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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046331
UUCD1 version UUC-HoS-00465
Ensembl Protein ID ENSP00000449784.2
UniProt Accession Q9Y4D8; L8B0P6; Q3MJD5; Q6P0A0; Q7L530; Q8NB70; Q8WU73; Q96NT9; Q9NZS4; Q9UFT6; HECD4_HUMAN
Genbank Protein ID BAM76724.1; AAH06270.2; AAH21144.1; AAH65706.1; AAI01483.1; BAC03671.1; BAA31589.3; AAF36539.1; CAB55944.1
Protein Name Probable E3 ubiquitin-protein ligase HECTD4; HECT domain-containing protein 4; HECT-type E3 ubiquitin transferase HECTD4
Genbank Nucleotide ID AB777655; AC073575; BC021144; BC065706; BC101482; AK054654; AB014514; AF174498; AL117469
Gene Name HECTD4; C12orf51; KIAA0614
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000173064.11 ENST00000377560.9 ENSP00000366783.7
ENSG00000173064.11 ENST00000548588.2 ENSP00000477079.1
ENSG00000173064.11 ENST00000550724.2 ENSP00000448061.2
ENSG00000173064.11 ENST00000550722.5 ENSP00000449784.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
ArrayExpressTCGAICGCTHPA
HPM
DNA & RNA Element
AREsitecircRNADbCircNetTRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
Mentha
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/HECT HECT 20175895
Classification
Family E-value Score Start End
E3 activity/HECT 2.70e-80 271.9 3918 4278
Active Site
Position(s) Description Evidence
3964 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.......lysendketlqpnpdsglknpehlklFeflGrllgkalqdgr 86
           d ++ ++++f+gEe+++++G++r+fl++++kelq+++l+l+       ++++++k+ l+p+p ++     +++l +flG+llg+a++ + 
   Q: 3918 DPTYAFNIRFTGEEVHGTSGSFRHFLWQVCKELQSSSLSLLllcpssaVNKNKGKYILTPSPITY----GEEQLLHFLGQLLGIAIRADV 4003
           5667788*********************************9999999888888***********9....789****************** PP
   S: 87   lldlplsksfyklllgkklsl.edleevdpelyks.lkeikenaesdieelgldltfs..vseei...............lgetkeeeLk 157
           +l+l+l +sf+k+l+g++l+  +dl+e d  +y++ +k+ + n+e+++e+l+++++++  +  ++                 + +e+eL+
   Q: 4004 PLPLDLLPSFWKTLVGEPLDPeQDLQEADILTYNYvKKFESINDETELEALCAEIASQhlA--TEspdspnkpccrftylTMTGEEVELC 4091
           *********************9*************56666677789999999999999532..33468999*******6555556667** PP
   S: 158  pgGenipVtneNkeeYvklvveyrlke.gikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspai 246
           ++G++i V++eNk+ Y  ++ ++rl+e +  e+v+a+r+G+ ++ipl+ll+++++ e+el +cG ++i++e lk++t+y+ g++e++++i
   Q: 4092 SRGRHILVAWENKDIYAAAIRSLRLRElQNVECVTAVRAGLGSIIPLQLLTMLSPLEMELRTCGLPYINLEFLKAHTMYQVGLMETDQHI 4181
           ***************************9************************************************************** PP
   S: 247  qwFwevleefsseerkafLqFvTgssrlPl......gGfaelk....prlfvirk...dasddrlPssnTCfnyLkLPeYsskeilkekL 323
           ++Fw +le+f++ee ++f++F+++++r+P+      gG ++ +    p+++  ++    + d+r+++++TC++++kLP+Yss ei+ ekL
   Q: 4182 EFFWGALEMFTQEELCKFIKFACNQERIPFtcpckdGGPDTAHvppyPMKIAPPDgtaGSPDSRYIRVETCMFMIKLPQYSSLEIMLEKL 4271
           ************************************99999999988888888889955555**************************** PP
   S: 324  lyAieet 330
           ++Ai+++
   Q: 4272 RCAIHYR 4278
           ****986 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
 E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Protein Sequence
(Fasta)
MGLLLVFPLI QSQSRTDPSL CNITAEVLLN CLRDCQPLSL TKEPADCLNG IETLLCSWLE 60
ETSDTGRHIP HKQKENAAAA LVALACARGS LKTFVHTVHL LQKQTDLGSL PVADVLYRLL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046331|E3,HECT|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGCCGGGAG CCCCGCCCCC AACATGGCGT CTCACTGACA GTTGGTTGCC GAGCGGCAGA 60
GGCGGATCCT GCTCCTGAGG GCGGCGGCGG CGGCGGCGGC GGCGGCGGCG GCAGGGCCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046331|E3,HECT|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
Interpro

IPR000569--HECT_dom
PROSITE

PS50237--HECT
Pfam

PF00632--HECT
SMART

SM00119--HECTc
Gene Ontology

GO:0016021--C:integral component of membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0042593--P:glucose homeostasis
GO:0006006--P:glucose metabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002256 Ailuropoda melanoleuca 96.95 0.00e+00 7261.00
IUUC-Apl-004161 Anas platyrhynchos 92.53 0.00e+00 5179.00
IUUC-Aca-005341 Anolis carolinensis 88.67 0.00e+00 6638.00
IUUC-Ame-011574 Astyanax mexicanus 81.33 0.00e+00 4880.00
IUUC-Bta-012514 Bos taurus 97.50 0.00e+00 1946.00
IUUC-Cja-019148 Callithrix jacchus 98.48 0.00e+00 5356.00
IUUC-Cfa-020499 Canis familiaris 97.83 0.00e+00 7777.00
IUUC-Cpo-021894 Cavia porcellus 97.25 0.00e+00 2773.00
IUUC-Csa-023079 Chlorocebus sabaeus 99.32 0.00e+00 7914.00
IUUC-Cho-024415 Choloepus hoffmanni 92.84 0.00e+00 5092.00
IUUC-Dre-027452 Danio rerio 79.57 0.00e+00 4859.00
IUUC-Dno-029595 Dasypus novemcinctus 97.06 0.00e+00 7757.00
IUUC-Dor-030849 Dipodomys ordii 96.58 0.00e+00 1796.00
IUUC-Ete-032563 Echinops telfairi 90.33 0.00e+00 1610.00
IUUC-Eca-034202 Equus caballus 97.00 0.00e+00 7183.00
IUUC-Eeu-035175 Erinaceus europaeus 96.93 0.00e+00 1071.00
IUUC-Fca-036295 Felis catus 97.40 0.00e+00 7097.00
IUUC-Fal-037003 Ficedula albicollis 92.65 0.00e+00 6727.00
IUUC-Gmo-038579 Gadus morhua 84.51 0.00e+00 2878.00
IUUC-Gga-040961 Gallus gallus 92.77 0.00e+00 7491.00
IUUC-Gac-041899 Gasterosteus aculeatus 84.30 0.00e+00 2911.00
IUUC-Ggo-045099 Gorilla gorilla 99.83 0.00e+00 6544.00
IUUC-Itr-048190 Ictidomys tridecemlineatus 96.84 0.00e+00 2149.00
IUUC-Lch-049923 Latimeria chalumnae 84.23 0.00e+00 2659.00
IUUC-Loc-052630 Lepisosteus oculatus 84.09 0.00e+00 4044.00
IUUC-Laf-053394 Loxodonta africana 97.15 0.00e+00 7614.00
IUUC-Mcc-055763 Macaca mulatta 99.32 0.00e+00 7905.00
IUUC-Meu-056039 Macropus eugenii 89.10 0.00e+00 5095.00
IUUC-Mga-059500 Meleagris gallopavo 91.59 0.00e+00 6974.00
IUUC-Mmr-060868 Microcebus murinus 94.82 0.00e+00 7557.00
IUUC-Mdo-062772 Monodelphis domestica 94.33 0.00e+00 7629.00
IUUC-Mmu-063606 Mus musculus 96.83 0.00e+00 7774.00
IUUC-Mpu-065860 Mustela putorius furo 95.03 0.00e+00 7130.00
IUUC-Mlu-067376 Myotis lucifugus 96.37 0.00e+00 5376.00
IUUC-Nle-069693 Nomascus leucogenys 97.46 0.00e+00 7755.00
IUUC-Opr-071065 Ochotona princeps 94.87 0.00e+00 1220.00
IUUC-Ont-072470 Oreochromis niloticus 82.15 0.00e+00 4650.00
IUUC-Oan-073693 Ornithorhynchus anatinus 92.69 0.00e+00 5231.00
IUUC-Ocu-074032 Oryctolagus cuniculus 96.99 0.00e+00 7815.00
IUUC-Ola-087433 Oryzias latipes 83.28 0.00e+00 1598.00
IUUC-Oga-088546 Otolemur garnettii 98.30 0.00e+00 7016.00
IUUC-Oar-089643 Ovis aries 91.65 0.00e+00 761.00
IUUC-Ptr-090504 Pan troglodytes 98.83 0.00e+00 7442.00
IUUC-Pan-092543 Papio anubis 99.18 0.00e+00 7895.00
IUUC-Psi-093952 Pelodiscus sinensis 89.53 0.00e+00 6854.00
IUUC-Pfo-096356 Poecilia formosa 80.79 0.00e+00 6620.00
IUUC-Pab-098240 Pongo abelii 99.39 0.00e+00 7906.00
IUUC-Pca-100994 Procavia capensis 97.13 0.00e+00 3006.00
IUUC-Pva-102263 Pteropus vampyrus 95.51 0.00e+00 7130.00
IUUC-Rno-104888 Rattus norvegicus 96.71 0.00e+00 7506.00
IUUC-Sha-106944 Sarcophilus harrisii 92.78 0.00e+00 7119.00
IUUC-Sar-113556 Sorex araneus 83.38 0.00e+00 976.00
IUUC-Ssc-116187 Sus scrofa 98.01 0.00e+00 5187.00
IUUC-Tgu-116655 Taeniopygia guttata 92.32 0.00e+00 5127.00
IUUC-Tru-118093 Takifugu rubripes 83.39 0.00e+00 3013.00
IUUC-Tni-119739 Tetraodon nigroviridis 83.38 0.00e+00 1608.00
IUUC-Tbe-127962 Tupaia belangeri 93.26 0.00e+00 1224.00
IUUC-Ttr-128819 Tursiops truncatus 93.15 0.00e+00 2879.00
IUUC-Vpa-130482 Vicugna pacos 94.21 0.00e+00 4463.00
IUUC-Xtr-132222 Xenopus tropicalis 86.30 0.00e+00 6611.00
Created Date 25-Jun-2017

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