iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000009946.6	ENSGALT00000058394.1	ENSGALP00000054062.1
ENSGALG00000009946.6	ENSGALT00000016171.6	ENSGALP00000016152.6

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.30e-123	412.3	2112	2570

Active Site

Position(s)	Description	Evidence
2539	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysen..dketlqpnpdsglknp..................... 65
           ++d+k++levef+gEeg++l G+t+ef+al+++e+q++dlg++l++++  d+e++q++   glk+p                     
   Q: 2112 HADRKSVLEVEFLGEEGTGL-GPTLEFYALVAAEFQRTDLGAWLCDDDfpDDESRQVDIGGGLKPPgyyvqrscglftapfpqdsde 2197
           6899****************.******************************************988********************* PP
   S: 66   ..ehlklFeflGrllgkalqdgrlldlplsksfykll.................................................. 100
             + +klF+flG++l+k++qd+rl+dlp+sk+f+kl+                                                  
   Q: 2198 leRITKLFHFLGIFLAKCIQDNRLVDLPISKPFFKLMcmgdiksnmskliyesrsdrdlhctesqseasteeghdslsvgsleedsk 2284
           *************************************99999999999999999999999999999999999999988888877777 PP
   S: 101  ...............lgkklsledleevdpelykslkeikenaes..................................dieelgld 138
                          ++  l++ed+e ++p+++++lkeik++a +                                  +ie+lgl+
   Q: 2285 sefildppkpkppawFNGILTWEDFELINPHRARFLKEIKDLAIKrrqilsnkslsedekntklqelmlknpsgsgpplSIEDLGLN 2371
           7777777666666666668***********************933445555566777778889999999999*************** PP
   S: 139  ltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeid 225
           ++f++s++++g t+++ LkpgGe++ Vt++N+eeYv+l++++++++gi++q+eafr+Gfn+v+p+e+ls+F++ee+++++cG+   +
   Q: 2372 FQFCPSSKVYGFTAVD-LKPGGEDETVTMDNAEEYVDLMFDFCMHTGIQKQMEAFRDGFNRVFPMEKLSSFSHEEVQMILCGN---Q 2454
           *************999.******************************************************************...6 PP
   S: 226  vedlkket..ky...kggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfn 306
           ++++++e+  +y   k gyt+dsp++ +F++vl+++ss+erkafLqF+Tg+s+lP+gG+a+l+prl+v+rk da+d+++Ps+nTC++
   Q: 2455 SPSWAAEDiiNYtepKLGYTRDSPGFLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRKvDATDASYPSVNTCVH 2541
           666666665555555************************************************************************ PP
   S: 307  yLkLPeYsskeilkekLlyAieetkgFels 336
           yLkLPeYss+ei++e+Ll+A++e kgF+l+
   Q: 2542 YLKLPEYSSEEIMRERLLAATME-KGFHLN 2570
           ***********************.****86 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP RTFLPALCKI 60
FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVDGAIK ALCNRLVVVE LNNRTSRDLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGAAAGCTG CAGGAGCCTG GGGCTGCTGA AGAGAAGAAT TGATCATATT CAACTTTATC 60
TGACTTGAAG AATTAAAGGA TATTATTGGT ACTTTTAAAT TTAAGCAGAG GCGGCTTTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR012919--SUN_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT
PS51416--MIB_HERC2

Pfam

PF12796--Ank_2
PF00632--HECT
PF06701--MIB_HERC2
PF07738--Sad1_UNC

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001987	Ailuropoda melanoleuca	97.43	0.00e+00	2862.00
IUUC-Apl-003493	Anas platyrhynchos	99.17	0.00e+00	2914.00
IUUC-Aca-004521	Anolis carolinensis	97.63	0.00e+00	4521.00
IUUC-Ame-011258	Astyanax mexicanus	91.90	0.00e+00	2401.00
IUUC-Bta-012835	Bos taurus	97.31	0.00e+00	2867.00
IUUC-Cel-018153	Caenorhabditis elegans	52.70	2.00e-173	604.00
IUUC-Cja-019174	Callithrix jacchus	95.77	0.00e+00	2778.00
IUUC-Cfa-021115	Canis familiaris	97.07	0.00e+00	2810.00
IUUC-Cpo-022382	Cavia porcellus	91.14	0.00e+00	2613.00
IUUC-Csa-023230	Chlorocebus sabaeus	97.55	0.00e+00	2864.00
IUUC-Cho-024711	Choloepus hoffmanni	93.60	0.00e+00	1610.00
IUUC-Cin-025342	Ciona intestinalis	53.11	0.00e+00	1386.00
IUUC-Csv-026031	Ciona savignyi	52.17	0.00e+00	1416.00
IUUC-Dre-027435	Danio rerio	91.10	0.00e+00	2649.00
IUUC-Dno-029954	Dasypus novemcinctus	97.73	0.00e+00	2842.00
IUUC-Dor-030734	Dipodomys ordii	93.13	0.00e+00	1421.00
IUUC-Dme-031739	Drosophila melanogaster	60.28	0.00e+00	1635.00
IUUC-Ete-033192	Echinops telfairi	90.17	0.00e+00	1179.00
IUUC-Eca-033434	Equus caballus	96.36	0.00e+00	2818.00
IUUC-Eeu-035031	Erinaceus europaeus	82.18	0.00e+00	1068.00
IUUC-Fca-035998	Felis catus	94.92	0.00e+00	2747.00
IUUC-Fal-037468	Ficedula albicollis	98.30	0.00e+00	4551.00
IUUC-Gmo-038495	Gadus morhua	91.33	0.00e+00	1375.00
IUUC-Gac-041777	Gasterosteus aculeatus	91.87	0.00e+00	2412.00
IUUC-Ggo-044677	Gorilla gorilla	93.13	0.00e+00	2675.00
IUUC-Hsa-045879	Homo sapiens	97.55	0.00e+00	2864.00
IUUC-Itr-048664	Ictidomys tridecemlineatus	97.73	0.00e+00	2867.00
IUUC-Lch-050444	Latimeria chalumnae	94.99	0.00e+00	2704.00
IUUC-Loc-051986	Lepisosteus oculatus	90.62	0.00e+00	2637.00
IUUC-Laf-054230	Loxodonta africana	97.20	0.00e+00	2799.00
IUUC-Mcc-054787	Macaca mulatta	97.55	0.00e+00	2864.00
IUUC-Meu-056502	Macropus eugenii	87.83	0.00e+00	1297.00
IUUC-Mga-059409	Meleagris gallopavo	99.72	0.00e+00	1962.00
IUUC-Mmr-061667	Microcebus murinus	96.38	0.00e+00	2825.00
IUUC-Mdo-061960	Monodelphis domestica	97.67	0.00e+00	2850.00
IUUC-Mmu-063941	Mus musculus	96.19	0.00e+00	2799.00
IUUC-Mpu-065939	Mustela putorius furo	97.43	0.00e+00	2863.00
IUUC-Mlu-068112	Myotis lucifugus	97.31	0.00e+00	2862.00
IUUC-Nle-069001	Nomascus leucogenys	97.55	0.00e+00	2865.00
IUUC-Opr-071222	Ochotona princeps	93.21	0.00e+00	2086.00
IUUC-Ont-072101	Oreochromis niloticus	87.00	0.00e+00	2637.00
IUUC-Oan-072814	Ornithorhynchus anatinus	98.09	0.00e+00	2861.00
IUUC-Ocu-074011	Oryctolagus cuniculus	97.49	0.00e+00	2865.00
IUUC-Ola-086412	Oryzias latipes	91.87	0.00e+00	2422.00
IUUC-Oar-089668	Ovis aries	97.43	0.00e+00	2859.00
IUUC-Ptr-090517	Pan troglodytes	96.66	0.00e+00	2812.00
IUUC-Pan-091849	Papio anubis	94.26	0.00e+00	2726.00
IUUC-Psi-093390	Pelodiscus sinensis	96.19	0.00e+00	4415.00
IUUC-Pma-094628	Petromyzon marinus	83.92	0.00e+00	1602.00
IUUC-Pfo-097075	Poecilia formosa	85.29	0.00e+00	2890.00
IUUC-Pab-098176	Pongo abelii	97.55	0.00e+00	2864.00
IUUC-Pca-101123	Procavia capensis	90.23	0.00e+00	1545.00
IUUC-Pva-103008	Pteropus vampyrus	98.75	0.00e+00	1587.00
IUUC-Rno-105885	Rattus norvegicus	96.89	0.00e+00	2848.00
IUUC-Sha-107048	Sarcophilus harrisii	97.21	0.00e+00	2839.00
IUUC-Sar-113071	Sorex araneus	93.05	0.00e+00	1270.00
IUUC-Ssc-115963	Sus scrofa	96.83	0.00e+00	2843.00
IUUC-Tgu-117167	Taeniopygia guttata	99.30	0.00e+00	1709.00
IUUC-Tru-118626	Takifugu rubripes	92.88	0.00e+00	2480.00
IUUC-Tsy-119504	Tarsius syrichta	94.07	0.00e+00	2263.00
IUUC-Tni-119877	Tetraodon nigroviridis	92.11	0.00e+00	2423.00
IUUC-Tbe-127602	Tupaia belangeri	89.19	0.00e+00	1025.00
IUUC-Ttr-128394	Tursiops truncatus	96.16	0.00e+00	1666.00
IUUC-Vpa-130280	Vicugna pacos	96.77	0.00e+00	2832.00
IUUC-Xtr-131787	Xenopus tropicalis	83.91	0.00e+00	3969.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence