iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-092241

Ensembl Protein ID

ENSPANP00000012548.1

UniProt Accession

A0A096NHV0; A0A096NHV0_PAPAN

Genbank Protein ID

ENSPANP00000012548

Protein Name

E3 ubiquitin-protein ligase RNF8; RING finger protein 8; RING-type E3 ubiquitin transferase RNF8

Genbank Nucleotide ID

AHZZ01085408

Gene Name

RNF8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000016475.1	ENSPANT00000013175.1	ENSPANP00000012548.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.40e-07	32.0	404	442

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC e f +  ++l+C H f+  C++ w       ++++ CP+Cr
   Q: 404  CIICSEYFIE-AVTLNCAHSFCSYCINEW------MKRKIECPICR 442
           ********99.899***************......**********8 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

MGEPGFFVTG DRAGGRSWCL RRVGMSAGWL LLEDGREVTV GRGFGVTYQL VSKICPLMIS 60
RNHCVLKQNP EGQWTIMDNK SLNGVWLNRA RLEPLRVYSI HQGDYIQLGV PLENKENAEY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGTCTCTTGC GCAGGCGCAG TGCTCCTGCT TCCTGGCCGA GGGCGGGCGA GCGGAGCCTG 60
CATTCGCAGC GATCGCTAGC GTGTGGTGAT TGCTTCTGTC TGTTGTTTAG ATATGGAAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0779--Telomere
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000253--FHA_dom
IPR017335--RNF8
IPR008984--SMAD_FHA_domain
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50006--FHA_DOMAIN
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00498--FHA

SMART

SM00240--FHA
SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0035861--C:site of double-strand break
GO:0000151--C:ubiquitin ligase complex
GO:0003682--F:chromatin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006302--P:double-strand break repair
GO:0070535--P:histone H2A K63-linked ubiquitination
GO:0034244--P:negative regulation of transcription elongation from RNA polymerase II promoter
GO:0045739--P:positive regulation of DNA repair
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0010212--P:response to ionizing radiation
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002124	Ailuropoda melanoleuca	83.64	0.00e+00	656.00
IUUC-Apl-003664	Anas platyrhynchos	78.89	6.00e-39	152.00
IUUC-Aca-005036	Anolis carolinensis	57.05	2.00e-121	429.00
IUUC-Ame-011537	Astyanax mexicanus	42.23	7.00e-88	317.00
IUUC-Bta-013297	Bos taurus	83.37	0.00e+00	631.00
IUUC-Cel-018658	Caenorhabditis elegans	41.07	1.00e-07	52.40
IUUC-Cja-019201	Callithrix jacchus	89.63	0.00e+00	729.00
IUUC-Cfa-021041	Canis familiaris	84.98	0.00e+00	701.00
IUUC-Csa-024133	Chlorocebus sabaeus	99.38	0.00e+00	868.00
IUUC-Cho-024624	Choloepus hoffmanni	74.63	6.00e-134	470.00
IUUC-Dre-027918	Danio rerio	42.04	5.00e-81	295.00
IUUC-Dno-029774	Dasypus novemcinctus	83.74	0.00e+00	684.00
IUUC-Dor-030190	Dipodomys ordii	71.60	1.00e-149	523.00
IUUC-Ete-032301	Echinops telfairi	66.87	9.00e-141	493.00
IUUC-Eca-033607	Equus caballus	85.78	1.00e-173	602.00
IUUC-Eeu-034888	Erinaceus europaeus	81.91	1.00e-122	432.00
IUUC-Fca-036075	Felis catus	83.54	0.00e+00	706.00
IUUC-Fal-037569	Ficedula albicollis	60.56	3.00e-117	415.00
IUUC-Gmo-038588	Gadus morhua	41.36	7.00e-73	268.00
IUUC-Gga-040777	Gallus gallus	58.39	6.00e-120	424.00
IUUC-Gac-042463	Gasterosteus aculeatus	42.15	4.00e-63	235.00
IUUC-Ggo-045269	Gorilla gorilla	98.15	0.00e+00	861.00
IUUC-Hsa-046249	Homo sapiens	97.12	0.00e+00	833.00
IUUC-Itr-048314	Ictidomys tridecemlineatus	84.19	0.00e+00	702.00
IUUC-Lch-049805	Latimeria chalumnae	50.64	1.00e-113	403.00
IUUC-Loc-052377	Lepisosteus oculatus	48.42	8.00e-92	330.00
IUUC-Mcc-055344	Macaca mulatta	99.38	0.00e+00	872.00
IUUC-Meu-055950	Macropus eugenii	63.09	7.00e-130	457.00
IUUC-Mla-059052	Melampsora laricipopulina	35.38	1.00e-09	56.20
IUUC-Mga-060049	Meleagris gallopavo	57.36	2.00e-117	415.00
IUUC-Mmr-061431	Microcebus murinus	85.51	0.00e+00	666.00
IUUC-Mdo-062016	Monodelphis domestica	67.87	2.00e-124	440.00
IUUC-Mmu-063235	Mus musculus	71.46	2.00e-179	621.00
IUUC-Mpu-066449	Mustela putorius furo	86.24	0.00e+00	736.00
IUUC-Mlu-067588	Myotis lucifugus	79.09	4.00e-179	620.00
IUUC-Nle-069192	Nomascus leucogenys	97.94	0.00e+00	857.00
IUUC-Opr-070300	Ochotona princeps	63.79	8.00e-142	496.00
IUUC-Ont-071998	Oreochromis niloticus	42.34	2.00e-66	246.00
IUUC-Oan-073610	Ornithorhynchus anatinus	66.09	4.00e-67	247.00
IUUC-Ocu-074603	Oryctolagus cuniculus	79.01	0.00e+00	638.00
IUUC-Ola-086681	Oryzias latipes	40.17	9.00e-71	261.00
IUUC-Oga-088183	Otolemur garnettii	85.77	0.00e+00	726.00
IUUC-Oar-090255	Ovis aries	83.71	8.00e-164	569.00
IUUC-Ptr-091029	Pan troglodytes	96.07	0.00e+00	775.00
IUUC-Psi-093506	Pelodiscus sinensis	61.07	2.00e-133	469.00
IUUC-Pma-094579	Petromyzon marinus	56.67	2.00e-26	113.00
IUUC-Pfo-097014	Poecilia formosa	43.53	1.00e-64	240.00
IUUC-Pab-098530	Pongo abelii	96.54	0.00e+00	790.00
IUUC-Pca-100939	Procavia capensis	62.14	2.00e-142	498.00
IUUC-Pva-103148	Pteropus vampyrus	78.19	0.00e+00	639.00
IUUC-Rno-105338	Rattus norvegicus	72.90	0.00e+00	643.00
IUUC-Sce-106282	Saccharomyces cerevisiae	33.71	4.00e-06	46.20
IUUC-Sha-107187	Sarcophilus harrisii	66.42	4.00e-107	381.00
IUUC-Sja-107948	Schizosaccharomyces japonicus	22.34	4.00e-09	55.80
IUUC-Sar-113356	Sorex araneus	64.85	1.00e-127	449.00
IUUC-Ssc-116290	Sus scrofa	84.27	0.00e+00	742.00
IUUC-Tru-117910	Takifugu rubripes	40.43	2.00e-60	226.00
IUUC-Tsy-119329	Tarsius syrichta	79.02	9.00e-168	582.00
IUUC-Tni-120521	Tetraodon nigroviridis	38.94	2.00e-61	229.00
IUUC-Tme-126989	Tuber melanosporum	32.20	5.00e-07	49.70
IUUC-Ttr-128997	Tursiops truncatus	78.62	1.00e-178	619.00
IUUC-Vpa-130154	Vicugna pacos	82.10	0.00e+00	694.00
IUUC-Xtr-132805	Xenopus tropicalis	50.52	2.00e-108	386.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence