iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Rno-105763

Ensembl Protein ID

ENSRNOP00000064264.2

UniProt Accession

M0R4H8; M0R4H8_RAT

Genbank Protein ID

ENSRNOP00000064264

Protein Name

Proto-oncogene vav

Genbank Nucleotide ID

AABR07066495

Gene Name

Vav1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000050430.2	ENSRNOT00000073294.2	ENSRNOP00000064264.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	5.10e-21	74.8	786	837

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ yd+ a +  eL+lk+Gd+++++ +++  +gW++g  e  g+ G fP+n+ve+
   Q: 786  KARYDFCARDRSELSLKEGDIIKIL-NKKGQQGWWRG--EIYGRIGWFPSNYVEE 837
           788**********************.89999******..9*************86 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MELWRQCTHW LIQCRVLPPS HRVTWEGAQV CELAQALRDG VLLCQLLNNL LPHAINLREV 60
NLWPQMSQFL CLKNIRTFLS TCCEKFGLKR SELFEAFDLF DVQDFGKVIY TLSALSWTPI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGCTCT GGCGACAGTG CACCCACTGG CTGATCCAGT GTCGGGTGCT GCCTCCCAGC 60
CACCGTGTGA CCTGGGAGGG GGCCCAGGTG TGTGAGCTGG CACAGGCACT GCGGGATGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR022613--CAMSAP_CH
IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain
IPR003096--SM22_calponin
IPR028530--Vav

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF11971--CAMSAP_CH
PF00621--RhoGEF
PF00017--SH2
PF00018--SH3_1
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00888--SM22CALPONIN

SMART

SM00109--C1
SM00033--CH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005622--C:intracellular
GO:0046872--F:metal ion binding
GO:0030676--F:Rac guanyl-nucleotide exchange factor activity
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0006955--P:immune response
GO:0007229--P:integrin-mediated signaling pathway
GO:0030593--P:neutrophil chemotaxis
GO:0006909--P:phagocytosis
GO:0045785--P:positive regulation of cell adhesion
GO:0045954--P:positive regulation of natural killer cell mediated cytotoxicity
GO:0072593--P:reactive oxygen species metabolic process
GO:0008361--P:regulation of cell size
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction
GO:0030217--P:T cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-013049	Bos taurus	78.75	0.00e+00	1179.00
IUUC-Cja-020009	Callithrix jacchus	89.82	0.00e+00	1513.00
IUUC-Cfa-020768	Canis familiaris	91.24	0.00e+00	1520.00
IUUC-Dno-029602	Dasypus novemcinctus	90.18	0.00e+00	1512.00
IUUC-Eca-033682	Equus caballus	90.65	0.00e+00	1514.00
IUUC-Fca-035629	Felis catus	90.19	0.00e+00	1544.00
IUUC-Gmo-039693	Gadus morhua	58.41	0.00e+00	922.00
IUUC-Gac-041567	Gasterosteus aculeatus	64.08	0.00e+00	979.00
IUUC-Hsa-045886	Homo sapiens	90.06	0.00e+00	1521.00
IUUC-Itr-048730	Ictidomys tridecemlineatus	87.83	0.00e+00	1447.00
IUUC-Loc-051761	Lepisosteus oculatus	69.78	0.00e+00	1145.00
IUUC-Laf-054537	Loxodonta africana	89.82	0.00e+00	1513.00
IUUC-Mcc-054726	Macaca mulatta	89.94	0.00e+00	1519.00
IUUC-Mmr-060980	Microcebus murinus	89.56	0.00e+00	1520.00
IUUC-Mdo-061926	Monodelphis domestica	83.02	0.00e+00	1264.00
IUUC-Mmu-063942	Mus musculus	95.15	0.00e+00	1595.00
IUUC-Mpu-066000	Mustela putorius furo	90.65	0.00e+00	1515.00
IUUC-Mlu-067818	Myotis lucifugus	87.87	0.00e+00	1451.00
IUUC-Ont-072213	Oreochromis niloticus	65.11	0.00e+00	1056.00
IUUC-Ocu-074830	Oryctolagus cuniculus	77.20	0.00e+00	1159.00
IUUC-Ola-087345	Oryzias latipes	61.37	0.00e+00	994.00
IUUC-Oga-089104	Otolemur garnettii	90.65	0.00e+00	1529.00
IUUC-Oar-089459	Ovis aries	89.47	0.00e+00	1493.00
IUUC-Ptr-090766	Pan troglodytes	89.45	0.00e+00	1404.00
IUUC-Pan-091994	Papio anubis	88.89	0.00e+00	1496.00
IUUC-Psi-093595	Pelodiscus sinensis	75.60	0.00e+00	1211.00
IUUC-Pfo-097210	Poecilia formosa	64.16	0.00e+00	1018.00
IUUC-Pab-098630	Pongo abelii	90.11	0.00e+00	1490.00
IUUC-Pva-102406	Pteropus vampyrus	89.35	0.00e+00	1474.00
IUUC-Pte-104123	Pyrenophora teres	49.15	2.00e-10	61.60
IUUC-Pyt-104567	Pyrenophora triticirepentis	53.06	3.00e-10	61.20
IUUC-Sha-106683	Sarcophilus harrisii	82.62	0.00e+00	1418.00
IUUC-Sly-111123	Solanum lycopersicum	51.72	8.00e-10	57.80
IUUC-Stu-112434	Solanum tuberosum	48.57	6.00e-10	58.50
IUUC-Sar-113457	Sorex araneus	75.51	0.00e+00	847.00
IUUC-Ssc-115338	Sus scrofa	90.62	0.00e+00	1417.00
IUUC-Tru-118199	Takifugu rubripes	62.12	0.00e+00	953.00
IUUC-Tni-120548	Tetraodon nigroviridis	62.65	0.00e+00	987.00
IUUC-Vpa-130066	Vicugna pacos	66.44	2.00e-49	191.00
IUUC-Xtr-132410	Xenopus tropicalis	68.98	0.00e+00	1184.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence