iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-034044

UUCD1 version

UUC-EqC-00658

Ensembl Protein ID

ENSECAP00000009563.1

UniProt Accession

F7AJR0; F7AJR0_HORSE

Protein Name

Uncharacterized protein

Gene Name

ZNRF3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000011694.1	ENSECAT00000012138.1	ENSECAP00000009563.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.00e-05	26.1	193	234

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiCle +   ++++v pC H fh++C+  w        ++ +CP Cr
   Q: 193  CAICLEKYidGEELRVIPCTHRFHRKCVDPW------LLQHHTCPHCR 234
           ********66334******************......9999******8 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MHPLGLCNNN DEEDLYEYGW VGVVKLEQPE LDPKPCLTVL GKAKRAVQRG ATAVIFDVSE 60
NPEAIDQLNQ GSEDPLKRPV VYVKGADAIK LMNIVNKQKV ARARIQHRPP RQPTEYFDMG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTCCTAGAT GCACCCACTG GGCCTGTGTA ATAACAATGA CGAAGAGGAC TTGTATGAAT 60
ATGGCTGGGT AGGAGTGGTG AAGCTGGAAC AGCCAGAGTT GGACCCGAAA CCATGCCTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005887--C:integral component of plasma membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0060070--P:canonical Wnt signaling pathway
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:2000051--P:negative regulation of non-canonical Wnt signaling pathway
GO:0072089--P:stem cell proliferation
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0038018--P:Wnt receptor catabolic process
GO:0060071--P:Wnt signaling pathway, planar cell polarity pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001916	Ailuropoda melanoleuca	87.95	0.00e+00	1282.00
IUUC-Apl-004188	Anas platyrhynchos	73.89	0.00e+00	1048.00
IUUC-Aca-004606	Anolis carolinensis	35.87	2.00e-26	113.00
IUUC-Aly-005850	Arabidopsis lyrata	42.68	5.00e-15	73.20
IUUC-Ath-007372	Arabidopsis thaliana	42.68	2.00e-14	71.60
IUUC-Ame-011764	Astyanax mexicanus	62.66	0.00e+00	739.00
IUUC-Bta-012478	Bos taurus	67.16	0.00e+00	670.00
IUUC-Bol-016217	Brassica oleracea	52.73	4.00e-14	70.50
IUUC-Bra-017407	Brassica rapa	52.73	3.00e-14	70.50
IUUC-Cja-019504	Callithrix jacchus	87.08	0.00e+00	1317.00
IUUC-Cfa-020048	Canis familiaris	89.32	0.00e+00	1333.00
IUUC-Cpo-021725	Cavia porcellus	82.67	0.00e+00	1214.00
IUUC-Csa-023586	Chlorocebus sabaeus	86.59	0.00e+00	1265.00
IUUC-Cho-024867	Choloepus hoffmanni	92.44	0.00e+00	693.00
IUUC-Cin-025569	Ciona intestinalis	46.22	2.00e-55	209.00
IUUC-Csv-025869	Ciona savignyi	45.04	6.00e-49	188.00
IUUC-Dre-027553	Danio rerio	64.71	0.00e+00	803.00
IUUC-Dno-029370	Dasypus novemcinctus	85.45	0.00e+00	1209.00
IUUC-Dor-030816	Dipodomys ordii	78.59	0.00e+00	1106.00
IUUC-Ete-033060	Echinops telfairi	74.80	0.00e+00	839.00
IUUC-Eeu-034591	Erinaceus europaeus	69.51	4.00e-145	508.00
IUUC-Fca-036000	Felis catus	92.54	0.00e+00	1371.00
IUUC-Fal-037147	Ficedula albicollis	71.79	0.00e+00	1055.00
IUUC-Gmo-039099	Gadus morhua	50.60	2.00e-120	426.00
IUUC-Gga-041243	Gallus gallus	68.76	0.00e+00	834.00
IUUC-Gac-041340	Gasterosteus aculeatus	50.69	7.00e-118	417.00
IUUC-Gma-044387	Glycine max	53.06	3.00e-14	71.60
IUUC-Ggo-044953	Gorilla gorilla	89.93	0.00e+00	1302.00
IUUC-Hsa-046484	Homo sapiens	88.93	0.00e+00	1310.00
IUUC-Itr-048470	Ictidomys tridecemlineatus	87.06	0.00e+00	1295.00
IUUC-Lch-050004	Latimeria chalumnae	59.18	0.00e+00	683.00
IUUC-Loc-051830	Lepisosteus oculatus	66.31	0.00e+00	781.00
IUUC-Laf-053975	Loxodonta africana	85.59	0.00e+00	1239.00
IUUC-Mcc-055302	Macaca mulatta	86.34	0.00e+00	1231.00
IUUC-Meu-056263	Macropus eugenii	76.94	0.00e+00	798.00
IUUC-Mtr-058744	Medicago truncatula	54.17	2.00e-13	68.20
IUUC-Mga-059706	Meleagris gallopavo	72.46	0.00e+00	1072.00
IUUC-Mmr-061372	Microcebus murinus	86.65	0.00e+00	1211.00
IUUC-Mdo-062651	Monodelphis domestica	66.03	0.00e+00	867.00
IUUC-Mmu-064339	Mus musculus	82.30	0.00e+00	1212.00
IUUC-Mac-065356	Musa acuminata	50.00	6.00e-13	68.20
IUUC-Mpu-066211	Mustela putorius furo	87.70	0.00e+00	1290.00
IUUC-Mlu-067058	Myotis lucifugus	90.56	0.00e+00	1270.00
IUUC-Nle-069886	Nomascus leucogenys	87.82	0.00e+00	1291.00
IUUC-Opr-070218	Ochotona princeps	80.00	0.00e+00	1076.00
IUUC-Ont-072483	Oreochromis niloticus	62.16	0.00e+00	776.00
IUUC-Oan-073718	Ornithorhynchus anatinus	72.38	0.00e+00	915.00
IUUC-Ocu-073847	Oryctolagus cuniculus	79.69	0.00e+00	1062.00
IUUC-Oin-079182	Oryza indica	53.06	2.00e-11	62.80
IUUC-Opu-083306	Oryza punctata	67.44	7.00e-13	67.00
IUUC-Oru-084953	Oryza rufipogon	53.06	3.00e-11	62.80
IUUC-Osa-085734	Oryza sativa	53.06	3.00e-11	62.80
IUUC-Ola-087358	Oryzias latipes	62.83	0.00e+00	780.00
IUUC-Oga-088362	Otolemur garnettii	85.56	0.00e+00	1305.00
IUUC-Oar-090197	Ovis aries	99.49	1.00e-96	347.00
IUUC-Ptr-091350	Pan troglodytes	88.68	0.00e+00	1308.00
IUUC-Pan-091700	Papio anubis	86.59	0.00e+00	1228.00
IUUC-Psi-093301	Pelodiscus sinensis	69.78	0.00e+00	998.00
IUUC-Pfo-096917	Poecilia formosa	62.44	0.00e+00	763.00
IUUC-Pab-097932	Pongo abelii	88.11	0.00e+00	1327.00
IUUC-Pop-099640	Populus trichocarpa	57.14	2.00e-14	72.40
IUUC-Pca-101054	Procavia capensis	93.21	0.00e+00	968.00
IUUC-Pva-102879	Pteropus vampyrus	92.60	0.00e+00	1373.00
IUUC-Pgr-103476	Puccinia graminis	41.27	3.00e-09	55.80
IUUC-Sha-106507	Sarcophilus harrisii	54.30	3.00e-164	572.00
IUUC-Sit-110656	Setaria italica	67.44	7.00e-13	66.60
IUUC-Stu-112289	Solanum tuberosum	38.96	5.00e-13	67.40
IUUC-Sar-113182	Sorex araneus	81.98	3.00e-111	395.00
IUUC-Ssc-115966	Sus scrofa	84.72	0.00e+00	1104.00
IUUC-Tgu-116864	Taeniopygia guttata	63.87	0.00e+00	691.00
IUUC-Tru-118502	Takifugu rubripes	61.55	0.00e+00	748.00
IUUC-Tsy-119210	Tarsius syrichta	86.47	0.00e+00	1244.00
IUUC-Tni-120344	Tetraodon nigroviridis	53.00	8.00e-127	447.00
IUUC-Tca-120966	Theobroma cacao	48.44	7.00e-14	71.20
IUUC-Tbe-127735	Tupaia belangeri	82.93	7.00e-137	481.00
IUUC-Ttr-128714	Tursiops truncatus	77.38	0.00e+00	1011.00
IUUC-Vvi-131280	Vitis vinifera	31.50	4.00e-13	68.90
IUUC-Xtr-132280	Xenopus tropicalis	59.42	0.00e+00	692.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence