhesion
GO:0045954--P:positive regulation of natural killer cell mediated cytotoxicity
GO:0072593--P:reactive oxygen species metabolic process
GO:0008361--P:regulation of cell size
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction
GO:0030217--P:T cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-013049	Bos taurus	70.75	0.00e+00	1045.00
IUUC-Cja-020009	Callithrix jacchus	78.34	0.00e+00	1188.00
IUUC-Cfa-020768	Canis familiaris	79.75	0.00e+00	1199.00
IUUC-Dno-029602	Dasypus novemcinctus	78.47	0.00e+00	1185.00
IUUC-Eca-033682	Equus caballus	78.85	0.00e+00	1197.00
IUUC-Fca-035629	Felis catus	78.75	0.00e+00	1210.00
IUUC-Hsa-045886	Homo sapiens	78.47	0.00e+00	1187.00
IUUC-Itr-048730	Ictidomys tridecemlineatus	74.43	0.00e+00	1093.00
IUUC-Laf-054537	Loxodonta africana	78.73	0.00e+00	1195.00
IUUC-Mcc-054726	Macaca mulatta	78.60	0.00e+00	1192.00
IUUC-Meu-056449	Macropus eugenii	74.32	9.00e-155	540.00
IUUC-Mmr-060980	Microcebus murinus	78.42	0.00e+00	1189.00
IUUC-Mdo-061926	Monodelphis domestica	71.77	0.00e+00	1068.00
IUUC-Mmu-063942	Mus musculus	77.45	0.00e+00	1174.00
IUUC-Mpu-066000	Mustela putorius furo	79.24	0.00e+00	1193.00
IUUC-Mlu-067818	Myotis lucifugus	78.58	0.00e+00	1170.00
IUUC-Oga-089104	Otolemur garnettii	79.62	0.00e+00	1207.00
IUUC-Oar-089459	Ovis aries	78.63	0.00e+00	1174.00
IUUC-Ptr-090766	Pan troglodytes	78.47	0.00e+00	1189.00
IUUC-Pan-091994	Papio anubis	77.61	0.00e+00	1172.00
IUUC-Pab-098630	Pongo abelii	78.27	0.00e+00	1160.00
IUUC-Pva-102406	Pteropus vampyrus	77.82	0.00e+00	1174.00
IUUC-Rno-105763	Rattus norvegicus	77.20	0.00e+00	1168.00
IUUC-Sha-106683	Sarcophilus harrisii	72.17	0.00e+00	1113.00
IUUC-Sly-111123	Solanum lycopersicum	44.44	2.00e-11	62.80
IUUC-Stu-112434	Solanum tuberosum	44.44	1.00e-11	63.90
IUUC-Sar-113457	Sorex araneus	75.05	0.00e+00	708.00
IUUC-Sbi-113981	Sorghum bicolor	21.01	6.80e-01	29.60
IUUC-Ssc-115338	Sus scrofa	79.77	0.00e+00	1197.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence