iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Itr-048907

Ensembl Protein ID

ENSSTOP00000017577.1

UniProt Accession

I3MZN1; I3MZN1_ICTTR

Genbank Protein ID

ENSSTOP00000017577

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

AGTP01062803

Gene Name

KMT2B

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000027453.1	ENSSTOT00000026389.1	ENSSTOP00000017577.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.80e-28	98.5	1157	1210

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsek..wiCpkCrsk 54
           k+C+vCg++g+++k+l+eCe+Cr+++HpaCl++s ++++ ++++  wiC+ C ++
   Q: 1157 KFCHVCGRKGRGSKHLLECERCRHAYHPACLGPS-YPTRATRKRrhWICSACVRC 1210
           58********************************.88888877777******876 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

XGRGRGWGPG PGRGCVPEEE SSDGDSDDEE FQGFHSDEDV APSSLRSALR SQRGRAPRGR 60
GRKHKTTLLP PPRLSDVTPT PPKTPARKRG EEGTERMVQA LTELLRRAQA PPAPRSRACE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

NGGGGCCGGG GCCGAGGCTG GGGCCCGGGG CCGGGCCGAG GCTGCGTGCC AGAGGAGGAG 60
AGCAGTGACG GGGATTCCGA CGATGAGGTG AGGTAGTCGG AGGCGTCCCC CGCGCCGGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011989--ARM-like
IPR001487--Bromodomain
IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS51058--ZF_CXXC
PS50016--ZF_PHD_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET
PF02008--zf-CXXC

SMART

SM00542--FYRC
SM00541--FYRN
SM00249--PHD
SM00508--PostSET
SM00317--SET

Gene Ontology

GO:0035097--C:histone methyltransferase complex
GO:0003677--F:DNA binding
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0008270--F:zinc ion binding
GO:0016458--P:gene silencing
GO:0080182--P:histone H3-K4 trimethylation
GO:0007613--P:memory
GO:0009994--P:oocyte differentiation
GO:0001541--P:ovarian follicle development
GO:0030728--P:ovulation
GO:0051569--P:regulation of histone H3-K4 methylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002367	Ailuropoda melanoleuca	91.95	0.00e+00	2489.00
IUUC-Atr-002455	Amborella trichopoda	48.10	3.00e-37	150.00
IUUC-Aca-004718	Anolis carolinensis	57.98	0.00e+00	1491.00
IUUC-Aly-006448	Arabidopsis lyrata	48.10	4.00e-37	150.00
IUUC-Ath-006690	Arabidopsis thaliana	44.16	3.00e-35	143.00
IUUC-Ame-010705	Astyanax mexicanus	44.64	0.00e+00	931.00
IUUC-Bta-013578	Bos taurus	93.61	0.00e+00	2184.00
IUUC-Bdi-014882	Brachypodium distachyon	33.99	1.00e-27	117.00
IUUC-Bol-016540	Brassica oleracea	44.81	8.00e-36	145.00
IUUC-Bra-017422	Brassica rapa	33.98	7.00e-28	119.00
IUUC-Cja-019138	Callithrix jacchus	88.29	0.00e+00	2534.00
IUUC-Cfa-020020	Canis familiaris	92.81	0.00e+00	2395.00
IUUC-Cpo-021552	Cavia porcellus	90.01	0.00e+00	3229.00
IUUC-Cre-022891	Chlamydomonas reinhardtii	53.12	1.00e-37	153.00
IUUC-Csa-024216	Chlorocebus sabaeus	91.15	0.00e+00	2523.00
IUUC-Cho-024565	Choloepus hoffmanni	77.16	4.00e-168	586.00
IUUC-Cin-025724	Ciona intestinalis	54.52	2.00e-95	343.00
IUUC-Csv-026268	Ciona savignyi	39.67	1.00e-129	457.00
IUUC-Dre-027440	Danio rerio	48.39	0.00e+00	782.00
IUUC-Dno-029583	Dasypus novemcinctus	93.34	0.00e+00	2284.00
IUUC-Dor-030903	Dipodomys ordii	88.72	0.00e+00	2200.00
IUUC-Dme-032023	Drosophila melanogaster	47.28	2.00e-92	336.00
IUUC-Eca-034026	Equus caballus	95.07	0.00e+00	1961.00
IUUC-Eeu-034687	Erinaceus europaeus	92.47	0.00e+00	1122.00
IUUC-Fca-036311	Felis catus	93.90	0.00e+00	2522.00
IUUC-Gmo-039265	Gadus morhua	46.37	0.00e+00	828.00
IUUC-Gac-042202	Gasterosteus aculeatus	48.41	0.00e+00	747.00
IUUC-Gma-043554	Glycine max	47.06	7.00e-36	145.00
IUUC-Ggo-044791	Gorilla gorilla	93.97	0.00e+00	2155.00
IUUC-Hsa-046988	Homo sapiens	91.09	0.00e+00	2469.00
IUUC-Hvu-047762	Hordeum vulgare	36.57	3.00e-20	93.20
IUUC-Lpe-051476	Leersia perrieri	31.96	2.00e-24	107.00
IUUC-Laf-053703	Loxodonta africana	93.04	0.00e+00	2227.00
IUUC-Mcc-054782	Macaca mulatta	90.11	0.00e+00	2508.00
IUUC-Meu-056046	Macropus eugenii	79.66	0.00e+00	1862.00
IUUC-Mtr-058327	Medicago truncatula	40.44	2.00e-36	147.00
IUUC-Mmr-061316	Microcebus murinus	90.15	0.00e+00	2838.00
IUUC-Mdo-062648	Monodelphis domestica	79.16	0.00e+00	2004.00
IUUC-Mmu-063579	Mus musculus	91.01	0.00e+00	3296.00
IUUC-Mac-064935	Musa acuminata	32.41	4.00e-30	126.00
IUUC-Mpu-066710	Mustela putorius furo	92.54	0.00e+00	2486.00
IUUC-Mlu-067559	Myotis lucifugus	88.93	0.00e+00	2440.00
IUUC-Nle-070085	Nomascus leucogenys	88.59	0.00e+00	2189.00
IUUC-Opr-071148	Ochotona princeps	89.44	0.00e+00	3204.00
IUUC-Ont-071626	Oreochromis niloticus	49.13	0.00e+00	788.00
IUUC-Ocu-074475	Oryctolagus cuniculus	90.05	0.00e+00	3141.00
IUUC-Obr-076458	Oryza brachyantha	34.98	3.00e-28	120.00
IUUC-Ogl-077851	Oryza glaberrima	36.81	2.00e-28	120.00
IUUC-Ogu-078706	Oryza glumaepatula	36.81	1.00e-28	121.00
IUUC-Oin-079802	Oryza indica	31.90	1.00e-23	104.00
IUUC-Olo-080577	Oryza longistaminata	40.38	1.00e-33	138.00
IUUC-Osa-085421	Oryza sativa	36.81	3.00e-28	120.00
IUUC-Ola-086609	Oryzias latipes	52.23	0.00e+00	756.00
IUUC-Oga-088140	Otolemur garnettii	90.30	0.00e+00	2417.00
IUUC-Oar-089447	Ovis aries	92.78	0.00e+00	2033.00
IUUC-Ptr-090902	Pan troglodytes	91.09	0.00e+00	2478.00
IUUC-Pan-091930	Papio anubis	91.03	0.00e+00	2521.00
IUUC-Ppa-095221	Physcomitrella patens	37.02	4.00e-31	129.00
IUUC-Pfo-096884	Poecilia formosa	46.70	0.00e+00	908.00
IUUC-Pab-098404	Pongo abelii	78.82	0.00e+00	1657.00
IUUC-Pop-099585	Populus trichocarpa	34.01	4.00e-27	116.00
IUUC-Pca-100949	Procavia capensis	81.47	0.00e+00	1236.00
IUUC-Ppe-101920	Prunus persica	33.50	4.00e-28	119.00
IUUC-Pva-102634	Pteropus vampyrus	89.99	0.00e+00	2519.00
IUUC-Rno-105870	Rattus norvegicus	90.14	0.00e+00	3351.00
IUUC-Smo-109164	Selaginella moellendorffii	48.70	4.00e-36	146.00
IUUC-Sit-110552	Setaria italica	34.83	4.00e-29	122.00
IUUC-Sly-111158	Solanum lycopersicum	38.32	2.00e-34	140.00
IUUC-Stu-112529	Solanum tuberosum	47.06	2.00e-36	147.00
IUUC-Sar-113289	Sorex araneus	89.51	0.00e+00	1767.00
IUUC-Ssc-115509	Sus scrofa	91.60	0.00e+00	2491.00
IUUC-Tru-117736	Takifugu rubripes	45.02	0.00e+00	827.00
IUUC-Tca-121624	Theobroma cacao	33.17	5.00e-28	119.00
IUUC-Tae-125629	Triticum aestivum	36.57	2.00e-20	93.60
IUUC-Tbe-127825	Tupaia belangeri	88.37	0.00e+00	1461.00
IUUC-Ttr-128754	Tursiops truncatus	93.09	0.00e+00	1233.00
IUUC-Vvi-131476	Vitis vinifera	47.47	4.00e-37	150.00
IUUC-Xtr-132838	Xenopus tropicalis	48.66	0.00e+00	1023.00
IUUC-Xma-133119	Xiphophorus maculatus	43.15	0.00e+00	977.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence